2018 American Transplant Congress
BETA-2 Score is an Excellent Tool for Monitoring of Islet Allograft Function and Early Detection of Transplant Dysfunction
1Surgery, University of Chicago, Chicago; 2Nephrology, Medical University of Gdańsk, Gdańsk, Poland.
After validation of BETA-2 scores in our cohort of patients in relation to standard stimulation tests, we decided to assess the practical utility of BETA-2…2018 American Transplant Congress
Circulating T Follicular Helper Cells Expand Following Transplantation and Exhibit a CD44hi Phenotype That Correlates with Peak Germinal Center Alloreactivity
Emory Transplant Center, Atlanta.
It is increasingly well-recognized that donor-specific antibodies (DSA) play a significant role in the development of chronic rejection and fibrosis that contribute to late renal…2018 American Transplant Congress
Impact of the New KAS on Transplant Rates in Highly-HLA Sensitized (HS) Patients after Desenstization (DES): 3yrs Post Implementation
Kidney Transplant, Cedars-Sinai Medical Center, LA, CA.
Introduction: The KAS aims to increase equity in organ allocation for broadly sensitized (HS) patients, especially (CPRA 99-100%). Coupling desensitization (DES) + KAS likely will…2018 American Transplant Congress
IL-10 Requirement in In Vitro Expanded Breg-Mediated Allograft Tolerance is Tissue Specific
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.
Introduction:Regulatory B cells (Bregs) have shown several multiple mechanisms of suppression, including Treg induction and IL-10 production. Consistent with work of other groups on Breg…2018 American Transplant Congress
Increase on Regulatory Cells in Kidney Transplanted Patients Presenting Donor-Specific Antibodies
The role of anti-HLA donor specific antibodies (DSA) in increasing the risk of graft rejection is known. Nevertheless, not all patients with DSA develop rejection…2018 American Transplant Congress
T Cell Exhaustion Contributes to Operational Tolerance of Liver Allografts in Pediatric Liver Transplant Recipients
Operational tolerance in the absence of immunosuppression can be successfully attained in pediatric liver transplant recipients. Although DSA are observed in a proportion of operationally…2018 American Transplant Congress
Achieving Allograft Tolerance through Antigen-Specific Regulatory B Cells
IntroductionA complete understanding of the role of antigen-specificity in the development of B cell mediated allograft tolerance has remained elusive. Previous work in our lab…2018 American Transplant Congress
Accommodation and Antibody Mediated Rejection Are Associated with Distinct TACI Polymorphisms in Kidney Transplant Recipients
1Surgery, University of Michigan, Ann Arbor, MI; 2Pathology, University of Michigan, Ann Arbor, MI.
A. Trans-membrane Activator and CAML Interactor (TACI) gene is among the 5% most polymorphic genes in humans, TACI controls B cell differentiation and memory and…2018 American Transplant Congress
Designing Novel Selective Immunoproteasome Inhibitors Reveals a Critical Role of the Immunoproteasome in Protecting Antibody Secreting B Cells from Apoptosis
Constitutive proteasomes (c-20S) are ubiquitously-expressed cellular proteases that degrade polyubiquitinated proteins and regulate cell functions. Its inhibitor, bortezomib, is a plasma cell-targeted therapy used in…2018 American Transplant Congress
Alloreactive B Cells Acquire Cell-Intrinsic Hyporesponsiveness in Tolerant Recipients
Donor-specific transplantation tolerance has long been an aspiration of clinical transplantation. Recently, we have reported that multiple mechanisms are required to reinforce profound hyporesponsiveness of…
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