2016 American Transplant Congress » Poster Session C: Ischemia Reperfusion Injury and Organ Preservation

Date: Monday, June 13, 2016

Time: 6:00pm-7:00pm

Location: Halls C&D

Session Type: Poster Session

Meeting: 2016 American Transplant Congress

6:00pm-7:00pm: Activating Transcription Factor 5 (ATF5) Regulates Liver Ischemia/Reperfusion Injury.

G.-Q. Shen,² M. Morita,¹ J. Fung,² L. Lu,^1,2 S. Qian.^1,2

6:00pm-7:00pm: Activation of Innate Immunity During Human OLT-IRI Triggers Adaptive Immunity and Correlates with the Degree of IRI Injury.

A. Zarrinpar,¹ R. Sosa,² P. Rao,² C. Lassman,² R. Busuttil,¹ D. Gjertson,² J. Kupiec-Weglinski,¹ E. Reed.²

6:00pm-7:00pm: Adding Anti-Inflammatory Agents During Normothermic Ex-Vivo Liver Perfusion Improves the Preservation of Pig Liver Grafts Before Transplantation.

N. Goldaracena, E. Juan, K. Moritz, V. Spetzler, A. Barbas, D. Grant, M. Selzner.

6:00pm-7:00pm: Allograft TLR4 Receptor Signaling Induces Specific Early Inflammatory Events in Promotes Allografts Subjected to Prolonged Cold Ischemic Storage.

T. Yagisawa, N. Kohei, D. Kish, R. Fairchild.

6:00pm-7:00pm: Alterations in Central Carbohydrate Metabolism in Porcine Liver Allografts Preserved with a Subnormothermic Machine Perfusion (SNMP) System.

B. Banan, A. Cyr, R. Lopez, G. Michalopoulos, P. Fontes.

6:00pm-7:00pm: Amino Acid (AA) Metabolism During Liver Allograft Preservation Comparing Subnormothermic Machine Perfusion (MP) Against Cold Storage (CS).

B. Banan, R. Lopez, C. Hughes, G. Michalopoulos, P. Fontes.

6:00pm-7:00pm: An Improved Flow Cytometry Based Platelet Counting in Xeno Perfusion Models.

S. Sendil,¹ G. Braileanu,¹ W. Sun,¹ W. Hassanein,¹ D. Parsell,¹ H. Crum,² L. Burdorf,¹ R. Pierson,¹ A. Azimzadeh.¹

6:00pm-7:00pm: Anti-Inflammatory Effects of AAV-Mediated TIMP-1 Gene Transfer in Hepatic Ischemia-Reperfusion Injury.

S. Duarte, T. Fujii, G. Lipshutz, R. Busuttil, A. Coito.

6:00pm-7:00pm: Anti-LG3 Antibodies Enhance Renal Microvascular Rarefaction, Fibrosis and Dysfunction Associated with Ischemia-Reperfusion Injury.

B. Yang,^1,3 K. Hamelin,^1,3 M. HÉnault-Rondeau,^1,3 N. Patey,^1,2,3 J. Turgeon,^1,3 S. Lan,^1,3 L. Pomerleau,¹ J. Peng,¹ J. Tremblay,¹ M. DieudÉ,^1,3 M.-J. HÉbert,^1,3 H. Cardinal.^1,3

6:00pm-7:00pm: Attenuation of Warm Hepatic Ischemia-Reperfusion Injury by Bruton's Tyrosine Kinase Inhibition.

A. Zarrinpar,¹ T. Palumbo,¹ K. Nakamura,¹ C. Lassman,² R. Busuttil,¹ J. Kupiec-Weglinski.¹

6:00pm-7:00pm: Bioinformatic Analysis of Pathways Mediating Clusterin Functions in Kidney Cells Under Normoxia and Hypoxia.

G. Dairi, Q. Guan, C. Collins, C. Ong, M. Gleave, C. Nguan, C. Du.

6:00pm-7:00pm: C1-Inhibitor Abrogated Ischemia/Reperfusion (I/R) Induced Inflammaging by Inhibiting Senescence-Associated Secretory Phenotype (SASP) in Tubular Epithelial Cells (TEC).

G. Castellano,¹ R. Franzin,¹ A. Stasi,¹ C. Divella,¹ M. Gigante,¹ S. Simone,¹ A. Intini,¹ A. Picerno,¹ P. Pontrelli,¹ A. Crovace,¹ M. Battaglia,¹ B. Oortwijn,² E. Amersfoort,² G. Grandaliano,³ L. Gesualdo.¹

6:00pm-7:00pm: Creation of a Small Animal Model of Ex-Vivo Normothermic Perfusion (EVNP) for Treatment of Kidney Ischemia-Reperfusion (I/R) Injury.

