Articles tagged "Biopsy"

2018 American Transplant Congress
Serelaxin-Notch1 Signaling Promotes Macrophage M2 Differentiation and Alleviates Hepatocellular Damage in Orthotopic Liver Transplantation: From Mouse-to-Human
S. Kageyama,¹ K. Nakamura,¹ B. Ke,¹ R. Sosa,² E. Reed,² F. Kaldas,¹ R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, UCLA, Los Angeles, CA; ²Pathology, UCLA, Los Angeles, CA.
Background/Aim: We have documented crucial role of macrophage Notch1 signaling in a mouse warm hepatic ischemia-reperfusion injury (IRI) model. However, its clinical relevance or therapeutic…
2018 American Transplant Congress
NK Cells in Allograft Kidney Biopsies during Rejection: Detection, Quantification, and Precise Localization Using Multiplex Immunofluorescence
M. Terada,¹ J. Duong Van Huyen,² F. Drieux,⁴ C. Legendre,³ P. Bruneval,¹ M. Rabant.²
¹Pathology Department, Georges Pompidou European Hospital, Paris, France; ²Pathology Department, Necker-Enfants Malades Hospital, Paris, France; ³Kidney Transplantation Department, Necker-Enfants Malades Hospital, Paris, France; ⁴Pathology Department, Centre Henri Becquerel, Rouen, France.
Introduction: Among the complex cellular interplay engaged in renal rejection, recent transcriptomic analysis of renal biopsies has detected NK cell transcripts in the setting of…
2018 American Transplant Congress
Distribution of Biopsy Proven Acute Rejection in a Large Pediatric Kidney Transplant Program: A Four Year Experience
C. Varnell, Jr.,¹ A. Carle,^2,3 D. Hooper.^1,2,3
¹Division of Nephrology & Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; ²James M. Anderson Center for Health Systems Excellence, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; ³Department of Pediatrics, University of Cincinnati, Cincinnati, OH.
Introduction: Kidney biopsy is the gold standard for diagnosing rejection, transplant glomerulopathy, and other pathology after transplantation. We aimed to understand the distribution of Banff…
2018 American Transplant Congress
“Majority Rules”: A Method to Reduce Variability in Diagnosing Antibody Mediated Rejection in Renal Allograft Biopsies Using Banff 2013
B. Smith,¹ L. Cornell,¹ M. Smith,² C. Cortese,³ X. Geiger,³ C. Schinstock,¹ W. Kremers,¹ M. Stegall.¹
¹Mayo Clinic, Rochester, MN; ²Mayo Clinic, Scottsdale, AZ; ³Mayo Clinic, Jacksonville, FL.
Introduction: The Banff 2013 criteria for diagnosing antibody-mediated rejection (ABMR) includes three lesions: glomerulitis (g), peritubularitis (PTC), and chronic glomerulopathy (cg). The poor reproducibility of…
2018 American Transplant Congress
Biopsy Correlates of DSA in Antibody-Mediated Rejection: C4d vs Microvascular Inflammation Scores
C. Harris, L. Anderson, R. Khaim, J. Choudhuri, R. Shapiro, S. Florman, F. Salem, M. Menon.
Icahn School of Medicine at Mount Sinai, New York, NY.
Background: The diagnosis of antibody-mediated rejection (AMR) requires the presence of both the histologic features of AMR as well as donor-specific antibodies (DSA). Whether anti-HLA…
2018 American Transplant Congress
Kidney Transplantation (KTx) Using Kidneys from Deceased Donors (DD) with Severe AKI Does Not Negatively Impact 1 Year Biopsy Chronic Changes
A. Kumar, A. Srinivasan, A. Mathur, J. Huskey, H. Khamash, M. Smith, A. Moss, K. Reddy, R. Heilman.
Mayo Clinic, Phoenix.
BackgroundDespite the persistent donor shortage, donor kidneys with an acute kidney injury are declined. The aim of this study to determine the difference in biopsy…
2018 American Transplant Congress
Molecular Analysis of Acute Cellular Rejection in Clinical Face Transplants
T. Win, B. Dyring-Andersen, J. Teague, N. Murakami, A. Chandraker, B. Pomahac, L. Riella, R. Clark.
Brigham and Women's Hospital, Boston.
Although monitoring and immunosuppression of vascularized composite allografts (VCA) draw experience from solid organ transplantation, VCAs pose unique challenges. A deeper understanding of mechanisms underlying…
2018 American Transplant Congress
Urinary Chemokine CXCL-10 in Long Term Renal Transplant Patients Associates with Urinary Tract Infections and Microvascular Damage
G. Irish,^1,2 M. Hockley,^1,2 S. Kireta,^1,2 J. Johnson,^1,2 R. Carroll.^1,2
¹Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia; ²The Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.
Non-invasive biomarkers are needed to predict rejection post kidney transplantation. In the early transplant period, urinary CXCL-9 and CXCL-10 associate with rejection. We assessed the…
2018 American Transplant Congress
DCD Kidneys with Remuzzi Scores of 4-5 Can Be Accepted for Solitary Kidney Transplantation
X-.P. Yuan, C-.B. Chen, Y. Zheng, J. Zhou, C. Wang, X. He.
Organ Transplant Center, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Background Baseline chronic donor kidney injury is usually scored using Remuzzi's classification. It has been suggested that kidneys with Remuzzi scores of 0-3 can be…
2018 American Transplant Congress
Factor Analysis (FA) Identifies 5 Major Axes of Kidney Transplant Biopsy (KTxBx) Pathology
L. Hunsicker,¹ J. Grande,² J. Cecka,³ A. Matas,⁴ The DeKaf Consortium.
¹Int. Med., U. Iowa, Iowa City, IA; ²Pathology, Mayo Clinic, Rochester, MN; ³Immunogenetics, UCLA, Los Angeles, CA; ⁴Surgery, U. Minnesota, Minneapolis, MN.
Definitions for acute rejection (ACR) and antibody mediated rejection (AMR) in KTxBx exist, but no data driven methods exist for quantitative analysis of all Banff,…