2019 American Transplant Congress » Poster Session D: Xenotransplantation

6:00pm-7:00pm

Absence of Antibodies in Human Neonates and Infants to Gtko/cmahko/β4galnt2ko (Triple Gene Knockout) Pig Cells: Relevance to Cardiac Xenotransplantation for Complex Congenital Heart Disease

H. Hara¹, Q. Li¹, C. A. Banks¹, T. Yamamoto¹, D. Ayares², D. C. Cleveland¹, D. K. Cooper¹

6:00pm-7:00pm

Donor Derived Neoplasia: Will It Be a Risk after Clinical Pig Organ Xenotransplantation?

A. Jagdale¹, H. Iwase¹, E. Klein², D. Cooper¹

6:00pm-7:00pm

Donor-Specific Tregs Prolong Peripheral Chimerism in Baboons Receiving GalTKO hCD47-tg Porcine Peripheral Blood Stem Cells

N. P. Llore¹, J. Stern¹, G. Pierre¹, E. Lopes¹, D. Ekanayake-Alper¹, P. Alonso-Guallart¹, K. Bruestle¹, H. Sakai¹, D. Ayares², M. Lorber², R. Hawley¹, D. H. Sachs¹, M. Sykes¹, A. D. Griesemer¹

6:00pm-7:00pm

Ex-vivo Xenoperfusion Of Wild Type And Galtko.hcd55 Pig Livers With Human Whole Blood

D. Detelich, C. Rickert, C. Eymard, C. Carroll, S. Kimura, H. Yeh, J. Markmann

6:00pm-7:00pm

Graft-Infiltrating Regulatory T Cells Are Associated with Long Term Cardiac Xenograft Survival

A. K. Singh¹, G. Braileanu¹, A. Hersfield¹, L. DiChiacchio¹, T. Zhang¹, I. Tatarov¹, D. Parsell¹, B. Lewis¹, F. Sentz¹, D. Ayares², M. Mohiuddin¹

6:00pm-7:00pm

Indicators of Impending Pig Organ Xenograft Failure: Relevance to Clinical Xenotransplantation

H. Iwase¹, A. Jagdale¹, T. Yamamoto¹, G. Zhang¹, Q. Li¹, J. Foote¹, D. Ayares², H. Hara¹, D. K. Cooper¹

6:00pm-7:00pm

Inhibition of Sialidase Activity and Galectin Binding Reduces Xenogeneic Neutrophil-Endothelial Adhesion

B. M. Cerel¹, B. M. French², D. G. Harris², C. Laird², L. Burdorf¹, X. Cheng², C. Feng³, A. S. Cross⁴, S. E. Goldblum⁴, G. R. Vasta³, R. N. Pierson III¹, A. M. Azimzadeh¹

6:00pm-7:00pm

Investigation and Regulation of Induced Anti-Pig Antibody Production in GTKO Pig-to-Cynomolgus Monkey Artery Retransplantation

S. Hurh¹, E. Lee¹, J. Jeong², G. Lee¹, S. Park¹, S. Ahn³, S. Min³, C. Ahn⁴

6:00pm-7:00pm

Novel Insights into Blocking the IL-6 / IL-6 Receptor Pathway after Pig Kidney Xenotransplantation in Baboons

H. Hara¹, G. Zhang¹, H. Iwase¹, T. Yamamoto¹, D. Ayares², D. E. Eckhoff¹, D. K. Cooper¹

6:00pm-7:00pm

Perioperative Cardiac Xenograft Dysfunction after Orthotopic Transplantation is for Real

M. Mohiuddin¹, A. Singh¹, L. DiChiacchio¹, D. Kaczorowski¹, B. Lewis¹, T. Zhang¹, F. Sentz¹, I. Tatarov¹, D. Parsell¹, P. Odonkor¹, E. Strauss¹, B. Williams¹, K. Deatrick¹, D. Ayares², B. Griffith¹, S. Bartlett¹

6:00pm-7:00pm

Prevention of Islet Allo- and Xenograft Rejection with Immunoglobulin M Immunotherapy

M. Ma, P. Chhabra, K. Brayman

6:00pm-7:00pm

Prolonged Heterotopic Cardiac Xenograft Survival from Thrombomudulin Expressing Multigene Donor Pig

A. K. Singh¹, L. DiChiacchio¹, T. Zhang¹, A. Hersfield¹, I. Tatarov¹, D. Parsell¹, B. Lewis¹, F. Sentz¹, D. Ayares², M. Mohiuddin¹

6:00pm-7:00pm

TCR Transgenes to Understand Human Xenotolerance Induction

G. Nauman, C. Borsotti, N. Danzl, M. Khosravi-Maharlooei, H. Li, E. Chavez, Y. Yang, M. Sykes

6:00pm-7:00pm

TMA Development in Kidney and Heart Xenografts Treated with Anti-CD40 or Anti-CD154 Antibodies

D. H. Ma¹, H. Sasaki¹, J. M. O¹, K. Ahrens¹, D. Becerra¹, C. G. Rickert¹, D. M. Detelich¹, T. Oura¹, W. Somer¹, I. Rosales², R. N. Pierson¹, J. Markmann¹, J. C. Madsen¹, T. Kawai¹

6:00pm-7:00pm

Targeted Epitope Mutagenesis as a Strategy to Decrease Xenoantibody Binding

J. Ladowski, G. Martens, Z. Wang, L. Reyes, M. Tector, J. Tector

6:00pm-7:00pm

The Effect of Intravenous Immunoglobulin on Human Complement-Dependent Cytotoxicity of Pig Cells: Benefit? Or Harm?

T. Yamamoto¹, Q. Li¹, A. Banks¹, H. Iwase¹, D. Ayares², D. K. Cooper¹, H. Hara¹

6:00pm-7:00pm

Xenorejection of Porcine Islets in Humanized Mice is Dominated by a Human Th17 Cytokine Immune Response

F. T. Lee¹, A. Dangi², M. Burnette², B. Hering³, X. Luo²

6:00pm-7:00pm

α -1,3-galactosyltransferase Knockout Porcine Tissue And Organ May Reduce The Risks Of Antibody Mediated Rejection Via Less Rhesus Igm Cross-reactivity.

J. Yoon, B. Ezekian, M. Manook, J. Kwun, S. Knechtle