2015 American Transplant Congress » Poster Session C: Translational Biomarkers and Immune Monitoring

Date: Monday, May 4, 2015

Time: 5:30pm-6:30pm

Location: Exhibit Hall E

Session Type: Poster Session

Meeting: 2015 American Transplant Congress

5:30pm-6:30pm: A Non-Invasive Urinary Common Rejection Module (uCRM) Gene Expression Score Enables Accurate Discrimination of Acute Rejection in Kidney Transplant Patients

O. Bestard,^1,2 T. Sigdel,¹ Y. Ng,¹ S.-C. Hsieh,¹ S. Roedder,¹ N. Dvorak,¹ T. Tran,¹ M. Sarwal.¹

5:30pm-6:30pm: A Primary Cytomegalovirus Infection Post-Transplantation Has a Significant Impact on Circulating T Cells and Renal Allograft Function

R. Meijers,¹ N. Litjes,¹ A. Langerak,² C. Baan,¹ M. Betjes.¹

5:30pm-6:30pm: Allo-Stimulated Interferon-γ Release and Natural Killer Cell Function Defines and Risk Stratifies Cancer Development in Kidney Transplant Recipients Who Have Cancer Post-transplantation

C. Hope,^1,2 A. Fuss,^1,2 W. Hanf,¹ P. Coates,^1,2 P. Heeger,³ R. Carroll.^1,2

5:30pm-6:30pm: Alterations in Peripheral Blood B Cell Subpopulations in Kidney Transplant Recipients With DSA

B. Ramaswami,¹ R. Ippolito,² B. Elinoff,¹ M. Marrari,³ K. Hadi,¹ C. Macedo,¹ D. Metes,¹ A. Shields,⁴ R. Alloway,⁵ A. Zeevi,³ F. Lakkis,¹ E. Woodle,⁴ G. Chalasani.^1,2

5:30pm-6:30pm: Assessment of Viral-Specific Memory T Cell Responses and Infection Rates in HLA-Sensitized (HS) Kidney Transplant Patients (Tx Pts) Treated With Everolimus & Low-Dose Tacrolimus (Eve/Tac)

S. Ge, J. Kahwaji, M. Chu, A. Karasyov, M. Castro, E. Hayrapetyan, D. Lovato, D. Thomas, J. Choi, S. Louie, A. Vo, S. Jordan, M. Toyoda.

5:30pm-6:30pm: Associations Between Deceased-Donor Urine Biomarkers of Kidney Injury and 6-Month Kidney Transplant Function

C. Parikh, I. Hall, M. Doshi, B. Schroppel, F. Weng, R. Hasz, P. Murray, V. Rao, H. Thiessen-Philbrook, J. Ficek, P. Reese.

5:30pm-6:30pm: Biomarker Panel Profile for Identification of High-Risk Patients After Heart Transplantation

M. Barten,¹ M.-T. Dieterlen,² J. Garbade,² F. Mohr.²

5:30pm-6:30pm: Biomarker for Calcineurin Inhibitors Nephrotoxicity in Solid Organ Transplantation: Validation of a Urine Gene Expression Panel

D. Maluf, R. Gehrau, J. Suh, K. Brayman, C. Bustamante, M. Edmunds, P. Darvishi, V. Mas.

5:30pm-6:30pm: Biopsychronology: Live Confocal Imaging of Biopsies to Assess Organ Function

M. Ashraf,¹ D. Fries,² W. Streif,³ F. Aigner,¹ P. Hengster,¹ J. Troppmair,¹ M. Hermann.²

5:30pm-6:30pm: Blood Gene Expression at 3 Months Post-Transplantation Predicts 1-Year Histological Features in Renal Transplantation

R. Danger,^1,2 K. Renaudin,^1,3,4 C. Paul,¹ G. Couvrat-Desvergnes,^1,3 J. Lozano,⁵ A. Sanchez-Fueyo,^2,5 V. Meas-Yedid,⁶ J. Olivo-Marin,⁶ E. Thervet,⁷ J. Dantal,^1,3,4 A. Moreau,^1,3,4 J.-P. Duong Van Huyen,⁸ J.-P. Soulillou,^1,3,4 M. Giral,^1,3,4 S. Brouard.^1,3,4

