2017 American Transplant Congress
AAV8 Delivery of TIMP-1 Prevents Hepatocyte Apoptosis After Liver Ischemia/Reperfusion Injury.
Dumont-UCLA Transplant Center, Los Angeles
Matrix metalloproteinase-9 (MMP-9) is a key mediator of leukocyte migration across vascular barriers in hepatic ischemia/reperfusion injury (IRI). Tissue inhibitor of metalloproteinase-1 (TIMP-1) is the…2017 American Transplant Congress
Dual Role for Caspase-3 in the Regulation of Tubular and Microvascular Damage Post-Renal Ischemia-Reperfusion Injury.
Ischemia-reperfusion injury (IRI) in renal transplant recipients is a risk factor of allograft dysfunction and reduced survival. Although tubular epithelial cells (TEC) are classically considered…2017 American Transplant Congress
Isoflurane Precondition Alleviated Murine Liver Ischemia and Reperfusion Injury by Restoring AMPK/mTOR-Mediated Autophagy.
Background: Isoflurane has a pharmacological precondition effect against ischemia injury in the heart, kidney and brain, but whether and how isoflurane precondition protects livers against…2017 American Transplant Congress
Proteasome Modulation an Effective Strategy to Ameliorate Steatotic Liver Grafts Viability After Preservation.
Recently we provided evidence for a possible protective role of proteasome inhibition during liver graft preservation. Although, several reported data confirmed that the proteolytic activity…2017 American Transplant Congress
Novel Application of Localized Nanodelivery of Anti-IL6 Protects Organ Transplant from Ischemia Reperfusion Injuries.
Ischemia reperfusion injury (IRI) evokes major intra-graft inflammatory responses that markedly augment alloimmune responses. Understanding mechanisms involved is critical for the development of novel therapeutic…2017 American Transplant Congress
Detection of Specific B Cell Memory to the Perlecan LG3 Antigen in the Normal Immune Repertoire.
Autoantibodies targeting the C-terminal fragment of perlecan (LG3) were identified in patients with kidney transplantation and are associated with rejection episodes. High anti-LG3 titers were…2016 American Transplant Congress
The 20S Proteasome, Active within Exosome-Like Vesicles Released by Apoptotic Cells Accelerates Rejection.
Apoptotic bodies (ApoBodies) and apoptotic exosome-like MV (ApoExo) released by apoptotic endothelial cells in vitro were purified by sequential centrifugation and analysed by electron microscopy…2016 American Transplant Congress
Elevated Intragraft Expression of Innate Immunity and Cell Death-Related Markers Characterizes Deceased Donor Conditions and Is a Risk Factor for Adverse Graft Outcome.
Background: The innate immune response is increasingly being recognized in allograft injury after kidney transplantation. We aimed to establish the relationship of innate immune gene…2016 American Transplant Congress
Mechanism of FK506 Induced TNF Related Apoptosis in Jurkat T Cells.
Department of Surgery, Chonnam National University Hospital, Gwangju, Korea.
Purpose: To elucidate the mechanism of FK506 induced TRAIL(TNF related apoptosis inducing ligand) –R1(DR4) and TRAIL-R2(DR5) in FK506-treated Jurkat T cells. And signal transduction pathway…2016 American Transplant Congress
Cytokine Storm in Acute Post-Hepatectmy Phase Associates with Liver Injury and Impaired Liver Regeneration.
Background Posthepatectomy liver failure and its transplant counterpart, small-for-size syndrome, remain poorly understood. Large increases in IL-6 are associated with poor allograft function and IL-6…
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