2018 American Transplant Congress » Poster Session A: Tolerance / Immune Deviation

Date: Saturday, June 2, 2018

Time: 5:30pm-7:30pm

Location: Hall 4EF

Session Type: Poster Session

Meeting: 2018 American Transplant Congress

5:30pm-7:30pm: α-1 Antitrypsin Facilitate Apoptosis Donor Cells Inducing Donor Specific Protection to Mice Cardiac Allografts

G. Chen, X. Lai, L. Qiu, Y. Zhao, S. Yu, C. Wang, J. Zhang, F. Ning, L. Chen.

5:30pm-7:30pm: A Novel Conditioning Approach to Establish Chimerism Using Manipulation of JAK-STAT Pathways

H. Xu, A. Merchak, L. Kahn, A. Chhabra, Y. Wen, Y. Huang, S. Ildstad.

5:30pm-7:30pm: ABO Tolerance after Treatment of Infant or Adult Mice with MHC-Matched A-Expressing Blood Cells

B. Motyka,¹ J. Fersovich,¹ B. Lamarche,¹ M. Sosniuk,¹ I. Adam,¹ J. Pearcey,¹ K. Tao,¹ C. Cairo,² P. Cowan,³ L. West.¹

5:30pm-7:30pm: Achieving Allograft Tolerance through Antigen-Specific Regulatory B Cells

C. Rickert,^1,2 S. Kimura,^1,2 L. Kojima,¹ K. Lee,¹ M. Aburawi,¹ F. Fontan,¹ K. Deng,¹ H. Yeh,^1,2 J. Markmann.^1,2

5:30pm-7:30pm: Acute Murine CMV Infection Results in Loss of Intragraft CD73^HIFR4^HIPD1⁺ CD4 T Cells and Graft Rejection in Previously Tolerant Recipients

A. Dangi,¹ L. Zhang,¹ X. Zhang,² X. Luo.^1,2

5:30pm-7:30pm: Anti-Thymocyte Globulin Directly Binds and Functionally Inhibits Allo-Regulatory Myeloid Derived Suppressor Cells

Y. Lee, E. Davila, J. Bromberg, J. Scalea.

5:30pm-7:30pm: Biomaterial-Based Localized and Controlled Delivery of Tofacitinib to Actuate Enhanced Costimulation Blockade and Promote Long-Term Transplant Survival

G. Raimondi,¹ P. Majumder,² V. Ivanova,¹ X. Calderon-Colon,³ A. Mirdad,¹ M. Iglesias Lozano,¹ W. Lee,¹ G. Brandacher,¹ J. Schneider,² J. Patrone.³

5:30pm-7:30pm: CD4⁺CD25^bright Regulatory T Cells Prevent Acute Xenogeneic GVHD

Y. Huang, A. Merchak, H. Xu, A. Chhabra, A. Khalil, Y. Wen, M. Binion, M. Badder, L. Kahn, S. Ildstad.

5:30pm-7:30pm: Characterization of Renal Allograft Tolerance Induction via Transient Mixed Chimerism in Non-Human Primates

H. Sasaki,¹ C. Thaiss,¹ T. Oura,¹ A. Rosales,² R. Smith,² R. Colvin,² B. Cosimi,¹ T. Kawai.¹

5:30pm-7:30pm: Donor T Cells Undermine the Graft-Protective Effect of DST Plus Anti-CD154

M. Iglesias, M. Chicco, W. Lee, G. Brandacher, G. Raimondi.

5:30pm-7:30pm: Effect of Erythropoietin on Cardiac Allograft Survival in Non-Human Primates

J. O.,¹ K. Robinson,¹ W. Sommer,¹ K. Pruner,¹ J. Paster,¹ M. Hanekamp,¹ A. Dehnadi,¹ I. Rosales,¹ R. Smith,¹ P. Cravedi,² P. Heeger,² G. Benichou,¹ J. Madsen.¹

5:30pm-7:30pm: Ex-Vivo Generation of Alloantigen-Specific Immunomodulatory Cells: Elucidating the Mechanistical Synergy of Cell Components