5:30pm-6:30pm: CD8 T Cell Biomarkers Improves the Capacities of the Kidney Transplant Failure Score for the Long-Term Prognostic of Kidney Graft Failures

N. Degauque,^1,2 M. Yap,¹ G. Tilly,^1,3 P. Guerrif,² M. Giral,² S. Brouard,^1,2 Y. Foucher.^2,3

5:30pm-6:30pm: CMV-Specific CD154+T-Cells and CMV Disease Status After Liver Or Intestine Transplantation (LTx, ITx)

C. Ashokkumar,¹ M. Ningappa,¹ G. Mazariegos,¹ K. Soltys,¹ G. Bond,¹ C. Trautz,¹ M. Green,² M. Michaels,² R. Sindhi.¹

5:30pm-6:30pm: Changes in Immunophenotypes After Conversion from Calcineurin Inhibitors to mTOR Inhibitors in Renal Transplant Recipients

A. Yildiz,^1,4 M. Cavusoğlu,¹ S. Adin,² Y. çaliskan,¹ A. Ozkok,¹ H. Tasçi,³ G. Deniz,² M. Sariyar.³

5:30pm-6:30pm: Chimeric Patients Who Undergo Combined Facilitating Cell-Enriched/HSC/Renal Transplant Exhibit Robust TCR Repertoire

I. Konieczna,¹ J. Mathew,¹ J. Miller,¹ S. Ildstad,^2,3 J. Leventhal.¹

5:30pm-6:30pm: Combination of Clinical and Genetic Factors for Delayed Kidney Graft Function Prediction

A. Goncalves-Primo,^1,2 E. Campos,^1,2 J. Medina-Pestana,^2,3 H. Tedesco-Silva,³ M. Gerbase-DeLima.^1,2

5:30pm-6:30pm: DNA Methylation of the IFNγ Promoter in CD8+ T Cell Subsets Is Modulated by CMV Infection but not by Alloreactivity in Kidney Transplantation Patients

K. Boer,¹ E. de Wit,¹ L. Hofland,² M. Betjes,¹ C. Baan.¹

5:30pm-6:30pm: Decreased Expression of Mitochondrial Aldehyde Dehydrogenase 2 Induces Liver Injury Via Activation of the MAPK Pathway in Grafts from Brain-Dead Donors

Z. Zhong,¹ S. Ye,¹ Y. Xiong,¹ X. Fan,¹ W. Huang,¹ D. Ko,³ Y. Wang,¹ Q. Ye.^1,2

5:30pm-6:30pm: Detection of Donor-Specific Anti-HLA Antibodies Is Associated With Changes in the Peripheral Distribution of NK Cell Subsets in Kidney Allograft Recipients

M. Crespo,¹ D. Redondo,¹ J. Yelamos,² A. Muntasell,² M. Pérez-Sáez,¹ M. Lopez-Montañes,³ C. Garcia,⁴ A. Torío,⁵ J. Hernandez,⁴ M. Mir,¹ M. Lopez-Botet,³ J. Pascual.¹

5:30pm-6:30pm: Development and Validation of a Genotype Guided Tacrolimus Dosing Equation for African American (AA) Kidney Transplant Recipients

K. Sanghavi,¹ R. Brundage,¹ M. Miller,² D. Schaldt,³ A. Israni,³ W. Guan,⁴ W. Oetting,¹ R. Mannon,⁵ R. Remmel,¹ A. Matas,⁶ P. Jacobson.¹

5:30pm-6:30pm: Dietary-Associated Trimethylamine N-Oxide (TMAO) Levels Is associated With Coronary Allograft Vasculopathy Following Heart Transplantation

S. Zeltzer,¹ Z. Wang,¹ M. Askar,² J. Coughlin,¹ T. Hudec,¹ D. Taylor,³ L. Li,¹ R. Starling,³ S. Hazen,¹ W. Tang.¹

5:30pm-6:30pm: Differentially Expressed IL-6Rα and GP130 Genes in Kidney Biopsies (Bxs) Suggests Different Roles of IL-6 Signaling in Antibody (ABMR)- and Cell (CMR)-Mediated Rejection

