ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Biopsy"

  • 2017 American Transplant Congress

    The Immunophenotype of Peritubular Capillaritis in Renal Transplant Biopsies.

    T. Chen,1 L. Rasch,1 T. Al Johani,2 H. McPhail,1 M. Willicombe,3 A. McLean,3 J. Galliford,3 T. Cook,1 C. Roufosse.1

    1Centre for Complement and Inflammation Research, Imperial College, London, United Kingdom; 2Cellular Pathology, King Saud University, Riyadh, Saudi Arabia; 3Dept Renal Medicine, Imperial College Healthcare NHS Trust, London, United Kingdom

    Background: Peritubular capillaritis (ptc) is a feature of acute antibody-mediated rejection (ABMR) in the renal allograft. However, it is not an specific feature for ABMR…
  • 2017 American Transplant Congress

    Quantitative Gene Expression Analysis of CRM-Panel Genes Using FFPE Kidney Tissues for Transplant Injuries.

    T. Sigdel, M. Nguyen, D. Dobi, S.-C. Hsieh, J. Liberto, F. Vincenti, M. Sarwal, Z. Laszik.

    University of California San Francisco, San Francisco

    Background: A common immune response module (CRM) of 11 genes was identified to define acute rejection (AR) through meta-analyses of 1030 different engrafted tissues including…
  • 2017 American Transplant Congress

    Integrated Magnetic-Electrochemical Exosome (iMEX) Technology to Detect Rejection in Kidney Transplant Recipients.

    J. Assaker, J. Park, S. Routray, S. Eskandari, H. Lee, J. Azzi.

    Transplantation Research Center, Harvard Medical School, Boston; Exosome Diagnostic Inc, Cambridge

    Methods for monitoring clinical rejection including increases in serum creatinine and urinary protein excretion may not reflect subclinical rejection. Similarly repeat biopsy may result in…
  • 2017 American Transplant Congress

    Transcriptomic Analysis Revealed a Fibrotic Role of Epithelial Cells Originated from the Recipient in Kidney Transplant.

    W. Zhang,1 Z. Yi,1 E. Stahl,2 M. Menon,1 K. Keung,3 K. Hao,2 P. O'Connell,3 B. Murphy.1

    1Medicine, Icahn School of Medicine at Mount Sinai, New York, NY; 2Department of Genetics and Genomic Science, Ichan School of Medicine at Mount Sinai, New York, NY; 3Renal Unit, University of Sydney at Westmead Hospital, Sydney, Australia

    Renal fibrosis is one of major causes for chronic renal dysfunction in kidney diseases and graft loss in kidney transplant. With an aim to better…
  • 2017 American Transplant Congress

    Persistence/Progression of Early Banff Borderline Changes (BBC) Is Associated with Chronic Renal Allograft Damage and Can Be Predicted by B Cell Cytokine Profile.

    A. Cherukuri, A. Sharma, R. Mehta, S. Hariharan, D. Rothstein.

    UPMC, Pittsburgh

    The clinical significance of early histological BBC in kidney transplant recipients (KTR) is unclear. It is also unknown if biomarkers predict progression to acute rejection…
  • 2017 American Transplant Congress

    Does Histologic Grade in BK Polyoma Nephropathy Associate with Viral Load, Allograft Dysfunction or Allograft Loss? A Single Center Experience.

    M. Swee,1 S. Kuppachi,1 M. Fraer,1 P. Rastogi,2 P. Ten Eyck,1 M. Sanders.1

    1Nephrology, University of Iowa, Iowa City, IA; 2Pathology, University of Iowa, Iowa City, IA

    Purpose: BK polyoma nephropathy (BKPyN) is a well-recognized cause of allograft dysfunction and loss after kidney transplant. Despite increased recognition, it is unclear if changes…
  • 2017 American Transplant Congress

    Impact of Six-Month Surveillance Biopsies and Monitoring in Pediatric Renal Transplant Recipients.

    J. Lyons,1,2,3 D. Ranch,1,2 R. Hall,1,2,3 P. Maxwell,1,2,3 K. Hitchman,1,2 Y. Hirase,3 B. Crowther.1,2,3

    1University Health System, San Antonio, TX; 2University of Texas Health Science Center San Antonio, San Antonio, TX; 3University of Texas College of Pharmacy, Austin, TX

    Purpose: Evaluate the utility of surveillance biopsies and monitoring 6 months post-transplant.Methods: A retrospective single center chart review of pediatric renal transplant recipients from 01/2011–10/2015…
  • 2017 American Transplant Congress

    Outcomes of Protocol Allograft Kidney Biopsy in DeNovo Donor Specific Antibodies.

    S. Parajuli, P. Reville, T. Ellis, A. Djamali, D. Mandelbrot.

    University of Wisconsin, Madison, WI

    There is limited information about the role of protocol kidney biopsies for de-novo donor specific antibodies (dnDSA) in kidney transplant recipients (KTR). We initiated monitoring…
  • 2017 American Transplant Congress

    Minor Degree of Persistent Microscopic Hematuria in Potential Living Kidney Donors Is Associated with Pathology.

    V. Kumar,1 M. Saha,1 J. Locke,2 R. Gaston,1 M. Hanaway.2

    1Medicine, Division of Nephrology, University of Alabama at Birmingham, Birmingham; 2Surgery, University of Alabama at Birmingham, Birmingham

    Purpose: A threshold of ≥3 rbc/hpf (red blood cells/high power field) or higher prompts additional testing when evaluating potential living kidney donors at most centers…
  • 2017 American Transplant Congress

    Importance of HLA-DR Expression in Pediatric Renal Transplant Biopsies.

    O. Moussa, S. Self, K. Twombley.

    Medical University of South Carolina, Charleston

    ObjectiveTo determine which types of injuries in pediatric kidney transplant patients were associated with HLA-DR expression.Design/MethodsA retrospective chart review was conducted of children receiving a…
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