2021 American Transplant Congress
HTFPI.hCD47 and Adhesion Inhibition in GTKO.hCD46 Pig Lung Xenograft Injury
*Purpose: We evaluate whether genetic expression of human tissue factor pathway inhibitor (TFPI, extrinsic coagulation pathway inhibitor) and human CD47 ("don’t eat me" immunoregulator), alone…2021 American Transplant Congress
CD80/PD-L1 Uniquely Regulates CD4 Effector T Cell Migration
1U Maryland, baltimore, MD, 2U Minnesota, Minneapolis, MN, 3Harvard U, boston, MA
*Purpose: CD80 is a costimulatory molecule expressed on antigen presenting cells (APCs) that binds CD28 and CTLA4, stimulating or inhibiting immunity, respectively. CD80 also binds…2021 American Transplant Congress
Treg Lymphotoxin Engages Lymphotoxin Receptor on Cancer and Endothelial Cells to Promote Cancer Metastatic Migration: Mechanisms for Treg-Cancer Interactions
*Purpose: Treg immune suppression which is critical for transplant graft survival may also enhance tumor growth and metastases. Treg lymphotoxin (LTα1β2) may directly engage the…2021 American Transplant Congress
Hypoxia Inducible Factor 1á (HIF-1á) Regulates Carcinoembryonic Antigen-related Cell Adhesion Molecule-1 (CEACAM1) Splice Isoforms to Protect Against Ischemic Injury in Mouse and Human Liver Transplantation
The Dumont-UCLA Transplantation Center, Los Angeles, CA
*Purpose: CEACAM1 (CC1) is a transmembrane glycoprotein that undergoes extensive alternative splicing (AS) to generate CC1-S and CC1-L. It is currently unclear which of these…2021 American Transplant Congress
PD-1/PD-L1 Selectively Regulates Treg Lymphatic Migration
*Purpose: The molecules that regulate Treg migration are incompletely identified. Programmed death-1 (PD-1) and its ligand PD-L1 are immune checkpoint proteins which regulate immune cell…2020 American Transplant Congress
PD-L1 Signals Lymphatic Endothelium for Treg Migration
*Purpose: Regulatory T cell (Treg) migration is important for tolerance, although the molecules that regulate Treg entry to lymphatics are poorly understood. Lymphatic endothelial cells…2020 American Transplant Congress
Oxidative Stress Induces Cytoprotective Alternative Splicing in Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 in Mouse Liver Ischemia-Reperfusion Injury
Surgery, Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: We have recently shown that carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) serves as a checkpoint regulator in liver transplant (LT) ischemia-reperfusion injury (IRI);…2020 American Transplant Congress
Anti-CD321 Antibody (90G4) Protects Liver against Ischemia Reperfusion Injury in a Murine Model
*Purpose: Ischemia reperfusion results in increased transmigration of leukocytes into tissue. This eventually leads to post transplant graft damage after organ transplantation. CD321 (also known…2020 American Transplant Congress
Ex Vivo Isolated Human Vessel Perfusion System for the Design and Assessment of Nanomedicines Targeted to the Endothelium
1Yale University, New Haven, CT, 2Yale School of Medicine, New Haven, CT
*Purpose: In solid organ transplantation the host immune system acts to reject the graft. This process is facilitated at the endothelial surface, where inflamed donor…2020 American Transplant Congress
Novel Technique to Analyze Blood-Endothelial Cell Interactions Under Flow Conditions
*Purpose: The Bioflux system has been used to study platelet-driven thrombosis and leukocyte adhesion. Typically, whole blood is stained with calcein (green) to evaluate platelet…
American Transplant Congress abstracts