M. Yao,¹ M. Kumagai-Braesch,¹ M. Watanabe,^1,2 K. Tokodai,¹ T. Lundgren,¹ M. Uhlin,¹ B. Ericzon.¹

5:30pm-7:30pm: Galangin Promotes Treg Development and Function

F. Liang,¹ H. Fang,¹ R. Zhang,¹ Q. Chen,² J. Ochando,³ Y. Ding,¹ J. Xu.¹

5:30pm-7:30pm: Heart En Bloc Thymus Cotransplantation in NHPs Controls Cellular but Not Humoral Alloreactivity

W. Sommer, J. O., K. Pruner, J. Paster, M. Hanekamp, A. Dehnadi, I. Rosales, R. Smith, R. Colvin, G. Benichou, J. Allan, J. Madsen.

5:30pm-7:30pm: High Fibre Diet Induces Donor Specific Kidney Allograft Tolerance in Mice

H. Wu,^1,2 T. Kwan,² Y. Loh,² C. Wang,² L. Macia,² S. Alexander,^2,3 S. Chadban.^1,2

5:30pm-7:30pm: Hsp70 Inhibitor Could Induce Transplant Tolerance through mTORC2/Akt Pathway

G. Gu, T. Lu, N. Xu, Q. Xia.

5:30pm-7:30pm: Human CD8⁺CD28^– T Cells Driven In Vitro by IL-15 Suppress in Allo-Specific Manner Partially through PD-1:PD-L1 Pathway

F. Feng,^1,2 G. Liu,¹ P. Zhu,¹ M. Zhu,¹ X. Lu,¹ J. Liu,² X. Luo,³ Y. Liu,¹ Y. Yu.²

5:30pm-7:30pm: Human CD8⁺CD28^– Ts Cells Expanded by Common Gamma Chain (γc) Cytokines Keep Steady Allospecific Suppressive Capacity In Vivo

G. Liu,¹ F. Feng,¹ P. Zhu,¹ J. Liu,² Y. Liu,¹ Y. Yu.²

5:30pm-7:30pm: IL-10 Requirement in In Vitro Expanded Breg-Mediated Allograft Tolerance is Tissue Specific

C. Dai, K. Lee, L. Kojima, K. Deng, S. Kimura, C. Rickert, H. Yeh, J. Markmann.

5:30pm-7:30pm: IL23R is a Pathogenic Gene in Type 1 Regulatory T Cells during Mouse Cardiac Transplantation Models

G. Gu, T. Lu, N. Xu, Q. Xia.

5:30pm-7:30pm: Immunomodulation of Alloantibody Responses

C. Schuetz, M. Climov, A. Paril, Z. Wang, A. Andrews Roy, N. Navarro Alvarez, A. Matar, D. Sachs, R. Duran-Struuck, C. Huang.

5:30pm-7:30pm: In Vitro α-Galactosylceramide Stimulation Expands CD4⁺CD25⁺Foxp3⁻ Regulatory T Cell Precursors in Murine Thymocytes

H. Katsumata,^1,2 M. Ikemiyagi,¹ T. Kanzawa,¹ H. Fukuda,¹ R. Ishii,¹ K. Saiga,^1,3 M. Okumi,¹ Y. Ishii,⁴ K. Tanabe.¹

5:30pm-7:30pm: Kidney Allografts Confer Tolerance upon Co-Transplanted Heart Allografts by Promoting Tregs

C. Yang,¹ T. Ashry,¹ I. Rosales,² J. Ge,¹ T. O'Shea,¹ R. White,² P. Russell,¹ J. Madsen,¹ R. Colvin,² A. Alessandrini.¹

5:30pm-7:30pm: LAG-3 Deletion Upregulates Memory in a Dendritic Cell-Dependent Process

S. Gibney,¹ M. Efre,¹ T. Ashry,¹ C. Yang,¹ T. O'Shea,^1,2 R. White,² P. Russell,¹ J. Madsen,¹ R. Colvin,² A. Alessandrini.^1,2

5:30pm-7:30pm: Long Noncoding RNA NEAT1 Induces Tolerogenic Dendritic Cells in Heart Transplantation

