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American Transplant Congress abstracts

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Articles tagged "B cells"

  • 2022 American Transplant Congress

    Contributions of Allogenicity and Antigen Presentation to Regulatory B Cell Suppression

    K. Lee, F. Qiang, K. Deng, R. Matheson, J. Lei, C. LeGuern, J. Markmann

    Center for Transplantation Sciences, Boston, MA

    *Purpose: We previously generated in vitro Toll-like receptor (TLR)-activated B cells became regulatory B cells (Bregs) that suppress T cell proliferation and promote allograft tolerance.…
  • 2022 American Transplant Congress

    Abnormal B Cell Profile Associated with Inadequate Antibody Response to MRNA SARS-COV-2 Vaccine Can Be Overcome with a Third Vaccine Dose in Adolescent Kidney Transplant Recipients

    C. Crane, E. Phebus, L. Loop, C. Anterasian, B. Geng, E. Ingulli

    Pediatrics, UCSD Rady Children's, San Diego, CA

    *Purpose: mRNA SARS-CoV-2 vaccines are highly efficacious in the general population but have shown a diminished response in immunosuppressed adolescent kidney allograft recipients. We investigated…
  • 2022 American Transplant Congress

    Specificity and Avidity of Donor MHC-Specific B Cells in Naive, Rejecting and Tolerant Mice

    I. Sayin1, S. Khiew2, D. Yin1, P. Sage3, C. B. Cavazzoni3, R. King4, A. Chong1

    1Department of Surgery, University of Chicago, Chicago, IL, 2Merck, Boston, MA, 3Brigham and Women's Hospital, Boston, MA, 4Department of Microbiology, University of Alabama, Birmingham, AL

    *Purpose: Antibody-mediated rejection is recognized as an important mediator of graft loss in the clinic, and the induction of donor-specific B cell tolerance may contribute…
  • 2022 American Transplant Congress

    Circulating and Intragraft Donor (HLA)-Specific B Cells Drive Allograft Rejection After Kidney Transplantation

    A. Torija1, N. Bolaños1, L. Donadeu1, M. Meneghini2, I. Torres2, A. Gabaldon2, M. Gomà3, E. Crespo1, F. Moreso4, O. Bestard2

    1Vall d'Hebron Research Institute (VHIR), Barcelona, Spain, 2Vall d'Hebron University Hospital, Barcelona, Spain, 3Bellvitge University Hospital, Barcelona, Spain, 4Vall d'Heron University Hospital, Barcelona, Spain

    *Purpose: Besides donor-specific antibodies (DSA), circulating donor(HLA)-specific memory B cells (mBc) have also shown to play a deleterious role driving antibody-mediated rejection (ABMR) in kidney…
  • 2022 American Transplant Congress

    Pre-Emptive Rituximab Use for Epstein-Barr Virus (EBV) Viremia in Cardiothoracic Solid Organ Transplant Recipients

    B. Astorga, A. Loethen, L. Potter

    University of Chicago Medicine, Chicago, IL

    *Purpose: EBV viremia is associated with potentially life-threatening post-transplant lymphoproliferative disorders (PTLD) after solid organ transplantation. The utility of rituximab for treating EBV viremia in…
  • 2022 American Transplant Congress

    Donor-Specificb Cell Dysfunction and Suppressive Ability Are Differentially Induced in Cob-Mediated Transplantation Tolerance

    S. Durgam1, D. Yin1, M. Alegre2, A. Chong1

    1Surgery, section of transplant immunology, University of Chicago, Chicago, IL, 2Medicine, section of rheumatology, University of Chicago, Chicago, IL

    *Purpose: B cells in mice tolerized to fully mismatched heart allografts with anti-CD154+donor spleen cells (CoB) are intrinsically dysfunctional and unable to differentiate into germinal…
  • 2022 American Transplant Congress

    Regulatory T and B Cell Responses Are Equally Compromised During Antibody-Mediated Rejection of Kidney Allografts

    K. Louis1, P. Fadakar2, C. Macedo2, M. Yamada2, M. Lucas2, X. Gu2, A. Zeevi2, P. Randhawa2, C. Lefaucheur3, D. Metes2

    1Inserm U976, Human Immunology and Immunopathology, Paris, France, 2Surgery, University of Pittsburgh, Pittsburgh, PA, 3Inserm U970, Paris Translational Research Center for Organ Transplantation, Paris, France

    *Purpose: Although considerable advances have been made in understanding the cellular effector mechanisms responsible for donor-specific antibody (DSA) generation leading to antibody-mediated rejection (ABMR), the…
  • 2022 American Transplant Congress

    Identification of a Human B Cell State with Allogeneic Antigen Cross-Presenting Potential

    U. Bhatia, E. C. Guinan

    Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA

    *Purpose: B cells are known to play a significant role in allograft tolerance or rejection, largely determined by production of cytokines and antibodies that suppress…
  • 2022 American Transplant Congress

    Optimal Development and Effector Function of Antibody-Suppressor CXCR5+CD8+ T Cells Requires Host IFN-γ and CD4+ T Cells

    J. Zimmerer, S. Chaudhari, M. Hart, J. Han, K. Koneru, G. Bumgardner

    OSUWMC, Columbus, OH

    *Purpose: We reported the discovery of a novel subset of CXCR5+IFNγ+CD8+ T cells that suppresses antibody production (CD8+ TAb-supp cells). Alloprimed CD8+ TAb-supp cells significantly…
  • 2022 American Transplant Congress

    Single Cell And Spatial Transcriptomics Of Blood And Biopsies Reveals Enhanced Alloantigen Presenting Function And T-follicular Helper Cell (tfh) Expansion Early After Pediatric Liver Transplantation

    R. Sindhi1, C. Ashokkumar1, M. Ningappa1, D. Rajasundaram1, B. W. Higgs1, Q. Xu2, A. Zeevi2, M. Reyes-Mugica1

    1Childrens Hospital of Pittsburgh of UPMC, Pittsburgh, PA, 2University of Pittsburgh Medical Center, Pittsburgh, PA

    *Purpose: We have previously reported enhanced B-cell presentation of donor antigen during early T-cell mediated liver transplant (LT) rejection.*Methods: To characterize B-cell related immunological mechanisms…
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