Articles tagged "Apoptosis"

2017 American Transplant Congress
GSK3β and VDAC in Endoplasmic Reticulum Stress and Apoptosis Modulation During Orthotropic Liver Transplantation.
M. Zaouali,^1,5 A. Panisello Roselló,¹ E. Folch Puy,¹ A. Lopez,² A. Rolo,³ C. Castro,² C. Palmeira,³ A. Garcia-Gil,⁴ R. Adam,² J. Roselló-Catafau.¹
¹Experimental Pathology, Institute of Biomedical Research of Barcelona (IIBB-CSIC), Barcelona, Spain; ²Hepato-Biliare,, Hôpital Paul Brousse, INSERM U-776,Université Paris Sud, Paris, France; ³Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal; ⁴Liver Surgery, Hospital Clínico, Zaragoza, Spain; ⁵Research Unit of Biology and Molecular Anthropology Applied to Development and Health (UR12ES11), Faculty of Pharmacy, University of Monastir, Monastir, Tunisia
Ischemia reperfusion injury(IRI) is a major cause of graft non-function following liver transplantation (LT). Mitochondrial dysfunction plays a central role in preventing liver IRI), associated…
2017 American Transplant Congress
Nafamostat Mesilate Ameliorates Ischemia-Reperfusion Renal Injury via Anti-Apoptotic Mechanism.
D. Choi,¹ J. Jeong,² H. Bae,¹ Y. Ham,¹ K. Lee,¹ K. Na.¹
¹Chungnam National University, Nephrology, Daejeon, Korea; ²Chungnam National University, Department of Medical Science, Daejeon, Korea
Purpose: It has been reported that nafamostat mesilate inhibits inflammatory injury via inhibition of complement activation in ischemic heart, liver, and intestine. However, it is…
2017 American Transplant Congress
Protective Effect of Crepidiastrum denticulatum Extract Pretreatment Against Hepatic Ischemia-Reperfusion Injury in Mice.
H. Jang, H. Lee, C. Park, D. Eom, J. Lee, M. Oh, J. Yoo, C. Rho.
Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Gangwon, Korea; Anesthesia, University of Ulsan, Gangneung Asan Hospital, Gangneung, Gangwon, Korea; Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Gangwon, Korea; Pathology, University of Ulsan, Gangneung Asan Hospital, Gangneung, Gangwon, Korea; Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Gangwon, Korea; Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Gangwon, Korea; Natural Medicine Center, Korea Institute of Science and Technology, Gangneung, Gangwon, Korea; Natural Medicine Center, Korea Institute of Science and Technology, Gangneung, Gangwon, Korea
Crepidiastrum denticulatum (CD) is a well-known, traditionally consumed vegetable in Korea, which was recently reported to have bioactive compounds with detoxification and antioxidant properties. Ischemia-reperfusion…
2017 American Transplant Congress
Apoptotic Exosome-Like Vesicles Released During Tissue Injury Trigger IL23/IL-17 Autoimmune Axis and Accelerate Rejection.
M. Dieudé,^1,4 J. Turgeon,^1,4 A. Karakeussian-Rimbault,^1,4 L. Pomerleau,¹ A. Robitaille,¹ N. Grandvaux,¹ É. Boilard,^2,4 M.-J. Hébert.^1,3,4
¹Research Centre, Centre Hospitalier de l'Université de Montréal, Montreal, Canada; ²CHU de Québec, Québec, Canada; ³Montreal University, Montreal, QC, Canada; ⁴Canadian National Transplantation Research Program, Edmonton, Canada
Autoantibodies to apoptotic antigens, such as perlecan/LG3, are present pre-transplantation and contribute to organ rejection. We previously showed that during tissue injury, apoptotic endothelial cells…
2017 American Transplant Congress
AAV8 Delivery of TIMP-1 Prevents Hepatocyte Apoptosis After Liver Ischemia/Reperfusion Injury.
