Articles tagged "Adverse effects"

2015 American Transplant Congress
Adverse Events of Maintenance Immunosuppression Following Kidney Transplantation Reported in Randomized Controlled Trials: A Systematic Review
M. Howell,^1,2 R. Yeo,² A. Tong,^1,2 J. Craig,^1,2 K. Howard,² G. Wong.^2,3
¹Centre for Kidney Research, The Children's Hospital at Westmead, Westmeand, NSW, Australia; ²School of Public Health, University of Sydney, Sydney, NSW, Australia; ³Centre for Transplant and Renal Research, Westmead Hospital, Westmead, NSW, Australia.
Aim: To evaluate the completeness of reporting of adverse events in randomized controlled trials (RCTs) of maintenance immunosuppression in kidney transplantation.Background: Side effects of maintenance…
2015 American Transplant Congress
Quality of Life, Financial, and Mental Health Outcomes for Individuals Turned Down for Live Kidney Donation
P. Reese,¹ C. Carney,¹ S. Levsky,¹ R. Pendse,¹ D. Leidy,¹ A. Mussell,¹ R. Bloom,¹ M. Allen,¹ D. Collins,¹ S. Keddem,¹ P. Abt,¹ J. Rodrigue,² E. Emanuel.¹
¹UPenn, Philadelphia, PA; ²Harvard, Cambridge, MA.
Introduction: Individuals considering live kidney donation should have a thorough understanding of the risks and benefits. Regulations focus exclusively on donation risks. However, no data…
2015 American Transplant Congress
Effect of Antibody Mediated Rejection on Long-Term Renal Allograft Function
M. John, A. Smith, I. Dortonne, A. Paramesh, M. Killackey, B. Lee, R. Zhang, J. Buell.
Transplant Institute, Tulane University, New Orleans, LA.
Historically we had poor understanding of chronic rejection attributing it to hypertension and non-compliance. However in the last decade we have begun to understand the…
2015 American Transplant Congress
De Novo Once-Daily Tacrolimus in Liver Transplantation: Long-Term Outcomes of a Single Center Cohort of 150 Patients
M. Gastaca, A. Valdivieso, J. Bustamante, P. Ruiz, J. Fernandez, A. Ventoso, M. Testillano, I. Palomares, P. Salvador, M. Prieto, A. Matarranz, M. Suarez, J. Ortiz de Urbina.
Liver Transplantation Unit, Cruces University Hospital. University of the Basque Country, Bilbao, Vizcaya, Spain.
Purpose: To describe the long-term safety and efficacy profile of de novo once-daily tacrolimus (Tac QD) in orthotopic liver transplantation (OLT)Patients and methods: A retrospective…
2015 American Transplant Congress
Tacrolimus Trough Concentrations Increase in Intestinal Transplant Recipients During Episodes of Acute Cellular Rejection
A. Lichvar,¹ D. Deen,² H. Johnson,¹ J. Bonner,³ G. Bond,⁴ G. Costa,⁴ R. Cruz,⁴ K. Abu-Elmagd,⁵ R. Venkataramanan.^6,7
¹Department of Pharmacy and Therapeutics, University of Pittsburgh Medical Center, Pittsburgh, PA; ²Department of Pharmacy, Memorial University Medical Center, Savannah, GA; ³Northern Institute for Cancer Research at Newcastle University, Tyne and Wear, United Kingdom; ⁴Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA; ⁵Center for Gut Rehabilitation and Transplantation, Cleveland Clinic, Cleveland, OH; ⁶Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA; ⁷Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Introduction: Acute cellular rejection (ACR) in small bowel transplant recipients is expected to increase intestinal permeability and to reduce intestinal CYP3A/p-glycoprotein activity. These changes may…
2015 American Transplant Congress
Impact of Machine Perfusion After Long Static Cold Storage On Delayed Graft Function Incidence and Duration and Time to Hospital Discharge
A. Matos,¹ M. Borrelli, Jr.,¹ L. Moura Requiao,¹ M. Nogueira, Jr.,¹ L. Pertusier,¹ G. Clarizia,¹ P. Ongaro,¹ S. Ximenes,¹ M. Durao, Jr.,^1,2 A. Pacheco-Silva.^1,2
¹Transplantation, Hospital Israelita Albert Einstein, Sao Paulo, Brazil; ²Medicine/Nephrology, Escola Paulista de Medicina, UNIFESP, Sao Paulo, Brazil.
Our transplant center is not involved in organ harvesting and usually we receive a kidney for transplant with more then 20 hours of static cold…
2015 American Transplant Congress
Systematic Medical Record Review to Identify Safety Risks in Living Liver Donors
B. Platt,⁵ D. Woods,⁵ R. Fisher,² J. Guarrera,³ E. Pomfret,⁴ M. Simpson,⁴ A. Daud,¹ T. Curtis,⁵ E. Reyes,⁵ E. Wymore,⁵ A. Skaro,¹ D. Ladner.¹
¹Northwestern University, Chicago, IL; ²Virginia Commonwealth University, Richmond, VA; ³Columbia University, New York, NY; ⁴Lahey Clinic, Boston, MA; ⁵CHS, Northwestern University, Chicago, IL.
BACKGROUNDPrevention of adverse events (AEs) is important in Living Donor Liver Transplantation (LDLT), as these are healthy volunteers who undergo a major procedure with no…
2015 American Transplant Congress
ABCB1 Haplotypes, Sex, Calcineurin Inhibitors and Lipid Profiles Post-Renal Transplant
C. Meaney,^1,2 R. Venuto,³ D. Brazeau,⁴ J. Consiglio,⁵ L. Cooper,¹ G. Wilding,⁵ K. Tornatore.^1,2,3
¹NYS Center of Excellence in Bioinformatics and Life Sciences, Buffalo, NY; ²School of Pharmacy, Buffalo, NY; ³Medicine, School of Medicine, Buffalo, NY; ⁴University of New England College of Pharmacy, Portland, ME; ⁵Biostatistics, School of Public Health, University at Buffalo, Buffalo, NY.
Purpose: Hyperlipidemia is common in renal transplant recipients (RTR) during calcineurin inhibitor (CNI) immunosuppression. P-glycoprotein (P-gp) is an efflux transporter encoded by ABCB1 that modulates…
2015 American Transplant Congress
Risks for Readmission Post-Renal Transplant: A Co-Morbid Condition
M. John, A. Smith, I. Dortonne, A. Paramesh, M. Killackey, B. Lee, R. Zhang, J. Buell.
Transplant Institute, Tulane University, New Orleans, LA.
Background: Recently CMS addressed “excessive” readmission rates with a punitive 5% cut in reimbursement. For decades renal transplantation has been highly regulated with published outcomes…