ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Adhesion molecules"

  • 2020 American Transplant Congress

    PD-L1 Signals Lymphatic Endothelium for Treg Migration

    W. Piao1, L. Li1, K. Hippen2, Y. Zhang2, V. Saxena3, Y. Xiong1, C. Paluskievicz1, M. WillsonShirkey1, B. Blazar2, L. Riella4, J. Bromberg5

    1Surgery, U of Maryland, Baltimore, MD, 2Pediatrics, U of Minnesota, Minneapolis, MN, 3U of Maryland, Baltimore, MD, 4Transplantation Research Center, Harvard U, Boston, MA, 5Surgery and Microbiology and Immunology, U of Maryland, Baltimore, MD

    *Purpose: Regulatory T cell (Treg) migration is important for tolerance, although the molecules that regulate Treg entry to lymphatics are poorly understood. Lymphatic endothelial cells…
  • 2020 American Transplant Congress

    Oxidative Stress Induces Cytoprotective Alternative Splicing in Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 in Mouse Liver Ischemia-Reperfusion Injury

    K. J. Dery, H. Hirao, K. Kadono, S. Kageyama, H. Kojima, R. W. Busuttil, J. W. Kupiec-Weglinski

    Surgery, Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA

    *Purpose: We have recently shown that carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) serves as a checkpoint regulator in liver transplant (LT) ischemia-reperfusion injury (IRI);…
  • 2020 American Transplant Congress

    Anti-CD321 Antibody (90G4) Protects Liver against Ischemia Reperfusion Injury in a Murine Model

    E. Yin1, T. Fukuhara2, H. Bashuda1, K. Uchida3

    1Atopy Research Center, Juntendo University School of Medicine, Tokyo, Japan, 2Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan, 3Juntendo Advanced Research Institute for Health Science, Juntendo University School of Medicine, Tokyo, Japan

    *Purpose: Ischemia reperfusion results in increased transmigration of leukocytes into tissue. This eventually leads to post transplant graft damage after organ transplantation. CD321 (also known…
  • 2020 American Transplant Congress

    Ex Vivo Isolated Human Vessel Perfusion System for the Design and Assessment of Nanomedicines Targeted to the Endothelium

    L. G. Bracaglia1, T. Lysyy2, L. Qin2, C. Albert1, J. S. Pober2, G. Tellides2, W. M. Saltzman1, G. T. Tietjen2

    1Yale University, New Haven, CT, 2Yale School of Medicine, New Haven, CT

    *Purpose: In solid organ transplantation the host immune system acts to reject the graft. This process is facilitated at the endothelial surface, where inflamed donor…
  • 2020 American Transplant Congress

    Novel Technique to Analyze Blood-Endothelial Cell Interactions Under Flow Conditions

    M. R. Connolly1, K. Petitpas1, L. Burdorf1, B. Cerel1, C. Laird2, D. Harris2, A. Azimzadeh1, R. N. Pierson III1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2University of Maryland, Baltimore, Baltimore, MD

    *Purpose: The Bioflux system has been used to study platelet-driven thrombosis and leukocyte adhesion. Typically, whole blood is stained with calcein (green) to evaluate platelet…
  • 2019 American Transplant Congress

    Proteomics Reveals Compartment-Specific Alterations in the Extracellular Matrix of Kidney Allografts with Antibody-Mediated Rejection

    S. Clotet Freixas1, C. McEvoy1, I. Batruch2, M. Kotlyar3, C. Pastrello3, J. Van1, A. Bozovic1, V. Kulasingam1, P. Chen4, I. Jurisica3, A. Chruscinski1, R. John1, A. Konvalinka1

    1University Health Network, Toronto, ON, Canada, 2Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada, 3Krembil Research Institute, Toronto, ON, Canada, 4Institute of Medical Science, University of Toronto, Toronto, ON, Canada

    *Purpose: Antibody-mediated rejection (AMR) is the most important cause of premature kidney graft loss. AMR is caused by anti-HLA and non-HLA antibodies against proteins in…
  • 2019 American Transplant Congress

    Inhibition of Sialidase Activity and Galectin Binding Reduces Xenogeneic Neutrophil-Endothelial Adhesion

    B. M. Cerel1, B. M. French2, D. G. Harris2, C. Laird2, L. Burdorf1, X. Cheng2, C. Feng3, A. S. Cross4, S. E. Goldblum4, G. R. Vasta3, R. N. Pierson III1, A. M. Azimzadeh1

    1Deparment of Surgery, Massachusetts General Hospital, Boston, MA, 2Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, 3Department of Microbiology and Immunology, and Institute of Marine and Environmental Technology, University of Maryland School of Medicine, Baltimore, MD, 4Department of Medicine Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD

    *Purpose: Immediate neutrophil sequestration occurs despite genetic modifications (Gal-a-1-3 galactosyl transferase knock out; human CD46 complement regulatory gene addition) to pig donor organs. Sialic acids…
  • 2019 American Transplant Congress

    Ligation Of Hla Class Il Molecules Disrupts Endothelial Barrier Through Src-dependent Ve-cadherin Destabilization

    F. Li1, R. A. Sosa1, N. M. Valenzuela1, E. Rozengurt2, E. F. Reed1

    1Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, 2Digestive Diseases Research Center, University of California, Los Angeles, Los Angeles, CA

    *Purpose: Microvascular inflammation, vascular permeability, and accumulation of intravascular mononuclear cells are characteristics of acute and chronic antibody-mediated rejection. Vascular endothelial cadherin (VE-Cadherin) is a…
  • 2019 American Transplant Congress

    Sphingosine 1-Phosphate Receptor 2 Regulates Migration through Endothelial Cell VCAM and Adherens Junctions

    Y. Xiong1, W. Piao1, C. Brinkman1, L. Li1, J. Kulinski2, A. Olivera2, A. Cartier3, T. Hla3, K. Hippen4, B. Blazar4, S. Schwab5

    1Surgery, UMB, Baltimore, MD, 2NIH, Bethesda, MD, 3Boston Children's hospital, Boston, MA, 4U.Minnesota, Minneapolis, MN, 5NYU, NY, NY

    *Purpose: Lymphatic endothelial cells (LEC) highly expres S1PR1 and S1PR2. The ligand S1P is produced by LEC and regulates T cell migration. The mechanisms of…
  • 2018 American Transplant Congress

    Endothelial Cell Heterogeneity Governs Basal and Inducible Inflammatory Responses Relevant to Allograft Injury

    N. Valenzuela.

    Pathology and Laboratory Medicine, UCLA, Los Angeles, CA.

    PurposeTransplanted tissues are differentially susceptible to ischemia/reperfusion and rejection. Endothelial cells (EC) are active regulators of inflammation. But model EC may not adequately reflect the…
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