Y. Smolin, I. Palma, C. Pivetti, S. Kabagambe, J. Woloszyn, Y. Chen, T. Boyer, I. Palma, J. Sageshima, C. Santhanakrishnan, R. Perez.

6:00pm-7:00pm: Distinctive Roles of Gsk3 Inhibitory Phosphorylation in Liver Inflammatory Immune Response and Hepatocellular Injury Against Ischemia Reperfusion.

H. Zhou,^1,2 J. Zhu,¹ S. Yue,¹ R. Busuttil,¹ J. Kupiec-weglinski,¹ L. Lu,² Y. Zhai.¹

6:00pm-7:00pm: ER Stress and Loss of GRP78 Expression Provides a Link Between Renal Ischemia/Reperfusion Injury and the Urinary Metabolome.

C. van Kooten,¹ T. Pacchiarotta,² P. van der Pol,¹ J. de Fijter,¹ N. Schlagwein,¹ D. van Gijlswijk,¹ O. Mayboroda.²

6:00pm-7:00pm: Ex Vivo Perfusion of Porcine Forelimbs to Prolong Allowable Ischemia Time.

N. Krezdorn,¹ M. Kueckelhaus,² A. Dermietzel,² M. Alhefzi,¹ M. Aycart,¹ S. Fischer,³ T.-S. Win,¹ H. Kiwanuka,¹ E. Bueno,¹ B. Pomahac.¹

6:00pm-7:00pm: Ex-Vivo Normothermic Perfusion (EVNP) Attenuation of Kidney Ischemia-Reperfusion Injury (IRI): A Proposed Mechanism.

I. Palma,¹ S. Kabagambe,¹ Y. Smolin,¹ T. Boyer,¹ I. Palma,¹ O. Fiehn,² Y.-J. Chen,¹ J. Sageshima,¹ C. Santhanakrishnan,¹ C. Troppmann,¹ R. Perez.¹

6:00pm-7:00pm: Heparanase: A New Factor Involved in the Pro-Fibrotic Renal Biological Machinery Activated by the Ischemia/Reperfusion (I/R) Injury.

G. Zaza,¹ V. Masola,¹ G. Gambaro,² M. Onisto,³ G. Bellin,¹ I. Vlodavsky,⁴ Z. Abassi,⁵ A. Lupo.¹

6:00pm-7:00pm: Histone Deacetylase-2 Gene Deletion in Mice Mitigates Liver Ischemia/Reperfusion Injury.

D. Murken,¹ D. Aufhauser Jr,¹ Z. Wang,² G. Ge,² W. Hancock,^2,3 M. Levine.^1,4

6:00pm-7:00pm: Hydrogen Sulfide Treatment Mitigates Donor Tissue Necrosis During Prolonged Cold Storage and Improves Survival Following Allogeneic Renal Transplantation.

I. Lobb,^1,3 W. Liu,² J. Jiang,³ D. Lian,³ A. Sener.^1,3,4

6:00pm-7:00pm: Immunosuppressive Actions of CLI95 and CORM401 on TLR4 in Renal Ischemia Reperfusion Injury.

P. Luke,^1,2,5 G. Cepinskas,^1,4 H. Alharbi,^3,5 A. Haig,^3,5 R. Bhattacharjee.^1,2,5

6:00pm-7:00pm: Liver Graft Rejuvenation Prior to Transplantation: A Bench-to-Bedside Approach.

A. Zarrinpar,¹ B. Ke,¹ H. Ji,¹ E. Reed,² R. Busuttil,¹ J. Kupiec-Weglinski.¹

6:00pm-7:00pm: Liver Ischemia Induces Kupffer Cell Necroptosis to Facilitate Liver Inflammatory Immune Activation.

S. Yue,¹ H. Zhou,^1,2 R. Busuttil,¹ J. Kupiec-Weglinski,¹ X. Wang,² Y. Zhai.¹

6:00pm-7:00pm: Local Infusion of MyD88 Inhibitor Inhibits Ischemia-Reperfusion Kidney Injury.

H. Cho,^1,3 J. Lee,^1,4 H. Kim,^1,2 Y. Han,² B. Kwon,^1,2 S. Park,^1,3 K. Park.⁴

6:00pm-7:00pm: Matrix Metalloproteinase-2 (MMP-2) Activity Protects Against Hepatic Ischemia Reperfusion Injury Through MMP-9-Dependent and MMP-9-Independent Mechanisms.

