Articles tagged "Alloantibodies"

2021 American Transplant Congress
Impact of Allosensitization on Xenotransplantation
D. Olaso¹, M. Manook¹, J. Yoon¹, Y. Bae¹, A. Barbas¹, A. Adams², S. Knechtle¹, J. Kwun¹
¹Department of Surgery, Duke Transplantation Center, Durham, NC, ²Department of Surgery, University of Minnesota, Minneapolis, MN
*Purpose: Sensitization to human leukocyte antigens (HLA) due to prior exposure to foreign antigens through events such as blood transfusions, previous kidney transplant, or pregnancy…
2021 American Transplant Congress
A Molecular Classifier Identifies Antibody-Mediated Rejection-Associated Changes in Lung Transplant Biopsies
K. S. Madill-Thomsen¹, K. M. Halloran², M. Parkes¹, P. F. Halloran¹, &. the INTERLUNG Study Group³
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²University of Alberta, Edmonton, AB, Canada, ³., ., AB, Canada
*Purpose: Identifying lung transplant antibody-mediated rejection (ABMR) has been controversial. We compared gene expression in donor-specific antibody (DSA) positive vs. DSA negative lung transbronchial biopsies…
2021 American Transplant Congress
Belatacept and Carfilzomib-based Treatment of Active Antibody-mediated Rejection in a Sensitized Nonhuman Primate Model
J. Kwun¹, R. Schmitz¹, M. Manook¹, Z. Fitch¹, D. Olaso¹, A. Choi¹, J. Yoon¹, Y. Bae¹, J. Lambris², S. Knechtle¹
¹Surgery, Duke University, Durham, NC, ²Pathology & Laboratory Medicine, University of Pennsylvania, Philadelphia, PA
*Purpose: One third of sensitized, HLA-incompatible transplant recipients experience antibody-mediated rejection (AMR) with limited effective treatment options. We tested a novel treatment strategy for AMR…
2021 American Transplant Congress
Engineered Human Glomerular Endothelial Cells to Identify Non-hla Antibodies and Decipher Their Pathogenicity After Kidney Transplantation
B. Lamarthée¹, C. Burger¹, C. Leclaire¹, L. Morin¹, F. Terzi¹, C. Tinel¹, D. Anglicheau²
¹Inserm U1151, Necker-Enfants Malades Institute, PARIS, France, ²Necker Hospital, AP-HP, Department of Nephrology and Kidney Transplantation, PARIS, France
*Purpose: In kidney transplantation recipients (KTRs), donor-specific antibodies directed against Human Leucocyte Antigens (HLA-DSA) are thought to drive antibody-mediated rejection (AMR) and poor transplant outcome.…
2021 American Transplant Congress
Impact of Bacterial Infection on HLA Allosensitization Among Kidney Recipients on the Waitlist
D. P. Cina¹, K. R. Sherwood², S. Dobrer², J. Wong³, F. Fenninger², M. Kadatz⁴, P. Keown⁴, J. Lan⁴
¹Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada, ²University of British Columbia, Vancouver, BC, Canada, ³Department of Laboratory Medicine, Vancouver General Hospital, Vancouver, BC, Canada, ⁴Department of Nephrology, University of British Columbia, Vancouver, BC, Canada
*Purpose: The clinical relevance of HLA allosensitization associated with bacterial infection remains poorly defined. The primary objective of this study is to determine the incidence,…
2021 American Transplant Congress
AT-1501, a Novel and Clinically Applicable CD40L Specific Monoclonal Antibody, Promotes Islet Allograft Survival in Nonhuman Primates
D. Berman¹, N. Kenyon¹, M. Willman¹, A. Gill², S. Perrin³, C. Ricordi¹
¹University of Miami, Miami, FL, ²ALS Therapy Development Institute, Cambridge, MA, ³Novus Therapeutics, Irvine, CA
*Purpose: Immune intervention with a CD40L specific monoclonal antibody (mAb, Hu5c8, Biogen) has previously been shown to safely and effectively prevent islet allograft (IA) rejection…
2021 American Transplant Congress
Antibody-mediated Rejection and Sponge Effect in a Redo Lung Transplant Recipient: A Case Report
A. Arjuna, M. T. Olson, S. Tokman, R. Walia, T. Mohanakumar, A. S. Hashimi, M. A. Smith, R. M. Bremner, A. Omar
Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ
*Purpose: Antibody-mediated rejection (AMR) typically presents with elevated titers of circulating donor specific antibodies (DSA) and increased mean fluorescence intensity (MFI), a surrogate marker for…
2021 American Transplant Congress
Natural Sensitization by Pregnancy, Testing Desensitization Strategies in Female NHPs Across Repeat Mismatches
M. Manook, J. Yoon, Z. Fitch, R. Schmitz, A. M. Jackson, J. Kwun, S. Knechtle
Duke Transplant Center, Duke University Medical Center, Durham, NC
*Purpose: Women are disproportionately represented in the highly sensitized patient cohort, and HLA-incompatible transplantation is undertaken predominantly in females. However, nonhuman primate (NHP) models to…
2021 American Transplant Congress
Clazakizumab (clz, Anti-il-6 Antibody) Treatment Affects Il-6/il-6r Signaling by Increasing Soluble Gp130 (sgp130) in Hla-sensitized Kidney Transplant Patients (hs Ktx Pts) Treated for Chronic Antibody-mediated Rejection (cabmr)
B. Shin, S. Ge, A. Jimenez, N. Ammerman, A. Vo, R. Zhang, S. C. Jordan, M. Toyoda
Cedars-Sinai Medical Center, Cerritos, CA
*Purpose: IL-6 is a pro-inflammatory cytokine responsible for chronic vascular inflammation and a promising target for cABMR modulation. IL-6/sIL-6R complex initiates more pathogenic trans-signaling pathways…
2021 American Transplant Congress
CD56^dimCD16^bright NK Cells from Kidney Transplant Recipients with Antibody-mediated Rejection Display Increased Proliferation, Type-1 Activation and Cytotoxic Profile
E. Bailly¹, C. Macedo¹, K. Louis¹, B. Ramaswami¹, M. Lucas¹, C. Bentlejewski¹, P. Randhawa¹, A. Zeevi¹, C. Lefaucheur², D. Metes¹
¹Department of Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, ²INSERM UMR-S976. Endothelium, Inflammation & Alloreactivity, Université de Paris, Paris, France
*Purpose: CD56dimCD16bright NK cells are highly potent for cytotoxicity through cell-mediated cytotoxicity (CMC), antibody-dependent cell-mediated cytotoxicity (ADCC) and INF-γ production. The contribution of NK cells…