Articles tagged "Biopsy"

2022 American Transplant Congress
Evaluation of the Significance of Isolated C4d Staining without Histological Evidence of Rejection on Kidney Biopsies After ABO-Compatible Transplantation in Pediatric Recipients
C. Duneton¹, M. Rabant², J. Duong-Van-Huyen², V. Baudouin¹, E. Cheyssac¹, O. Boyer³, J. Hogan¹
¹Pediatric Nephrology, Robert Debré Hospital, APHP, Paris, France, ²Pathology, Necker Hospital, Paris, France, ³Pediatric Nephrology, Necker Hospital, Paris, France
*Purpose: C4d staining in peritubular capillaries has been part of ABMR Banff definition since 2003. Despite relatively high specificity, c4d staining shows limited sensitivity, and…
2022 American Transplant Congress
Transbronchial Cryobiopsy vs Conventional Forceps Biopsy in Lung Transplant Recipients Multicenter Study
M. Svorcova¹, J. Vachtenheim¹, J. Havlin¹, P. Jakubec², D. Rakita³, J. Balko⁴, J. Simonek¹, J. Kolarik¹, J. Pozniak¹, R. Lischke¹
¹3rd Surgery Department, 1st Faculty of Medicine, Charles University in Prague and Motol University, National Lung Transplant Program Prague, Prague, Czech Republic, ²Department of respiratory disease and tuberculosis, University Hospital Olomouc, Olomouc, Czech Republic, ³Department of pneumology, 2nd Faculty of Medicine, Charles University in Prague and Motol University, Prague, Czech Republic, ⁴Department of Pathology and Molecular Medicine, 2nd Faculty of Medicine, Charles University in Prague and Motol University, Prague, Czech Republic
*Purpose: Transbronchial biopsy is considered the gold standard in the diagnosis of acute cellular rejection after lung transplantation. There still remains the discussion in conventional…
2022 American Transplant Congress
Histopathology at Diagnosis and One-Year Outcomes in Antibody Mediated Rejection in Pediatric Kidney Transplant Recipients: Preliminary Findings from the Paramour “Pediatric Renal AMR Outcomes” Study
R. Zahr¹, D. Puliyanda², I. Ashoor³, N. Hayde⁴, S. Solomon⁵, R. Engen⁶, L. Harshman⁷, C. Peterson⁸, S. McEwen⁹, A. Jain¹⁰, R. Garro¹¹, A. Mansuri¹², M. Kallash¹³, K. Twombley¹⁴
¹Pediatrics, University of Tennessee Health Science Center, Memphis, TN, ²Cedars-Sinai Med Ctr, West Hollywood, CA, ³Pediatrics, Lousiana State University, New Orleans, LA, ⁴Montefiore Medical Center, Bronx, NY, ⁵The Children's Hospital at Montefiore, New York, NY, ⁶Pediatrics, University of Wisconsin Madison, Madison, WI, ⁷University of Iowa Children's Hospital, Iowa City, IA, ⁸University of Utah, Salt Lake City, UT, ⁹University of Minnesota, Minneapolis, MN, ¹⁰Pediatrics, Wayne State University, Troy, MI, ¹¹Emory University, Atlanta, GA, ¹²Pediatrics, Augusta University, Augusta, GA, ¹³Pediatrics, The Ohio State Univesrity, Columbus, OH, ¹⁴Medical University of South Carolina, Charleston, SC
*Purpose: Antibody mediated rejection (AMR) is a major cause of kidney allograft dysfunction leading to graft loss. There is a paucity of data regarding how…
2022 American Transplant Congress
Diagnostic Performance of Donor-Derived Cell-Free DNA Assay (AlloSure®) in Kidney Transplant Recipients with Graft Dysfunction: A Single Center Study
M. S. Naseer¹, H. Shokouh-Amiri², T. Creamer¹, R. McMillan², S. Tandukar¹, D. Aultman¹, G. B. Zibari¹, N. Singh¹
¹Transplant, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA, ²John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA
*Purpose: Circulating donor-derived cell-free DNA (dd-cf-DNA) is a non-invasive biomarker of kidney allograft injury with a high negative predictive value for ruling out active rejection…
2022 American Transplant Congress
Deceased Donor Procurement Biopsy Practices, Interpretation, and Histology-Based Decision Making: A Survey of US Transplant Centers
