2022 American Transplant Congress
Proteinuria in Diseased Kidney Transplant Donors for Prediction of Chronic Lesions in Pre-Transplant Biopsies – A Prospective Observational Study
*Purpose: Pre-transplant kidney graft biopsies have been suggested for organ quality assessment. Data on the association between donor proteinuria and organ quality of deceased donors…2022 American Transplant Congress
TCMR in Late Kidney Transplant Biopsies Shows Less Molecular TCMR Activity and More Fibrosis Despite Persistence of Tubulitis and Interstitial Infiltrate
1Alberta Transplant Applied Genomics Centre, Edmonton AB, AB, Canada, 2., ., AB, Canada
*Purpose: We studied the relationship between time post-transplant and molecular T cell-mediated rejection (TCMR) activity in a population of indication kidney transplant biopsies.*Methods: Updated rejection-based…2022 American Transplant Congress
Evaluation of Genotype Based Clustering Method of Single-Cell RNA-Sequencing Data from Human Kidney Allograft Biopsies
1Weill Cornell Medicine, Doha, Qatar, 2Weill Cornell Medicine, New York, NY
*Purpose: Single-cell RNA sequencing (scRNA-seq) characterizes expression profiles of individual cells, providing novel insights into new cell types or new cell states that were not…2022 American Transplant Congress
A Novel Approach to Non-Invasive Multimodality Testing with Allosure and Allomap Predicts Microvascular Inflammation with High Accuracy in Kidney Transplant Recipients
University of Wisconsin, Madison, WI
*Purpose: The most prominent histologic lesion in antibody-mediated rejection (ABMR) is microvascular inflammation (MVI); however, its recognition and scoring can be challenging and poorly reproducible…2022 American Transplant Congress
The Correlation Between Kidney Donor Risk Index, Kidney Graft Function and Histological Changes in Early Post-Transplant Renal Biopsy
*Purpose: An appropriate assessment of donor organ quality is crucial to optimize the kidney allocation and improve the long-term outcomes. Kidney Donor Risk Index (KDRI),…2022 American Transplant Congress
Molecular Associations in Kidney Transplant Biopsies in the Trifecta Study Indicate That at Least Three Distinct Processes Release Dd-cfDNA: ABMR, TCMR, and Injury
*Purpose: In the Trifecta study (ClinicalTrials.gov # NCT04239703 53), elevated plasma dd-cfDNA is associated with molecular rejection in kidney transplant indication biopsies, particularly active ABMR…2022 American Transplant Congress
Deep-Learning Based Pathological Assessment of Frozen Procurement Kidney Biopsies
*Purpose: Organ shortage in kidney transplantation is a major issue for ESKD individuals on the waiting list. Sclerotic glomeruli or interstitial fibrosis on procurement donor…2022 American Transplant Congress
Histologic Borderline Reflects Molecular Injury Not Rejection: Results from the Trifecta Study
*Purpose: In the Trifecta study (NCT04239703), we recently compared indication biopsy diagnoses (MMDx and histology) and plasma %dd-cfDNA levels for indication biopsies (JASN in press…2022 American Transplant Congress
Reassessment of Previous Kidney Discards from a Single Large Organ Procurement Organization
1David Geffen School of Medicine, Los Angeles, CA, 2One Legacy, Los Angeles, CA
*Purpose: After deceased donor kidneys are recovered, they are offered according to UNOS policy and are discarded if no centers in the country would use…2022 American Transplant Congress
The Relative Association of Clinical Variables and Histologic Lesions with Molecular Rejection in Kidney Transplant Biopsies
*Purpose: Availability of molecular assessment (MMDx) independent of conventional variables (time, clinical, histologic, and HLA antibody) presents an opportunity to re-assess the relative strength of…
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