S. Duarte, P. Matian, M. Miller, R. Busuttil, A. Coito.
Dumont-UCLA Transplant Center, Los Angeles
Matrix metalloproteinase-9 (MMP-9) is a key mediator of leukocyte migration across vascular barriers in hepatic ischemia/reperfusion injury (IRI). Tissue inhibitor of metalloproteinase-1 (TIMP-1) is the…
2017 American Transplant Congress
Dual Role for Caspase-3 in the Regulation of Tubular and Microvascular Damage Post-Renal Ischemia-Reperfusion Injury.
B. Yang,^1,2,3 S. Lan,^1,2,3 N. Patey,^1,3,4 J. Turgeon,^1,3 M. Dieudé,^1,3 M.-J. Hébert.^1,2,3
¹Research Centre, Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada; ²Canadian National Transplant Research Program, Edmonton, AB, Canada; ³Université de Montréal, Montreal, QC, Canada; ⁴Department of Pathology, CHU Ste-Justine, Université de Montréal, Montreal, QC, Canada
Ischemia-reperfusion injury (IRI) in renal transplant recipients is a risk factor of allograft dysfunction and reduced survival. Although tubular epithelial cells (TEC) are classically considered…
2016 American Transplant Congress
Short-Term Starvation Attenuates Liver Ischemia Reperfusion Injury by SIRT1-Autophagy Signaling in Mice.
J. Rao,¹ H. Zhou,¹ F. Zhang,¹ X. Wang,¹ Y. Zhai,² L. Lu.¹
¹Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, China; ²Dumont-UCLA Transplant Center, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles.
Calorie restriction or starvation (fasting) has some beneficial effects on prolongation of life and increased resistance to stress. Calorie restriction has also been shown to…
2016 American Transplant Congress
The Apoptosis of the Tracheal Epithelia Increase the Recipient's MSCs Derived Myofibroblasts in Allografts to Exacerbate Obliterative Bronchiolitis After Tracheal Transplantation in Mice.
C. Wang,¹ T. Xia,¹ X. Zhang,² K. Jiang,¹ J. Wang,¹ J. Nie.¹
¹Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuahn, Hubei, China; ²Department of Integrative Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuahn, Hubei, China.
Background: The long-term outcome of lung transplantation is impeded by obliterative bronchiolitis (OB). However, the current treatment cannot effectively prevent the process of OB. The…
2016 American Transplant Congress
Activated Cytoprotective Mechanisms in DBD Kidneys Correlate with Kidney Function in Transplant Recipients: A Study Using Clinical Samples from the UK QUOD Biobank.
M. Kaisar,¹ L. van Dullemen,² Z. Akhtar,¹ M. Lo Faro,¹ H. Huang,¹ H. Leuvenink,² B. Kessler,¹ R. Ploeg.¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; ²UMCG, UMCG, Groningen, Netherlands.
The onset of abnormal pathophysiological changes following brain death adversely impact kidney function following transplantation. Understanding the biological mechanisms that affect kidney quality will allow…
2016 American Transplant Congress
Intracellular OPN Is an Essential Protective Factor for Cardiac Endothelial Cell and the Long Term Heart Graft Survival.
Y. Su,^1,2,3 Z.-X. Zhang,^1,2,3 Z.-Q. Yin,¹ X.-Y. Huang,¹ A. Jevnikar.^1,2,3,4
¹Matthew Mailing Centre for Translational Transplantation Studies, Lawson Health Research Institute, London Health Sciences Centre, London Health Sciences Centre, Lodon, ON, Canada; ²Departments of Medicine, London Health Sciences Centre, Lodon, ON, Canada; ³Departments of Pathology, London Health Sciences Centre, London, ON, Canada.
[Background] Endothelial cell (EC) injury is central to cardiac allograft vasculopathy and premature graft loss. Osteopontin (OPN) is a multifunctional anti-apoptotic protein that is involved…