ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Apoptosis"

  • 2020 American Transplant Congress

    Torc1 Inhibition Protects Activated Human Regulatory T Cells from Self-Inflicted Damage via Granzyme B

    J. B. Alhaddad, H. Allos, B. S. Al Dulaijan,, S. K. Eskandari, I. Sulkaj, G. Melhem, J. Y. Choi, J. R. Azzi

    Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    *Purpose: The use of Regulatory T cells (Tregs) in adoptive cell therapy has been hindered by their short survival following their adoptive transfer. We have…
  • 2020 American Transplant Congress

    Cell-Free DNA (cfDNA) is Released by Necroptosis and Promotes Kidney Ischemia Reperfusion Injury

    A. C. Dionne

    Microbiology and Immunology, Western University, London, ON, Canada

    *Purpose: Transplantation is invariably associated with ischemia reperfusion injury (IRI) which causes organ dysfunction. IRI is also directly linked to several forms of programmed cell…
  • 2020 American Transplant Congress

    FcγRIIIb Inhibits Renal Transplant Rejection by Inducing Neutrophils Apoptosis

    J. Zhang, J. Chen

    Kidney Disease Center, The First Affiliated Hospital of Zhejiang University, Hangzhou, China

    *Purpose: Fcγ receptors (FcγR) have been proposed to be involved in the pathogenesis of acute rejection (AR) after organ transplantation. However, the mechanisms by which…
  • 2020 American Transplant Congress

    Exosomes Derived from MSC Ameliorate Renal Ischemic-Reperfusion Injury Through Inhibiting Inflammation and Cell Apoptosis

    Y. Jia, M. Xu, T. Zhu

    Shanghai Key Laboratory of Organ Transplantation, Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China

    *Purpose: Investigate the underlying mechanism of mesenchymal stem cells (MSCs) on protection of renal ischemia reperfusion injury (IRI) .*Methods: Exosomes originated from MSCs (MSC-ex) were…
  • 2020 American Transplant Congress

    Induction of Transplant Tolerance by Modulating the Metabolic Stress Pathways

    X. Xiao, L. Zhang, Y. Ying, Y. Wang, P. Arnold, Z. Zhang, X. Li

    Houston Methodist Research Institute, Houston, TX

    *Purpose: T cell activation and effector differentiation precede graft rejection, and this process is associated with robust metabolic burst to meet the energy demand of…
  • 2019 American Transplant Congress

    Bcl-2 Inhibition with Venetoclax Promotes Induction of Mixed Chimerism and Renal Allograft Tolerance without Severe Myelosuppression in Non-Human Primate

    H. Sasaki1, D. Ma1, T. Oura1, A. Dehnadi1, I. Rosales2, B. Cosimi1, P. Cippa3, T. Fehr3, T. Kawai1

    1Surgery, Massachusetts General Hospital, Boston, MA, 2Pathology, Massachusetts General Hospital, Boston, MA, 3Medicine, University of Zurich, Zurich, Switzerland

    *Purpose: Specific Bcl-2 inhibition has been shown to promote mixed chimerism and skin allograft tolerance without myelosuppressive conditioning in murine models. To extend this approach…
  • 2019 American Transplant Congress

    The Impact of Thrombin / Protease-Activated Receptor-1 Pathway in Hepatic Ischemia-Reperfusion Injury in Mice

    D. Noguchi, N. Kuriyama, T. Fujii, H. Kato, M. Kishiwada, S. Mizuno, M. Usui, H. Sakurai, S. Isaji

    Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu City, Mie, Japan

    *Purpose: Coagulation cascade is an important pathway in the pathophysiology of hepatic ischemia-reperfusion injury(IRI). Generation of thrombin is a critical factor of coagulation induced by…
  • 2019 American Transplant Congress

    Apoptotic Exosome-Like Vesicles Induce Endothelial Cell Plasticity and Accelerate Allograft Vascular Remodeling

    F. Migneault1, M. Dieudé1, J. Turgeon1, A. Karakeussian Rimbaud1, D. Beillevaire1, M. Hardy2, A. Brodeur1, N. Thibodeau1, C. Perreault2, M. Hébert1

    1CRCHUM, Montreal, QC, Canada, 2IRIC, Montreal, QC, Canada

    *Purpose: Acute vascular rejection of allografts is associated with endothelial apoptosis which in turn contributes to the development of transplant vasculopathy. We previously showed that…
  • 2019 American Transplant Congress

    Nephrotoxicity Caused by Calcineurin Inhibitors is Meditated by BAX, NOL3 and XIAP Apoptotic Genes Dysregulation

    G. Queipo1, M. Fonsecha-Sanchez1, J. Sanchez1, L. Garcia1, M. Carmona2, E. Villanueva1, G. Melendez1, L. Morales-Buenrostro3, M. Alamilla1

    1Hospital General de Mexico-Eduardo Liceaga Facultad de Medicina UNAM, Mexico City, Mexico, 2Facultad de Medicina UNAM, Mexico City, Mexico, 3Instituto Nacional de Ciencias Médicas Salvador Zubirán, Mexico City, Mexico

    *Purpose: Calcineurin inhibitors (CNI) remain the most effective and widely used immunosuppressive agents in kidney transplantation. Nephrotoxicity is a major secondary effect, and renal biopsy…
  • 2019 American Transplant Congress

    Glycogen Synthase Kinase 3alpha Serine 21 Phosphorylation Inhibits Hepatocyte Autophagy to Facilitate Liver Ischemia Reperfusion Injury

    M. Ni1, H. Zhou2, R. Busuttil1, J. Kupiec-Weglinski1, X. Wang2, Y. Zhai1

    1Surgery, Dumont-UCLA Transplant Center, Los Angeles, CA, 2Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    *Purpose: Glycogen synthase kinase 3 (Gsk3) has α and β isoforms. They are constitutively active in cells and inhibited upon stimulations by N-terminal serine phosphorylation.…
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