2020 American Transplant Congress
Utilization of Direct Acting Oral Anticoagulation in Solid Organ Transplant Patients: A National Survey of Institutional Practices
*Purpose: The safety and efficacy of direct acting oral anticoagulants (DOACs) and reversal strategies are not well established in the solid organ transplant population. This…2020 American Transplant Congress
Evaluation of Apixaban Usage in Solid Organ Transplant Patients with Renal Impairment
Pharmacy, CHI St. Luke's Health-Baylor St. Luke's Medical Center, Houston, TX
*Purpose: There remains a gap in the literature for apixaban dosing recommendations for treatment of deep vein thrombosis (DVT) or pulmonary embolism (PE) in special…2020 American Transplant Congress
The Effects of Rivaroxaban and Apixaban on Tacrolimus Pharmacokinetics
*Purpose: To clarify the pharmacokinetic impact of rivaroxaban (RIVA) and apixaban (APIX) on tacrolimus (TAC) concentrations.*Methods: Solid organ transplant recipients 18-years or older who were…2020 American Transplant Congress
Perioperative Anticoagulation Decreases Graft Thrombosis in Pancreas Transplantation
*Purpose: Pancreas transplant thrombosis is the most common cause of graft failure in the early postoperative period, occurring 5-20% of cases. Bleeding (which occurs ~30%…2020 American Transplant Congress
Evaluation of Clinical Outcomes in Patients Receiving Antithrombotic Therapy Prior to Kidney Transplantation
*Purpose: Patients with end stage renal disease (ESRD) often have significant cardiovascular comorbidities. Utilization of therapeutic anticoagulation (AC) and/or antiplatelet (AP) therapy poses an increased…2020 American Transplant Congress
Is Bridging Anticoagulation or Antiplatelet Reversal Necessary Prior to Kidney Transplantation?
AHN Transplant Institute, Allegheny General Hospital, Pittsburgh, PA
*Purpose: Pre-kidney transplant patients are often placed on anticoagulation or antiplatelet therapy, and their perioperative management is often challenging. The aim of this study is…2020 American Transplant Congress
Life Supporting Orthotopic Cardiac Xenotransplantation from Genetically Engineered Donor Pigs
*Purpose: Cardiac xenotransplantation (CXTx) might be an alternative treatment for end-stage cardiac failure patients. The prolonged survival of a heterotopic genetically-engineered (GE) pig heart is…2020 American Transplant Congress
Human Thrombomodulin Gene Expression on Genetically Modified Donor Pig Hearts is Correlated with Long Term Xenograft Survival
Department of Surgery, University of Maryland Baltimore, Baltimore, MD
*Purpose: Thrombomodulin (TBM) is a coagulation regulatory protein which has shown a protective role against coagulation dysregulation and prevented thrombotic microangiopathy and premature loss of…2020 American Transplant Congress
The Effect of Human Thrombomodulin on Thrombotic Complications in Life Supporting Pig-to-Baboon Cardiac Xenotransplantation
1Surgery, University of Maryland School of Medicine, Baltimore, MD, 2Revivicor, Blacksburg, VA
*Purpose: Transplantation of organs from animals to humans (xenotransplantation) has been proposed to address the critical shortage of organs for transplantation. The use of genetically…2020 American Transplant Congress
Less Bleeding Associated with Apixaban versus Other Direct Acting Oral Anticoagulation in Solid Organ Transplant Recipients
*Purpose: Owing to their fixed dosing and favorable drug interaction profiles, direct acting oral anticoagulants (DOACs) have supplanted warfarin as the standard of care for…
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