Articles tagged "B cells"

2015 American Transplant Congress
The Molecular Landscape of Atrophy-Fibrosis in Human Kidney Transplants: The Dominant Role of Acute Parenchymal Injury
J. Venner, P. Halloran.
University of Alberta, Edmonton, Canada.
We studied the effect of time post-transplant on atrophy-fibrosis (AF) and molecular associations with AF in 703 kidney transplant indication biopsies (bx) 3 days to…
2015 American Transplant Congress
B-Cell Activation in Acute Kidney Injury and Delayed Graft Function
M. Schiffer,¹ F. Wiehler,¹ R. Song,¹ R. Chen,¹ L. Schiffer,¹ M. Mengel,² H. Haller,¹ F. Gueler.¹
¹Nephrology, Hannover Medical School, Hannover, Germany; ²Pathology, University of Alberta, Edmonton, Canada.
Background:Acute kidney injury (AKI) is a relevant complication after kidney transplantation and also after non-renal solid organ transplantation. Growing evidence points towards an important role…
2015 American Transplant Congress
The Effect of Rituximab Therapy on Regulatory B Cell and Prevention of Chronic Antibody Mediated Rejection in Kidney Transplantation Recipients
M. Ikemiyagi, R. Ishii, S. Miyairi, T. Hirai, K. Omoto, K. Tanabe.
Urology, Tokyo Women's Medical University, Tokyo, Japan.
We previously reported that a single administration of low dose rituximab (RIT) before kidney transplant reduced the incidence rate of chronic antibody mediated rejection (CAMR)…
2015 American Transplant Congress
Assessing Pre-Vaccination Cytokine Levels to Predict Immunogenicity to Seasonal Trivalent Influenza Vaccine in Solid Organ Transplant Recipients
M. Fernandez-Ruiz, A. Humar, S. Keshwani, S. Husain, D. Kumar.
Multi-Organ Transplant Program, University Health Network, Toronto, Canada.
Background: The immunogenicity of seasonal trivalent influenza vaccine (TIV) in solid organ transplant (SOT) recipients remains suboptimal. We hypothesized that analysis of pre-vaccination T- and…
2015 American Transplant Congress
CFZ533: Assessment of Immunomodulatory Activity Following Single Doses of a Novel Anti-CD40 mAb in Healthy Volunteers
A. Slade,¹ J. Doucet,² P. Koo,¹ P. Espie,² J. Rush,² C. Tomek,³ J. Klupp.²
¹Novartis Institute for Biomedical Research, East Hanover, NJ; ²Novartis Institute for Biomedical Research, Basel, Switzerland; ³Celerion, Inc, Lincoln, NE.
Blocking the CD40-CD154 pathway has been shown to effectively prolong renal allograft survival in non-human primates. CFZ533 is a novel, fully human, Fc-silent, anti-CD40 monoclonal…
2015 American Transplant Congress
Efficacy and Safety of Desensitization Protocol Based On Rituximab Plus MMF in ABO-Incompatible Kidney Transplantation Without Splenectomy
K. Takahashi,¹ K. Saito,² S. Takahara,³ S. Fuchinoue,⁴ T. Yagisawa,⁵ A. Aikawa,⁶ Y. Watarai,⁷ N. Yoshimura,⁸ K. Tanabe,⁴ K. Morozumi,⁹ M. Shimazu.¹⁰
¹Niigata Organ Transplant Foundation, Niigata, Japan; ²Graduate School of Medical ＆ Dental Sciences, Niigata University, Niigata, Japan; ³Osaka University Graduate School of Medicine, Osaka, Japan; ⁴Tokyo Women's Medical University, Tokyo, Japan; ⁵Jichi Medical University Hospital, Tochigi, Japan; ⁶Toho University, Faculty of Medicine, Tokyo, Japan; ⁷Nagoya Daini Red Cross Hospital, Aichi, Japan; ⁸Kyoto Prefectural University of Medicine, Kyoto, Japan; ⁹Masuko Memorial Hospital, Aichi, Japan; ¹⁰Tokyo Medical University Hachioji Medical Center, Tokyo, Japan.
Purpose: An open-label, single arm, multicenter clinical study has been conducted in Japan for prospective examination of the efficacy and safety of desensitization protocol with…