ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Antilymphocyte antibodies"

  • 2016 American Transplant Congress

    Investigating Posttransplant Allo-Donor Specific CD57+ Cells in Patients with Alemtuzumab Induction and Belatacept-Based Regimen.

    H. Xu, F. Feng, A. Kirk.

    Department of Surgery, Duke University, Durham, NC.

    Recent studies have showed correlation between CD4+CD57+PD1- cells and costimulation blockade resistant rejection (CoBRR) in patients treated with belatacept without depletional induction. We have recently…
  • 2016 American Transplant Congress

    Thymus Is Required for T Cells Reconstitution Following Antibody-Mediated Lymphoablation.

    K. Ayasoufi, R. Fan, A. Valujskikh.

    Cleveland Clinic, Cleveland.

    Antibody-mediated lymphocyte depletion is used as induction therapy in sensitized transplant recipients. Following lymphoablation, peripheral lymphopenia triggers homeostatic T cell proliferation (HP) and enhanced thymopoiesis.…
  • 2016 American Transplant Congress

    Absence of Acute Allograft Rejection in the Early Post Operative Period in a Full Face VCA Recipient with a Positive B-Cell Flow Cytometric Crossmatch Utilizing an Induction Immunosuppression Regimen Including Anti-thymocyte and Anti-CD20 Agents.

    B. Gelb,3 M. Plana,1 D. Dadhania,2 M. Suthanthiran,2 J. Diaz-Siso,1 E. Rogriguez.1

    1Plastic and Reconstructive Surgery, NYU Langone, New York; 2Rogosin Institute, New York; 3Transplant Surgery, NYU Langone, New York.

    Background: The presence of donor-specific antibodies (DSA) to human leukocyte antigen (HLA) convey increased risk of allograft rejection. Patients suffering full-thickness burns to the face…
  • 2016 American Transplant Congress

    Kidney Transplantation in HIV Patients: Effect of Race on the Choice of Anti-Thymocyte Globulin Induction Immunosuppression.

    M. Casey, T. Aijaz, X. Wen, S. Rehman, A. Santos, E. Thomas, K. Andreoni, K. Womer.

    University of Florida, Gainesville, FL.

    Introduction: HIV positive status is a well-known risk factor for acute rejection (AR) in kidney transplant recipients (KTR). In the United States, the majority of…
  • 2015 American Transplant Congress

    Steroid Free Immunosuppression Protocol in Pediatric Kidney Transplant Recipients Using Alemtuzumab: A Retrospective Single Center Study

    R. Shah,1 Z. Kadry,1 S. Wassner,2 D. Kees-Folts,2 M. Freeman,2 P. Freeman,1 B. Olenowski,1 A. Jain.1

    1Surgery, Hershey Medical Center, Hershey, PA; 2Pediatric Nephrology, Hershey Medical Center, Hershey, PA.

    Background: Steroid free immunosuppression is attractive in pediatric kidney transplantation (KTx). Aim of the present study is to examine the patient survival, graft survival, rate…
  • 2015 American Transplant Congress

    Reduced Incidence of Cytomegalovirus Infection in Kidney Transplant Recipients Receiving Everolimus

    H. Tedesco-Silva,1 C. Felipe,1 A. Ferreira,1 M. Cristelli,1 T. Sandes- Freitas,1 N. Oliveira,1 W. Aguiar,2 G. Bassos,1 M. Franco,3 M. Gerbase- Lima,4 E. Campos,4 J. Medina-Pestana.1

    1Nephrology, Hospital do Rim UNIFESP, Sao Paulo, Brazil; 2Urology, Hospital do Rim UNIFESP, Sao Paulo, Brazil; 3Pathology, UNIFESP, Sao Paulo, Brazil; 4Immunogenetic, AFIP, Sao Paulo, Brazil.

    BACKGROUND: CMV infection is associated with inferior long-term kidney transplant outcomes. This study compared the incidence of CMV infection/disease in de novo kidney transplant recipients…
  • 2015 American Transplant Congress

    Blocking CD4 T Cell Helper Functions Improves Efficacy of ATG Treatment in Sensitized Transplant Recipients

    K. Ayasoufi, X. Wang, H. Yu, V. Gorbacheva, F. Ran, R. Fairchild, A. Valujskikh.

    Immunology, Cleveland Clinic, Cleveland, OH.

    Antibody mediated lymphocyte depletion is used in clinical transplantation to improve graft function. While the presence of donor-reactive memory T cells is the primary rationale…
  • 2015 American Transplant Congress

    Reciprocal Relationship Between Cytomegalovirus Infection and Graft Rejection in Intestinal/Multivisceral Transplantation: Impact on Survival and Ideal Immunosuppression Protocol

    S. Nagai, R. Mangus, E. Anderson, K. Doan, B. Ekser, C. Kubal, J. Fridell, A. Tector.

    Transplant Surgery, Indiana University School of Medicine, Indianapolis, IN.

    Background: Cytomegalovius (CMV) infection and graft rejection are opposing complications of isolated intestinal/multivisceral transplantation (IIT/MVT), a procedure requiring precise balance of immunosuppression. The aim of…
  • 2015 American Transplant Congress

    Viral Prophylaxis Is Unnecessary in CMV Low Risk Kidney Transplant Recipients Who Receive Lymphocyte Depleting Induction

    M. Gillespie,1 B. Sirandas,2 A. Carlson,2 S. Lee,3 L. Smith.2

    1Pharmacy, University of Maryland, Baltimore; 2Transplant, University of Utah, Salt Lake City; 3Transplant, University of Southern California, Los Angeles.

    Background: Both the international CMV consensus and AST guidelines recommend against the routine use of CMV prophylaxis in CMV D-/R- kidney transplant recipients (KTR), but…
  • 2015 American Transplant Congress

    Ideal Versus Total Body Weight Dosing of Rabbit Anti-Thymocyte Globulin Induction Therapy on Patient Outcomes in High Immunological Risk Kidney Transplant

    M. Vacha, J. Gommer, A. Rege, S. Sanoff, D. Sudan, M. Harris.

    Duke University Hospital, Durham, NC.

    BackgroundThe optimal dose of rabbit anti-thymocyte globulin (rATG) induction therapy in high immunological risk kidney transplantation (KTx) lacks consensus and the effect of dosing weight…
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