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American Transplant Congress abstracts

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Articles tagged "B cells"

  • 2022 American Transplant Congress

    Assessment of Circulating B Cell Developmental Stages Early After Kidney Transplantation. Preliminary Data from a Single Center

    A. Fouza1, A. Fylaktou2, A. Xohelli2, E. Sampani3, B. Nikolaidou2, D. Asouhidou2, N. Antoniadis1, E. Kasimatis3, M. Stangou3, G. Tsoulfas1, A. Papagianni3

    1Division of Transplantation, Department of Surgery, Aristotle University of Thessaloniki, Thessaloniki, Greece, 2National Peripheral Histocompatibility Center, Immunology Department, Hippokration General Hospital of Thessaloniki, Thessaloniki, Greece, 3Department of Nephrology, Aristotle University of Thessaloniki, Thessaloniki, Greece

    *Purpose: B lymphocytes (BL) is an important immune component in the function of kidney transplants, through antibody production, antigen-presentation to T cells, secretion of cytokines,…
  • 2022 American Transplant Congress

    Characterization Of Gzmb+ Bregs Using Single Cell Rnaseq

    N. Sailliet, H. Le Mai, A. Dupuy, C. Fourgeux, M. Chesneau, J. Poschmann, R. Danger, S. Brouard

    CRT2I INSERM UMR1064, Nantes, France

    *Purpose: Granzyme B (GZMB)+ B cells are increased in blood from transplanted patients who tolerate a kidney graft without immunosuppressive treatment. We demonstrated that these…
  • 2022 American Transplant Congress

    Lung Allograft-Resident Eosinophils Maintain Long-Term Graft Integrity by Restraining Humoral Alloimmunity

    Z. Mei1, Y. Guo1, D. Li1, M. Khalil1, A. Banerjee1, A. Gelman2, D. Kreisel2, A. Krupnick3

    1Department of Surgery, University of Maryland, Baltimore, Baltimore, MD, 2Washington University in St. Louis, St. Louis, MO, 3Department of Surgery, University of Maryland, Baltimore, baltimore, MD

    *Purpose: The finding that eosinophils facilitate immunosuppression-mediated acceptance of murine lung allograft by downregulating alloreactive CD8+ T cells has been recently described by our group.…
  • 2022 American Transplant Congress

    Deficiency of Antibody-Suppressor CXCR5+CD8+ T Cells (Not CD4+ Tregs) Drive High Alloantibody Production in CCR5 KO Kidney Transplant Recipients

    J. L. Han1, J. M. Zimmerer1, Q. Zeng2, S. Chaudhari1, C. K. Breuer2, G. L. Bumgardner1

    1Dept of Surgery, The Ohio State University, Columbus, OH, 2Center for Regen. Med., The Research Institute at Nationwide Children's Hospital, Columbus, OH

    *Purpose: Kidney transplant (KTx) into CCR5 KO mice is an excellent model to study AMR immunobiology due to high alloantibody (alloAb) production, rapid allograft rejection,…
  • 2022 American Transplant Congress

    Clazakizumab® (anti-il-6) Desensitization in Highly-HLA Sensitized Patients Awaiting Kidney Transplant (nct03380962): Long-Term Follow Up

    A. Vo1, J. Tang1, N. Ammerman1, E. Huang1, X. Zhang2, M. Haas3, A. Peng1, R. Najjar1, S. Williamson1, C. Meyers1, S. Sethi1, K. Lim1, M. Gillespie1, N. Badash1, S. Jordan1

    1Comprehensive Transplant Center, Cedars Sinai Medical Ctr, Los Angeles, CA, 2HLA Laboratory, Cedars Sinai Medical Ctr, Los Angeles, CA, 3Pathology, Cedars Sinai Medical Ctr, Los Angeles, CA

    *Purpose: IL-6 is a cytokine critical for B-cell activation and IgG production. Clazakizumab (CSL Behring LLC) is a humanized monoclonal aimed at the cytokine IL-6.…
  • 2022 American Transplant Congress

    Transitional-1 B Cell IL-10/TNFα Ratio Risk-Stratifies Renal Transplant Patients with Early Borderline Change

    A. Cherukuri, P. Randhawa, S. Hariharan, D. Rothstein

    Thomas E. Starzl Transplantation Institute, UPMC, Pittsburgh, PA

    *Purpose: Recent studies have shown that Banff borderline change (BLC) on allograft biopsies (Bx) is associated with decreased graft survival. However, many patients with BLC…
  • 2022 American Transplant Congress

    Bone Marrow Resident Long-Lived Plasma Cells as Source of Chronic Donor-Specific Antibodies

    M. Muckenhuber, S. Pichler, A. M. Weijler, T. Wekerle

    Dept. of General Surgery, Div. of Transplantation, Medical University of Vienna, Vienna, Austria

    *Purpose: The importance of bone marrow resident plasma cells for long-lasting humoral immunity has been highlighted in several models for vaccination and infectious diseases. To…
  • 2022 American Transplant Congress

    Dynamic Changes of Serum Soluble B Cell Activating Factor in Kidney Transplant with De Novo Donor Specific Antibody

    S. Wu1, X. Su1, Y. Gao1, Y. Wei1, Q. Ye1, M. Huang2, Y. Chen1, J. Wang1, Q. Zhang3, Q. Fu1, J. Li2, H. Huang2, B. Xu2, H. Zhang1, L. Liu2, C. Wang2

    1Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, 2The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, 3Charité - Universitätsmedizin Berlin, Berlin, Germany

    *Purpose: De novo donor specific antibody (dnDSA) plays a crucial role in the development of antibody mediated rejection (ABMR) and is correlated to the worse…
  • 2022 American Transplant Congress

    Longitudinal Characterization of Memory B Cells During Antibody Mediated Rejection Treated with Plasmapheresis, Bortezomib, and Belatacept in Heart Transplant Recipients

    F. Alkhunaizi1, M. Ellison2, V. Berrich1, M. Siegelin1, M. Szabolcs1, G. F. Sayer1, N. Uriel1, S. Restaino1, A. Chong3, A. Zeevi2, M. Habal1

    1Columbia University Medical Center, New York, NY, 2University of Pittsburgh Medical Center, Pittsburgh, PA, 3University of Chicago, Chicago, IL

    *Purpose: Donor specific antibodies (DSA) and antibody mediated rejection (AMR) continue to limit allograft longevity after heart transplant. Effective treatments are limited and often complicated…
  • 2022 American Transplant Congress

    A Novel Immunosuppressive Compound (79-6) That Targets Bcl6 Prevents the Humoral Alloresponse

    R. Kraaijeveld, D. A. Hesselink, C. C. Baan

    Internal medicine - Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, Netherlands

    *Purpose: BCL6, is a transcription factor involved in B cell activation and differentiation. BCL6-expressing B cells play a crucial role in the development and maintenance…
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