ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Alloantibodies"

  • 2022 American Transplant Congress

    Desensitization Protocol to Prevent Severe Oliguric Antibody-Mediated Rejection

    H. Ishida1, K. Unagami1, T. Kamzawa1, K. Omoto1, H. Shimizu1, K. Tanabe2

    1Tokyo Womens, Tokyo 162-8666, Japan, 2Tokyo Women's Medical University, Tokyo, Japan

    *Purpose: Antibody-mediated rejection in a case with a positive crossmatch test can be severe and result in sudden onset of oliguria and sometimes, anuria, leading…
  • 2022 American Transplant Congress

    Regulatory T and B Cell Responses Are Equally Compromised During Antibody-Mediated Rejection of Kidney Allografts

    K. Louis1, P. Fadakar2, C. Macedo2, M. Yamada2, M. Lucas2, X. Gu2, A. Zeevi2, P. Randhawa2, C. Lefaucheur3, D. Metes2

    1Inserm U976, Human Immunology and Immunopathology, Paris, France, 2Surgery, University of Pittsburgh, Pittsburgh, PA, 3Inserm U970, Paris Translational Research Center for Organ Transplantation, Paris, France

    *Purpose: Although considerable advances have been made in understanding the cellular effector mechanisms responsible for donor-specific antibody (DSA) generation leading to antibody-mediated rejection (ABMR), the…
  • 2022 American Transplant Congress

    The Impact of Soluble Human Leukocyte Antigen (HLA) on Renal Antibody-Mediated Rejection (AMR) After Simultaneous Liver Kidney Transplantation (SLKT)

    H. Me1, A. Jaramillo1, D. Ramon1, L. G. Olsen1, R. Heilman1, H. Khamash1, T. Mohanakumar2, R. Ravichandran2

    1Mayo Clinic, Phoenix, AZ, 2St. Joseph's Hospital and Medical Center, Phoenix, AZ

    *Purpose: The lower incidence of AMR and higher incidence of rejection-free grafts survival in SLKT recipients as compared to kidney transplant recipients have been clearly…
  • 2022 American Transplant Congress

    Ixazomib for Desensitization (IXADES): Results of a Phase II Clinical Trial

    N. Wilson1, S. R. Reese2, L. Ptak3, F. Aziz2, S. Parajuli2, V. Jucaud4, S. Denham4, A. Mishra5, P. Hematti5, A. Djamali2

    1University of Wisconsin, Madison, WI, 2Medicine, University of Wisconsin, Madison, WI, 3Administration, University of Wisconsin, Madison, WI, 4Terasaki Institute, Los Angeles, CA, 5UW Comprehensive Cancer Center, University of Wisconsin, Madison, WI

    *Purpose: Ixazomib is a second-generation oral proteasome inhibitor, FDA approved for the treatment of refractory multiple myeloma. The purpose of the study was (1) to…
  • 2022 American Transplant Congress

    ABO Hemagglutination Titres Do Not Accurately Reflect ABO Antibody Levels

    A. Halpin1, T. Ellis2, J. Pearcey2, B. Motyka2, T. L. Lowary3, C. Cairo4, S. Maier2, L. J. West5

    1Pediatrics/Dept of Laboratory Medicine, University of Alberta/Alberta Precision Laboratories, Edmonton, AB, Canada, 2Pediatrics, University of Alberta, Edmonton, AB, Canada, 3Academia Sinica, Institute of Biological Chemistry, Taipei, Taiwan, 4Chemistry, University of Alberta, Edmonton, AB, Canada, 5Pediatrics, University of Alberta, Canadian Donation and Transplant Research Program, Edmonton, AB, Canada

    *Purpose: ABO antibody (ABO-Ab) quantification is essential for risk assessment for ABO-incompatible (ABOi) transplantation, but the hemagglutination assay (HA) for ABO-Ab titres is known to…
  • 2022 American Transplant Congress

    Comprehensive Profiling of Monocytes During Cellular (TCMR) or Mixed Antibody-Mediated Rejection (ABMR) After Kidney Transplantation

    C. Macedo1, E. Bailly1, K. Louis2, X. Gu1, M. Lucas1, A. Zeevi1, P. Randhawa1, A. Bansal3, D. Metes1

    1Starzl Transplantation Institute, Pittsburgh, PA, 2INSERM UMR-S976, Paris, France, 3University of Pittsburgh, Pittsburgh, PA

    *Purpose: Monocytes play an important role in the immune defense by initiating adaptive immunity. They are heterogeneous, plastic, and present different subsets: classical (CD14++CD16-), intermediate…
  • 2022 American Transplant Congress

    De Novo Donor-Specific Antibody Development in Heart Transplant Recipients Following COVID-19 Vaccination

    M. Cheng1, O. Behbahani-Nejad1, D. Gupta2

    1Internal Medicine, Emory University School of Medicine, Atlanta, GA, 2Internal Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA

    *Purpose: To determine the incidence of de novo donor-specific antibodies (DSAs) in recipients of orthotopic heart transplants (OHT) who received an mRNA vaccine against SARS-CoV-2.*Methods:…
  • 2022 American Transplant Congress

    Desensitization Using Costimulatory Blockade and Bortezomib to Prevent DSA Formation and Rejection in Reconstructive Transplantation

    B. Oh, F. Messner, Y. Guo, G. Brandacher

    Johns Hopkins University School of Medicine, Baltimore, MD

    *Purpose: Sensitization in form of donor-specific antibodies (DSA) and subsequent antibody-mediated rejection constitute some of the greatest risk factors for allograft rejection and long-term graft…
  • 2022 American Transplant Congress

    Lung Allograft-Resident Eosinophils Maintain Long-Term Graft Integrity by Restraining Humoral Alloimmunity

    Z. Mei1, Y. Guo1, D. Li1, M. Khalil1, A. Banerjee1, A. Gelman2, D. Kreisel2, A. Krupnick3

    1Department of Surgery, University of Maryland, Baltimore, Baltimore, MD, 2Washington University in St. Louis, St. Louis, MO, 3Department of Surgery, University of Maryland, Baltimore, baltimore, MD

    *Purpose: The finding that eosinophils facilitate immunosuppression-mediated acceptance of murine lung allograft by downregulating alloreactive CD8+ T cells has been recently described by our group.…
  • 2022 American Transplant Congress

    Association of Pre-Transplant Anti A1 IgM Antibody Titers with Survival Outcomes in A2/A2B to B Kidney Transplantation

    M. Fallahzadeh, D. Shaffer, A. El Chediak, I. Feurer, S. Rega, J. L. Triozzi, S. Shawar

    Vanderbilt University Medical Center, Nashville, TN

    *Purpose: The new kidney allocation system implemented in 2014 has allowed blood type B recipients to receive kidneys from A2/A2B donors. Although many centers use…
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