Articles tagged "Biopsy"

2022 American Transplant Congress
Enhanced Histological Yield and Actionable Findings When Biopsy is Guided by Donor-Derived Cell-Free DNA (dd-cfDNA)
M. R. Weir¹, D. Mandelbrot², J. S. Bromberg¹, S. Mehta³, E. Poggio⁴, E. Huang⁵, G. Shekhtman⁶, N. Agrawal⁷, W. Tian⁸, M. Cooper⁹
¹University of Maryland School of Medicine, Baltimore, MD, ²University of Wisconsin, Madison, WI, ³University of Alabama, Birmingham, AL, ⁴Cleveland Clinic, Cleveland, OH, ⁵Cedars-Sinai Medical Center, Los Angeles, CA, ⁶CareDx Inc., Brisbane, CA, ⁷CareDx Inc, Brisbane, CA, ⁸CareDx, Brisbane, CA, ⁹MedStar Georgetown Transplant Institute, Washington, DC
*Purpose: Implementation of molecular biomarkers in kidney transplantation has expanded the amount of information available to clinicians before deciding to pursue biopsy. We evaluated how…
2022 American Transplant Congress
Association Between Histopathological Features on Implantation Renal Biopsies and Graft Outcomes and Kdpi
C. Khor, S. McGinn, C. Fisher, R. Yang, K. Richards, K. Muir, J. Lu
Nephrology, Royal North Shore Hospital, Sydney, Australia
*Purpose: The global shortage of organs and the increasing use of marginal kidneys for transplantation necessitates an accurate assessment of deceased donor kidneys. The kidney…
2022 American Transplant Congress
Study of the Composition of the Inflammatory Burden on a Cohort of 125 Rejections by Multiplex Immunofluorescence
A. Mobio¹, M. Eloudzeri², L. Morin¹, J. Duong Van Huyen³, D. Anglicheau¹, M. Rabant³
¹Kidney transplantation, Necker-Enfants Malades Hospital, Paris, France, ²U1151, INEM, Paris, France, ³Pathology, Necker-Enfants Malades Hospital, Paris, France
*Purpose: The exact composition of the inflammatory burden during kidney transplant rejection has not been studied on large cohorts. Moreover, the determinants and impact of…
2022 American Transplant Congress
Defining New Arterial and Arteriolar Lesions Accompanying Transplant Glomerulopathy: Potential Additions to the Histologic Assessment of ABMR
A. Perkowska-Ptasinska¹, D. Deborska-Materkowska², M. Ciszek³, M. Myslak⁴, J. Chang⁵, J. Reeve⁶, P. Halloran⁷
¹Pathology, Medical University of Warsaw, Warsaw, Poland, ²Transplantation Medicine, Nephrology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland, ³Immunology, Transplantation Medicine and Internal Diseases, Medical University of Warsaw, Warsaw, Poland, ⁴Infectious Diseases, Hepatology and Liver Transplantation, Pomeranian Medical University, Szczecin, Poland, ⁵Alberta Transplant Applied Genomics Center, Edmonton, AB, Canada, ⁶Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ⁷Pathology, Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada
*Purpose: Transplant glomerulopathy (TG) results from chronic endothelial injury most commonly related to ABMR. Surprisingly, except for PTC, the relation between TG and other vascular…
2022 American Transplant Congress
Urinary Cell CTOT-04 Signature is Diagnostic of Glomerulitis in Kidney Allograft Biopsies
T. Salinas¹, C. Li¹, C. Snopkowski¹, K. Chen¹, S. Albakry¹, S. Salvatore², S. Seshan², J. R. Lee¹, M. Thangamani¹, D. Dadhania¹, M. Suthanthiran¹
¹Nephrology, Weill Cornell-NYPH, New York, NY, ²Pathology, Weill Cornell-NYPH, New York, NY
*Purpose: Antibody mediated rejection is a significant complication after kidney transplantation and is an important cause of allograft failure. In the multicenter CTOT-04 study, we…
