Articles tagged "Adhesion molecules"

2022 American Transplant Congress
Pd-1 Licenses Activated Treg for Lymphatic Migration
W. Piao¹, L. Li¹, V. Saxena¹, K. Hippen², M. Shirkey¹, B. Blazar², I. Lape³, y. zhang³, J. Bromberg¹
¹Surgery, University of Maryland, Baltimore, MD, ²University of Minnesota, Minneapolis, MN, ³Harvard Medical School, Boston, MA
*Purpose: In addition to serving as fluid conduits, lymphatic vessels are critical portals for immune cell migration. Lymphatic endothelial cells (LECs) constitutively express high levels…
2022 American Transplant Congress
Delivery of Extracellular Matrix Targeted Regulatory T Cells by Novel Nanofiber Coatings for Transplantation Therapies
L. Gallon¹, J. K. Carrow², J. He¹, Y. Sambandam¹, X. Lai¹, J. Mathew¹, L. C. Palmer², J. R. Leventhal¹, Z. Zhang¹, S. I. Stupp²
¹Surgery - Transplant, Northwestern University, Chicago, IL, ²Simpson Querrey Institute, Northwestern University, Chicago, IL
*Purpose: Regulatory CD4+CD25+FOXP3+ T cells (Tregs) have been shown to induce tolerance in transplantation models and can mitigate transplant rejection or injury following ischemic reperfusion…
2022 American Transplant Congress
TEMRA CD8 T Cells from Kidney Transplant Recipients Exhibit Enhanced Purinergic P2x4 Receptor-Dependent Proinflammatory and Migratory Responses
G. Tilly¹, T. Doan-Ngoc¹, O. Bonizec¹, C. Masset², R. Danger³, P. Guérif¹, S. Bruneau¹, J. Harb¹, M. Giral¹, C. Pecqueur⁴, S. Brouard¹, N. Degauque¹
¹Nantes Université, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes, France, ²University Hospital of Nantes, Nantes, France, ³CRTI- INSERM UMR 1064, Nantes, France, ⁴Nantes Université, Univ Angers, INSERM, CNRS, CRCINA, F-44000 Nantes, Nantes, France
*Purpose: Whereas the role of effector memory and TEMRA CD8 in allotransplantation has been clearly evidenced and particularly the direct correlation between intragraft infiltrating CD8…
2021 American Transplant Congress
PD-1/PD-L1 Selectively Regulates Treg Lymphatic Migration
W. Piao¹, L. Li¹, C. Paluskievicz¹, Y. Zhang², V. Saxena³, K. Hippen², B. Blazar², L. Riella⁴, J. Bromberg¹
¹Surgery, U Maryland, Baltimore, MD, ²U Minnesota, Minneapolis, MN, ³U Maryland, Baltimore, MD, ⁴Harvard U, Boston, MA
*Purpose: The molecules that regulate Treg migration are incompletely identified. Programmed death-1 (PD-1) and its ligand PD-L1 are immune checkpoint proteins which regulate immune cell…
2021 American Transplant Congress
Hypoxia Inducible Factor 1á (HIF-1á) Regulates Carcinoembryonic Antigen-related Cell Adhesion Molecule-1 (CEACAM1) Splice Isoforms to Protect Against Ischemic Injury in Mouse and Human Liver Transplantation
K. J. Dery, H. Kojima, K. Kadono, H. Hirao, J. W. Kupiec-Weglinski
The Dumont-UCLA Transplantation Center, Los Angeles, CA
*Purpose: CEACAM1 (CC1) is a transmembrane glycoprotein that undergoes extensive alternative splicing (AS) to generate CC1-S and CC1-L. It is currently unclear which of these…
2021 American Transplant Congress
Treg Lymphotoxin Engages Lymphotoxin Receptor on Cancer and Endothelial Cells to Promote Cancer Metastatic Migration: Mechanisms for Treg-Cancer Interactions
W. Piao, R. Oakes, C. Paluskievicz, J. Christopher, J. Bromberg
U Maryland, Baltimore, MD
*Purpose: Treg immune suppression which is critical for transplant graft survival may also enhance tumor growth and metastases. Treg lymphotoxin (LTα1β2) may directly engage the…
2021 American Transplant Congress
CD80/PD-L1 Uniquely Regulates CD4 Effector T Cell Migration
W. Piao¹, L. Li¹, Y. Zhang², K. Hippen², M. WillsonShirkey¹, B. Blazar², L. Riella³, J. Bromberg¹
¹U Maryland, baltimore, MD, ²U Minnesota, Minneapolis, MN, ³Harvard U, boston, MA
*Purpose: CD80 is a costimulatory molecule expressed on antigen presenting cells (APCs) that binds CD28 and CTLA4, stimulating or inhibiting immunity, respectively. CD80 also binds…
2021 American Transplant Congress
HTFPI.hCD47 and Adhesion Inhibition in GTKO.hCD46 Pig Lung Xenograft Injury
S. Miura¹, L. Burdorf¹, Z. Habibabady¹, A. Dandro², M. Connolly¹, S. Pratts¹, C. Phelps², W. Eyestone², D. Ayares², A. Azimzadeh¹, R. Pierson III¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Charlestown, MA, ²Revivicor, Inc, Blacksburg, VA
*Purpose: We evaluate whether genetic expression of human tissue factor pathway inhibitor (TFPI, extrinsic coagulation pathway inhibitor) and human CD47 ("don’t eat me" immunoregulator), alone…
2020 American Transplant Congress
PD-L1 Signals Lymphatic Endothelium for Treg Migration
W. Piao¹, L. Li¹, K. Hippen², Y. Zhang², V. Saxena³, Y. Xiong¹, C. Paluskievicz¹, M. WillsonShirkey¹, B. Blazar², L. Riella⁴, J. Bromberg⁵
¹Surgery, U of Maryland, Baltimore, MD, ²Pediatrics, U of Minnesota, Minneapolis, MN, ³U of Maryland, Baltimore, MD, ⁴Transplantation Research Center, Harvard U, Boston, MA, ⁵Surgery and Microbiology and Immunology, U of Maryland, Baltimore, MD
*Purpose: Regulatory T cell (Treg) migration is important for tolerance, although the molecules that regulate Treg entry to lymphatics are poorly understood. Lymphatic endothelial cells…
2020 American Transplant Congress
Oxidative Stress Induces Cytoprotective Alternative Splicing in Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 in Mouse Liver Ischemia-Reperfusion Injury
K. J. Dery, H. Hirao, K. Kadono, S. Kageyama, H. Kojima, R. W. Busuttil, J. W. Kupiec-Weglinski
Surgery, Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: We have recently shown that carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) serves as a checkpoint regulator in liver transplant (LT) ischemia-reperfusion injury (IRI);…