2016 American Transplant Congress
Cross-Talk Between TLR and BCR Pathways Induces CNI-Resistance in B-Cells Responding to Blood Group A-Antigens: A Novel Paradigm for Treatment with TLR-Inhibitor for CNI-Resistant AMR.
Hiroshima University, Hiroshima, Japan.
[Aim] Bacterial infections after ABO-incompatible transplantation are associated with refractory antibody (Ab)-mediated rejection (AMR). We demonstrated that bacterial pathogens provoke B cells, responding to human…2016 American Transplant Congress
Attenuation of Warm Hepatic Ischemia-Reperfusion Injury by Bruton's Tyrosine Kinase Inhibition.
1Surgery, Dumont-UCLA Translant Center, Los Angeles, CA; 2Pathology, UCLA, Los Angeles, CA.
Bruton's tyrosine kinase (Btk) is a central player in multiple signaling pathways in lymphoid and myeloid cells, including neutrophils. Neutrophils are crucial effectors in the…2016 American Transplant Congress
B Lymphocytes Prevent Transplantation Tolerance in NOD Mice by Limiting CD4 Treg Function.
Pediatrics, Vanderbilt University, Nashville, TN.
IntroductionType 1 Diabetes is a significant barrier to islet transplant as grafts are subject to both alloimmunity and recurrent autoimmunity. No better is this clinical…2016 American Transplant Congress
Limited Efficacy of Bortezomib on Desensitization via Rapid Humoral Compensation in a Sensitized Rhesus Model.
1Surgery, Duke University, Durham; 2Surgery, Emory University, Atlanta.
Sensitized patients comprise a significant proportion (30%) of candidates on the waiting list for transplantation. With recent evidence that the presence of donor-specific antibodies (DSA)…2016 American Transplant Congress
Direct Detection of T and B Memory Lymphocytes Reveals HCMV Exposure That Serum Antibodies Fail to Identify.
Research and Development, Cellular Technology Ltd, Shaker Hts, OH.
It is essential to identify donors who have not been infected with HCMV in order to avoid transmission of HCMV to human recipients of transfusion…2016 American Transplant Congress
Expansion of Regulatory B-Cells and Their Potential Role in Transplantation Tolerance.
Massachusetts General Hospital, Boston, MA.
IntroductionRegulatory B (Bregs) cells, B cells which produce IL-10, have been shown to play a critical role in immune homeostasis and autoimmunity models. Despite the…2016 American Transplant Congress
Ibrutinib Suppresses Alloantibody Responses in A Mouse Model of Allosensitization: A Preliminary Report.
CTC/Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.
Background Ibrutinib is a Bruton tyrosine Kinase (BTK) antagonist that inhibits B cell receptor (BCR) signaling, therefore blocking B cell activation. Ibrutinib is approved by…2016 American Transplant Congress
CD8+TCR– Facilitating Cells in Mobilized Peripheral Blood Mononuclear Cells Are Enriched with IL-10 Producing B Cells.
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.
We recently reported that facilitating cell (FC) enriched hematopoietic progenitor stem cell (HSPC) allografts (FCRx) induced tolerance without graft-versus-host disease (GVHD) or engraftment syndrome in…2016 American Transplant Congress
Tracking Endogenous B Cells Recognizing Allogeneic MHC Class II in Mice.
Clinical data suggest that donor-specific antibody (DSA)-mediated rejection is currently the leading cause of kidney allograft failure, with anti-donor Class II Abs tending to be…2016 American Transplant Congress
The Role of B Cells in Liver Transplant Tolerance.
Scarcely one would argue that donor-specific B cells and antibodies contribute to rejection of transplants. However, studies published in the past few years have provided…
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