2016 American Transplant Congress
Transitional B Cell T1/T2 Ratio Is a Prognostic Marker for Human Renal Allograft Deterioration.
1UPMC, Pittsburgh; 2University of Leeds, Leeds, United Kingdom.
Human transitional B cells (TrB) may play a significant role in auto and alloimmune disease. TrB express a high IL10:TNFα ratio and this fell with…2016 American Transplant Congress
TGFb in Regulatory B Cells-Dependent Tolerance.
Surgery, Massachusetts General Hospital, Boston, MA.
In transplantation, increasing evidence support that B cells can play a major regulatory role in addition to their critical functions in allo-immunity and graft rejection.…2016 American Transplant Congress
MHC/HLA-Specific IgE in Allotransplantation.
Background: Donor-specific antibodies (DSA) are recognized as important factors in determining outcome in renal transplantation.Typically DSAs of the IgG isotype are measured, but little is…2016 American Transplant Congress
Designing and Synthesizing a Novel Highly Selective Immunoproteasome Inhibitor That Promotes Long Term Heart Allograft Acceptance While Reducing Plasma Cells and Donor Specific Antibodies.
Antibody mediated rejection (AMR) is one of the most important barriers to improving long-term transplant outcomes. Traditional therapies for AMR do not deplete the source…2016 American Transplant Congress
VDJ Immune Repertoire Sequencing Predicts Patients at Risk of Alloimmune Injury.
1Surgery and Bioinformatics, UCSF, San Francisco, CA; 2Genetics, Stanford University, Palo Alto, CA.
Background: The complex repertoire of immune receptors generated by B cells enables allo-recognition in the context of transplantation across HLA barriers, and is a major…2016 American Transplant Congress
Patients Treated with Belatacept Show Low Levels of APRIL and HLA Antibodies.
Belatacept, a fusión protein that blocks the B7-CD28 costimulation pathway, decreases the level of antibodies in non-human primates and murine models but, few studies have…2016 American Transplant Congress
Selective Deletion of Notch2 on B Cells Abrogates Alloantibody Production in Fully MHC-Mismatched Cardiac and Skin Transplant Models.
Alloantibody-mediated injury remains a major challenge for the improvement of long-term graft survival and there is no effective therapy to prevent alloantibody generation post-transplant. The…2016 American Transplant Congress
Human B Cell Cytokines Predict Renal Allograft Rejection and Early Transplant Outcomes.
In renal transplantation, non-invasive biomarkers that are predictive and allow for early intervention are limited. Here we report findings from a prospective longitudinal study of…2016 American Transplant Congress
Breadth of HLA-Specific B Cell Reactivity and Frequency Assessed by a Novel Multiplex Bead Based Assay Predicts and Correlates with Rejection in Kidney Transplant Recipients.
Northwestern University, Chicago.
Introduction: Recipients with broad sensitization to HLA defined by a high percentage of Panel Reactive Antibodies (PRA) are at higher immunologic risk for poor graft…2016 American Transplant Congress
Prolongation of Graft Survival by Anti-TIM1 Is Specifically Mediated by IL-10+ Bregs and Is Not Dependent on IL-35 or Plasma Cell Differentiation.
In B cell-deficient mice, prolonged islet allograft survival (GS) mediated by anti-TIM1 depends on transfer of IL-10 competent B cells. However, such regulatory B cells…
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