Articles tagged "Antilymphocyte antibodies"

2016 American Transplant Congress
Impact of Early Red Blood Cell Transfusion After Kidney Transplantation on De Novo HLA Sensitization in the Setting of Antithymocyte Globulin Induction.
T. Jouve,^1,2 G. Rigault,^1,2 B. Janbon,¹ R. Tetaz,¹ N. Terrier,¹ D. Masson,³ L. Rostaing,^1,2 P. Malvezzi.¹
¹Nephrology and Kidney Transplantation Unit, Grenoble University Hospital, Grenoble, France, Metropolitan; ²Grenoble Alpes University, Grenoble, France, Metropolitan; ³Etablissement Francais du Sang, Grenoble, France, Metropolitan.
Introduction:HLA specific antibodies detection (HSA) and that of Donor Specific Antibodies (DSA) were revolutionized by the introduction of solid phase assays (Luminex®), therefore making these…
2016 American Transplant Congress
Clinical Factors That Determine the More Appropriate Induction Agent: ATG versus IL-2 Receptor Antagonists.
S. Bae, A. Massie, S. DiBrito, X. Luo, L. Kucirka, F. Al Ammary, D. Segev.
Johns Hopkins, Baltimore, MD.
Antithymocyte globulin (ATG) is recommended over IL-2 receptor antagonist (IL2) in high-risk recipients for induction immunosuppression. However, “high-risk” status has not been defined in an…
2016 American Transplant Congress
Outcomes in Elderly Renal Transplant Recipients Using Thymoglobulin or Interleukin-2 Receptor Antagonist Induction.
N. Jasiak,¹ J. Thielke,¹ J. Chen,² N. Hilal,¹ S. Salah,¹ D. Wu,¹ E. Benedetti,² P. West-Thielke.^1,2
¹Pharmacy, University of Illinois, Chicago; ²Transplant Surgery, University of Illinois, Chicago.
Background: Approximately 20% of all renal transplants performed in the US in 2014 occurred in elderly patients. Elderly patients are known to be at higher…
2016 American Transplant Congress
Outcomes in Obese Renal Transplant Recipients Using High versus Low-Dose Thymoglobulin.
N. Jasiak,¹ C. Stromayer,¹ J. Thielke,¹ J. Chen,² J. Chen,¹ B. Talon,¹ R. Rubin-Tobar,¹ E. Benedetti,² P. West-Thielke.^1,2
¹Pharmacy, University of Illinois, Chicago; ²Transplant Surgery, University of Illinois, Chicago, IL.
Background: Dosing of rabbit anti-thymocyte globulin (rATG) induction in renal transplant recipients is highly variable by transplant center. Optimizing rATG dose becomes extremely important for…
2015 American Transplant Congress
Single Center Experience With the Use of an Abbreviated Anti-Thymocyte Globulin and Basiliximab Combination Protocol in Renal Transplantation
V. Whittaker,¹ D. Halleran,¹ S. Narsipar,¹ J. Melancon.²
¹Surgery, State University New York Upstate Medical University, Syracuse, NY; ²Surgery, George Washington University, Washington, DC.
Purpose: To report one year outcomes from single center experience with a novel induction regimen using anti-thymocyte globulin ( ATG)(rabbit)rATG (3 mg/kg) in divided doses…
2015 American Transplant Congress
Maximizing Peri-Operative Value-Based Care in Kidney Transplant Induction
J. Fleming,¹ J. Casale,¹ K. Covert,¹ K. Boyle,¹ D. Taber,² H. Meadows,¹ C. Mardis,¹ N. Pilch,¹ M. Posadas-Salas,³ T. Srinivas,³ C. Bratton,² J. McGillicuddy,² K. Chavin,² P. Baliga.²
¹Pharmacy, MUSC, Charleston, SC; ²Surgery, MUSC, Charleston, SC; ³Nephrology, MUSC, Charleston, SC.
Due to the dwindling reimbursement for kidney transplants (KTx), there must be a continuous effort to provide the best value-based care. The purpose of this…
2015 American Transplant Congress
Immunomodulation of Human T Cells by a Novel RALG Preparation With Higher Specificity Toward Activating T Cells
K. Samy, H. Xu, A. Kirk.
Surgery, Duke University Medical Center, Durham, NC.
