ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Alloantibodies"

  • 2022 American Transplant Congress

    Longitudinal Characterization of Memory B Cells During Antibody Mediated Rejection Treated with Plasmapheresis, Bortezomib, and Belatacept in Heart Transplant Recipients

    F. Alkhunaizi1, M. Ellison2, V. Berrich1, M. Siegelin1, M. Szabolcs1, G. F. Sayer1, N. Uriel1, S. Restaino1, A. Chong3, A. Zeevi2, M. Habal1

    1Columbia University Medical Center, New York, NY, 2University of Pittsburgh Medical Center, Pittsburgh, PA, 3University of Chicago, Chicago, IL

    *Purpose: Donor specific antibodies (DSA) and antibody mediated rejection (AMR) continue to limit allograft longevity after heart transplant. Effective treatments are limited and often complicated…
  • 2022 American Transplant Congress

    Perturbing Proteostasis to Deplete Plasma Cells

    A. Rossi1, A. Burg1, K. Roskin1, A. Shields2, R. Alloway2, E. Woodle2, D. Hildeman1

    1Cincinnati Children's Hospital, Cincinnati, OH, 2University of Cincinnati College of Medicine, Cincinnati, OH

    *Purpose: Alloantibodies play critical roles in rejection and often prevent sensitized patients from receiving life-sustaining transplants. One approach for enhancing transplantation rates and survival for…
  • 2022 American Transplant Congress

    Anti-HLA Antibodies Do Not Increase in Kidney Transplant Recipients During COVID-19 Infection

    A. Girnita1, L. Wang1, P. Ahearn1, A. Colovai2, M. Fernandez-Vina1, E. Woodle3, T. Yalamarti1, M. Menon4, Y. Azzi2, M. Melcher1, R. Bray5, H. Gebel5, P. Cravedi4, J. Maltzman1, E. Akalin2

    1Stanford University, Palo Alto, CA, 2Albert Einstein College of Medicine, New York, NY, 3University of Cincinnati, Cincinnati, OH, 4Mount Sinai, New York, NY, 5Emory University Hospital, Atlanta, GA

    *Purpose: To determine if HLA allo-antibody levels are affected by COVID-19 in renal transplanted patients and to compare the immunoglobulin class and subclass profiles as…
  • 2022 American Transplant Congress

    Leveraging Car T Cells To Achieve Desensitization And Enable Transplantation

    V. BHOJ

    UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

    *Purpose: Pre-existing allo-antibodies (allo-Abs), that preclude transplant due to the risk of hyperacute rejection, lead to prolonged wait times and high mortality rates. Current desensitization…
  • 2022 American Transplant Congress

    Time-Dependent Blood Eosinophilia Count Increases the Risk of Kidney Allograft Rejection

    L. Colas1, L. Bui2, C. Kerleau3, M. Lemdani4, K. Autain-Renaudin5, A. Magnan6, M. Giral3, S. Brouard1

    1CRT2I, Université de Nantes, Nantes, France, 2Service de Néphrologie, Centre Hospitalier de Mouscron, Mouscron, Belgium, 3Service de Néphrologie et Immunologie Clinique, CHU de Nantes, Nantes, France, 4Département de Biomathématiques, Université de Lilles, Lilles, France, 5Service d'Anatomie et Cytologie Pathologique, CHU de Nantes, Nantes, France, 6INRAe UMR 0892, Université de Versailles Saint-Quentin Paris-Saclay, Paris, France

    *Purpose: There is growing evidence that type 2 immune effectors (immunoglobulin E, eosinophils, mast cells/basophils) play a role in autoimmune disorders and solid organ transplantation.…
  • 2022 American Transplant Congress

    Role for Club Cell Secretory Protein in Inducing Exosomes and Activation of Immune Responses in Lung Transplanted Recipients for Cystic Fibrosis

    R. Ravichandran1, V. Kaza2, R. Bremner1, M. Smith1, T. Mohanakumar1

    1St. Joseph’s Hospital and Medical Center, Phoenix, AZ, 2University of Texas Southwestern, Dallas, TX

    *Purpose: Our lab has demonstrated that lower club cell secretory protein leads to immune responses to donor HLA and lung self-antigens (Collagen V, Kα1 Tubulin),…
  • 2022 American Transplant Congress

    Allo-Sensitization is Increased in Liver Transplant Recipients Following Ischemia-Reperfusion Injury

    R. A. Sosa, A. Q. Terry, Y. Yin, B. V. Naini, F. M. Kaldas, R. W. Busuttil, D. W. Gjertson, J. W. Kupiec-Weglinski, E. F. Reed

    UCLA, Los Angeles, CA

    *Purpose: Recipient sensitization to donor HLA antigens remains an important clinical problem in transplantation, leading to increased wait times to find a compatible donor and…
  • 2022 American Transplant Congress

    Donor-Specificb Cell Dysfunction and Suppressive Ability Are Differentially Induced in Cob-Mediated Transplantation Tolerance

    S. Durgam1, D. Yin1, M. Alegre2, A. Chong1

    1Surgery, section of transplant immunology, University of Chicago, Chicago, IL, 2Medicine, section of rheumatology, University of Chicago, Chicago, IL

    *Purpose: B cells in mice tolerized to fully mismatched heart allografts with anti-CD154+donor spleen cells (CoB) are intrinsically dysfunctional and unable to differentiate into germinal…
  • 2022 American Transplant Congress

    Baseline Trends in Tacrolimus Intrapatient Variability in Pediatric and Young Adult Kidney Transplant Recipients

    K. Piburn1, L. Maestretti2, M. V. Patton2, A. M. McGrath2, O. S. Indridason3, A. Chaudhuri1, P. Grimm1, V. Sigurjonsdottir1

    1Pediatric Nephrology, Stanford University, Palo Alto, CA, 2Pediatric Kidney Transplant, Lucile Packard Children's Hospital, Palo Alto, CA, 3Division of Nephrology, Landspitali – the National University Hospital of Iceland, Reykjavik, Iceland

    *Purpose: High tacrolimus intrapatient variability (IPV) is a known risk factor for poor graft outcomes in kidney transplantation. Baseline trends in tacrolimus IPV have not…
  • 2022 American Transplant Congress

    Antibody-Mediated Allograft Rejection is Associated with an Increase in Peripheral Differentiated Cd28-cd8+ T Cells – Analyses of a Cohort of 1032 Kidney Transplant Recipients

    H. L. Mai1, N. Degauque1, S. Le Bot1, M. Rimbert1, K. Renaudin1, R. Danger1, F. Le Borgne2, C. Kerleau1, F. Delbos3, M. Giral1, S. Brouard1

    1UMR 1064 - CRTI, INSERM - CHU de Nantes, Nantes, France, 2UMR 1046 - SPHERE, INSERM - IDBC-A2COM, Nantes, France, 3Etablissement Français du Sang (EFS) - CHU de Nantes, Nantes, France

    *Purpose: CD28-CD8+ T cells represent a differentiated CD8+ T cell subset that is found to be increased in various conditions associated with chronic antigenic stimulation…
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