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American Transplant Congress abstracts

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Articles tagged "Alloantibodies"

  • 2021 American Transplant Congress

    A Molecular Classifier Identifies Antibody-Mediated Rejection-Associated Changes in Lung Transplant Biopsies

    K. S. Madill-Thomsen1, K. M. Halloran2, M. Parkes1, P. F. Halloran1, &. the INTERLUNG Study Group3

    1Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, 2University of Alberta, Edmonton, AB, Canada, 3., ., AB, Canada

    *Purpose: Identifying lung transplant antibody-mediated rejection (ABMR) has been controversial. We compared gene expression in donor-specific antibody (DSA) positive vs. DSA negative lung transbronchial biopsies…
  • 2021 American Transplant Congress

    Impact of Allosensitization on Xenotransplantation

    D. Olaso1, M. Manook1, J. Yoon1, Y. Bae1, A. Barbas1, A. Adams2, S. Knechtle1, J. Kwun1

    1Department of Surgery, Duke Transplantation Center, Durham, NC, 2Department of Surgery, University of Minnesota, Minneapolis, MN

    *Purpose: Sensitization to human leukocyte antigens (HLA) due to prior exposure to foreign antigens through events such as blood transfusions, previous kidney transplant, or pregnancy…
  • 2021 American Transplant Congress

    Perioperative Blood Transfusion is Associated with the Development of New HLA Antibodies After Adult Lung Transplantation

    A. Hicks1, A. Stoker2, M. Cooter2, A. Ali3, J. Klapper4, J. Poisson5, D. Chen5, J. Haney4, K. Ghadimi2, M. Hartwig4, I. Welsby2, B. Bottiger2

    1Anesthesiology, Duke University Hospital, South Portland, ME, 2Anesthesiology, Duke University Hospital, Durham, NC, 3Pulmonology, Allergy and Critical Care Medicine, Duke University Hospital, Durham, NC, 4Cardiothoracic Surgery, Duke University Hospital, Durham, NC, 5Pathology, Duke University Hospital, Durham, NC

    *Purpose: Lung transplant (LT) recipients who develop new antibodies to human leukocyte antigen (HLA) have associated with chronic lung allograft dysfunction and worsened outcomes. We…
  • 2021 American Transplant Congress

    Belatacept and Rapamycin Maintenance Immunosuppression in a Sensitized Nonhuman Primate Kidney Allotransplantation Model

    R. Schmitz1, Z. W. Fitch1, M. Manook1, J. Yoon1, A. B. Farris2, J. Kwun1, S. J. Knechtle1

    1Department of Surgery, Duke University Medical Center, Durham, NC, 2Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA

    *Purpose: Desensitization with costimulation blockade and proteasome inhibition prior to kidney transplantation prevents early antibody-mediated rejection (AMR) and prolongs graft survival in highly sensitized nonhuman…
  • 2021 American Transplant Congress

    Identification of Distinct Blood Monocyte Phenotypes from Transplant Kidney Recipients Undergoing Cellular (TCMR) and Mixed Antibody Mediated Rejection (ABMR)

    C. Macedo, E. Bailly, K. Louis, M. Lucas, A. Zeevi, P. Randhawa, D. Metes

    Starzl Transplantation Institute, Pittsburgh, PA

    *Purpose: Monocytes play an important role in immune defense by initiating adaptive immunity. They are heterogeneous, plastic, and present different subsets: classical (CD14++CD16-), intermediate (CD14+CD16+),…
  • 2021 American Transplant Congress

    Autoantibodies Against Ro/SS-A, CENP-B, and La/SS-B are Increased in Patients with Kidney Allograft Antibody-mediated Rejection

    S. Clotet-Freixas1, M. Kotlyar2, C. M. McEvoy1, C. Pastrello2, S. Rodríguez-Ramírez1, S. Farkona1, H. Cardinal3, M. Dieudé3, M. Hébert3, Y. Li1, O. Famure1, P. Chen1, S. Kim1, E. Chan4, I. Jurisica2, R. John1, A. Chruscinski1, A. Konvalinka1

    1Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, 2Krembil Research Institute, University Health Network, Toronto, ON, Canada, 3Centre de Recherche du Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada, 4Department of Medicine, Division of Nephrology, University Health Network, Toronto, ON, Canada

    *Purpose: Antibody-mediated rejection (AMR) causes >50% of late kidney graft losses. Although donor-specific antibodies (DSA) against HLA cause AMR, antibodies against non-HLA antigens are also…
  • 2021 American Transplant Congress

    DSA is Associated with Molecular Changes in Many Hearts with Minor Abnormalities but Not Diagnosed as Antibody-Mediated Rejection

    P. Halloran1, K. S. Madill-Thomsen1, &. the INTERHEART Study Group2

    1Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, 2., ., AB, Canada

    *Purpose: We previously developed a microarray-based diagnostic system (MMDx) for heart transplant endomyocardial biopsies, measuring gene expression and interpreting antibody-mediated and T cell-mediated rejection (ABMR,…
  • 2021 American Transplant Congress

    Quantifying Hidden Sensitization: HLA-reactive Memory B Cells in the Spleens of Sensitized Women

    J. T. Killian1, J. A. Houp1, A. Nellore2, R. G. King3, P. M. Porrett1, F. E. Lund3

    1Department of Surgery, University of Alabama at Birmingham School of Medicine, Birmingham, AL, 2Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, AL, 3Department of Microbiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL

    *Purpose: Measurement of circulating anti-HLA antibody (anti-HLA-Ab) in transplant candidates and recipients is required for successful organ transplantation. However, serum Ab measurement alone likely underestimates…
  • 2021 American Transplant Congress

    Measuring the Impact of Targeting FcRn-Mediated IgG Recycling on Donor-Specific Alloantibodies in a Sensitized NHP Model

    M. Manook1, W. Flores2, R. Schmitz1, Z. Fitch1, J. Yoon1, Y. Bae1, B. I. Shaw1, M. Harnois3, S. Permar3, A. Kirk1, D. Magnani2, J. Kwun1, S. Knechtle1

    1Duke Transplant Center, Duke University Medical Center, Durham, NC, 2Massbiologics, University of Massachusetts Medical School, Boston, MA, 3Human Vaccine Institute, Duke University Medical Center, Durham, NC

    *Purpose: In transplantation, plasmapheresis and IVIg provide the mainstay of treatment directed at reducing or removing circulating donor specific antibody (DSA), yet both have limitations.…
  • 2021 American Transplant Congress

    A Novel Mouse Model of Cardiac Allograft Vasculopathy

    H. Tsuda1, E. Reed2, W. Baldwin1, R. Fairchild1

    1Inflammation and Immunity, Cleveland Clinic, Cleveland, OH, 2Pathology and Laboratory Medicine, University of California, Los Angeles, CA

    *Purpose: Cardiac allograft vasculopathy (CAV) is a major long-term complication of heart transplantation and the presence of donor specific antibodies (DSA) is associated with an…
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