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American Transplant Congress abstracts

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Articles tagged "B cells"

  • 2020 American Transplant Congress

    A Two-Step Cell-Based Assay Predicts Immunosuppression-Related Adverse Events in Kidney Transplant Recipients

    F. Bouchard-Boivin, O. Désy, S. Béland, S. De Serres

    Transplantation Unit, Renal Division, Medecine Department, Laval University, Québec, QC, Canada

    *Purpose: No clinical tool is available to dynamically access immunosuppression status, which results in serious, often life-threatening adverse effects of immunosuppressants. We recently validated that…
  • 2020 American Transplant Congress

    Naïve B Cells Regulation by TLR-Breg Cells In Vitro

    Q. Fu, K. Lee, G. Huai, K. Deng, N. J. Feeney, C. Leguern, S. Deng, J. F. Markmann

    Center for Transplant Science, MGH, Boston, MA

    *Purpose: Regulatory B cells (Bregs) have shown great potential in cell therapies for murine organ transplantation by inhibiting the proliferation of cytotoxic and helper T…
  • 2020 American Transplant Congress

    Transplant Monitoring and PTLD Detection with B Cell Receptor Repertoire Analysis in a Large Prospective Pediatric Cohort

    K. Jackson1, O. Martinez2, S. Krams2, M. Robien3, M. Lapasaran2, B. Armstrong4, C. Twist5, K. Weinberg6, D. Gratzinger1, B. Tam1, M. Sever4, M. Brown3, D. Bernstein6, C. Esquivel2, S. D. Boyd1

    1Department of Pathology, Stanford Univ School of Med, Stanford, CA, 2Department of Surgery/Division of Abdominal Transplantation, Stanford Univ School of Med, Stanford, CA, 3NIAID, NIH, Bethesda, MD, 4Rho, Chapel Hill, NC, 5Roswell Park, Buffalo, NY, 6Department of Pediatrics, Stanford Univ School of Med, Stanford, CA

    *Purpose: Post-transplant lymphoproliferative disorder (PTLD) remains a serious problem in the pediatric transplant population. The Clinical Trials of Organ Transplantation in Children (CTOT-C)-06 is a…
  • 2020 American Transplant Congress

    Donor-Specific B Cell Frequency Assessed by a Novel Multiplex Bead-Based Assay Predicts Graft Failure in Kidney Transplant Recipients

    Z. Ilyas, A. Akl, D. Pinelli, L. Gallon, A. R. Tambur, M. Ansari

    Northwestern University Feinberg School of Medicine, Chicago, IL

    *Purpose: Kidney transplant recipients with sensitization to HLA defined by a high percentage of Panel Reactive Antibodies (PRA) or Donor-specific anti-HLA antibodies (DSA) are at…
  • 2020 American Transplant Congress

    Sex and ABO Antibodies: High-Level Natural ABO Antibody Production and IgM to IgG Class Switch in Female vs. Male Mice

    B. Anjum, B. Motyka, I. Adam, J. Fersovich, M. Sulzer, J. Pearcey, K. Tao, L. J. West

    Dept Pediatrics, Alberta Transplant Institute, University of Alberta, Edmonton, AB, Canada

    *Purpose: ABO histo-blood group incompatibility is a barrier in solid organ transplant due to the presence of ‘natural’ preformed ABO antibodies. However, ABO-incompatible (ABOi) heart…
  • 2020 American Transplant Congress

    Tertiary Lymphoid Organs in Renal Chronic Allograft Rejection

    K. Abou Daya, D. Zhao, K. Biery, M. Oberbarnscheidt

    Starzl Transplantation Institute, Pittsburgh, PA

    *Purpose: Chronic allograft rejection remains a major obstacle to long-term allograft survival. Tertiary lymphoid organs (TLOs) are ectopic lymphoid structures that arise in non-lymphoid tissues…
  • 2020 American Transplant Congress

    Transitional B Cell Cytokines for the Early Prediction of Long-Term Renal Allograft Decline

    A. Cherukuri1, A. Salama2, A. Sharma1, R. Mehta1, S. Hariharan1, D. Rothstein1

    1Starzl Transplantation Institute, UPMC, Pittsburgh, PA, 2UCL, London, London, United Kingdom

    *Purpose: Early prediction of allograft loss using potentially modifiable risk factors is vital for conceiving novel therapeutic interventions to improve outcomes.*Methods: In this prospective, multicenter…
  • 2020 American Transplant Congress

    Erythropoietin Reduces Alloantibody Formation by Inhibiting T Follicular Helper Cells

    C. Cantarelli1, C. Guglielmo2, S. Bin2, A. Cumpelik2, C. Donadei3, L. Anderson4, S. Hartzell2, K. Budge2, M. Haverly2, A. Angeletti3, G. La Manna3, E. Fiaccadori1, U. Maggiore1, P. Heeger2, P. Cravedi2

    1Parma University, Parma, Italy, 2Icahn School of Medicine at Mount Sinai, New York, NY, 3St. Orsola Hospital University of Bologna, Bologna, Italy, 4Icahn School of Medicine, New York, NY

    *Purpose: Donor-specific antibodies (DSA) develop in a significant minority of transplant recipients and are associated with increased morbidity and mortality, underscoring the need to identify…
  • 2020 American Transplant Congress

    Generation of Insulin-Producing Cells via Multiplex Epigenetic Engineering of Human Somatic Cells in 2 Weeks

    R. A. Naqvi1, W. Zhang1, A. Isidan1, C. Evans-Molina2, J. A. Fridell1, P. Li1, B. Ekser1

    1Division of Transplant Surgery, Indiana University, Indianapolis, IN, 2Diabetes Research Center, Indiana University, Indianapolis, IN

    *Purpose: Stem cell-derived β-cells not only promise a renewable supply of insulin-producing cells with negligible immunosuppression but may also provide a substrate for the identification…
  • 2020 American Transplant Congress

    Dominant Negative Polymorphisms in TNFRSF13B are Associated with Poor Transplant Outcome

    M. G. de Mattos-Barbosa1, E. T. Luning Prak2, E. Farkash3, J. L. Platt4, M. Cascalho4

    1Transplant Surgery, University of Michigan, Ann Arbor, MI, 2Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 3Pathology, University of Michigan, Ann Arbor, MI, 4Transplant Surgery and Microbiology and Immunology, University of Michigan, Ann Arbor, MI

    *Purpose: Transmembrane Activator and CAML Interactor (TACI) is a highly polymorphic receptor that controls B cell activation and differentiation into antibody-secreting cells. Allelic variants of…
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