2020 American Transplant Congress
Life Supporting Orthotopic Cardiac Xenotransplantation from Genetically Engineered Donor Pigs
*Purpose: Cardiac xenotransplantation (CXTx) might be an alternative treatment for end-stage cardiac failure patients. The prolonged survival of a heterotopic genetically-engineered (GE) pig heart is…2020 American Transplant Congress
Human Thrombomodulin Gene Expression on Genetically Modified Donor Pig Hearts is Correlated with Long Term Xenograft Survival
Department of Surgery, University of Maryland Baltimore, Baltimore, MD
*Purpose: Thrombomodulin (TBM) is a coagulation regulatory protein which has shown a protective role against coagulation dysregulation and prevented thrombotic microangiopathy and premature loss of…2020 American Transplant Congress
The Effect of Human Thrombomodulin on Thrombotic Complications in Life Supporting Pig-to-Baboon Cardiac Xenotransplantation
1Surgery, University of Maryland School of Medicine, Baltimore, MD, 2Revivicor, Blacksburg, VA
*Purpose: Transplantation of organs from animals to humans (xenotransplantation) has been proposed to address the critical shortage of organs for transplantation. The use of genetically…2020 American Transplant Congress
Less Bleeding Associated with Apixaban versus Other Direct Acting Oral Anticoagulation in Solid Organ Transplant Recipients
*Purpose: Owing to their fixed dosing and favorable drug interaction profiles, direct acting oral anticoagulants (DOACs) have supplanted warfarin as the standard of care for…2020 American Transplant Congress
Anticoagulation in Simultaneous Pancreas Kidney (SPK) Transplantation- On What Basis?
Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom
*Purpose: Despite technical refinements, early pancreas graft loss due to thrombosis continues to occur. Conventional coagulation tests do not detect hypercoagulability and hence is left…2020 American Transplant Congress
Safety and Efficacy of Direct-Acting Oral Anticoagulants versus Warfarin in Kidney Transplant Recipients
*Purpose: Safety and efficacy of direct-acting oral anticoagulants (DOACs) have not been well studied in solid organ transplant. The purpose of our study was to…2020 American Transplant Congress
Adult Liver Transplant Recipients Show Increased Fibrinolysis Resistance Compared with Pediatric Recipients: The Potential Impact of Anticoagulation between the Two Populations
University of Colorado, Aurora, CO
*Purpose: Fibrinolytic changes in adult liver transplant patients have previously been demonstrated large transitions from excessive fibrinolysis (hyperfibrinolysis) to fibrinolysis resistance (shutdown) within 2 hours…2019 American Transplant Congress
Postoperative Atrial Fibrillation in Kidney Transplant Recipients: A Retrospective Study Evaluating Risk of Anticoagulation
*Purpose: Patients with atrial fibrillation (AF) have a higher risk of mortality and adverse cardiovascular events. Pre-operative AF has around 5-9% prevalence and roughly 5%…2019 American Transplant Congress
Effect of Enoxaparin Prophylaxis on Early VTE Post Lung Transplant
*Purpose: Thromboembolic complications are common post-transplant leading to significant morbidity. We instituted early enoxaparin prophylaxis (ppx) in lung transplant recipients (LTR) due to an observed…2019 American Transplant Congress
Safety and Efficacy of Anti Xa Inhibitors Post-Transplant with Concomitant Calcineurin Inhibitors
*Purpose: Despite demonstrated benefits of Anti-Xa Inhibitors (ATIs) in the general population, ATIs have not gained uniform acceptance in SOT due to lack of supportive…
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