Articles tagged "B cells"

2022 American Transplant Congress
Pre-Emptive Rituximab Use for Epstein-Barr Virus (EBV) Viremia in Cardiothoracic Solid Organ Transplant Recipients
B. Astorga, A. Loethen, L. Potter
University of Chicago Medicine, Chicago, IL
*Purpose: EBV viremia is associated with potentially life-threatening post-transplant lymphoproliferative disorders (PTLD) after solid organ transplantation. The utility of rituximab for treating EBV viremia in…
2022 American Transplant Congress
Donor-Specificb Cell Dysfunction and Suppressive Ability Are Differentially Induced in Cob-Mediated Transplantation Tolerance
S. Durgam¹, D. Yin¹, M. Alegre², A. Chong¹
¹Surgery, section of transplant immunology, University of Chicago, Chicago, IL, ²Medicine, section of rheumatology, University of Chicago, Chicago, IL
*Purpose: B cells in mice tolerized to fully mismatched heart allografts with anti-CD154+donor spleen cells (CoB) are intrinsically dysfunctional and unable to differentiate into germinal…
2022 American Transplant Congress
Regulatory T and B Cell Responses Are Equally Compromised During Antibody-Mediated Rejection of Kidney Allografts
K. Louis¹, P. Fadakar², C. Macedo², M. Yamada², M. Lucas², X. Gu², A. Zeevi², P. Randhawa², C. Lefaucheur³, D. Metes²
¹Inserm U976, Human Immunology and Immunopathology, Paris, France, ²Surgery, University of Pittsburgh, Pittsburgh, PA, ³Inserm U970, Paris Translational Research Center for Organ Transplantation, Paris, France
*Purpose: Although considerable advances have been made in understanding the cellular effector mechanisms responsible for donor-specific antibody (DSA) generation leading to antibody-mediated rejection (ABMR), the…
2022 American Transplant Congress
Identification of a Human B Cell State with Allogeneic Antigen Cross-Presenting Potential
U. Bhatia, E. C. Guinan
Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA
*Purpose: B cells are known to play a significant role in allograft tolerance or rejection, largely determined by production of cytokines and antibodies that suppress…
2022 American Transplant Congress
Optimal Development and Effector Function of Antibody-Suppressor CXCR5⁺CD8⁺ T Cells Requires Host IFN-γ and CD4⁺ T Cells
J. Zimmerer, S. Chaudhari, M. Hart, J. Han, K. Koneru, G. Bumgardner
OSUWMC, Columbus, OH
*Purpose: We reported the discovery of a novel subset of CXCR5+IFNγ+CD8+ T cells that suppresses antibody production (CD8+ TAb-supp cells). Alloprimed CD8+ TAb-supp cells significantly…
2022 American Transplant Congress
Single Cell And Spatial Transcriptomics Of Blood And Biopsies Reveals Enhanced Alloantigen Presenting Function And T-follicular Helper Cell (tfh) Expansion Early After Pediatric Liver Transplantation
R. Sindhi¹, C. Ashokkumar¹, M. Ningappa¹, D. Rajasundaram¹, B. W. Higgs¹, Q. Xu², A. Zeevi², M. Reyes-Mugica¹
¹Childrens Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ²University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: We have previously reported enhanced B-cell presentation of donor antigen during early T-cell mediated liver transplant (LT) rejection.*Methods: To characterize B-cell related immunological mechanisms…
2022 American Transplant Congress
Validation of Donor Specific Antibody Characteristics Associated with Deleterious Outcomes: A Single Center Study of 940 Kidney Allograft Recipients
P. Lamba¹, I. Lamba¹, R. Friedlander², V. Sharma³, J. Lee², J. B. Lee⁴, C. Hartono⁵, M. Thangamani⁶, D. Sawinski², T. Salinas⁷, M. Suthanthiran⁸, D. Dadhania⁹
¹Nephrology, Hypertension and Transplantation, New York Presbyterian/Weill Cornell Medicine, New York, NY, ²New York Presbyterian/Weill Cornell Medicine, New York, NY, ³The Rogosin Inst Cornell UMC, New York, NY, ⁴Rogosin Institute, New York, NY, ⁵New York Presbyterian Hospital-Weill Cornell, New York, NY, ⁶Cornell, New York, NY, ⁷Nephrology, NY Presbyterian- Weill Cornell, New York, NY, ⁸Weill Cornell Med Ctr., New York, NY, ⁹Weill Cornell Medicine - NYPH, New York, NY
*Purpose: A reproducibility crisis is pervasive in scientific literature. We aimed to investigate whether the DSA characteristics we previously associated with antibody mediated rejection (AMR)…
2022 American Transplant Congress
Comparison of IGG and IGM Type B Cell Receptor-Mediated MTOR Phosphorylation Signal
Y. Matsuda
Division of Transplant Immunology, Division of Transplant Immunology, Tokyo, Japan
*Purpose: IgG and IgM memory B cells (mBCs) corresponding donor-specific antigen are closely involved in the activation of humoral immunity against transplanted grafts. Therefore, it…
2022 American Transplant Congress
Local Intragraft Humoral Immune Response in Chronic Lung Allograft Dysfunction
E. Miyamoto¹, S. C. Juvet², D. Vosoughi², J. Wang², J. Al-Refaee², T. Daigneault², A. Duong², S. Moshkelgosha², S. Keshavjee², K. Tinckam², A. Chruscinski³, D. Hwang⁴, T. Martinu²
¹Tenri Hospital Japan, University Health Network Canada, Nara, Japan, ²University Health Network, Toronto, ON, Canada, ³Multi-Organ Transplantation, University Health Network, Toronto, ON, Canada, ⁴Sunnybrook Health Science Centre, Toronto, ON, Canada
*Purpose: Donor HLA-specific antibody (DSA) and antibody against self-antigens (self-antigen antibody) can cause injury and lead to chronic lung allograft dysfunction (CLAD) after lung transplantation…
2022 American Transplant Congress
CD40 Expressed by FRC Regulates Lymph Node Structure and Function
M. W. Shirkey¹, L. Li¹, R. Abdi², J. S. Bromberg¹
¹University of Maryland School of Medicine, Baltimore, MD, ²Transplant Research Center, Harvard Medical School, Boston, MA
*Purpose: Fibroblastic reticular cells (FRC) support lymph node (LN) structure and can regulate T cell function through the CD40-CD40L pathway. Our previous work showed that…

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