Articles tagged "Bile duct"

2020 American Transplant Congress
Post Liver Transplant Biliary Complications in the Post HCV Era
M. Birch, K. Halazun, D. Tsapepas, C. Brenna, B. Samstein
New York Presbyterian - Weill Cornell Medical Center, New York, NY
*Purpose: Biliary complications in the post HCV era has not been well defined.*Methods: We retrospective studied 209 patients transplanted from April 2015 to November 2019…
2020 American Transplant Congress
Percutaneous Choledochoscopy and Laser Biliary Stricturoplasty: A Case Series of Novel Management of Refractory Post-Liver Transplant Biliary Complications
W. E. Jackson¹, P. S. Trivedi², J. J. Pomposelli³, T. J. Pshak³
¹Division of Gastroenterology and Hepatology, University of Colorado, Aurora, CO, ²Division of Vascular and Interventional Radiology, University of Colorado, Aurora, CO, ³Division of Transplant Surgery, University of Colorado, Aurora, CO
*Purpose: Anastomotic biliary strictures are a well-recognized complication after living and deceased donor liver transplant (LDLT and DDLT). Management focuses on utilizing endoscopic retrograde cholangiography…
2020 American Transplant Congress
3D Bioprinted Intrahepatic Cholangiocarcinoma Model and 7-Day Perfusion with Gemcitabine and Cisplatin: Modeling the Tumor Microenvironment and Response to Chemotherapy
A. M. Chen¹, W. Zhang¹, J. Sterner², L. Kennedy³, A. Isidan¹, E. Gramelspacher¹, H. L. Francis³, G. Alpini³, L. J. Smith², P. Li¹, B. Ekser¹
¹Division of Transplant Surgery - Indiana University, Indianapolis, IN, ²3D Bioprinting Core and Department of Radiology and Imaging Sciences - Indiana University, Indianapolis, IN, ³Division of Gastroenterology, Richard L. Roudebush VA Medical Center and Indiana University, Indianapolis, IN
*Purpose: Over 8,000 patients are newly diagnosed with cholangiocarcinoma (CCA) in the United States each year.Understanding the CCA microenvironment will facilitate the development of novel…
2020 American Transplant Congress
Prophylactic Biliary Intra-Operative Stents at Orthotopic Liver Transplantation (OLTx)
M. Aldamry
Mcgill University, Montreal, QC, Canada
*Purpose: Biliary complications can affect up to 40% of patients after orthotopic liver transplantation (OLTx). Endoscopic management has a high success rate but involves multiple…
2019 American Transplant Congress
Management of Anastomotic Biliary Strictures after Liver Transplant: Role of Covered Metal Stents
A. Watson¹, K. Haq¹, K. Khorfan², S. Singla¹, A. Yoshida³, D. Moonka¹
¹Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, MI, ²Internal Medicine, Henry Ford Hospital, Detroit, MI, ³Transplant Institute, Henry Ford Hospital, Detroit, MI
*Purpose: Biliary complications, including anastomotic biliary strictures (ABS), remain the most common cause of morbidity in liver transplant (LT) patients. Endoscopic therapy has become the…
2019 American Transplant Congress
Epithelial to Mesenchymal Transition: A Cellular Mediator of Ischemic Cholangiopathy after Liver Transplant
N. A. Wickramaratne¹, R. Li², R. C. Fyffe-Freil², T. Tian², M. J. Mangino²
¹VCUHealth, Richmond, VA, ²Department of Surgery, VCUHealth, Richmond, VA
*Purpose: Epithelial-to-mesenchymal transition (EMT) is a genetic reprogramming that causes epithelial cells to assume a migratory, mesenchymal phenotype, and it is induced by hypoxia. Ischemic…
2019 American Transplant Congress
Ischemia-Free Liver Transplantation Protects Bile Duct from Ischemia/Reperfusion Injury
J. Yang, S. Huang, Z. Zhang, Q. Zhao, W. Ju, Z. Zhu, Y. Tang, L. Wang, Y. Zhang, C. Sun, L. Wu, Z. Guo, X. He
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: Ischemia-free liver transplantation (IFLT), based on normothermic machine perfusion and innovations in surgical technique, can provide continue blood supply from procurement to implantation that…
2019 American Transplant Congress
Pharmacological Enhancement of Bile Duct Preservation and Function during Ex-Situ Normothermic Machine Perfusion
Y. L. Boteon, J. Attard, A. P. Boteon, L. Wallace, G. Reynolds, D. Mirza, H. Mergental, R. Bhogal, S. Afford
Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom
*Purpose: Whilst ex-situ normothermic machine perfusion (NMP) of the liver limits the ischaemic injury to the organ, benefits for biliary complications post-transplantation are not yet…
2019 American Transplant Congress
Normothermic Ex-Situ Liver Perfusion Parameters of Liver Viability in a Porcine Model of Liver Transplantation with Marginal Grafts
I. Linares-Cervantes¹, J. Echeverri¹, S. Cleland¹, M. Kaths¹, R. Rosales¹, T. Goto¹, D. Kollmann¹, M. Hamar¹, P. Urbanellis¹, L. Mazilescu¹, S. Ganesh¹, O. Adeyi¹, P. Yip¹, B. Bojko², P. Gorynzka², K. Gorynski², D. Grant¹, N. Selzner¹, M. Wasowicz¹, M. Selzner¹
¹Toronto General Hospital, Toronto, ON, Canada, ²University of Nicolaus Copernicus, Torun, Poland
*Purpose: Evaluate parameters of liver viability during normothermic ex-situ liver perfusion (NEsLP) prior to transplantation.*Methods: In this study, we investigated prior assessed parameters and new…
2019 American Transplant Congress
Bile Duct Anastomosis over Intraluminal Plastic Biliary Stent in Liver Transplant: Clinical Outcome
H. Samant¹, K. Patel¹, W. Manatsathit², N. Singh¹, H. S. Amiri³, G. Zibari³
¹Louisiana State University and Health Science Center, Shreveport, LA, ²University of Nebraska Meical Center, Omaha, NE, ³John C McDonald Transplant Center, Shreveport, LA
*Purpose: Biliary complications have been known as “Achilles Heel” of orthotropic liver transplantation (OLT) with high morbidity and mortality. Intra-luminal plastic biliary stents replacing T-tubes…