Articles tagged "Alloantibodies"

2022 American Transplant Congress
Longitudinal Characterization of Memory B Cells During Antibody Mediated Rejection Treated with Plasmapheresis, Bortezomib, and Belatacept in Heart Transplant Recipients
F. Alkhunaizi¹, M. Ellison², V. Berrich¹, M. Siegelin¹, M. Szabolcs¹, G. F. Sayer¹, N. Uriel¹, S. Restaino¹, A. Chong³, A. Zeevi², M. Habal¹
¹Columbia University Medical Center, New York, NY, ²University of Pittsburgh Medical Center, Pittsburgh, PA, ³University of Chicago, Chicago, IL
*Purpose: Donor specific antibodies (DSA) and antibody mediated rejection (AMR) continue to limit allograft longevity after heart transplant. Effective treatments are limited and often complicated…
2022 American Transplant Congress
Perturbing Proteostasis to Deplete Plasma Cells
A. Rossi¹, A. Burg¹, K. Roskin¹, A. Shields², R. Alloway², E. Woodle², D. Hildeman¹
¹Cincinnati Children's Hospital, Cincinnati, OH, ²University of Cincinnati College of Medicine, Cincinnati, OH
*Purpose: Alloantibodies play critical roles in rejection and often prevent sensitized patients from receiving life-sustaining transplants. One approach for enhancing transplantation rates and survival for…
2022 American Transplant Congress
Anti-HLA Antibodies Do Not Increase in Kidney Transplant Recipients During COVID-19 Infection
A. Girnita¹, L. Wang¹, P. Ahearn¹, A. Colovai², M. Fernandez-Vina¹, E. Woodle³, T. Yalamarti¹, M. Menon⁴, Y. Azzi², M. Melcher¹, R. Bray⁵, H. Gebel⁵, P. Cravedi⁴, J. Maltzman¹, E. Akalin²
¹Stanford University, Palo Alto, CA, ²Albert Einstein College of Medicine, New York, NY, ³University of Cincinnati, Cincinnati, OH, ⁴Mount Sinai, New York, NY, ⁵Emory University Hospital, Atlanta, GA
*Purpose: To determine if HLA allo-antibody levels are affected by COVID-19 in renal transplanted patients and to compare the immunoglobulin class and subclass profiles as…
2022 American Transplant Congress
Leveraging Car T Cells To Achieve Desensitization And Enable Transplantation
V. BHOJ
UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA
*Purpose: Pre-existing allo-antibodies (allo-Abs), that preclude transplant due to the risk of hyperacute rejection, lead to prolonged wait times and high mortality rates. Current desensitization…
2022 American Transplant Congress
Time-Dependent Blood Eosinophilia Count Increases the Risk of Kidney Allograft Rejection
L. Colas¹, L. Bui², C. Kerleau³, M. Lemdani⁴, K. Autain-Renaudin⁵, A. Magnan⁶, M. Giral³, S. Brouard¹
¹CRT2I, Université de Nantes, Nantes, France, ²Service de Néphrologie, Centre Hospitalier de Mouscron, Mouscron, Belgium, ³Service de Néphrologie et Immunologie Clinique, CHU de Nantes, Nantes, France, ⁴Département de Biomathématiques, Université de Lilles, Lilles, France, ⁵Service d'Anatomie et Cytologie Pathologique, CHU de Nantes, Nantes, France, ⁶INRAe UMR 0892, Université de Versailles Saint-Quentin Paris-Saclay, Paris, France
*Purpose: There is growing evidence that type 2 immune effectors (immunoglobulin E, eosinophils, mast cells/basophils) play a role in autoimmune disorders and solid organ transplantation.…
2022 American Transplant Congress
Role for Club Cell Secretory Protein in Inducing Exosomes and Activation of Immune Responses in Lung Transplanted Recipients for Cystic Fibrosis
R. Ravichandran¹, V. Kaza², R. Bremner¹, M. Smith¹, T. Mohanakumar¹
¹St. Joseph’s Hospital and Medical Center, Phoenix, AZ, ²University of Texas Southwestern, Dallas, TX
*Purpose: Our lab has demonstrated that lower club cell secretory protein leads to immune responses to donor HLA and lung self-antigens (Collagen V, Kα1 Tubulin),…
2022 American Transplant Congress
Allo-Sensitization is Increased in Liver Transplant Recipients Following Ischemia-Reperfusion Injury
R. A. Sosa, A. Q. Terry, Y. Yin, B. V. Naini, F. M. Kaldas, R. W. Busuttil, D. W. Gjertson, J. W. Kupiec-Weglinski, E. F. Reed
UCLA, Los Angeles, CA
*Purpose: Recipient sensitization to donor HLA antigens remains an important clinical problem in transplantation, leading to increased wait times to find a compatible donor and…
2022 American Transplant Congress
Donor-Specificb Cell Dysfunction and Suppressive Ability Are Differentially Induced in Cob-Mediated Transplantation Tolerance
S. Durgam¹, D. Yin¹, M. Alegre², A. Chong¹
¹Surgery, section of transplant immunology, University of Chicago, Chicago, IL, ²Medicine, section of rheumatology, University of Chicago, Chicago, IL
*Purpose: B cells in mice tolerized to fully mismatched heart allografts with anti-CD154+donor spleen cells (CoB) are intrinsically dysfunctional and unable to differentiate into germinal…
2022 American Transplant Congress
Baseline Trends in Tacrolimus Intrapatient Variability in Pediatric and Young Adult Kidney Transplant Recipients
K. Piburn¹, L. Maestretti², M. V. Patton², A. M. McGrath², O. S. Indridason³, A. Chaudhuri¹, P. Grimm¹, V. Sigurjonsdottir¹
¹Pediatric Nephrology, Stanford University, Palo Alto, CA, ²Pediatric Kidney Transplant, Lucile Packard Children's Hospital, Palo Alto, CA, ³Division of Nephrology, Landspitali – the National University Hospital of Iceland, Reykjavik, Iceland
*Purpose: High tacrolimus intrapatient variability (IPV) is a known risk factor for poor graft outcomes in kidney transplantation. Baseline trends in tacrolimus IPV have not…
2022 American Transplant Congress
Antibody-Mediated Allograft Rejection is Associated with an Increase in Peripheral Differentiated Cd28-cd8+ T Cells – Analyses of a Cohort of 1032 Kidney Transplant Recipients
H. L. Mai¹, N. Degauque¹, S. Le Bot¹, M. Rimbert¹, K. Renaudin¹, R. Danger¹, F. Le Borgne², C. Kerleau¹, F. Delbos³, M. Giral¹, S. Brouard¹
¹UMR 1064 - CRTI, INSERM - CHU de Nantes, Nantes, France, ²UMR 1046 - SPHERE, INSERM - IDBC-A2COM, Nantes, France, ³Etablissement Français du Sang (EFS) - CHU de Nantes, Nantes, France
*Purpose: CD28-CD8+ T cells represent a differentiated CD8+ T cell subset that is found to be increased in various conditions associated with chronic antigenic stimulation…