H. Zhang,¹ D. Thomas,¹ J. Kowalewska,² E. Suviolahti,¹ H. Shafi,² C. Nast,² A. Gertych,² A. Vo,¹ M. Haas,² S. Jordan,¹ M. Toyoda.¹

5:30pm-6:30pm: Distinct Clinical Relevance of BAFF Expression Within the Kidney Graft and Soluble BAFF Serum Levels Indicate Confined Alloimmune Responses Disconnected from the Periphery

E. Campos,^1,2 K. Mine,¹ A. Goncalves-Primo,^1,2 M. Soares,⁴ M. Franco,² J. Medina-Pestana,^2,3 H. Tedesco-Silva,³ M. Gerbase-DeLima.^1,2

5:30pm-6:30pm: Does Switching Predict Conversion: IgM De Novo Donor Specific HLA Antibodies Class Switch to IgG in Subclinical Antibody Mediated Rejection in Heart Transplant Recipients

M. Askar,¹ R. Rodriguez,¹ L. Klingman,¹ D. Thomas,¹ A. Zhang,¹ H. Morf,² N. Hamon,¹ N. Moazami,¹ E. Hsich,¹ D. Taylor,¹ R. Starling,¹ C. Tan.¹

5:30pm-6:30pm: Donor CD47 Plays a Critical Role in the Control of Alloreactive T Cell Activation Following Hepatocyte Transplantation

M. Zhang,^1,2 H. Wang,¹ N. Navarro-Alvarez,¹ Y. Zheng,² Y.-G. Yang.¹

5:30pm-6:30pm: Donor Lung Preservation With the Organ Care System® Promotes a Tissue Protective and Anti-Inflammatory Response During Transplantation

B. Wiegmann,¹ C. Falk,² M. Seyda,² C. Neudörfl,² A. Akhdar,² C. Kühn,¹ I. Tudorache,¹ M. Avsar,¹ A. Haverich,¹ G. Warnecke.¹

5:30pm-6:30pm: Donor Serum and Urine Proteomic Signatures Differentiate Between Immediate and Delayed Graft Function in Kidney Transplantation

M. Kaisar,^1,2 H. Huang,^1,2 Z. Akhtar,¹ H. Leuvenink,³ B. Kessler,² R. Ploeg.¹

5:30pm-6:30pm: Early Detection of HCC Mutations in Indeterminate Lesions Using Liquid Biopsies

Y. Lin,¹ K. Cavaness,² Z. Zhang,¹ S. Lin,³ K. Korenblat,¹ G. Klintmalm,² W. Chapman.¹

5:30pm-6:30pm: Effect of Living Kidney Donation on Glucose Metabolism and Insulin Resistance

B. Tanriover,¹ P. Mohan,² S. Cremers,³ I. Lingvay.⁴

5:30pm-6:30pm: Elderly ESRD Patients Have a Significantly Narrowed T-Cell Receptor Repertoire Diversity

L. Huang,¹ A. Langerak,² I. Wolvers - Tettero,² R. Meijers,¹ C. Baan,¹ N. Litjens,¹ M. Betjes.¹

5:30pm-6:30pm: Eomesodermin Expression By Alloreactive Non-Human Primate CD8+ Memory T Cells: Influence of CTLA4Ig and Regulatory DC Infusion in Renal Allograft Recipients

M. Ezzelarab,¹ L. Lu,¹ H. Guo,¹ A. Zahorchak,¹ W. Shufesky,¹ D. Cooper,¹ A. Morelli,^1,2 A. Thomson.^1,2

5:30pm-6:30pm: Evaluation of Natural Killer Cell Activation by NK Cell-Specific Interferon-Gamma-Releasing Assay

J. Ryu,¹ K. Park,¹ Y. Kim,² E.-J. Oh.²

5:30pm-6:30pm: Evaluation of Preformed Anti-HLA Antibody of "Unknown Origin" after Kidney Transplant in a Brazilian Center

