Articles tagged "B cells"

2020 American Transplant Congress
A Two-Step Cell-Based Assay Predicts Immunosuppression-Related Adverse Events in Kidney Transplant Recipients
F. Bouchard-Boivin, O. Désy, S. Béland, S. De Serres
Transplantation Unit, Renal Division, Medecine Department, Laval University, Québec, QC, Canada
*Purpose: No clinical tool is available to dynamically access immunosuppression status, which results in serious, often life-threatening adverse effects of immunosuppressants. We recently validated that…
2020 American Transplant Congress
Naïve B Cells Regulation by TLR-Breg Cells In Vitro
Q. Fu, K. Lee, G. Huai, K. Deng, N. J. Feeney, C. Leguern, S. Deng, J. F. Markmann
Center for Transplant Science, MGH, Boston, MA
*Purpose: Regulatory B cells (Bregs) have shown great potential in cell therapies for murine organ transplantation by inhibiting the proliferation of cytotoxic and helper T…
2020 American Transplant Congress
Transplant Monitoring and PTLD Detection with B Cell Receptor Repertoire Analysis in a Large Prospective Pediatric Cohort
K. Jackson¹, O. Martinez², S. Krams², M. Robien³, M. Lapasaran², B. Armstrong⁴, C. Twist⁵, K. Weinberg⁶, D. Gratzinger¹, B. Tam¹, M. Sever⁴, M. Brown³, D. Bernstein⁶, C. Esquivel², S. D. Boyd¹
¹Department of Pathology, Stanford Univ School of Med, Stanford, CA, ²Department of Surgery/Division of Abdominal Transplantation, Stanford Univ School of Med, Stanford, CA, ³NIAID, NIH, Bethesda, MD, ⁴Rho, Chapel Hill, NC, ⁵Roswell Park, Buffalo, NY, ⁶Department of Pediatrics, Stanford Univ School of Med, Stanford, CA
*Purpose: Post-transplant lymphoproliferative disorder (PTLD) remains a serious problem in the pediatric transplant population. The Clinical Trials of Organ Transplantation in Children (CTOT-C)-06 is a…
2020 American Transplant Congress
Donor-Specific B Cell Frequency Assessed by a Novel Multiplex Bead-Based Assay Predicts Graft Failure in Kidney Transplant Recipients
Z. Ilyas, A. Akl, D. Pinelli, L. Gallon, A. R. Tambur, M. Ansari
Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: Kidney transplant recipients with sensitization to HLA defined by a high percentage of Panel Reactive Antibodies (PRA) or Donor-specific anti-HLA antibodies (DSA) are at…
2020 American Transplant Congress
Sex and ABO Antibodies: High-Level Natural ABO Antibody Production and IgM to IgG Class Switch in Female vs. Male Mice
B. Anjum, B. Motyka, I. Adam, J. Fersovich, M. Sulzer, J. Pearcey, K. Tao, L. J. West
Dept Pediatrics, Alberta Transplant Institute, University of Alberta, Edmonton, AB, Canada
*Purpose: ABO histo-blood group incompatibility is a barrier in solid organ transplant due to the presence of ‘natural’ preformed ABO antibodies. However, ABO-incompatible (ABOi) heart…
2020 American Transplant Congress
Tertiary Lymphoid Organs in Renal Chronic Allograft Rejection
K. Abou Daya, D. Zhao, K. Biery, M. Oberbarnscheidt
Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: Chronic allograft rejection remains a major obstacle to long-term allograft survival. Tertiary lymphoid organs (TLOs) are ectopic lymphoid structures that arise in non-lymphoid tissues…
2020 American Transplant Congress
Transitional B Cell Cytokines for the Early Prediction of Long-Term Renal Allograft Decline
A. Cherukuri¹, A. Salama², A. Sharma¹, R. Mehta¹, S. Hariharan¹, D. Rothstein¹
¹Starzl Transplantation Institute, UPMC, Pittsburgh, PA, ²UCL, London, London, United Kingdom
*Purpose: Early prediction of allograft loss using potentially modifiable risk factors is vital for conceiving novel therapeutic interventions to improve outcomes.*Methods: In this prospective, multicenter…
2020 American Transplant Congress
Erythropoietin Reduces Alloantibody Formation by Inhibiting T Follicular Helper Cells
C. Cantarelli¹, C. Guglielmo², S. Bin², A. Cumpelik², C. Donadei³, L. Anderson⁴, S. Hartzell², K. Budge², M. Haverly², A. Angeletti³, G. La Manna³, E. Fiaccadori¹, U. Maggiore¹, P. Heeger², P. Cravedi²
¹Parma University, Parma, Italy, ²Icahn School of Medicine at Mount Sinai, New York, NY, ³St. Orsola Hospital University of Bologna, Bologna, Italy, ⁴Icahn School of Medicine, New York, NY
*Purpose: Donor-specific antibodies (DSA) develop in a significant minority of transplant recipients and are associated with increased morbidity and mortality, underscoring the need to identify…
2020 American Transplant Congress
Generation of Insulin-Producing Cells via Multiplex Epigenetic Engineering of Human Somatic Cells in 2 Weeks
R. A. Naqvi¹, W. Zhang¹, A. Isidan¹, C. Evans-Molina², J. A. Fridell¹, P. Li¹, B. Ekser¹
¹Division of Transplant Surgery, Indiana University, Indianapolis, IN, ²Diabetes Research Center, Indiana University, Indianapolis, IN
*Purpose: Stem cell-derived β-cells not only promise a renewable supply of insulin-producing cells with negligible immunosuppression but may also provide a substrate for the identification…
2020 American Transplant Congress
Dominant Negative Polymorphisms in TNFRSF13B are Associated with Poor Transplant Outcome
M. G. de Mattos-Barbosa¹, E. T. Luning Prak², E. Farkash³, J. L. Platt⁴, M. Cascalho⁴
¹Transplant Surgery, University of Michigan, Ann Arbor, MI, ²Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, ³Pathology, University of Michigan, Ann Arbor, MI, ⁴Transplant Surgery and Microbiology and Immunology, University of Michigan, Ann Arbor, MI
*Purpose: Transmembrane Activator and CAML Interactor (TACI) is a highly polymorphic receptor that controls B cell activation and differentiation into antibody-secreting cells. Allelic variants of…