Articles tagged "Apoptosis"

2017 American Transplant Congress
Nafamostat Mesilate Ameliorates Ischemia-Reperfusion Renal Injury via Anti-Apoptotic Mechanism.
D. Choi,¹ J. Jeong,² H. Bae,¹ Y. Ham,¹ K. Lee,¹ K. Na.¹
¹Chungnam National University, Nephrology, Daejeon, Korea; ²Chungnam National University, Department of Medical Science, Daejeon, Korea
Purpose: It has been reported that nafamostat mesilate inhibits inflammatory injury via inhibition of complement activation in ischemic heart, liver, and intestine. However, it is…
2017 American Transplant Congress
Protective Effect of Crepidiastrum denticulatum Extract Pretreatment Against Hepatic Ischemia-Reperfusion Injury in Mice.
H. Jang, H. Lee, C. Park, D. Eom, J. Lee, M. Oh, J. Yoo, C. Rho.
Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Gangwon, Korea; Anesthesia, University of Ulsan, Gangneung Asan Hospital, Gangneung, Gangwon, Korea; Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Gangwon, Korea; Pathology, University of Ulsan, Gangneung Asan Hospital, Gangneung, Gangwon, Korea; Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Gangwon, Korea; Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Gangwon, Korea; Natural Medicine Center, Korea Institute of Science and Technology, Gangneung, Gangwon, Korea; Natural Medicine Center, Korea Institute of Science and Technology, Gangneung, Gangwon, Korea
Crepidiastrum denticulatum (CD) is a well-known, traditionally consumed vegetable in Korea, which was recently reported to have bioactive compounds with detoxification and antioxidant properties. Ischemia-reperfusion…
2017 American Transplant Congress
Apoptotic Exosome-Like Vesicles Released During Tissue Injury Trigger IL23/IL-17 Autoimmune Axis and Accelerate Rejection.
M. Dieudé,^1,4 J. Turgeon,^1,4 A. Karakeussian-Rimbault,^1,4 L. Pomerleau,¹ A. Robitaille,¹ N. Grandvaux,¹ É. Boilard,^2,4 M.-J. Hébert.^1,3,4
¹Research Centre, Centre Hospitalier de l'Université de Montréal, Montreal, Canada; ²CHU de Québec, Québec, Canada; ³Montreal University, Montreal, QC, Canada; ⁴Canadian National Transplantation Research Program, Edmonton, Canada
Autoantibodies to apoptotic antigens, such as perlecan/LG3, are present pre-transplantation and contribute to organ rejection. We previously showed that during tissue injury, apoptotic endothelial cells…
2017 American Transplant Congress
AAV8 Delivery of TIMP-1 Prevents Hepatocyte Apoptosis After Liver Ischemia/Reperfusion Injury.
S. Duarte, P. Matian, M. Miller, R. Busuttil, A. Coito.
Dumont-UCLA Transplant Center, Los Angeles
Matrix metalloproteinase-9 (MMP-9) is a key mediator of leukocyte migration across vascular barriers in hepatic ischemia/reperfusion injury (IRI). Tissue inhibitor of metalloproteinase-1 (TIMP-1) is the…
2017 American Transplant Congress
Dual Role for Caspase-3 in the Regulation of Tubular and Microvascular Damage Post-Renal Ischemia-Reperfusion Injury.
B. Yang,^1,2,3 S. Lan,^1,2,3 N. Patey,^1,3,4 J. Turgeon,^1,3 M. Dieudé,^1,3 M.-J. Hébert.^1,2,3
¹Research Centre, Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada; ²Canadian National Transplant Research Program, Edmonton, AB, Canada; ³Université de Montréal, Montreal, QC, Canada; ⁴Department of Pathology, CHU Ste-Justine, Université de Montréal, Montreal, QC, Canada
Ischemia-reperfusion injury (IRI) in renal transplant recipients is a risk factor of allograft dysfunction and reduced survival. Although tubular epithelial cells (TEC) are classically considered…
2017 American Transplant Congress
Isoflurane Precondition Alleviated Murine Liver Ischemia and Reperfusion Injury by Restoring AMPK/mTOR-Mediated Autophagy.