S. Duarte, P. Matian, H. Kato, R. Busuttil, A. Coito.

6:00pm-7:00pm: Mesenchymal Stem Cells Reprogram Macrophage Polarization and Attenuate Liver Ischemia and Reperfusion Injury by Regulating Notch/Cox2/PGE2 Signaling Pathway.

C. Li,¹ S. Yue,¹ R. Busuttil,¹ J. Kupiec-Weglinski,¹ B. Ke.¹

6:00pm-7:00pm: Metabolic Dysregulation and Mitochondrial Dysfunction Are Key Features of Injury Profiles of Donor Kidneys After Brain Death.

M. Lo Faro,¹ M. Akhtar,¹ H. Huang,¹ M. Kaisar,¹ R. Robolledo,² K. Morten,¹ L. Heather,¹ A. Dona,³ H. Leuvenink,² S. Fuggle,¹ B. Kessler,¹ C. Pugh,¹ R. Ploeg.¹

6:00pm-7:00pm: Mitochondrial Membrane Potential Correlates with Ischemic Injury and Kidney Graft Function in Rats.

M. Chen, J. Huang, L. Qi, S. Kwon, R. Montgomery, Z. Sun.

6:00pm-7:00pm: NecroX-7 Attenuates Ischemia-Reperfusion Renal Injury.

K. Lee,¹ Y. Ham,¹ J. Jeon,¹ Y. Chang,² S. Chung,¹ K. Na,¹ D. Choi.¹

6:00pm-7:00pm: Normothermic Perfusion of Livers Donated After Circulatory Death: A New Clinically Relevant Experimental Model.

Y. Cao,¹ H. Chew,^1,2 K. Fernandez,¹ L. Gao,¹ J. Villanueva,¹ M. Hicks,¹ P. Macdonald,^1,2 K. Dhital,^1,2 H. Pleass.³

6:00pm-7:00pm: Persufflation Improves Viability and Function of Porcine Kidneys Relative to Static Cold Storage.

C. Min,¹ L. Steyn,² A. Pandey,³ R. Harland,² J.-P. Galons,⁴ K. Papas.²

6:00pm-7:00pm: Prolonged Cold Ischemia Time Negatively Impacts Graft and Recipient Survival in a Murine Orthotopic Hindlimb Transplant Model.

N. Datta, S. Devaney, A. Allen, R. Busuttil, K. Azari, J. Kupiec-Weglinski.

6:00pm-7:00pm: Prolonged Normothermic Ex Vivo Kidney Perfusion Is a Safe Preservation Technique for Kidney Transplantation: A New Opportunity for the Storage, Assessment and Repair of Kidney Grafts.

J. Kaths,^1,2,3 J. Echeverri,¹ N. Goldaracena,¹ K. Louis,¹ Y.-M. Chun,¹ I. Linares,^1,3 A. Wiebe,¹ P. Yip,⁵ R. John,⁵ I. Mucsi,⁶ A. Ghanekar,¹ D. Bagli,^7,3 D. Grant,¹ L. Robinson,^2,3 M. Selzner.^1,3

6:00pm-7:00pm: Protective Effects of Nrf2 Over-Activation in Myeloid Cells During Hepatic Ischemia Reperfusion Correlates with Stat3 Signaling in Hepatocytes.

C. Harberg,¹ L.-Y. Lee,¹ S. Werner,² D. Johnson,³ J. Johnson,³ D. Foley.¹

6:00pm-7:00pm: Re-Examining the Role of B-1 Cells in a Murine Model of Renal Ischemia Reperfusion Injury.

D. Firl,^1,2,3 A. Das,¹ J. Fung,² M. Carroll.¹

6:00pm-7:00pm: Reciprocal Effects of HDAC1 and HDAC2 Deletion on Renal Cold Ischemia Survival and Nuclear Co-Repressor Complex Expression.

D. Aufhauser Jr,¹ D. Murken,¹ Z. Wang,¹ A. Samanta,² G. Ge,¹ T. Bhatti,³ W. Hancock,^2,3 M. Levine.¹

6:00pm-7:00pm: Recombinant TSGL-Ig Protects Liver Endothelial Cells Against Prolonged Cold Preservation Injury in Mouse Liver Transplantation.