J. Wu,^1,2 Y. Zheng,^1,2 S. Li,^1,2 M. Zhang,^1,2 H. Zhang,^1,2 X. Zheng,^1,2 Y. Sun,^1,2 B. Yu.^1,2

5:30pm-7:30pm: Long-Term Nonhuman Primate Renal Allograft Survival without Ongoing Immunosuppression in Recipients of Delayed Donor Bone Marrow Transplantation

K. Hotta, T. Oura, A. Dehnadi, M. Matsunami, I. Rosales, R. Smith, R. Colvin, A. Cosimi, T. Kawai.

5:30pm-7:30pm: Loss of HIF-1α in CD4 T Cell Improve Outcome of Mouse Vascularized Osteomyocutaneous Allotransplantation under Costimulation Blockade

C-.H. Lin,^1,2 M. Anggelia,^1,2 H. Yang,³ W. Chuang,⁴ H. Cheng,¹ F-.C. Wei,^1,2 G. Brandacher.⁵

5:30pm-7:30pm: Low Intensity Conditioning Protocol for Inducing Chimerism-Based Tolerance in Non-Obese Diabetic Mice

A. Chhabra, Y. Huang, H. Xu, A. Merchak, S. Ildstad.

5:30pm-7:30pm: Lymph Node Reprogramming: Microparticle Delivery of Immune Signals to Induce Tolerance and Prolong Allograft Survival

Y. Xiong,¹ L. Tostanoski,² C. Jewell,² J. Bromberg.¹

5:30pm-7:30pm: M-CSF and TNF-α Induce Human MDSCs That Attenuate GVHD

F. Han, C. Ding, Y. Zhao, P. Tian.

5:30pm-7:30pm: Mitochondrial Membrane Permeability Plays a Critical Role for Endothelial Cell Necroptosis and Cardiac Allograft Rejection

I. Gan, J. Jiang, D. Lian, X. Huang, W. Liu, A. Haig, A. Jevnikar, Z. Zhang.

5:30pm-7:30pm: Myeloid Derived Suppressor Cells Are Induced after Transplantation and Home to the Transplanted Kidney

Y. Lee, E. Davila, J. Bromberg, J. Scalea.

5:30pm-7:30pm: NOS2 Deficiency Limits Long Term Survival of Murine Kidney Allografts

I. Aljabban,^1,2 B. Jiang,¹ C. Yang,¹ T. O'Shea,¹ D. Ndishabandi,¹ R. White,¹ P. Russell,¹ R. Colvin,¹ J. Madsen,¹ A. Alessandrini.¹

5:30pm-7:30pm: Organ-Specific Differences in a Thymoglobulin and Belatacept-Based Protocol for Tolerance Induction in Non-Human Primates

W. Sommer, J. O., K. Robinson, A. Dehnadi, M. Hanekamp, I. Rosales, K. Pruner, R. Smith, R. Colvin, T. Kawai, G. Benichou, J. Madsen, J. Allan.

5:30pm-7:30pm: Post-Transplant High Dose Cyclophosphamide Treatment Induces Thymus-Independent Immune Tolerance of Vascularized Composite Allografts via Complete Depletion of the Alloreactive TCR Repertoire.

G. Furtmüller,¹ B. Oh,¹ J. Sidhom,² M. Fryer,¹ V. Malek,¹ X. Zhou,¹ D. Cooney,¹ C. Brayton,³ J. Dodd-o,⁴ S. Ganguly,² G. Raimondi,¹ W. Lee,¹ L. Luznik,² G. Brandacher.¹

5:30pm-7:30pm: Prolongation of Skin Allograft Survival through Dietary Supplementation of Ayrl Hydrocarbon Receptor Ligands

A. Afrazi, L. Owens, J. Fechner, C. O'Driscoll, J. Mezrich.

5:30pm-7:30pm: Renal Allograft Molecular Pathways Associated with Tolerance Induction in Renal Transplantation

L. Gallon,¹ J. Mathew,¹ S. Bontha,² C. Dumur,² P. Dalal,¹ L. Nadimpalli,¹ D. Maluf,² A. Shetty,¹ S. Ildstad,³ J. Leventhal,¹ V. Mas.²

5:30pm-7:30pm: Standard Induction Immunosuppression Interferes with the Role of Vascularized Bone Marrow in Vascularized Composite Allograft Protection

