ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Apoptosis"

  • 2020 American Transplant Congress

    Caspase-1 Knockout Mice Have Increased Survival after Cold Ischemia in a Murine Kidney Transplant Model

    S. Jain1, R. Plenter2, T. Nydam2, A. Jani1

    1Renal, University of Colorado, Aurora, CO, 2Transplant Microsurgery Program, University of Colorado, Aurora, CO

    *Purpose: Prolonged cold ischemia (CI) is a known risk factor for acute kidney injury (AKI) after kidney transplantation. However, the mechanism by which CI leads…
  • 2020 American Transplant Congress

    Immunomodulation with FasL Presenting Biomaterials Achieves Long-Term Survival of Allogeneic Islets in the Absence of Chronic Immunosuppression in a Non-Human Primate Model

    J. Lei1, H. Deng1, T. Chen1, K. Lee1, C. Peters1, Z. Yang1, K. Deng1, G. Rickert1, I. Rosales1, N. Serifis1, M. Coronel2, M. Hunckler2, E. Yolcu3, H. Shirwan3, A. García2, J. Markmann1

    1Surgery, Mass General, Boston, MA, 2School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 3School of Mechanical Engineering, University of Louisville School of Medicine, Louisville, KY

    *Purpose: The full potential of islet transplantation will only be realized by the development of tolerogenic strategies that obviate the need for maintenance immunosuppressants. We…
  • 2020 American Transplant Congress

    3D Bioprinted Intrahepatic Cholangiocarcinoma Model and 7-Day Perfusion with Gemcitabine and Cisplatin: Modeling the Tumor Microenvironment and Response to Chemotherapy

    A. M. Chen1, W. Zhang1, J. Sterner2, L. Kennedy3, A. Isidan1, E. Gramelspacher1, H. L. Francis3, G. Alpini3, L. J. Smith2, P. Li1, B. Ekser1

    1Division of Transplant Surgery - Indiana University, Indianapolis, IN, 23D Bioprinting Core and Department of Radiology and Imaging Sciences - Indiana University, Indianapolis, IN, 3Division of Gastroenterology, Richard L. Roudebush VA Medical Center and Indiana University, Indianapolis, IN

    *Purpose: Over 8,000 patients are newly diagnosed with cholangiocarcinoma (CCA) in the United States each year.Understanding the CCA microenvironment will facilitate the development of novel…
  • 2020 American Transplant Congress

    Endothelial Cells Internalize Apoptotic Exosome-Like Vesicles Through Phosphatidylserine-Dependent Macropinocytosis

    F. Migneault, M. Dieudé, A. Brodeur, N. Thibodeau, D. Beillevaire, M. Hébert

    CRCHUM, Montreal, QC, Canada

    *Purpose: Ischemia-reperfusion and rejection favor endothelial apoptosis, which in turn contributes to maladaptive vascular repair leading to transplant vasculopathy. Apoptotic endothelial cells (EC) release exosome-like…
  • 2020 American Transplant Congress

    Activation of Tacrolimus Induced Cytotoxicity Through Apoptotic Pathways

    S. Chung, S. Choi

    Department of Surgery, Chonnam National University, Gwangju, Korea, Republic of

    *Purpose: To elucidate the mechanism of cytotoxicity in FK506-treated Jurkat T cells, signal transduction pathway of TNF-related events was studied.*Methods: Viability of Jurkat T cells…
  • 2020 American Transplant Congress

    Apoptotic Exosome-Like Vesicles are Associated with Alloimmune Vascular Injury in Kidney Transplant Recipients

    M. Dieude1, E. Boilard2, I. Allaeys2, A. Deneault-Marchand1, J. Turgeon1, E. Dore2, S. Lariviere-Beaudoin1, A. Karakeussian-Rimbaud1, S. Collette3, L. Senecal3, M. Hebert1, H. Cardinal1

    1Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada, 2Centre de Recherche du Centre Hospitalier de l'Université de Québec, Quebec, QC, Canada, 3Hopital Maisonneuve-Rosemont, Montreal, QC, Canada

    *Purpose: There is no non-invasive biomarker of alloimmune vascular injury. We have previously characterized exosome-like vesicles enriched in active proteasome and LG3 (ApoExo) that are…
  • 2020 American Transplant Congress

    Lack of Dj-1 Amplifies Sepsis-Associated Acute Kidney Injury and Increases Parenchymal Apoptosis

    J. Leeds1, Y. Scindia2, E. Ghias1, S. Cechova1, V. Loi1, E. Mandziak1, S. Swaminathan1

    1University of Virginia, Charlottesville, VA, 2University of Florida, Gainesville, FL

    *Purpose: Sepsis following kidney transplantation is a frequent complication due to mandatory immunosuppression and increased infection risk. Kidney transplant recipients who develop sepsis show inferior…
  • 2020 American Transplant Congress

    The Inflammatory Response in the Context of Tissue Injury: Roles of Tyro3, Axl, and Mer (TAM) Receptors in Liver Ischemia/Reperfusion Injury

    J. Zhang, M. Ni, D. Jin, H. Zhang, R. Busuttil, J. Kupiec-Weglinski, Y. Zhai

    Dumont-UCLA Transplant Center, Los Angeles, CA

    *Purpose: Although the inflammatory response in liver ischemia reperfusion injury has been studied extensively, how the context of tissue injury (presence of necrotic/apoptotic cells) regulates…
  • 2020 American Transplant Congress

    Graphene Quantum Dots Prevent Glomerular and Interstitial Injury in Murine Adriamycin Nephropathy Through Macrophage Depletion

    Y. Kim1, K. Kim1, J. Lee1, J. Moon1, J. Kim1, J. Lee2, Y. Kim1, S. Yang1

    1Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, 2Internal Medicine, Nephrology Clinic, National Cancer Center, Seoul, Korea, Republic of

    *Purpose: Macrophage infilatration is a key feature of the pathogenicity associated with glomerular and tubulo-interstitial injury in kidney disease. Graphene quantum dots (GQDs) are considered…
  • 2020 American Transplant Congress

    CEACAM1 / ASK1 / p38 Signaling Axis Alleviates Peri-Transplant Liver Injury: From Mouse-to-Human

    H. Hirao1, K. Nakamura2, S. Kageyama1, T. Ito1, K. Kadono1, H. Kojima1, K. J. Dery1, S. Younan1, R. W. Busuttil1, F. M. Kaldas1, J. Kupiec-Weglinski1

    1UCLA, Los Angeles, CA, 2Kyoto University, Kyoto, Japan

    *Purpose: Although CEACAM1 (CM1; carcinoembryonic antigen-related cell adhesion molecule 1; CD66a) regulates hepatic metabolic homeostasis, its role in orthotopic liver transplantation (OLT) remains unknown. A…
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