2019 American Transplant Congress
CEACAM1 – p38 Signaling Axis Alleviates Peri-Transplant Liver Injury: From Mouse-to-Human
1UCLA, Los Angeles, CA, 2City of Hope, Duarte, CA
*Purpose: Although CEACAM1 (CM1; carcinoembryonic antigen-related cell adhesion molecule 1; CD66a) regulates hepatic metabolism, its role in orthotopic liver transplantation (OLT) is unknown. A recent…2019 American Transplant Congress
Quantitative Proteome Profiling in T Cell-Mediated Rejection
*Purpose: The proteomic analyses through formalin-fixation and paraffin embedding (FFPE) specimens reflects systemic and inherent renal injury perturbations for different kidney transplant injury states. In…2019 American Transplant Congress
Increased Number of Intragraft FoxP3+ T Cells is Strongly Correlated with Decreased Graft Survival in Chronic Active Antibody Mediated Rejection
1Erasmus MC, Rotterdam, Netherlands, 2Amsterdam UMC, Amsterdam, Netherlands
*Purpose: Chronic-active antibody-mediated rejection (c-aABMR) is the most important cause of late renal allograft failure. However, renal inflammation and rate of loss of renal allograft…2019 American Transplant Congress
Ikaros/IRF4 Signaling Regulates SIRT1-Mediated Macrophage M2 Shift in Liver Ischemia-Reperfusion Injury: From Mouse-to-Human
1Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA, 2NIEHS, Durham, NC
*Purpose: Hepatic ischemia-reperfusion injury (IRI) represents a risk factor for early graft dysfunction and rejection in liver transplantation (LT). Despite the efficacy of Sirtuin 1…2019 American Transplant Congress
Are Protocol Biopsies Necessary for Pediatric Renal Transplant Recipients?
Pediatrics, UCSD, San Diego, CA
*Purpose: Renal allograft survival indirectly correlates with acute rejection episodes. Subacute rejection is also associated with decreased graft survival. Protocol biopsies (bxs) have been implemented…2018 American Transplant Congress
Validating Molecular Microscope Readings and Estimating Agreement with Histology
We previously described a microarray diagnostic system (MMDx) for rejection in 1208 kidney transplant biopsies (J. Reeve et al. JCI Insight 2 (12), 2017). The…2018 American Transplant Congress
Impact of On-Site Overestimation of Macrosteatosis on Donor Liver Biopsy
Multi-Organ Transplant Institute, Ochsner Clinic Foundation, New Orleans.
Introduction: Estimation of hepatic steatosis is an important variable in determining suitability of a donor liver allograft for transplantation. Differentiation between and quantification of macro-…2018 American Transplant Congress
Preoperative Antibiotics Treatment Decreases Endoplasmic Reticulum Stress and Protects Liver Transplant from Ischemia-Reperfusion Injury
Department of Surgery, The Dumont-UCLA Transplant Center, Los Angeles, CA.
Ischemia-reperfusion injury (IRI) represents a major risk factor of graft dysfunction in liver transplantation (LT). We have reported a critical role of endoplasmic reticulum (ER)…2018 American Transplant Congress
Medullary Tissue Sampling in Renal Allograft Biopsy is More Sensitive for Pathologic Diagnosis of PVN
Background Post-transplant polyoma virus nephropathy (PVN) prevalence is 1-10%. Definitive PVN diagnosis requires polyoma virus presence in infected cells, done with immunohistochemical staining for SV40…2018 American Transplant Congress
Real-Time Expert Evaluation of Liver Biopsy for Transplant: The Significance of Smartphone and Microscope Adapter in Telepathology
Introduction: Liver biopsy at the time of procurement plays a crucial role in the acceptance of marginal grafts. Local pathologists and transplant surgery fellows are…
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