2017 American Transplant Congress
Rejection of Human Kidney Allografts According to BANFF Classification Is Associated with a Chemokine-Enriched Protein Microenvironment in Biopsy Tssue.
Background: Expression profiling efforts of biopsy tissue after kidney transplantation indicate that rejection can be defined by distinct signatures. Based on pathological evaluation (BANFF) as…2017 American Transplant Congress
Human Transitional B Cell Cytokine Profile Predicts Renal Allograft Rejection and Clinical Course.
In Kidney Transplant Recipients (KTRs), non-invasive predictive biomarkers that allow early intervention are limited. Here we report findings from a prospective longitudinal study using B…2017 American Transplant Congress
The Immunophenotype of Peritubular Capillaritis in Renal Transplant Biopsies.
Background: Peritubular capillaritis (ptc) is a feature of acute antibody-mediated rejection (ABMR) in the renal allograft. However, it is not an specific feature for ABMR…2017 American Transplant Congress
Quantitative Gene Expression Analysis of CRM-Panel Genes Using FFPE Kidney Tissues for Transplant Injuries.
University of California San Francisco, San Francisco
Background: A common immune response module (CRM) of 11 genes was identified to define acute rejection (AR) through meta-analyses of 1030 different engrafted tissues including…2017 American Transplant Congress
Integrated Magnetic-Electrochemical Exosome (iMEX) Technology to Detect Rejection in Kidney Transplant Recipients.
Transplantation Research Center, Harvard Medical School, Boston; Exosome Diagnostic Inc, Cambridge
Methods for monitoring clinical rejection including increases in serum creatinine and urinary protein excretion may not reflect subclinical rejection. Similarly repeat biopsy may result in…2017 American Transplant Congress
Transcriptomic Analysis Revealed a Fibrotic Role of Epithelial Cells Originated from the Recipient in Kidney Transplant.
Renal fibrosis is one of major causes for chronic renal dysfunction in kidney diseases and graft loss in kidney transplant. With an aim to better…2017 American Transplant Congress
Persistence/Progression of Early Banff Borderline Changes (BBC) Is Associated with Chronic Renal Allograft Damage and Can Be Predicted by B Cell Cytokine Profile.
The clinical significance of early histological BBC in kidney transplant recipients (KTR) is unclear. It is also unknown if biomarkers predict progression to acute rejection…2017 American Transplant Congress
Does Histologic Grade in BK Polyoma Nephropathy Associate with Viral Load, Allograft Dysfunction or Allograft Loss? A Single Center Experience.
1Nephrology, University of Iowa, Iowa City, IA; 2Pathology, University of Iowa, Iowa City, IA
Purpose: BK polyoma nephropathy (BKPyN) is a well-recognized cause of allograft dysfunction and loss after kidney transplant. Despite increased recognition, it is unclear if changes…2017 American Transplant Congress
Impact of Six-Month Surveillance Biopsies and Monitoring in Pediatric Renal Transplant Recipients.
Purpose: Evaluate the utility of surveillance biopsies and monitoring 6 months post-transplant.Methods: A retrospective single center chart review of pediatric renal transplant recipients from 01/2011–10/2015…2017 American Transplant Congress
Outcomes of Protocol Allograft Kidney Biopsy in DeNovo Donor Specific Antibodies.
University of Wisconsin, Madison, WI
There is limited information about the role of protocol kidney biopsies for de-novo donor specific antibodies (dnDSA) in kidney transplant recipients (KTR). We initiated monitoring…
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