2020 American Transplant Congress
Thymoglobulin Dose and Incidence of Biopsy Proven Acute Rejections in the Early Post Transplant Period
University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: Optimal dosing of thymoglobulin (ATG) for induction has not been well defined. Our protocol aims for 5-6mg/kg cumulative dose divided over 4 doses. However,…2020 American Transplant Congress
Natural Course of Borderline Changes in Kidney Allografts: A MMDx Study
*Purpose: Molecular assessment of kidney allograft biopsies with Banff borderline changes (BL) category has showed only 30% of rejection phenotype in various post-transplant follow-up and…2020 American Transplant Congress
Impact of Variation in Histological Assessments and Their Impact on Clinical Trial Enrollment and Endpoints – Preliminary Report of The Gen04 Study
*Purpose: Renal allograft histology is often used as inclusion criteria for clinical trials. This includes Gen04, which is an NIH sponsored multi-center clinical trial involving…2020 American Transplant Congress
Machine Learning to Predict Deceased Donor Kidney Biopsy Results
United Network for Organ Sharing, Richmond, VA
*Purpose: Despite inconclusive evidence that kidney biopsy findings are associated with graft outcomes, biopsies are often cited as a key factor on whether to accept…2020 American Transplant Congress
Calcium Oxalate Deposition in Kidney Allografts: Clinical Chracteristics and Outcome
*Purpose: To better understand its clinical significance and prognostic value, we investigated the clinical characteristics and outcomes of patients with calcium oxalate deposition in kidney…2020 American Transplant Congress
The Role of the Molecular Microscope to Guide Therapy for T-Cell Mediated Rejection in Kidney Transplants
1Virginia Commonwealth University, Glen Allen, VA, 2ATAGC, Edmonton, AB, Canada
*Purpose: Histologic lesions (I+T) to characterize T-cell mediated rejection (TCMR) can be non-specific. In some cases the inflammation may represent a ‘response to wounding’ rather…2020 American Transplant Congress
Impact of Severity of Glomerulosclerosis on Long-Term Outcomes in Deceased Donor Renal Transplant Recipients with Donor Acute Kidney Injury
*Purpose: With long waitlist times for renal transplantation,there is a need to reduce discard rates of donor kidneys.The purpose of this study is to assess…2020 American Transplant Congress
Calcium Phosphate Crystals: An Under Recognized Cause of Kidney Allograft Injury?
Vanderbilt University Medical Center, Nashville, TN
*Purpose: Calcium phosphate (CaPhos) crystals are a known cause of dysfunction in native kidneys. Our objectives were to describe the incidence of CaPhos crystal deposition…2020 American Transplant Congress
Use of tCRM to Aid Diagnosis of Allograft Rejection in Kidney Transplantation
*Purpose: To apply an unbiased, quantitative, molecular profiling score for graft inflammation using standardized assays, in the context of a prospective clinical trial in kidney…2020 American Transplant Congress
Impact of Chronic Changes on Preimplantation Biopsy (PBx) on Outcomes after Deceased Donor Kidney Transplantation (DDKTx)
*Purpose: The value of PBx is unclear. The aim of this study was to determine the prognostic value of chronic changes on PBx on graft…
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