Articles tagged "Biopsy"

2018 American Transplant Congress
Outcomes of C4d+ Immunostaining in Heart Transplantation: Is All Immunologic AMR Bad?
M. Rafiei, J. Patel, E. Kransdorf, R. Levine, S. Dimbil, S. Mersola, G. Esmailian, D. Geft, D. Chang, L. Czer, J. Kobashigawa.
Cedars Sinai Medical Center, Los Angeles, CA.
Purpose: Antibody-mediated rejection (AMR) remains a threat to patients (pts) following heart transplant (HTx). C4d immunostaining is one component involved in the diagnosis of AMR…
2018 American Transplant Congress
Validation Study of Gene Expression Signatures Associated with Antibody-Mediated Rejection (ABMR) and Cell-Mediated Rejection (CMR) in Renal Allograft Biopsies (Bx) Suggests Complexity of Molecular Diagnosis for ABMR Compared to CMR
H. Zhang,¹ C. Nast,² J. Doldron,² M. Cheung,² A. Vo,³ S. Jordan,³ M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; ²Pathology, Cedars-Sinai Medical Center, Los Angeles, CA; ³Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: Various molecular signatures specific to ABMR and CMR based on gene expression in renal allograft Bx or peripheral blood mononuclear cells (PBMC) of renal…
2018 American Transplant Congress
Age Difference between Donor and Recipient Predisposes to Early Interstitial Fibrosis and Tubular Atrophy in Pediatric Kidney Transplantation
S. Panombualert, M. Pearl, P. Weng, R. Ettenger.
Pediatric Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Introduction: Previous studies in adult kidney transplant recipients (KTRs) have shown that an increased age difference between donor and recipient increases the risk of arterial…
2018 American Transplant Congress
Noninvasive Quantization of Intra-Renal Allograft C4d Deposition with Targeted Ultrasound Imaging
T. Liao,¹ Y. Zhang,¹ J. Ren,² H. Zheng,¹ H. Zhang,² X. Liu,¹ T. Yin,² Q. Sun.¹
¹Organ Transplantation Research Institute, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; ²Department of Medical Ultrasound, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Antibody-mediated rejection (AMR) has emerged as the major cause of renal allograft dysfunction. C4d, a specific marker of AMR diagnosis, was strongly recommended for routine…
2018 American Transplant Congress
Recombinant Relaxin Protects Liver Transplants from Ischemia-Reperfusion Damage via Hepatocyte Glucocorticoid Receptor: From Bench-to-Bedside
S. Kageyama,¹ K. Nakamura,¹ T. Ito,¹ A. Aziz,¹ B. Ke,¹ R. Sossa,² E. Reed,² F. Kaldas,¹ R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Surgery, Division of Liver Transplantation, UCLA, Los Angeles, CA; ²Pathology, UCLA, Los Angeles, CA.
Hepatic ischemia-reperfusion injury (IRI) represents a major risk factor of early graft dysfunction and acute/chronic rejection as well as a key obstacle to expanding the…
2018 American Transplant Congress
Eluates from Fine-Needle Allograft Biopsy Increase Donor-Specific Antibody Identification in Antibody Mediated Rejection
A. Girnita,^1,2 E. Portwood,² P. Brailey,² M. Cuffy,¹ M. Cardi,¹ F. Paterno,¹ T. Diwan,¹ S. Shah,¹ A. Govil,¹ R. Alloway,¹ E. Woodle.¹
¹University of Cincinnati, Cincinnati; ²Hoxworth Blood Center, Cincinnati.
Aim. Antibody mediated rejection (AMR) represents a risk for graft loss, and the presence of circulating donor-specific antibody (cDSA) is a major criterion for AMR…
2018 American Transplant Congress
Influence of 6 Months Protocol Biopsies with and without Intervention on Course of GFR after Pediatric Renal Transplantation
L. Pape, C. Lerch, T. Ahlenstiel-Grunow, J. Bräsen, N. Kanzelmeyer.
Pediatric Nephrology, Hannover Medical School, Hannover, Germany; Pathology, Hannover Medical School, Hannover, Germany.
Data on protocol biopsies in childhood are rare. We evaluated renal function in 86 children after kidney transplantation (KTX) who underwent a protocol biopsy 6…
2017 American Transplant Congress
Reliability of Donor Kidney Biopsies from Time of Organ Recovery Compared to Immediate Post-Reperfusion Biopsies.
M. Barrett, A. Prater, E. Farkash, D. Christopher, D. Fritze, N. Matusko, R. Sung, K. Woodside.
University of Michigan, Ann Arbor
Frozen section or rapid permanent biopsies of donor kidneys are frequently obtained for higher risk kidneys. We sought to investigate agreement between the procurement donor…
2017 American Transplant Congress
Safety of Percutaneous Pancreas Allograft Biopsy in Enteric Drained Pancreas Transplants.
Y. Kassis, E. Poggio, Z. Zaky.
Nephrology and Hypertension, Cleveland Clinic Foundation, Cleveland, OH
Background: Pancreas allograft biopsy (Bx) is the gold standard in diagnosing allograft rejection. The safety of this procedure has been controversial, thus limiting its widespread…
2017 American Transplant Congress
Zero-Time Biopsy of Potential Donor Kidneys to Aid Decision-Making: A 9-Year Single-Center Experience.
Y. Luque, O. Aubert, F. Martinez, L. Amrouche, C. Tinel, L. Galmiche, L.-H. Noel, J.-P. Duong, F. Audenet, C. Legendre, D. Anglicheau, M. Rabant.
Necker-Enfants Malades, Tenon and European Georges Pompidou Hospitals, Paris, France
The added benefits of zero-time biopsy of a potential donor kidney on top of standard donor biological and clinical data to aid in the decision…