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American Transplant Congress abstracts

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Articles tagged "B cells"

  • 2020 American Transplant Congress

    Thymic B Cells: A Means to Control Regulatory Tolerance

    C. LeGuern1, S. Germana1, N. Feeney1, Z. Wang2, N. Tanimine1, C. Huang3, C. Rickert1, J. Markmann1

    1Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Charlestown, MA, 2University of Colorado Denver, Aurora, CO, 3Surgery, University of Colorado Denver, Aurora, CO

    *Purpose: Therapies involving CD4 regulatory T cells (Tregs) are promising approaches to mitigate graft rejection and autoimmunity. Understanding of the activation mechanisms that initiate Treg…
  • 2020 American Transplant Congress

    Characterization of Non HLA Antibodies in Kidney Transplant Recipients

    S. Rodriguez Ramirez1, S. Clotet-Freixas1, C. Mcevoy1, M. Kotlyar2, I. Jurisica2, A. Chruscinski1, A. Konvalinka3

    1Kidney Transplant, Toronto General Hospital Research Institute, Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada, 2Kidney Transplant, Krembil Research Institute, University Health Network, Toronto, ON, Canada, 3Kidney Transplant, Department of Medicine, Division of Nephrology, University Health Network, Toronto, ON, Canada

    *Purpose: Antibody mediated rejection (AMR) causes more than 60 percent of late graft failures in kidney transplants (KT). Although antiHLA donor specific antibodies are the…
  • 2020 American Transplant Congress

    Allograft Repopulating Recipient B Cells after Human Intestinal Transplantation and Their Association with Donor Specific Antibody Secretion and Rejection

    E. Waffarn1, J. Fu1, K. Frangaj1, W. Meng2, A. M. Rosenfeld2, M. Li3, K. Rodgers1, R. Vasilescu3, E. T. Luning Prak2, A. Griesemer1, T. Kato4, M. Martinez5, M. Sykes1

    1Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, 2Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, 3Department of Pathology, Columbia University, New York, NY, 4Department of Surgery, Columbia University, New York, NY, 5Department of Pediatrics, Columbia University, New York, NY

    *Purpose: Alloantibodies produced by recipient B cells are associated with rejection after intestinal transplantation (ITx) and negatively impact patient and graft survival. However, the dynamics…
  • 2020 American Transplant Congress

    Novel Treatment of Acute Antibody-Mediated Rejection in a Nonhuman Primate Model of Kidney Allotransplantation

    R. Schmitz1, Z. W. Fitch1, A. Y. Choi1, M. Manook1, J. Yoon1, J. D. Lambris2, J. Kwun1, S. J. Knechtle1

    1Department of Surgery, Duke University Medical Center, Durham, NC, 2Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA

    *Purpose: One third of sensitized, HLA-incompatible transplant recipients experience acute antibody mediated rejection (AMR) with limited treatment options. We tested a novel treatment strategy for…
  • 2020 American Transplant Congress

    The Effect of B Cell Depletion Therapies on Preformed Xenoantibodies in Transplant Recipient

    S. Yeh1, N. A. Wilson2, A. Djamali2, R. Redfield3

    1Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, 2Medicine/Nephrology, University of Wisconsin-Madison, Madison, WI, 3Surgery, University of Wisconsin-Madison, Madison, WI

    *Purpose: To assess the effect of B cell depletion therapies on preformed xenoantibodies in transplant recipient. Preformed xenoantibodies are a significant barrier to successful xenotransplantation.…
  • 2020 American Transplant Congress

    Ex Vivo Generated Regulatory B Cells Can Suppress Donor-Specific CD4 T Cells Proliferation In Vivo

    G. Huai1, K. M. Lee1, Q. Fu1, K. Deng1, N. J. Feeney1, C. Leguern1, N. Tanimine1, C. G. Rickert1, S. Deng2, J. F. Markmann1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 2Organ Transplantation Center, Sichuan Provincial People's Hospital and School of Medicine, University of Electronic Science and Technology of China, Chengdu, China

    *Purpose: B cells expanded in vitro via TLR9 agonist CpG and activated by LPS, PMA and ionomycin have been previously denoted “TLR-Bregs” by our team.…
  • 2020 American Transplant Congress

    Transient Cd4+ T Cell and Cd20+ B Cell Depletion Leads to Prolonged Pig-To-Primate Kidney Xenograft Survival

    B. P. Lovasik1, A. J. Matar1, D. A. Faber1, D. V. Mathews1, C. Breeden1, S. C. Kim1, A. J. Tector2, A. B. Adams1

    1Emory University School of Medicine, Atlanta, GA, 2University of Miami, Miami, FL

    *Purpose: “Delayed” antibody-mediated xenograft rejection is the one of the most important obstacle to clinical application of pig organ xenografts. The aim of this study…
  • 2020 American Transplant Congress

    Splenectomy Impedes B Cell Infiltration Associated with Rejection of Neonatal Porcine Islet Xenografts

    Z. W. Fitch, M. Song, R. Schmitz, F. Leopardi, M. Ribeiro, A. Miller, G. Devi, B. Collins, X. Luo, A. D. Kirk

    Duke University, Durham, NC

    *Purpose: Xenotransplantation has historically been frustrated by antibody-mediated rejection. Splenectomy has shown efficacy in mediating humoral immunity. We hypothesized that adding splenectomy to a clinically…
  • 2020 American Transplant Congress

    Characterization of a Novel CD8+ B Cell Subset in Monkeys Tolerant of Heart Allografts

    J. A. Morrissette1, K. Pruner1, S. Lee1, J. Paster1, W. Sommer1, J. O1, I. Hanekamp1, P. Sage2, G. Benichou1, J. C. Madsen3

    1Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA, 2Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 3Center for Transplantation Sciences, Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA

    *Purpose: We have previously reported that transient mixed hematopoietic chimerism induced via donor bone marrow transplantation can achieve tolerance to cardiac allografts in non-human primates…
  • 2020 American Transplant Congress

    Early Prediction of Human Renal Allograft Rejection (AR) by Inflammatory Transitional B Cells

    A. Cherukuri1, A. Sharma1, R. Mehta1, H. Sundaram1, A. Salama2, D. Rothstein1

    1Starzl Transplantation Institute, UPMC, Pittsburgh, PA, 2UCL, London, United Kingdom

    *Purpose: Early prediction of AR within the 1st post-transplant year could identify at-risk patients for targeted therapeutic interventions to mitigate risk and improve outcomes.*Methods: In…
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