2022 American Transplant Congress
Histologic Predictors of Graft Loss in Early Clinically Indicated Biopsies After Kidney Transplantation
M. Ajaimy¹, V. Hemmige², L. E. Liriano-Ward³, Y. Azzi¹, S. Kapoor⁴, P. Loarte¹, C. Pynadath⁵, A. Colovai¹, E. Akalin⁶
¹Einstein-Montefiore Transplant Center, Bronx, NY, ²Montefiore Medical Center, Bronx, NY, ³Transplant, Montefiore Medical Center, Bronx, NY, ⁴Montefiore Medical Center, New York, NY, ⁵Einstein-Montefiore Transplant Center, Scarsdale, NY, ⁶Albert Einstein College of Medicine, Montefiore Medical Ctr, Bronx, NY
*Purpose: We aimed to investigate histopathological predictors of graft lost in patients who underwent clinically indicated biopsies for worsening kidney function and/or proteinuria within 3…
2022 American Transplant Congress
Unravelling the Stage-Shift of Acute Rejection by Urine QSant
W. Yazar¹, N. Titzler¹, R. Sarwal¹, M. Sarwal², S. Ghosh¹
¹Nephrosant, Brisbane, CA, ²NephroSant, Brisbane, CA
*Purpose: Suboptimal performance in current methods for allograft monitoring underscores the unmet need for enhanced immunosurveillance accuracy, to uncover the alloimmunity flux. QSant[Yang et al,…
2022 American Transplant Congress
Poor Outcomes in Patients with Transplant Glomerulopathy Independent of Banff Categorization or Therapeutic Interventions
K. Wu¹, D. Schmidt¹, C. Lopez del Moral¹, Q. Zhang¹, F. Halleck¹, M. G. Naik¹, N. Lachmann², B. Rudolph³, K. Budde¹
¹Department of Nephrology, Charite Campus Mitte, Berlin, Germany, ²Institut für Transfusionsmedizin, Charite Virchow Klinikum, Berlin, Germany, ³Institut für Pathologie, Charite Campus Mitte, Berlin, Germany
*Purpose: Banff classification is an accepted diagnostic tool, but also used as a tool to define endpoints in clinical trials. There is a need to…
2022 American Transplant Congress
A Comparison of Vibration Controlled Transient Elastography, FAST, AGILE-3 and AGILE-4 Scores in Liver Transplant Recipients
T. Arshad¹, M. Tseng², B. Anh³, T. Syed⁴, A. Miller⁵, V. Patel⁴, A. Asgharpour⁴, I. O. Michael⁶, S. Patel⁵, M. Muthiah⁷, M. S. Siddiqui⁴
¹Department of Internal Medicine, VCU, Richmond, VA, ²Internal Medicine, VCU, Richmond, VA, ³Department of Statistical Sciences & Operations Research, VCU, Richmond, VA, ⁴Division of Gastroenterology and Hepatology, VCU, Richmond, VA, ⁵VCU, Richmond, VA, ⁶Department of Pathology, VCU, Richmond, VA, ⁷National University of Singapore, Singapore, Singapore
*Purpose: Hepatic fibrosis is a strong predictor of clinical outcomes following liver transplantation (LT), however, non-invasive fibrosis assessment remains challenging. Vibration controlled transient elastography has…
2022 American Transplant Congress
Novel Biopsy-Based Clinical Phenotype Clustering to Predict Kidney Transplant Outcomes
A. Ahmed¹, L. Allegretti², C. Rebello³, B. Kinsella³, K. Guo³, S. Park⁴, J. Friedewald³
¹Chicago Medical School at Rosalind Franklin University, Chicago, IL, ²University of Wisconsin, Madison, WI, ³Northwestern University, Chicago, IL, ⁴Transplant Nephrology, Northwestern University, Chicago, IL
*Purpose: The purpose of this study was to define novel clinical phenotypes based on biopsy results to enhance biomarker discovery.*Methods: Retrospective analysis of kidney biopsy…