D. Glasberg,¹ D. Monteiro de Carvalho,² T. Matuck,² G. Fabricio-Silva,³ M. Barbosa,¹ A. Borela,¹ L. Christiani,¹ R. Malta,¹ L. Porto.³

5:30pm-6:30pm: Ex Vivo Lung Perfusion: Revisit to the Optimal Oxygenation Circulating Lungs for Graft Preservation

K. Noda, S. Haam, J. D'Cunha, J. Luketich, C. Bermudez, N. Shigemura.

5:30pm-6:30pm: Fibrosis, Not Quantitative NGAL-Staining, in Day-10 Protocol Biopsies Predicts Prolonged Duration of Functional Delayed Graft Function in a Cohort of DCD Kidney Transplant Recipients

J. Bank,¹ M. Reinders,¹ M. Mallat,¹ N. Schlagwein,¹ S. van der Kooij,¹ D. van Gijlswijk,¹ I. Bajema,² C. van Kooten,¹ H. de Fijter.¹

5:30pm-6:30pm: Frequencies of CD4⁺25^hiFoxp3⁺T Cells in Long-Term Follow-Up of Sirolimus-Converted Kidney Transplant Recipients

O. Traitanon,^1,2 A. Alvarado,¹ E. Tantisattamo,^1,2 A. Shetty,^1,2 M. Ansari,^1,2 J. Mathew,¹ J. Leventhal,¹ V. Mas,³ L. Gallon.^1,2

5:30pm-6:30pm: Identification of miRNAs Associated With Induced Tolerance to Allografts

M. Vitalone, L. Wei, C. Esquivel, S. Busque, O. Martinez, S. Krams.

5:30pm-6:30pm: Impact of Alloreactivity On Intra-Graft T Cell Homeostasis Following Small Bowel Transplantation

J. Zuber, B. Shonts, S. Lau, S. Coley, S. Yang, J. Weiner, S. DeWolf, D. Farber, Y. Shen, M. Martinez, T. Kato, M. Sykes.

5:30pm-6:30pm: Impact of Serial Change of Donor Specific Antibodies On the Graft Outcomes After Liver Transplantation

D. Joo,^1,2 J. Lee,³ J. Lee,^1,2 J. Lee,^1,2 S. Kim,⁴ D. Han,^1,2 M. Ju,^1,2 J. Choi,^1,2 S. Kim,^1,2 M. Kim.^1,2

5:30pm-6:30pm: Implication of Intragraft γδ T Cell Profiles in Operational Tolerance After Clinical Transplantation of Highly Immunogenic Intestine -Difference from Immunoprivileged Liver

Y. Li,¹ X. Zhao,¹ H. Ohe,² H. Nafady-Hego,³ A. Bishop,⁴ J. Pirenne,⁵ T. Koshiba.⁶

5:30pm-6:30pm: Increased Vascular Stiffness in Pediatric Renal Transplant Recipients Despite Normal Kidney Function, Blood Pressure, and Body Mass Index

M. Seifert,^1,2 N. Kulsum-Mecci,² L. de las Fuentes,² V. Davila-Roman,² K. Hruska.²

5:30pm-6:30pm: Inflammatory Profiling of Hypothermic Machine Pumped Kidney Allografts

J. Cohen, E. Ratigan, A. Shigeoka, R. Steiner, L. Stocks, D. McKay.

5:30pm-6:30pm: Ischemia Reperfusion Injury in Orthotopic Liver Transplantation Primes the Adaptive Immune Response and Generation of Proinflammatory Cytokines

A. Zarrinpar,¹ P. Rao,² C. Lassman,² V. Agopian,¹ F. Kaldas,¹ D. Farmer,¹ R. Busuttil,¹ Y. Zhai,¹ J. Kupiec-Weglinski,¹ E. Reed.²

5:30pm-6:30pm: Metabolomic Analysis of Remote Ischemic Preconditioning in Renal Ischemia Reperfusion Injury

A. Han,¹ S.-I. Min,¹ K. Cho,² C. Choi,¹ S.-K. Min,¹ S. Kim,³ M. Park,⁴ J.-Y. Cho,² J. Ha.¹

5:30pm-6:30pm: MicroRNA-21 (miR-21) Expression in Hypothermic Machine Perfusate May Predict Early Outcomes in Kidney Transplantation

