ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Antilymphocyte antibodies"

  • 2020 American Transplant Congress

    Carfilzomib-Based Desensitization: Effects on HLA, Non-HLA, Auto, and Antiviral Antibodies

    S. Tremblay1, E. Portwood1, A. R. Shields2, R. R. Alloway1, P. A. Brailey1, E. Woodle1

    1U Cincinnati, Cincinnati, OH, 2U Cincinnati, Christ Hospital, Cincinnati, OH

    *Purpose: An important question in plasma cell (PC) therapies is the specificity of therapy for PC populations. It is known that plasmablast populations are exquisitely…
  • 2020 American Transplant Congress

    Thymoglobulin Dose and Incidence of Biopsy Proven Acute Rejections in the Early Post Transplant Period

    K. Shimko, K. Schonder, D. Jorgensen, K. Kalra, A. Cherukuri, R. Mehta, I. Melgarejo, P. Sood, S. Hariharan, R. Mehta

    University of Pittsburgh Medical Center, Pittsburgh, PA

    *Purpose: Optimal dosing of thymoglobulin (ATG) for induction has not been well defined. Our protocol aims for 5-6mg/kg cumulative dose divided over 4 doses. However,…
  • 2020 American Transplant Congress

    Short Term Outcomes in Kidney Transplant Patients Receiving De Novo Belatacept with Anti-Thymocyte Globulin Induction

    B. Carlson, P. Cabrera, T. Harrison, K. Tejani, A. Centeno

    Pharmacy, Jackson Memorial Hospital, Miami, FL

    *Purpose: Mainstay immunosuppressive therapy after kidney transplant is a calcineurin inhibitor (CNI) based regimen. Nephrotoxicity is a common adverse effect of CNIs which can lead…
  • 2020 American Transplant Congress

    Outcomes of Induction with T Lymphocyte-Depleting and IL-2 Receptor Blocking (IL-2RB) Antibodies in the Non-Broadly Sensitized Adult Deceased-Donor Kidney Transplant Recipients: Analysis in the Context of the CPRA Allocation System

    A. H. Santos Jr1, Y. Li2, K. Alquadan1, M. Leghrouz1, X. Wen3

    1Div. of Nephrology, Univ. of Florida, Gainesville, FL, 2Univ. of Florida, Gainesville, FL, 3Univ. of Rhode Island, Kingston, RI

    *Purpose: We studied outcomes of induction in non-broadly-sensitized adult deceased-donor kidney transplant recipients(DD-KTRs) in the context of the calculated panel reactive antibody (CPRA) allocation system.*Methods:…
  • 2020 American Transplant Congress

    Induction Therapy with Basiliximab versus Thymoglobulin in African-American Kidney Transplant Recipients in the Current Era of Immunosuppression

    M. Zachariah1, I. Mallawaarachchi2, N. Meeks3, D. Wright1, R. Minawala1, V. Liu1, J. Rolls4, S. Hussein4, C. Jarrin5

    1Wayne State University, Detroit, MI, 2Division of Biostatistics, University of Virginia, Charlottsville, VA, 3Wayne State University School of Medicine, Detroit, MI, 4Surgery, Detroit Medical Center, Detroit, MI, 5Infectious Disease, Wayne State University, Detroit, MI

    *Purpose: It is now common practice in the transplant community to select induction therapy on the basis of perceived immunological risk for acute rejection which…
  • 2020 American Transplant Congress

    Renal Transplant Induction Therapy Safety Outcomes Comparison

    R. M. Hofmann1, J. Combs2, K. J. Schmidt3, T. Dyckman4

    1Nephrology, Renal Associates of West Michigan, Grand Rapids, MI, 2Pharmacy/Transplant, Mercy Health St. Mary's, Grand Rapids, MI, 3Pharmacy, Ferris State University College of Pharmacy, Big Rapids, MI, 4Pharmacy, Mercy Health St. Mary's, Grand Rapids, MI

    *Purpose: Induction immunosuppression with alemtuzumab and rabbit anti-thymocyte globulin (r-ATG) reduces acute rejection following kidney transplantation. Efficacy is thought to be similar between the agents…
  • 2020 American Transplant Congress

    Causal Relationship between Anti-Thymocyte Globulin Induction Therapy and Development of Monomorphic PTLD in Renal Transplant Recipients

    K. Soliman1, H. Ali2, T. Fulop1, A. Osman3, A. Halawa4

    1Medicine, Medical University of South Carolina, Charleston, SC, 2Medicine, Royal Stoke, Royal Stoke, United Kingdom, 3Medicine, Cairo University, Cairo, Egypt, 4Medicine, University of Liverpool, Liverpool, United Kingdom

    *Purpose: The aim of our study is to explore the causality between ATG and different types of post-transplant lymphoproliferative disorder (PTLD) in renal transplant recipients…
  • 2020 American Transplant Congress

    Comparison of Short-Term Outcomes of Induction Therapy with Alemtuzumab versus Rabbit Antithymocyte Globulin in Lung Transplantation

    V. Liu, M. W. Soto-Arenall, A. Patel

    Pharmacy, Mayo Clinic, Jacksonville, FL

    *Purpose: To identify the short-term efficacy and safety outcomes of alemtuzumab (C1H) versus rabbit antithymocyte globulin (rATG) in lung transplant patients. The objectives are to…
  • 2020 American Transplant Congress

    A Recombinant, Fully Human ATG Polyclonal Antibody Drug Drives Immune Cell Depletion in a Model of Graft-versus-Host Disease

    S. M. Keating, A. S. Adler, R. A. Mizrahi, J. Leong, M. A. Asensio, Y. W. Lim, A. R. Niedecken, Y. Chiang, R. Leong, D. S. Johnson

    Immunology, GigaGen, South San Francisco, CA

    *Purpose: Anti-thymocyte globulin (ATGs) are polyclonal antibody products that target and deplete T cells for immunosuppression in transplantation (prophylaxis of rejection). Since ATGs are derived…
  • 2020 American Transplant Congress

    Depletional Profiles of Human and Rhesus Specific Anti-Thymocyte Globulins in Rhesus Macaques

    B. I. Shaw1, R. Schmitz1, D. M. Magnani2, F. Leopardi1, A. D. Kirk1

    1Surgery, Duke University, Durham, NC, 2Medicine, MassBiologics of the University of Massachusetts Medical School, Boston, MA

    *Purpose: Rabbit anti-human ATG (rATG; Thymoglobulin®) is the most commonly used formulation for depletional induction therapy in the United States. However, given that it is…
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