V. Fleetwood¹, D. Axelrod², Y. Caliskan¹, H. Randall¹, J. Wellen³, M. Lichtenberger³, C. Dedert¹, R. Rothweiler⁴, G. F. Marklin⁴, D. Brockmeier⁴, M. A. Schnitzler¹, S. A. Husain⁵, S. Mohan⁵, B. Kasiske⁶, M. Cooper⁷, K. L. Lentine¹
¹Saint Louis U., St. Louis, MO, ²U. of Iowa, Iowa City, IA, ³WUSTL, St. Louis, MO, ⁴Mid-Am. Trans., St. Louis, MO, ⁵Columbia U., New York, NY, ⁶Hennepin Healthcare, Minneapolis, MN, ⁷MedStar Transpl. Inst., Washington, DC
*Purpose: In light of contemporary controversies on the utility of kidney procurement biopsies in predicting allograft outcomes and guiding organ acceptance, we surveyed transplant providers…
2022 American Transplant Congress
Surveillance with Protocol Biopsies for Rejection Significantly Impacts Survival Following Intestine Transplant
J. R. Sherwood¹, Y. Ichkhanian², N. Beltran³, S. Nagai³, S. Jafri⁴
¹Wayne State School of Medicine, Detroit, MI, ²Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, ³Department of Transplant Surgery, Henry Ford Hospital, Detroit, MI, ⁴Division of Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, MI
*Purpose: Frequent surveillance biopsy is required on the first month post intestinal transplant(IT) due to high-risk of acute rejection. However, the utility and the frequency…
2022 American Transplant Congress
Using a Unique Repository of Pancreas Transplant Biopsies to Validate the Tissue Common Response Module (tCRM) Score as a Tool to Assess the Severity of Pancreas Transplant Rejection
Y. Kelly¹, A. Zarinsefat¹, R. Meier², M. Sarwal¹, P. Stock¹, Z. Laszik¹, T. Sigdel¹
¹University of California, San Francisco, San Francisco, CA, ²University of Maryland Medical Center, Baltimore, MD
*Purpose: Analysis of transcriptional data from kidney, heart, liver, and lung transplant rejection led to development of the tissue Common Response Module (tCRM) score based…
2022 American Transplant Congress
The Prediction of Renal Allograft Rejection by Time-Dependent Two-Signature Predictors
M. Liao¹, Q. Fu², L. Wei³, H. Yang³, G. Zhao³, S. Deng³, J. F. Markmann²
¹School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, ²Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ³University of Electronic Science and Technology of China, Chengdu, China
*Purpose: The study aims to develop RNA signature predictors using preemptive biopsy transcriptome data to predict future allograft rejection and reveal the predictors' time-dependent features.*Methods:…
2022 American Transplant Congress
Rapid Formalin-Fixed Deceased Donor Kidney Biopsy Protocol – A Proof Of Concept
M. R. Marvin¹, G. Chen², A. Kotru¹, C. Koo¹, P. Sanghi³, M. Moritz⁴, J. Clarke⁴, R. Hasz⁴
¹Transplant, Geisinger Medical Center, Danville, PA, ²Pathology, Geisinger Medical Center, Danville, PA, ³Transplant Nephrology, Geisinger Medical Center, Danville, PA, ⁴Gift of Life Donor Program, Philadelphia, PA
*Purpose: Reducing kidney discard is a major priority for the transplant community. While frozen section biopsies are the current standard, they are fraught with technical…
2022 American Transplant Congress
Temporal Changes in the Peripheral Immune Profile of Acute Rejection Highlight New Mechanisms of Alloimmunity and Potential Non-Invasive Biomarkers of Rejection in Pediatric Liver Transplantation
D. N. Sarode¹, B. Rocque¹, A. Barbetta¹, P. Singh¹, C. Goldbeck¹, C. Weaver², O. Akbari¹, R. Kohli², J. Emamaullee¹
¹University of Southern California Keck School of Medicine, Los Angeles, CA, ²Children's Hospital Los Angeles, Los Angeles, CA
*Purpose: Acute rejection (AR) is common in pediatric liver transplantation (LT) and can impact late graft loss. Immune subpopulations mediating AR in LT have not…