Articles tagged "Apoptosis"

2015 American Transplant Congress
The Immunogenic Perlecan Fragment LG3 Is Released Through Apoptotic Extracellular Vesicles Downstream of Caspase-3 Activation
D. Beillevaire,¹ J. Turgeon,¹ D. Gingras,² é. Boilard,³ M. Dieudé,¹ M.-J. Hébert.¹
¹CNTRP, CRCHUM, Université de Montréal, Montréal, Canada; ²Université de Montréal, Montréal, Canada; ³CNTRP, CHUL, Québec, Canada.
LG3, a C-terminal fragment of perlecan, has been implicated in aggravation of renal allograft rejection and vascular injury. LG3 is known to be produced at…
2015 American Transplant Congress
The 20S Proteasome Is Active in Apoptotic Nanovesicles and Controls Anti-LG3 Antibody Production
M. Dieudé,^1,4 C. Bell,^2,4 J. Turgeon,^1,4 D. Beillevaire,^1,4 K. Hamelin,^1,4 S. Qi,^1,4 N. Pallet,^1,4 C. Rondeau,³ D. Gingras,³ M. Desjardins,³ P. Thibault,^2,4 M.-J. Hébert.^1,4
¹Research Centre, Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada; ²Institute for Research in Immunology and Cancer (IRIC), Montreal, QC, Canada; ³Université de Montréal, Montreal, QC, Canada; ⁴Canadian National Transplant Research Program (CNTRP), Montreal, Canada.
Humoral autoreactivity to apoptotic cells and perlecan/LG3, a proteoglycan fragment released by apoptotic cells, predicts poor allograft outcomes in renal transplant patients. How apoptotic cells…
2015 American Transplant Congress
Anti-LG3 Antibodies Aggravate Ischemia-Reperfusion Injury
B. Yang,¹ K. Hamelin,¹ L. Pomerleau,¹ J. Peng,¹ J. Tremblay,¹ N. Patey,² M.-J. Hébert.¹
¹Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Université de Montréal, Montréal, Canada; ²Department of Pathology, CHU Ste-Justine Université de Montréal, Montréal, Canada.
Ischemia-Reperfusion Injury (IRI) is a significant cause of renal allograft dysfunction and a risk factor for poor long-term graft outcomes. Microvascular injury is an important…
2015 American Transplant Congress
Decreased Expression of Mitochondrial Aldehyde Dehydrogenase 2 Induces Liver Injury Via Activation of the MAPK Pathway in Grafts from Brain-Dead Donors
Z. Zhong,¹ S. Ye,¹ Y. Xiong,¹ X. Fan,¹ W. Huang,¹ D. Ko,³ Y. Wang,¹ Q. Ye.^1,2
¹Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei, China; ²The 3rd Xiangya Hospital of Central South University, Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology, Changsha, Hunan, China; ³Massachusetts General Hospital, Department of Urology, Boston, MA.
Objective: To determine the role of ALDH2 in the injury of liver from brain-dead donors.Methods: Using brain-dead rabbit model, the expression of ALDH2 and apoptosis…
2015 American Transplant Congress
Absence of Nucleotide-Binding Oligomerization Domain-Containing Protein 1 and 2 Modifies Adaptive Immune Responses
S. Kasimsetty, A. Shigeoka, D. McKay.
Medicine, UCSD, La Jolla, CA.
Background:The NOD family of intracellular pattern recognition receptors (PRRs) plays a key role in immune responses to microbial and danger signals. This family of proteins…
2015 American Transplant Congress
Phenotype of Renal Tubular Cell Death During Delayed Graft Function
S. Jain,¹ R. Plenter,¹ T. Nydam,¹ C. Ruller,¹ C. Edelstein,^1,2 A. Jani.^1,2
¹University of Colorado, Aurora, CO; ²Veterans Affairs Medical Center, Denver, CO.
Background: Delayed graft function (DGF) independently predicts reduced 5 yr kidney transplant survival. Treatments of DGF are lacking. Cold ischemia (CI) is a significant risk…
2015 American Transplant Congress
A Novel Signaling Approach for the Prevention of Ischemia/Reperfusion Injury (IRI)
S. Khalid,¹ M. Haller,¹ K. Koziel,¹ M. Enthammer,¹ M. Hermann,² M. Thurner,¹ L. Kremser,³ H. Lindner,³ J. Troppmair.¹
¹VTT, DSL, Innsbruck Medical University, Innsbruck, Austria; ²Anestesiology and Critical Care Medicine, Innsbruck Medical Unversity, Innsbruck, Austria; ³Division of Clinical Biochemistry, Innsbruck Medical University, Innsbruck, Austria.
Mitochondrial reactive oxygen species (ROS) produced during early reperfusion are important triggers for the development of ischemia/reperfusion injury (IRI). However, antioxidants yielded little clinical benefit…
2015 American Transplant Congress
Engagement of the Vasopressin Receptor On Hepatocytes Protects Liver from Ischemia-Reperfusion Injury Via the WNT-β-Catenin-SGK1-FOXO Pathway
X. Liu,¹ T. Billiar,² R. Tao.¹
¹Department of Hepatobiliary-Pancreatic Surgery, Zhejiang Provincial Peoples' Hospital, Hangzhou, Zhejiang Province, China; ²Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
The synthetic vasopressin analogue, terlipressin, has been extensively used in the management of certain complications associated with end-stage liver diseases (ESLDs), however concerns have been…
2015 American Transplant Congress
Loss of RIPK3 and Caspase-8 Enhance Intrinsic Apoptosis in Tubular Epithelial Cell (TEC) Death and Contributes to Kidney Ischemia Reperfusion Injury (IRI)
B. Sung,¹ Y. Su,³ A. Lau,³ J. Jiang,³ A. Haig,² D. Green,⁴ Z. Zhang,² A. Jevnikar.¹
¹Microbiology and Immunology, Western University, London, ON, Canada; ²Pathology, Western University, London, ON, Canada; ³Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; ⁴St. Jude Children's Research Hospital, Memphis, TN.
[Background] Ischemia-reperfusion injury (IRI), a complex limiting factor in organ transplant survival, is related to multiple death pathways. Eliminating the key necroptotic molecule (RIPK3) improves…
2015 American Transplant Congress
Losartan Benefits Are Mediated Through SIRT1 Activation in Rat Reduced Size Orthotopic Liver Transplantation
E. Pantazi,¹ M. Bejaoui,¹ M. Zaouali,¹ E. Folch-Puy,¹ A. Rolo,^2,3 A. Panisello,¹ C. Palmeira,² J. Rosello-Catafau.¹
¹Experimental Pathology, Institute of Biomedical Research of Barcelona (IIBB-CSIC), Barcelona, Spain; ²Department of Life Sciences, Faculty of Science and Technology, University of Coimbra, Coimbra, Portugal; ³Center for Neurosciences and Cell Biology, Department of Zoology, University of Coimbra, Coimbra, Portugal.
Background: Silent Information Regulator 1 (SIRT1) is a histone deacetylase that has been associated with protective mechanisms against IRI, but its role in liver transplantation…