N. Shockcor, E. Buckingham, W. Hassanein, A. Nam, S. Bartlett, R. Barth.

5:30pm-7:30pm: T Cell Immunomonitoring Including Donor Specific Treg Expansion Prospectively Predicts Renal Allograft Tolerance Induced by Transient Mixed Chimerism

K. Hotta, T. Oura, A. Dehnadi, K. Huh, M. Matsunami, H. Sasaki, G. Benichou, J. Madsen, A. Cosimi, T. Kawai.

5:30pm-7:30pm: TGF-b Plus Rapamycin Induce Foxp3 and Promote iTreg Development and Suppressive Function, Leading to Long-Term Allograft Survival

L. Wang, A. Samanta, R. Han, N. Zhou, W. Hancock.

5:30pm-7:30pm: The LncRNA MALAT1 Induces Tolerogenic DCs and Antigen Specific Tregs Subsequently Mediating Cardiac Allograft Tolerance in Mice via MiR-155/DC-SIGN/IL10 Axis

M. Zhang,^1,2 J. Wu,^1,2 H. Zhang,^1,2 M. Liu,^1,2 Y. Zheng,^1,2 X. Jin,^1,2 S. Li,^1,2 Q. Zhao,^1,2 X. Liu,^1,2 Y. Sun,^1,2 B. Yu.^1,2

5:30pm-7:30pm: The Regulatory Role of Plasma Cells (as Bregs) is Counterbalanced by a NOVEL Inflammatory Role in Murine Transplant and Autoimmune Models

Z. Song,^1,2 Y. Zhou,² Q. Ding,¹ D. Rothstein.¹

5:30pm-7:30pm: The Role of pDCs in Formation of Treg-Rich Organized Lymphoid Structures in Spontaneously Accepted Murine Kidney Allografts is Dependent on Mismatching of MHC Class II Molecules at the H2-I-A^b Locus

T. O'Shea,^1,2 C. Yang,¹ I. Rosales,² N. Oh,¹ D. Ndishibandi,^1,2 T. Ashry,¹ P. Russell,¹ J. Madsen,¹ R. Colvin,² A. Alessandrini.^1,2

5:30pm-7:30pm: Thymus Co-Transplantation Promotes Donor-Specific Tolerance in Allogeneic Heart Transplantation

J. Kwun,¹ J. Li,² C. Rouse,³ J. Park,¹ A. Kirk,¹ L. Markert.²

5:30pm-7:30pm: Tipping the “Immune Balance” towards Tolerance by Specific and Systematic Depletion of Donor and Host Effector Cells

R. Bascom, K. Tao, L. West.

5:30pm-7:30pm: Tomotherapy and Donor Hematopoietic Cells for Tolerance to Kidney Transplants in Rhesus Macaques

D. Kaufman,¹ L. Haynes,¹ P. Hematti,¹ W. Burlingham,¹ L. Forest,² J. Post,¹ R. Redfield,¹ L. Fernandez,¹ A. D'Alessandro,¹ J. Haynes,¹ K. Jensen,³ S. Strober.³

5:30pm-7:30pm: Type-1 Interferon Impairs the Immunoregulatory Activity of IL-10: Understanding the Mechanisms of Abrogation of Transplant Tolerance

M. Iglesias, A. Arun, M. Chicco, B. Lam, V. Ivanova, W. Lee, G. Brandacher, G. Raimondi.

5:30pm-7:30pm: Umbilical Cords-Derived Mesenchymal Stem Cells Ameliorates Hepatic Ischemia-Reperfusion Injury via Activating the AMPK-mTOR/ULK1 Signaling Pathway Enhanced Autophagy

J. Zheng,^1,2 J. Cai,^1,2 L. Chen,^1,2 J. Yao,^1,2 K. Zeng,^1,2 H. Li,^1,2 Y. Zhang,^1,2 Y. Yang.^1,2

5:30pm-7:30pm: Vendor-Specific Differences in Identical Strains of Mice Yield Dichotomous Result in Lung Allograft Rejection

Y. Guo, Q. Wang, O. Onyema, A. Gelman, D. Kreisel, A. Krupnick.

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