2021 American Transplant Congress
Contribution of T-bet Expressing CD27+ CD21- Activated Memory B Cells Poised for Plasma Cell Differentiation to Antibody-mediated Rejection of Kidney Transplants
*Purpose: Alloimmunity triggered by donor-specific antibodies (DSAs) and ensuing development of antibody-mediated rejection (ABMR) are detrimental to organ transplants. Yet, the cellular states underlying B…2021 American Transplant Congress
The Relevance of Naturally Occurring Non-HLA Antibody to Antibody Mediated Rejection in Patients without Anti-HLA Antibodies After Kidney Transplantation
*Purpose: Very few papers describe the association between non-HLA antibodies and the incidence of antibody mediated rejection (AMR) in kidney recipients. We investigated the incidence…2021 American Transplant Congress
Novel Discovery of Super-antigen That Mobilize Regulatory Cd8 T Cells Inhibits Donor-specific Antibody and Protects Heart Allografts from Antibody-mediated Rejection
*Purpose: Antibody-mediated rejection (AMR) is a critical barrier to long-term allograft survival. We showed that Qa-1 (HLA-E in humans) restricted CD8+ T cells (CD8 Treg)…2021 American Transplant Congress
Safety and Tolerability of Tacrolimus Extended-Release (astagraf Xl) in Hla Sensitized Kidney Transplant Recipients: A Single Center Experience
Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: Pill burden is a limitation in kidney transplant. Tacrolimus extended-release (Astagraf XL) is a once daily formulation approved for kidney transplantation. Increased compliance could…2021 American Transplant Congress
DSA Causes Mild Molecular ABMR-like Changes in Many Biopsies Not Diagnosed as Rejection
1Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, 2., ., AB, Canada
*Purpose: In the multicenter study INTERCOMEX, we developed a microarray-based system (MMDx) for diagnosing antibody-mediated and T cell-mediated rejection (ABMR, TCMR) in kidney transplant biopsies…2021 American Transplant Congress
Outcomes of Kidney Transplant Recipients with Antibody-mediated Allograft Rejection: A Retrospective Study
*Purpose: The optimal regimen for treating acute and chronic antibody-mediated rejection (AMR) in kidney transplant recipients has yet to be established. The purpose of the…2021 American Transplant Congress
The Trifecta Study: Calibrating Circulating Donor-Derived Cell-Free DNA at the Time of Indication Biopsies Against the Molecular Phenotype of the Biopsy Reveals a Prominent Association with NK Cell Genes
1Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, 2Natera Inc., San Carlos, CA
*Purpose: The international, multicenter, prospective Trifecta study was designed to calibrate dd-cfDNA% measurements in blood at the time of indication biopsy against the molecular characteristics…2021 American Transplant Congress
The Clinical Significance of Preformed Anti-HLA-DQ Donor-specific Antibodies on Allograft Outcomes in Kidney Transplantation
*Purpose: De-novo anti-HLA-DQ donor-specific antibody (DSA) has been identified as a risk factor for late graft dysfunction and graft loss in kidney transplantation (KT). The…2021 American Transplant Congress
CD56dimCD16bright NK Cells from Kidney Transplant Recipients with Antibody-mediated Rejection Display Increased Proliferation, Type-1 Activation and Cytotoxic Profile
*Purpose: CD56dimCD16bright NK cells are highly potent for cytotoxicity through cell-mediated cytotoxicity (CMC), antibody-dependent cell-mediated cytotoxicity (ADCC) and INF-γ production. The contribution of NK cells…2021 American Transplant Congress
Clazakizumab (clz, Anti-il-6 Antibody) Treatment Affects Il-6/il-6r Signaling by Increasing Soluble Gp130 (sgp130) in Hla-sensitized Kidney Transplant Patients (hs Ktx Pts) Treated for Chronic Antibody-mediated Rejection (cabmr)
Cedars-Sinai Medical Center, Cerritos, CA
*Purpose: IL-6 is a pro-inflammatory cytokine responsible for chronic vascular inflammation and a promising target for cABMR modulation. IL-6/sIL-6R complex initiates more pathogenic trans-signaling pathways…
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