Articles tagged "Antilymphocyte antibodies"

2016 American Transplant Congress
Surveillance Biopsy Findings with Alemtuzumab (ALZ) Induction in Kidney Transplantation.
H. Madariaga,¹ R. Ugarte,¹ C. Drachenberg,² N. Costa,¹ B. Thomas,¹ J. Bromberg,³ M. Weir,¹ A. Haririan.¹
¹Department of Medicine, University of Maryland Medical Center, Baltimore, MD; ²Department of Pathology, University of Maryland Medical Center, Baltimore, MD; ³Department of Surgery, University of Maryland Medical Center, Baltimore, MD.
The risk of subclinical histological changes in renal allografts with ALZ induction is not well defined. Hence, we performed a retrospective analysis of 527 surveillance…
2016 American Transplant Congress
Continuous Antithymocyte Globulin (rATG) for Treatment of Renal Allograft Rejection: Preliminary Analysis of a Prospective, Randomized Trial.
S. Patel, R. Knight, S. Kuten, J. Nolte, A. Gaber.
Houston Methodist Hospital, Houston, TX.
Intravenous (IV) rATG for acute rejection (AR) is primarily given on an inpatient basis due to its daily administration, IV access requirement, and monitoring. The…
2016 American Transplant Congress
CD45RO+/CD62L- Effector Memory T Cells Mediate Depletion Resistant Allograft Rejection in Intestinal Transplant Recipients.
C. Cosentino, J. Kaiser, A. Shukla, C. Desai, R. Girlanda, J. Hawksworth, C. Matsumoto, M. Zasloff, T. Fishbein, A. Kroemer.
MedStar Georgetown Transplant Institute, Washington DC.
A. A high risk of acute cellular rejection (ACR) is one of the key factors limiting intestinal transplantation (ITx). An extremely poor prognosis is related…
2016 American Transplant Congress
Limiting Helper Functions of CD4 T Cells Improves Efficacy of Induction Therapy without Compromising Responses to Third Party Antigens.
K. Ayasoufi, V. Gorbacheva, F. Ran, A. Valujskikh.
Cleveland Clinic, Cleveland.
Antibody mediated lymphocyte depletion is commonly used in clinical transplantation. However, memory T cells undermine the efficacy of lymphoablative induction therapies in sensitized transplant recipients.…
2015 American Transplant Congress
Viral Prophylaxis Is Unnecessary in CMV Low Risk Kidney Transplant Recipients Who Receive Lymphocyte Depleting Induction
M. Gillespie,¹ B. Sirandas,² A. Carlson,² S. Lee,³ L. Smith.²
¹Pharmacy, University of Maryland, Baltimore; ²Transplant, University of Utah, Salt Lake City; ³Transplant, University of Southern California, Los Angeles.
Background: Both the international CMV consensus and AST guidelines recommend against the routine use of CMV prophylaxis in CMV D-/R- kidney transplant recipients (KTR), but…
2015 American Transplant Congress
Ideal Versus Total Body Weight Dosing of Rabbit Anti-Thymocyte Globulin Induction Therapy on Patient Outcomes in High Immunological Risk Kidney Transplant
M. Vacha, J. Gommer, A. Rege, S. Sanoff, D. Sudan, M. Harris.
Duke University Hospital, Durham, NC.
BackgroundThe optimal dose of rabbit anti-thymocyte globulin (rATG) induction therapy in high immunological risk kidney transplantation (KTx) lacks consensus and the effect of dosing weight…
2015 American Transplant Congress
Efficacy and Safety of Induction Therapy With Monoclonal Versus Polyclonal Antibodies in Kidney Transplant Recipients in the Last Five Years (2008-2013) in Our Institution
M. Fernández, M. López, M. Ferreira, A. Aguilar, C. Jiménez, R. Selgas.
Nephrology, La Paz Hospital, Madrid, Spain.
Induction immunosuppression in renal transplantation is not clearly defined. We analyze the efficacy and safety of the used regimens at our institution in the last…
2015 American Transplant Congress
Early Use of Anti-Lymphocyte Antibody in Kidney Transplant Recipients With Delayed Graft Function Can Produce Desirable Post-Transplant Results
J. Lee, J. Lee, D. Joo, K. Huh, S. Kim, Y. Kim, M. Kim.
Department of Transplantation Surgery, Yonsei University Health System, Seoul, Republic of Korea.
Proper management of delayed graft function (DGF) is essential for successful post-transplant result in deceased donor kidney transplantation. We compared the effect of anti-lymphocyte antibody…
2015 American Transplant Congress
Single Center Experience With the Use of an Abbreviated Anti-Thymocyte Globulin and Basiliximab Combination Protocol in Renal Transplantation
V. Whittaker,¹ D. Halleran,¹ S. Narsipar,¹ J. Melancon.²
¹Surgery, State University New York Upstate Medical University, Syracuse, NY; ²Surgery, George Washington University, Washington, DC.
Purpose: To report one year outcomes from single center experience with a novel induction regimen using anti-thymocyte globulin ( ATG)(rabbit)rATG (3 mg/kg) in divided doses…
2015 American Transplant Congress
Maximizing Peri-Operative Value-Based Care in Kidney Transplant Induction
J. Fleming,¹ J. Casale,¹ K. Covert,¹ K. Boyle,¹ D. Taber,² H. Meadows,¹ C. Mardis,¹ N. Pilch,¹ M. Posadas-Salas,³ T. Srinivas,³ C. Bratton,² J. McGillicuddy,² K. Chavin,² P. Baliga.²
¹Pharmacy, MUSC, Charleston, SC; ²Surgery, MUSC, Charleston, SC; ³Nephrology, MUSC, Charleston, SC.
Due to the dwindling reimbursement for kidney transplants (KTx), there must be a continuous effort to provide the best value-based care. The purpose of this…