Current induction therapy using thymoglobulin (ATG) results in nonspecific T cell depletion. We have generated a polyclonal rabbit anti-human leukocyte globulin (RALG) by immunizing rabbits…
2015 American Transplant Congress
Increased Late Graft Loss in Kidney Recipients With Serum Sickness Disease Following Anti-Thymocyte Globulin Induction: Relation With an Anti-Neu5Gc Response
A. Salama,^1,2 G. Couvrat-Desvergnes,¹ M. Lorent,^1,3 G. Evanno,¹ L. Le Berre,¹ P. Hruba,⁴ P. Vesely,⁵ P. Guerif,¹ A. Nicot,¹ J.-M. Bach,⁶ Y. Foucher,^1,3 S. Brouard,¹ S. Castagnet,⁷ O. Viklicky,⁴ M. Giral,¹ J. Harb,¹ S. Jean-Paul.¹
¹INSERM UMR 1064, ITUN, CHU de Nantes, Nantes University, Nantes, France; ²Société d'Accélération du Transfert de Technologies Ouest Valorisation, Rennes, France; ³EA 4275 SPHERE, Biostatistics, Clinical Research and Pharmaco-Epidemiology, Nantes, France; ⁴Transplant Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; ⁵Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic; ⁶IECM, EA4644 University/ONIRIS USC1383 INRA, ONIRIS, Nantes, France; ⁷EFS Pays de la Loire, Nantes, France.
Anti-thymocyte globulins (ATG) are rabbit IgGs against human T cells widely used as induction treatment of kidney recipients. ATG can induce immune-complex diseases including Serum…
2015 American Transplant Congress
Characteristics of IgGs Produced in Neu5Gc and α1-3 Gal Double Knock-Out Pigs
A. Salama,^1,2 S. Conchon,¹ A. Perota,³ B. Martinet,¹ J.-P. Judor,¹ G. Evanno,¹ S. Le-Bas Bernardet,¹ L. Le Berre,¹ J. Hervouet,¹ D. Minault,¹ J.-P. Concordet,⁴ E. Dugast,¹ B. Vanhove,¹ J. Abadie,⁵ N. Gaide,⁵ I. Lagutina,³ R. Duchi,³ G. Lazzari,³ D. Sachs,⁶ O. Gauthier,⁷ S. Brouard,¹ E. Cozzi,⁸ G. Blancho,¹ H. Perreault,⁹ J.-M. Bach,¹⁰ C. Galli,^3,11 J.-P. Soulillou.¹
¹INSERM UMR 1064, ITUN, CHU de Nantes, Nantes University, Nantes, France; ²Société d'Accélération du Transfert de Technologies Ouest Valorisation, Rennes, France; ³Avantea, Laboratory of Reproductive Technologies, Cremona, Italy; ⁴INSERM U565, CNRS UMR7196, MNHN USM503, Paris, France; ⁵AMaROC, ONIRIS, Nantes, France; ⁶Massachusetts General Hospital, Transplantation Biology Research Center, Boston, MA; ⁷Centre de Recherche et d'Investigation Préclinique, ONIRIS, Nantes, France; ⁸Padua General Hospital and Consortium for Research in Organ Transplantation, Padua, Italy; ⁹Chemistry Department, University of Manitoba, Winnipeg, Canada; ¹⁰IECM, EA4644 University/ONIRIS USC1383 INRA, ONIRIS, Nantes, France; ¹¹Dept. of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.
Xenotransplantation offers a large number of potential applications, including solid organs, pancreatic islets, acellular tissues such as heart valves and skin grafts, and new bioreagents…
2015 American Transplant Congress
Antithymocyte Globulin-Induced Platelet Hypercoagulability Is a Consequence of Complement Activation and Microvesicle Release
D. Zecher,^1,4 A. Cumpelik,¹ D. Tsakiris,² M. Dickenmann,³ J. Schifferli.¹
¹Department of Research, Basel University Hospital, Basel, Switzerland; ²Department of Hematology, Basel University Hospital, Basel, Switzerland; ³Department of Nephrology, Basel University Hospital, Basel, Switzerland; ⁴Department of Nephrology, Regensburg University Hospital, Regensburg, Germany.
T cell depletion with antithymocyte globulins (ATG) can be complicated by thrombopenia andhypercoagulability. The underlying mechanism is still unclear. We found that binding of ATG…