C. Zhang,^1,2 H. Ji,¹ Y. Liu,^1,2 Y. Zhang,^1,2 X.-D. Shen,¹ F. Gao,¹ R. Busuttil, G. Shaw, J. Kupiec-Weglinski.

6:00pm-7:00pm: Replacing Cold Storage with Normothermic Ex Vivo Kidney Perfusion Improves Function of Grafts Retrieved After Circulatory Death (DCD).

J. Kaths,^1,2 Y.-M. Chun,¹ D. Cen,¹ J. Echeverri,¹ I. Linares,¹ P. Yip,³ R. John,³ D. Bagli,⁴ I. Mucsi,⁵ A. Ghanekar,¹ D. Grant,¹ L. Robinson,² M. Selzner.¹

6:00pm-7:00pm: Role of TGF-β in Ischemia and Reperfusion Injury Induced Renal Fibrosis in Human Proximal Tubular Epithelial Cells.

R. Kapoor, N. Sheerin, J. Kirby.

6:00pm-7:00pm: Short, Cool and Well Oxygenated – HOPE for DCD Kidneys.

P. Kron, A. Schlegel, O. de Rougemont, C. Oberkofler, P.-A. Clavien, P. Dutkowski.

6:00pm-7:00pm: Short-Term Starvation Attenuates Liver Ischemia Reperfusion Injury by SIRT1-Autophagy Signaling in Mice.

J. Rao,¹ H. Zhou,¹ F. Zhang,¹ X. Wang,¹ Y. Zhai,² L. Lu.¹

6:00pm-7:00pm: Signs of a Dying Organ: Beyond Resistance in Subnormothermic Kidney Perfusion.

M. Blum, D. Urcuyo, Q. Liu, B. Soliman, T. Okamoto, D. Goldfarb, C. Quintini.

6:00pm-7:00pm: Sphingosine-1 Phosphate Receptor 1 Agonist SEW2871 Ameliorates Hepatocellular Injury on Ischemic Reperfusion in Mice: A New Therapeutic Target.

T. Ito, N. Kuriyama, A. Matsuda, H. Kato, Y. Iizawa, Y. Murata, A. Tanemura, Y. Azumi, M. Kishiwada, S. Mizuno, M. Usui, H. Sakurai, S. Isaji.

6:00pm-7:00pm: Stem Cell-Mediated Regeneration of Ischemically Damaged Renal Allografts During Ex Vivo Warm Perfusion.

L. Brasile,¹ N. Henry,¹ B. Stubenitsky.²

6:00pm-7:00pm: Subnormothermic Machine Perfusion (SNMP) of Liver Allografts with a Novel Hemoglobin-Based Oxygen Carrier (HBOC) Increases β-Oxidation of Fatty Acids and Decreases Lipid Peroxidation (LP).

B. Banan, R. Lopez, C. Hughes, G. Michalopoulos, P. Fontes.

6:00pm-7:00pm: Subnormothermic Machine Perfusion (SNMP) with a Hemoglobin Based Oxygen Carrier (HBOC) Solution Reprograms Dynamic Inflammation Networks When Compared to Cold Storage (CS) in a Porcine Liver Allograft Model.

D. Sadowsky, R. Zamora, B. Banan, D. Barclay, J. Yin, Y. Vodovotz, P. Fontes.

6:00pm-7:00pm: The Effects of Brain Death and Ischemia on Tolerance Induction Are Organ-Specific.

S. Michel,^1,2 M. Madariaga,¹ G. LaMuraglia II,¹ R. Colvin,³ E. Farkash,³ J. Allan,^1,4 D. Sachs,¹ K. Yamada,¹ J. Madsen.^1,5

6:00pm-7:00pm: The Fine-Tuning of CXCL8 Protects Kidney Against Ischemia-Reperfusion Injury in Mice Lacking MicroRNA-146a.

L. Amrouche,^1,2 G. Desbuissons,¹ M. Rabant,^1,2 C. Legendre,^1,2 F. Terzi,² D. Anglicheau.^1,2

6:00pm-7:00pm: The mTORC2 Activation Is Critical for Hepato-Cytoprotection Against Ischemia and Reperfusion Injury.

H. Zhou,^1,2 J. Zhu,^1,3 S. Yue,¹ R. Busuttil,¹ J. Kupiec-Weglinski,¹ X. Wang,² Y. Zhai.¹

6:00pm-7:00pm: Tissue Inhibitor of Metalloproteinase-3 (TIMP-3) Protects Against Loss of Hepatic Integrity After Ischemia-Reperfusion Injury.

T. Fujii, S. Duarte, R. Busuttil, A. Coito.

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