2018 American Transplant Congress
Factor Analysis (FA) of Renal Transplant Biopsy (KTxBx) Data Enables Objective Assessment of Risk for Subsequent Death Censored Graft Failure (DCGF)
We examined the impact of five axes of injury identified by FA in the KTxBx on the hazard for subsequent DCGF in two DeKAF cohorts.Methods:…2018 American Transplant Congress
A Substantial Fraction of Surveillance Transplant Biopsies Have Clinically Actionable Findings
1Pathology, Michigan Medicine, Ann Arbor; 2Nephrology, Michigan Medicine, Ann Arbor.
Background: Surveillance biopsies in renal transplant recipients may detect subclinical disease that affects graft longevity. At our transplant center, most patients with stable allograft function…2018 American Transplant Congress
Novel Approach to Molecular Testing Using Routine Diagnostic Tissue
1University of Glasgow, Glasgow, United Kingdom; 2Columbia University, New York.
Currently, molecular diagnostics in kidney transplantation requires dedicated fresh tissue. This requirement limits use in mainstream clinical settings due to perceived increased patient risk in…2018 American Transplant Congress
Predictors of Graft Survival at the Time of a Kidney Transplant Indication Biopsy
We predicted kidney transplant graft survival after indication biopsy in 884 patients. Analysis was performed using random forests, a multivariate machine learning method to assess…2018 American Transplant Congress
Diabetic Nephropathy after Kidney Transplantation in Patients with Pre-Transplantation Type II Diabetes May Occur Later and Be Less Common Than Previously Thought
Surgery, University of Maryland, Baltimore, MD.
Background: Classical medical teaching suggests that diabetic nephropathy occurs more quickly in transplanted kidneys than in the native kidneys. The largest report of post-transplantation diabetic…2018 American Transplant Congress
Prospective Study of Switching from Tacrolimus to Low-Dose Cyclosporine A Preserving Allograft Function in BK Virus-Associated Nephropathy
Background: Tacrolimus(Tac) -mycophenolic acid compared to cyclosporine is an independent risk factor for BK virus-associated nephropathy (BKVAN). Cyclosporine A (CsA) can inhibit BKV replication in…2018 American Transplant Congress
Non-Invasive Diagnostic of Renal Allograft Rejection via Urine Metabolites Using NMR-Spectroscopy
Introduction and BackgroundPost-transplant surveillance for acute rejection is typically based on regular monitoring of serum creatinine levels and consecutive biopsies upon functional renal impairment. Attempts…2018 American Transplant Congress
Donor TM6SF2 rs58542926 Genotype is a Risk Factor for Liver Graft Steatosis
Background & Aims: The rs58542926 c.449C>T (p.E167K) polymorphism in TM6SF2 (transmembrane 6 superfamily member 2) is one of genetic factors predisposing to nonalcoholic fatty liver…2018 American Transplant Congress
Incidence of BK Viraemia and BK Virus Associated Nephropathy with Standard vs. Augmented Immunosuppression
Renal Transplant, University Hospitals of Coventry and Warwickshire, Coventry, United Kingdom.
Introduction:It has been long established that over-immunosuppressed state leads to BK virus reactivation. BK viraemia (BKV) can progress to BK virus associated nephropathy (BKVAN) which…2018 American Transplant Congress
Validating Molecular Microscope Readings and Estimating Agreement with Histology
We previously described a microarray diagnostic system (MMDx) for rejection in 1208 kidney transplant biopsies (J. Reeve et al. JCI Insight 2 (12), 2017). The…
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