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American Transplant Congress abstracts

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Articles tagged "Apoptosis"

  • 2020 American Transplant Congress

    Activation of Tacrolimus Induced Cytotoxicity Through Apoptotic Pathways

    S. Chung, S. Choi

    Department of Surgery, Chonnam National University, Gwangju, Korea, Republic of

    *Purpose: To elucidate the mechanism of cytotoxicity in FK506-treated Jurkat T cells, signal transduction pathway of TNF-related events was studied.*Methods: Viability of Jurkat T cells…
  • 2020 American Transplant Congress

    Apoptotic Exosome-Like Vesicles are Associated with Alloimmune Vascular Injury in Kidney Transplant Recipients

    M. Dieude1, E. Boilard2, I. Allaeys2, A. Deneault-Marchand1, J. Turgeon1, E. Dore2, S. Lariviere-Beaudoin1, A. Karakeussian-Rimbaud1, S. Collette3, L. Senecal3, M. Hebert1, H. Cardinal1

    1Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada, 2Centre de Recherche du Centre Hospitalier de l'Université de Québec, Quebec, QC, Canada, 3Hopital Maisonneuve-Rosemont, Montreal, QC, Canada

    *Purpose: There is no non-invasive biomarker of alloimmune vascular injury. We have previously characterized exosome-like vesicles enriched in active proteasome and LG3 (ApoExo) that are…
  • 2020 American Transplant Congress

    Lack of Dj-1 Amplifies Sepsis-Associated Acute Kidney Injury and Increases Parenchymal Apoptosis

    J. Leeds1, Y. Scindia2, E. Ghias1, S. Cechova1, V. Loi1, E. Mandziak1, S. Swaminathan1

    1University of Virginia, Charlottesville, VA, 2University of Florida, Gainesville, FL

    *Purpose: Sepsis following kidney transplantation is a frequent complication due to mandatory immunosuppression and increased infection risk. Kidney transplant recipients who develop sepsis show inferior…
  • 2020 American Transplant Congress

    The Inflammatory Response in the Context of Tissue Injury: Roles of Tyro3, Axl, and Mer (TAM) Receptors in Liver Ischemia/Reperfusion Injury

    J. Zhang, M. Ni, D. Jin, H. Zhang, R. Busuttil, J. Kupiec-Weglinski, Y. Zhai

    Dumont-UCLA Transplant Center, Los Angeles, CA

    *Purpose: Although the inflammatory response in liver ischemia reperfusion injury has been studied extensively, how the context of tissue injury (presence of necrotic/apoptotic cells) regulates…
  • 2020 American Transplant Congress

    Graphene Quantum Dots Prevent Glomerular and Interstitial Injury in Murine Adriamycin Nephropathy Through Macrophage Depletion

    Y. Kim1, K. Kim1, J. Lee1, J. Moon1, J. Kim1, J. Lee2, Y. Kim1, S. Yang1

    1Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, 2Internal Medicine, Nephrology Clinic, National Cancer Center, Seoul, Korea, Republic of

    *Purpose: Macrophage infilatration is a key feature of the pathogenicity associated with glomerular and tubulo-interstitial injury in kidney disease. Graphene quantum dots (GQDs) are considered…
  • 2020 American Transplant Congress

    CEACAM1 / ASK1 / p38 Signaling Axis Alleviates Peri-Transplant Liver Injury: From Mouse-to-Human

    H. Hirao1, K. Nakamura2, S. Kageyama1, T. Ito1, K. Kadono1, H. Kojima1, K. J. Dery1, S. Younan1, R. W. Busuttil1, F. M. Kaldas1, J. Kupiec-Weglinski1

    1UCLA, Los Angeles, CA, 2Kyoto University, Kyoto, Japan

    *Purpose: Although CEACAM1 (CM1; carcinoembryonic antigen-related cell adhesion molecule 1; CD66a) regulates hepatic metabolic homeostasis, its role in orthotopic liver transplantation (OLT) remains unknown. A…
  • 2020 American Transplant Congress

    Torc1 Inhibition Protects Activated Human Regulatory T Cells from Self-Inflicted Damage via Granzyme B

    J. B. Alhaddad, H. Allos, B. S. Al Dulaijan,, S. K. Eskandari, I. Sulkaj, G. Melhem, J. Y. Choi, J. R. Azzi

    Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    *Purpose: The use of Regulatory T cells (Tregs) in adoptive cell therapy has been hindered by their short survival following their adoptive transfer. We have…
  • 2020 American Transplant Congress

    Cell-Free DNA (cfDNA) is Released by Necroptosis and Promotes Kidney Ischemia Reperfusion Injury

    A. C. Dionne

    Microbiology and Immunology, Western University, London, ON, Canada

    *Purpose: Transplantation is invariably associated with ischemia reperfusion injury (IRI) which causes organ dysfunction. IRI is also directly linked to several forms of programmed cell…
  • 2020 American Transplant Congress

    FcγRIIIb Inhibits Renal Transplant Rejection by Inducing Neutrophils Apoptosis

    J. Zhang, J. Chen

    Kidney Disease Center, The First Affiliated Hospital of Zhejiang University, Hangzhou, China

    *Purpose: Fcγ receptors (FcγR) have been proposed to be involved in the pathogenesis of acute rejection (AR) after organ transplantation. However, the mechanisms by which…
  • 2020 American Transplant Congress

    Exosomes Derived from MSC Ameliorate Renal Ischemic-Reperfusion Injury Through Inhibiting Inflammation and Cell Apoptosis

    Y. Jia, M. Xu, T. Zhu

    Shanghai Key Laboratory of Organ Transplantation, Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China

    *Purpose: Investigate the underlying mechanism of mesenchymal stem cells (MSCs) on protection of renal ischemia reperfusion injury (IRI) .*Methods: Exosomes originated from MSCs (MSC-ex) were…
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