2020 American Transplant Congress
Torc1 Inhibition Protects Activated Human Regulatory T Cells from Self-Inflicted Damage via Granzyme B
Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
*Purpose: The use of Regulatory T cells (Tregs) in adoptive cell therapy has been hindered by their short survival following their adoptive transfer. We have…2020 American Transplant Congress
Cell-Free DNA (cfDNA) is Released by Necroptosis and Promotes Kidney Ischemia Reperfusion Injury
Microbiology and Immunology, Western University, London, ON, Canada
*Purpose: Transplantation is invariably associated with ischemia reperfusion injury (IRI) which causes organ dysfunction. IRI is also directly linked to several forms of programmed cell…2020 American Transplant Congress
FcγRIIIb Inhibits Renal Transplant Rejection by Inducing Neutrophils Apoptosis
Kidney Disease Center, The First Affiliated Hospital of Zhejiang University, Hangzhou, China
*Purpose: Fcγ receptors (FcγR) have been proposed to be involved in the pathogenesis of acute rejection (AR) after organ transplantation. However, the mechanisms by which…2020 American Transplant Congress
Exosomes Derived from MSC Ameliorate Renal Ischemic-Reperfusion Injury Through Inhibiting Inflammation and Cell Apoptosis
*Purpose: Investigate the underlying mechanism of mesenchymal stem cells (MSCs) on protection of renal ischemia reperfusion injury (IRI) .*Methods: Exosomes originated from MSCs (MSC-ex) were…2020 American Transplant Congress
Induction of Transplant Tolerance by Modulating the Metabolic Stress Pathways
Houston Methodist Research Institute, Houston, TX
*Purpose: T cell activation and effector differentiation precede graft rejection, and this process is associated with robust metabolic burst to meet the energy demand of…2019 American Transplant Congress
Bcl-2 Inhibition with Venetoclax Promotes Induction of Mixed Chimerism and Renal Allograft Tolerance without Severe Myelosuppression in Non-Human Primate
*Purpose: Specific Bcl-2 inhibition has been shown to promote mixed chimerism and skin allograft tolerance without myelosuppressive conditioning in murine models. To extend this approach…2019 American Transplant Congress
The Impact of Thrombin / Protease-Activated Receptor-1 Pathway in Hepatic Ischemia-Reperfusion Injury in Mice
*Purpose: Coagulation cascade is an important pathway in the pathophysiology of hepatic ischemia-reperfusion injury(IRI). Generation of thrombin is a critical factor of coagulation induced by…2019 American Transplant Congress
Apoptotic Exosome-Like Vesicles Induce Endothelial Cell Plasticity and Accelerate Allograft Vascular Remodeling
1CRCHUM, Montreal, QC, Canada, 2IRIC, Montreal, QC, Canada
*Purpose: Acute vascular rejection of allografts is associated with endothelial apoptosis which in turn contributes to the development of transplant vasculopathy. We previously showed that…2019 American Transplant Congress
Nephrotoxicity Caused by Calcineurin Inhibitors is Meditated by BAX, NOL3 and XIAP Apoptotic Genes Dysregulation
*Purpose: Calcineurin inhibitors (CNI) remain the most effective and widely used immunosuppressive agents in kidney transplantation. Nephrotoxicity is a major secondary effect, and renal biopsy…2019 American Transplant Congress
Glycogen Synthase Kinase 3alpha Serine 21 Phosphorylation Inhibits Hepatocyte Autophagy to Facilitate Liver Ischemia Reperfusion Injury
*Purpose: Glycogen synthase kinase 3 (Gsk3) has α and β isoforms. They are constitutively active in cells and inhibited upon stimulations by N-terminal serine phosphorylation.…
- « Previous Page
- 1
- 2
- 3
- 4
- 5
- 6
- …
- 13
- Next Page »