Articles tagged "B cells"

2022 American Transplant Congress
Complement 5 Regulation Ameliorates Antibody-Mediated Rejection After Liver Transplantation in Rats
T. Tajima¹, K. Hata¹, J. Kusakabe¹, H. Miyauchi¹, X. Zhao¹, S. Kageyama¹, T. Okamoto¹, Y. Wang², E. Hatano¹
¹Dept. of HBP Surgery & Transplantation, Kyoto University, Kyoto, Japan, ²Alexion Pharmaceuticals Inc., New Haven, CT
*Purpose: Antibody-mediated rejection (AMR) is a refractory rejection after donor-specific antibody (DSA)-positive or blood-type incompatible organ transplantation. Since AMR significantly deteriorates transplant outcomes, there is…
2022 American Transplant Congress
Influence of Regulatory B Cells on B Cells
Q. Fu¹, K. M. Lee², K. Deng², D. Agarwal¹, R. Matheson³, T. Press¹, J. Lei⁴, H. Yang⁵, C. LeGuern², S. Deng⁵, J. F. Markmann²
¹Center for Transplant Science, MGH, Boston, MA, ²Massachusetts General Hospital, Boston, MA, ³Transplantation Surgery Research, Massachusetts General Hospital, Boston, MA, ⁴Surgery, Mass General, Boston, MA, ⁵Sichuan Provincial People's Hospital, University of Electronic Sciences and Technology of China, Chengdu, China
*Purpose: Our previous study showed that Bregs-TLR, one type of previously studied Breg expanded in vitro, are capable of suppressing naïve B cell proliferation in…
2022 American Transplant Congress
Peripheral Blood Immune Cell Profiles of Corneal Transplant with and without Acute Rejection
J. Hjortdal¹, M. Griffin², C. C. Murphy³, S. Brouard⁴, N. Degauque⁴
¹Department of Ophthalmology, Aarhus University Hospital, Aarhus, Denmark, ²National University of Ireland, Galway, Galway, Ireland, ³Royal Victoria Eye and Ear Hospital, Dublin, Ireland, ⁴Université de Nantes, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes, France
*Purpose: Acute rejection (AR) of allogeneic corneal transplantation (CT) has a profound effect on subsequent graft survival, indicating that immunological damage is often not fully…
2022 American Transplant Congress
Dynamic Changes in Titer and Specificity Autoantibodies in Chronic Bm12 to B/6 Kidney Rejection
I. Sayin¹, D. Yin¹, D. Ghosh², M. Clark², A. Chong¹
¹Department of Surgery, University of Chicago, Chicago, IL, ²Department of Medicine, University of Chicago, Chicago, IL
*Purpose: Loss of autoreactive B cell tolerance and production of non-HLA autoantibodies have been observed in patients undergoing chronic rejection, however, how autoreactive B cells…
2022 American Transplant Congress
Characterization of GZMB+ Bregs Transcriptome and Their Impact on Target Cells in Single-Cell RNA-seq
N. Sailliet, H. Le Mai, A. Dupuy, F. Cynthia, M. Chesneau, J. Poschmann, R. Danger, S. Brouard
CRTI- INSERM UMR 1064, Nantes, France
*Purpose: During the inflammatory process, the immune system capacity to regulate itself is mandatory to balance effector positive feedback, avoid allergies and autoimmunity. Different subsets…
2022 American Transplant Congress
Long-Term Kidney Allotransplant Acceptance is Defined by a Shift from a T Cell to a B Cell Rich Immune Microenvironment Within the Graft
E. S. Szuter¹, T. Yokose¹, M. T. Guinn¹, J. Ge², I. Rosales³, B. Kwon⁴, P. S. Russell¹, A. Cuenca², D. Kreisel⁵, P. Sage⁶, J. C. Madsen¹, R. B. Colvin³, A. Alessandrini¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Surgery, Boston Children's Hospital, Boston, MA, ³Department of Pathology, Massachusetts General Hospital, Boston, MA, ⁴Harvard College, Cambridge, MA, ⁵Department of Surgery, Washington University, St. Louis, MO, ⁶Transplantation Research Center, Renal Division, Brigham and Women’s Hospital, Boston, MA
*Purpose: Mouse kidney allografts are spontaneously accepted in select, fully-mismatched donor-recipient strain combinations, such as DBA/2J to C57BL/6 (B6). Tolerant renal grafts develop aggregates of…
2022 American Transplant Congress
Disruption of B Cell Population is Associated with Increased Infections in Pediatric Transplant Recipients
B. Geng, L. Loop, C. Anterasian, D. Mortazavi, J. Kitsen, C. Collins, K. Newton, E. Ingulli
Pediatrics, UCSD Rady Children's, San Diego, CA
*Purpose: Solid-organ transplant recipients are placed on long-term immunosuppression, preventing graft rejection but increasing the risk of infection. Pediatric transplant recipients are at increased risk…
2022 American Transplant Congress
Tolerant B Cells Suppress Memory B Cells in a Donor Specific Manner in CoB Mediated Transplantation Tolerance
S. Durgam¹, D. Yin¹, M. Alegre², A. Chong¹
¹Surgery, section of transplant immunology, University of Chicago, Chicago, IL, ²Medicine, section of rheumatology, University of Chicago, Chicago, IL
*Purpose: We previously reported that B cells in recipients made tolerant to fully mismatched heart allografts by anti-CD154+donor spleen cells (CoB) become dysfunctional in their…
2022 American Transplant Congress
Contributions of Allogenicity and Antigen Presentation to Regulatory B Cell Suppression
K. Lee, F. Qiang, K. Deng, R. Matheson, J. Lei, C. LeGuern, J. Markmann
Center for Transplantation Sciences, Boston, MA
*Purpose: We previously generated in vitro Toll-like receptor (TLR)-activated B cells became regulatory B cells (Bregs) that suppress T cell proliferation and promote allograft tolerance.…
2022 American Transplant Congress
Abnormal B Cell Profile Associated with Inadequate Antibody Response to MRNA SARS-COV-2 Vaccine Can Be Overcome with a Third Vaccine Dose in Adolescent Kidney Transplant Recipients
C. Crane, E. Phebus, L. Loop, C. Anterasian, B. Geng, E. Ingulli
Pediatrics, UCSD Rady Children's, San Diego, CA
*Purpose: mRNA SARS-CoV-2 vaccines are highly efficacious in the general population but have shown a diminished response in immunosuppressed adolescent kidney allograft recipients. We investigated…

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