ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Apoptosis"

  • 2020 American Transplant Congress

    Induction of Transplant Tolerance by Modulating the Metabolic Stress Pathways

    X. Xiao, L. Zhang, Y. Ying, Y. Wang, P. Arnold, Z. Zhang, X. Li

    Houston Methodist Research Institute, Houston, TX

    *Purpose: T cell activation and effector differentiation precede graft rejection, and this process is associated with robust metabolic burst to meet the energy demand of…
  • 2020 American Transplant Congress

    Prophylactic Treatment with Antioxidant Nanoparticles Attenuate Ischemia/Reperfusion Injury in BALB/c Mice

    S. Yoon1, K. Lee1, W. Hwang1, S. Yun1, K. Yoon2

    1Nephrology, Konyang University Hospital, Daejeon, Korea, Republic of, 2Chemistry, Hannam University, Daejeon, Korea, Republic of

    *Purpose: Kidney is more susceptible to hypoxic damage than other organ because kidney tissue consumes most of oxygen to move various solute across membrane. Ischemia/reperfusion…
  • 2020 American Transplant Congress

    Cyclophilin-D Inhibition Mitigates Cardiac Allograft Ischemia-Reperfusion Injury and Rejection

    A. Qamar1, P. McLeod2, J. Jiang2, X. Huang2, A. M. Jevnikar2, Z. Zhang2

    1Pathology & Laboratory Medicine, University of Western Ontario, London, ON, Canada, 2London Health Sciences Center, London, ON, Canada

    *Purpose: The clinical relevance of ischemia-reperfusion injury (IRI) in the context of organ transplantation is well-established. IRI is associated with various forms of programmed cell…
  • 2020 American Transplant Congress

    XIAP Enhances Xenoislet Survival: Novel Models to Evaluate Pretransplantation Gene Modifications

    G. R. Devi1, Z. Fitch1, M. Song1, M. Ribeiro1, A. McGowan1, X. Luo2, B. H. Collins1, A. D. Kirk1

    1Department of Surgery, Duke Univesity School of Medicine, Durham, NC, 2Division of Nephrology, Duke Univesity School of Medicine, Durham, NC

    *Purpose: Porcine islet xenotransplantation offers a reliable and near limitless supply of islets for the treatment of type 1 diabetes. Intraportal infusion of cells exposes…
  • 2020 American Transplant Congress

    Inhibiting NLRP3 Inflammasome Ameliorates Glucose Fluctuation Through Reducing Apoptosis and Infiltration of Inflammatory Cells after Intraportal Islet Transplantation in Rodent Model

    G. Yoshimatsu, T. Matsuoka, K. Chinen, N. Sakata, S. Kodama

    Department of Regenerative Medicine and Transplantation, Faculty of Medicine, Fukuoka University, Fukuoka, Japan

    *Purpose: Islet transplantation is a useful treatment option for insulin dependent diabetes mellitus with severe hypoglycemic event. However, intraportal islet transplantation is known to induce…
  • 2019 American Transplant Congress

    Role of NF-kB in Release of Isletokines via Exosomes in Response to Islet Stress

    P. Saravanan1, M. Kanak1, J. Kalivarathan1, M. Lawrence2, M. Levy1, B. Naziruddin3

    1Department of Surgery, Virginia Commonwealth University, VCU Health, Richmond, VA, 2Islet Cell Lab, Baylor Scott and White Research Institute, Dallas, TX, 3Simmons Transplant Institute, Baylor Scott and White Medical Center, Dallas, TX

    *Purpose: Human islets are exposed to a range of inflammatory stimuli upon transplantation that leads to poor graft survival. Identifying the various signaling events may…
  • 2019 American Transplant Congress

    Cyclo (his-pro) Protects Against Gentamicin Induced Cell Apoptosis And Cisplatin Induced Acute Kidney Injury Through Inhibiting P53 Mediated Apoptotic Pathway.

    Y. Kim1, J. Moon1, J. Jeong1, J. Kim1, S. Lee1, M. Yu2, C. Lee3, Y. Kim1, S. Yang4

    1Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, 2Internal Medicine, Hanyang University Medical Center, Seoul, Korea, Republic of, 3Internal Medicine, Cheju Halla General Hospital, Cheju, Korea, Republic of, 4Kidney Research Institute, Seoul National University Hospital, Seoul, Korea, Republic of

    *Purpose: Cyclo(His-Pro) (CHP) is an endogenous cyclic dipeptide that exerts cellular protective effects against anti-oxdative damages. However, the role and mechanisms for CHP in preventing…
  • 2019 American Transplant Congress

    FcγRIIB is a Novel CD8+ Effector T Cell Intrinsic Regulatory Pathway That Correlates with Freedom from Rejection in Renal Transplant Patients

    A. B. Morris1, D. F. Pinelli1, D. Liu1, J. M. Boss2, C. D. Scharer2, M. Fribourg3, P. Cravedi3, P. S. Heeger3, M. L. Ford1

    1Surgery, Emory University, Atlanta, GA, 2Micro & Immuno, Emory University, Atlanta, GA, 3Center for Translational Transplant Research, Icahn SOM at Mount Sinai, New York, NY

    *Purpose: To understand the functional role and clinical relevance of FcγRIIB on CD8+ T cells in transplantation.*Methods: See results*Results: FcγRIIB is the sole inhibitory Fcγ…
  • 2019 American Transplant Congress

    Bcl-2/Bcl-xL Inhibition by Navitoclax vs. Bcl-2 Alone Inhibition by Venetoclax for Induction of Mixed Chimerism in Non-Human Primates

    H. Sasaki1, D. Ma1, T. Oura1, A. Dehnadi1, I. Rosales2, B. Cosimi1, P. Cippa3, T. Fehr3, T. Kawai1

    1Surgery, Massachusetts General Hospital, Boston, MA, 2Pathology, Massachusetts General Hospital, Boston, MA, 3Medicine, University of Zurich, Zurich, Switzerland

    *Purpose: We recently demonstrated that a specific Bcl-2 inhibitor, Venetoclax, can promote mixed chimerism and renal allograft tolerance in non-human primates (NHPs) with reduced myelosuppressive…
  • 2019 American Transplant Congress

    NQO-1 Attenuates Renal Ischemia-Reperfusion Injury in Mice

    D. Choi1, J. Hwang2, J. Jeong3, K. Lee1, K. Na1, Y. Ham1, J. Jeon1, H. Kim1, Y. Chang1

    1Nephrology, Chungnam National University, Daejeon, Korea, Republic of, 2Laboratory Animal Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea, Republic of, 3Medical Science, Chungnam National University, Daejeon, Korea, Republic of

    *Purpose: Ischemia-reperfusion (I-R)-induced reactive oxygen species (ROS) are thought to be a major factor in the development of acute renal injury by promoting the initial…
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