U. Khalid,^1,2 E. Ablorsu,² L. Szabo,² R. Jenkins,¹ T. Bowen,¹ D. Fraser,¹ R. Chavez.^1,2

5:30pm-6:30pm: Molecular Marker Strategies Supporting the Novartis US92 Study- A Discovery Study of Protein Biomarkers for Kidney Function (eGFR) and Acute Rejection in Serum from Renal Transplant Patients

U. Christians,¹ J. Klepacki,¹ A. Karimpour-fard,¹ G. Ingle,² D. Patel,² K. Johnson,³ D. Cibrik,³ J. Klawitter.¹

5:30pm-6:30pm: Molecular and Functional Immune Assays as Non-Invasive Diagnostic Tools to Assess the Risk of Acute Subclinical Rejection After Kidney Transplantation

O. Bestard,^1,2 E. Crespo,¹ T. Sigdel,² S. Roedder,² Y. Ng,² J. Cruzado,¹ M. Lúcia,¹ S.-C. Hsieh,¹ T. Tran,¹ J. Grinyó,¹ M. Sarwal.¹

5:30pm-6:30pm: Non-Invasive Imaging Modalities for Immune Monitoring of Vascularized Composite Allografts Using a Translational Large Animal Model

G. Furtmüller,¹ N. Crane,² R. Luthra,² E. Swanson,¹ H.-T. Cheng,¹ B. Oh,¹ M. Fryer,¹ E. Elster,² W. Lee,¹ G. Brandacher.¹

5:30pm-6:30pm: Phenotypic Personalized Medicine: Mechanism-Independent Convergence Into Target Serum Tacrolimus Levels for Optimized Liver Transplant Immunosuppression

A. Zarrinpar,¹ A. Silva,² D.-K. Lee,³ N. Datta,¹ C.-M. Ho,² D. Ho.³

5:30pm-6:30pm: Pre-Transplant Levels of TFH cell-Inducing Pro-Inflammatory Cytokines Correlate With DSA Formation After Kidney Transplantation

C. Macedo,¹ K. Hadi,¹ B. Elinoff,¹ M. Marrari,¹ A. Zeevi,¹ B. Ramaswami,¹ G. Chalasani,¹ A. Shields,² R. Alloway,³ E. Woodle,² F. Lakkis,¹ D. Metes.¹

5:30pm-6:30pm: Precision Diagnosis in Kidney Transplantation

P. Kadota, D. Perkins.

5:30pm-6:30pm: Systemic and Local NK and Regulatory Cell Phenotypes and mTori-Induced Tumor-Specific Effector T-Cell Responses Are Key Players Favoring the Development of Squamous Cell Skin Carcinoma Among Kidney Transplant Patients

E. Crespo,¹ M. Lucia,¹ L. Fernandez,³ E. Melilli,² S. Luque,¹ R. Lauzurica,³ J. Cruzado,^1,2 J. Torras,^1,2 J. Grinyó,^1,2 O. Bestard.^1,2

5:30pm-6:30pm: The Association of Systemic Indoleamine 2,3 Dioxygenase (IDO) Activity Simultaneous With Chronic Rejection On Allograft Kidney Biopsy

V. Dharnidharka, L. Hesemann, J. Mitsios, H. O'Gorman, M. Gunasekaran, D. Dietzen, T. Mohanakumar.

5:30pm-6:30pm: The Potential Use of the Plasma Biomarker CXCL9 (MIG), Interleukin 2 Receptor alpha (IL2Rα) and SCGF-b as Predictors of Renal Graft Rejection

C. Blume,¹ S. Michael,² N. Christine,³ H. Hermann,⁴ F. Christine.³

5:30pm-6:30pm: Vaccine Responses in Combined Hematopoeitic Stem Cell-Kidney Transplant Recipients

C. Feng,¹ M. Ison,¹ J. Galvin,¹ S. Ildstad,^2,3 D. Stare,¹ J. Leventhal.¹

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