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Articles tagged "Anticoagulation"

  • 2020 American Transplant Congress

    Less Bleeding Associated with Apixaban versus Other Direct Acting Oral Anticoagulation in Solid Organ Transplant Recipients

    M. Thornberg1, J. Scheffert1, D. Jennings2, J. Hedvat1, N. Lange1, H. Robbins3, D. Salerno1

    1NewYork-Presbyterian Hospital, Department of Pharmacy, New York, NY, 2Long Island University School of Pharmacy, Brooklyn, NY, 3Columbia Irving University Medical Center, Department of Medicine, New York, NY

    *Purpose: Owing to their fixed dosing and favorable drug interaction profiles, direct acting oral anticoagulants (DOACs) have supplanted warfarin as the standard of care for…
  • 2020 American Transplant Congress

    Anticoagulation in Simultaneous Pancreas Kidney (SPK) Transplantation- On What Basis?

    J. Gopal, P. Herbert, J. Crane, F. Dor, V. Papalois, A. Muthusamy

    Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom

    *Purpose: Despite technical refinements, early pancreas graft loss due to thrombosis continues to occur. Conventional coagulation tests do not detect hypercoagulability and hence is left…
  • 2020 American Transplant Congress

    Safety and Efficacy of Direct-Acting Oral Anticoagulants versus Warfarin in Kidney Transplant Recipients

    A. L. Bixby1, S. A. Shaikh2, A. S. Naik3, L. Cotiguala3, K. McMurry3, M. D. Samaniego-Picota4, V. D. Marshall5, J. M. Park3

    1University Hospitals Cleveland Medical Center, Cleveland, OH, 2Keck Medical Center of USC, University of Southern California, Los Angeles, CA, 3Michigan Medicine, Ann Arbor, MI, 4Henry Ford Transplant Institute, Detroit, MI, 5University of Michigan College of Pharmacy, Ann Arbor, MI

    *Purpose: Safety and efficacy of direct-acting oral anticoagulants (DOACs) have not been well studied in solid organ transplant. The purpose of our study was to…
  • 2020 American Transplant Congress

    Adult Liver Transplant Recipients Show Increased Fibrinolysis Resistance Compared with Pediatric Recipients: The Potential Impact of Anticoagulation between the Two Populations

    H. B. Moore, T. Nydam, R. Choudhury, A. Schulick, C. Walker, M. Wachs, M. A. Adams

    University of Colorado, Aurora, CO

    *Purpose: Fibrinolytic changes in adult liver transplant patients have previously been demonstrated large transitions from excessive fibrinolysis (hyperfibrinolysis) to fibrinolysis resistance (shutdown) within 2 hours…
  • 2020 American Transplant Congress

    Utilization of Direct Acting Oral Anticoagulation in Solid Organ Transplant Patients: A National Survey of Institutional Practices

    D. Pierce1, A. Lichvar1, D. Salerno2, P. Klem3, G. Waldman4, J. M. Park5

    1University of Illinois at Chicago, Chicago, IL, 2NewYork-Presbyterian Hospital, New York, NY, 3University of Colorado Hospital, Aurora, CO, 4Massachusetts General Hospital, Boston, MA, 5University of Michigan, Ann Arbor, MI

    *Purpose: The safety and efficacy of direct acting oral anticoagulants (DOACs) and reversal strategies are not well established in the solid organ transplant population. This…
  • 2020 American Transplant Congress

    Evaluation of Apixaban Usage in Solid Organ Transplant Patients with Renal Impairment

    L. Rakouki, R. Yau, C. Tunwar

    Pharmacy, CHI St. Luke's Health-Baylor St. Luke's Medical Center, Houston, TX

    *Purpose: There remains a gap in the literature for apixaban dosing recommendations for treatment of deep vein thrombosis (DVT) or pulmonary embolism (PE) in special…
  • 2020 American Transplant Congress

    The Effects of Rivaroxaban and Apixaban on Tacrolimus Pharmacokinetics

    A. C. Scheibner1, C. Franco-Martinez1, E. Kincaide1, R. Hall1, C. Long2

    1Pharmacotherapy Division, College of Pharmacy, The University of Texas at Austin, University Health System, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 2Feik School of Pharmacy, University of the Incarnate Word, University Health System, The University of Texas Health Science Center at San Antonio, San Antonio, TX

    *Purpose: To clarify the pharmacokinetic impact of rivaroxaban (RIVA) and apixaban (APIX) on tacrolimus (TAC) concentrations.*Methods: Solid organ transplant recipients 18-years or older who were…
  • 2020 American Transplant Congress

    Perioperative Anticoagulation Decreases Graft Thrombosis in Pancreas Transplantation

    N. M. Handy1, L. Skoval1, J. Wingate2, C. Kuhr3, N. Cowan3, J. Brandenberger1

    1Section of General, Thoracic, and Vascular Surgery, Virginia Mason Medical Center, Seattle, WA, 2Department of Urology, Madigan Army Medical Center, Tacoma, WA, 3Section of Urology, Virginia Mason Medical Center, Seattle, WA

    *Purpose: Pancreas transplant thrombosis is the most common cause of graft failure in the early postoperative period, occurring 5-20% of cases. Bleeding (which occurs ~30%…
  • 2020 American Transplant Congress

    Evaluation of Clinical Outcomes in Patients Receiving Antithrombotic Therapy Prior to Kidney Transplantation

    A. Diamond1, C. Antonacci2, K. Lau3, A. Di Carlo3, S. Karhadkar3

    1Pharmacy, Temple University Hospital, Philadelphia, PA, 2Temple University School of Medicine, Philadelphia, PA, 3Surgery, Temple University Hospital, Philadelphia, PA

    *Purpose: Patients with end stage renal disease (ESRD) often have significant cardiovascular comorbidities. Utilization of therapeutic anticoagulation (AC) and/or antiplatelet (AP) therapy poses an increased…
  • 2020 American Transplant Congress

    Is Bridging Anticoagulation or Antiplatelet Reversal Necessary Prior to Kidney Transplantation?

    J. C. Alonso-Escalante, R. P. Tindall, L. Machado, K. R. Tabar, N. Thai, T. Uemura

    AHN Transplant Institute, Allegheny General Hospital, Pittsburgh, PA

    *Purpose: Pre-kidney transplant patients are often placed on anticoagulation or antiplatelet therapy, and their perioperative management is often challenging. The aim of this study is…
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