Z. Rao,¹ H. Zhou,² X. Pan,¹ M. Gao,¹ Z. Wang,¹ J. Sun,¹ C. Liu,¹ Z. Ding.¹
¹Department of Anesthesiology, First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China; ²Department of Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Background: Isoflurane has a pharmacological precondition effect against ischemia injury in the heart, kidney and brain, but whether and how isoflurane precondition protects livers against…
2017 American Transplant Congress
Proteasome Modulation an Effective Strategy to Ameliorate Steatotic Liver Grafts Viability After Preservation.
M. Zaouali,¹ A. Panisello Roselló,¹ T. Carbonell,² A. Garcia-Gil,³ A. Lopez,⁴ R. Adam,⁴ J. Rosello-Catafau.¹
¹Patología Experimental, Instituto de Investigaciones Biomédicas de Barcelona, CSIC, Barcelona, Spain; ²Phisiology, Fac. of Biology, Universitat de Barcelona, Barcelona, Spain; ³Transplantation, Hospital Clínico, Zaragoza, Spain; ⁴Hepato- Biliare Unit, Hôpital Paul Brousse, INSERM U-776, Université Paris Sud, Paris, France
Recently we provided evidence for a possible protective role of proteasome inhibition during liver graft preservation. Although, several reported data confirmed that the proteolytic activity…
2017 American Transplant Congress
Novel Application of Localized Nanodelivery of Anti-IL6 Protects Organ Transplant from Ischemia Reperfusion Injuries.
M. Uehara,¹ Z. Solhjou,¹ B. Bahmani,¹ O. Maarouf,¹ T. Ichimura,² C. Brooks,² W. Xu,¹ V. Kasinath,¹ N. Banouni,¹ A. Elkhal,³ I. Guleria,² M. McGrath,¹ S. Tullius,³ R. Abdi.¹
¹Transplantation Research Center/Renal Devision, Brigham and Women's Hospital/ Harvard Medical School, Boston; ²Renal Division, Brigham and Women's Hospital/ Harvard Medical School, Boston; ³Division of Transplant Surgery and Transplantation Surgery Research Laboratory, Brigham and Women's Hospital/ Harvard Medical School, Boston
Ischemia reperfusion injury (IRI) evokes major intra-graft inflammatory responses that markedly augment alloimmune responses. Understanding mechanisms involved is critical for the development of novel therapeutic…
2017 American Transplant Congress
Detection of Specific B Cell Memory to the Perlecan LG3 Antigen in the Normal Immune Repertoire.
L. Padet,^1,2,3 M. Dieude,^1,2 B. Yang,^1,2,3 J. Turgeon,^1,2 H. Cardinal,^1,2 M.-J. Hebert.^1,2,3
¹Research Center of Montreal Hospital Center (CRCHUM), Montreal, Canada; ²Canadian National Transplant Research Program (CNTRP), Edmunton, Canada; ³Université de Montréal, Montreal, Canada
Autoantibodies targeting the C-terminal fragment of perlecan (LG3) were identified in patients with kidney transplantation and are associated with rejection episodes. High anti-LG3 titers were…
2017 American Transplant Congress
Scoring of Distinct Tubular Injury Features and Assessment of Cellular Proliferation and of Non-Apoptotic Cell Death by the Novel Marker FACL4 Allow to Determine the Long-Term Prognosis of Renal Grafts.
A. Bohlmann,¹ J. Schmitz,¹ A. Melk,¹ R. Schmitt,¹ I. Scheffner,¹ V. Broeker,² H. Haller,¹ J. Metzger,³ J. Braesen,¹ W. Gwinner.¹
¹Hannover Medical School, Hannover, Germany; ²University of Gothenburg, Gothenburg, Sweden; ³Mosaiques Diagnostics, Hannover, Germany
Acute tubular injury (ATI) is common in renal grafts and is related to an inferior long-term function. There is no consensus which of the tubular…

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