2018 American Transplant Congress » Poster Session A: Kidney Acute Antibody Mediated Rejection

Date: Saturday, June 2, 2018

Time: 5:30pm-7:30pm

Location: Hall 4EF

Session Type: Poster Session

Meeting: 2018 American Transplant Congress

5:30pm-7:30pm: A Pre-Transplant Blood-Based Lipid Signature for Prediction of Antibody-Mediated Rejection in Kidney Transplant Patients

G. Gupta, S. Bobba, D. Contaifer, P. Kimball, A. King, D. Kumar, M. Levy, J. Stern, D. Wijesinghe.

5:30pm-7:30pm: ABO-Incompatibility Lower Incidence of DSA-Induced Antibody-Mediated Rejection

D. Lee,¹ B. Kim,¹ J. KIm,¹ I. KIm,¹ M. Jeon.¹

5:30pm-7:30pm: An Increase in Spot Urine Protein Excretion during the First Year after Kidney Transplantation Associates with Subclinical De-Novo Donor-Specific Antibodies and Microvascular Inflammation at 1-Year Surveillance Biopsies

M. Arnol,¹ G. Mlin[scaron]ek,¹ M. Oblak,¹ A. Kandus,¹ N. Kojc,² J. Buturović-Ponikvar.¹

5:30pm-7:30pm: An Integrative Approach for the Assessment of Peritubular Capillaritis Extent and Score in Microvascular Inflammation – Association with Transplant Glomerulopathy and Graft Loss

N. Kozakowski,¹ H. Herkner,² F. Eskandary,³ M. Eder,³ W. Winnicki,³ G. Bond,³ Ž. Kikić.³

5:30pm-7:30pm: Antibody Mediated Kidney Transplant Rejection Treated with Bortezomib – Case Series from a Single Center

G. Piecha,¹ R. Król,² H. Karkoszka,¹ A. Wiecek.¹

5:30pm-7:30pm: Biopsy Correlates of DSA in Antibody-Mediated Rejection: C4d vs Microvascular Inflammation Scores

C. Harris, L. Anderson, R. Khaim, J. Choudhuri, R. Shapiro, S. Florman, F. Salem, M. Menon.

5:30pm-7:30pm: C1q-Binding Donor-Specific Anti-HLA Antibodies for Clinical Decision Making in Kidney Recipients with Antibody-Mediated Rejection Receiving Standard of Care Treatment

C. Lefaucheur,¹ D. Viglietti,¹ Y. Bouatou,¹ O. Aubert,¹ A. Zeevi,² A. Loupy.¹

5:30pm-7:30pm: CD19+ Cell Ratio as a Predictive Marker of Antibody Mediated Rejection in ABO Incompatible Kidney Transplantation

K. Unagami,¹ R. Maenosono,² M. Furusawa,² Y. Kakuta,² M. Okumi,² H. Ishida,² K. Tanabe,² K. Nitta.¹

5:30pm-7:30pm: Can We Expect the “Unexpected”?

D. Pinelli, A. Tambur.

5:30pm-7:30pm: Clinical Heterogeneity of Early Anamnestic Donor Specific Antibody Responses in Kidney Transplantation

A. Loethen,¹ A. Lichvar,¹ S. Tremblay,¹ A. Shields,^1,2 A. Dao,¹ M. Cardi,² P. Brailey,¹ A. Girnita,¹ B. Abu Jawdeh,¹ R. Alloway,¹ E. Woodle.¹

5:30pm-7:30pm: Clinical Response to Salvage Bortezomib Therapy for Antibody Mediated Rejection and Mixed Acute Rejection in a High Immunologic Risk Renal Transplant Population

A. Lichvar, J. Benken, E. Benedetti.

5:30pm-7:30pm: Clinical Significance of Microvascular Inflammation in the Absence of Anti-HLA DSA in Kidney Transplantation

S. Parajuli, R. Redfield, F. Aziz, N. Garg, M. Mohamed, W. Zhong, T. Ellis, A. Djamali, D. Mandelbrot.

5:30pm-7:30pm: Comparison of Bortezomib in Addition to Rituximab Based Treatment of Acute Antibody Mediated Rejection in Kidney Transplantation

A. Mattiazzi,^1,2 J. Pagan,^1,2 A. Arunachalam,¹ I. De la Cruz Alcantara,¹ J. Revollo,² A. Centeno,² A. Valdes,^1,2 G. Guerra.^1,2

5:30pm-7:30pm: Comparison of C1Q Binding and Flow Cytometric Crossmatch Results Provides an Accurate Evaluation of Hypersensitive Kidney Transplant Patients

E. Eksioğlu-Demiralp,¹ A. Türkmen,² B. Yelken,² S. Görçin,² O. Elbasi,¹ F. Yalçin,³ B. Koçak,² C. Karatas,⁴ M. Tuncer,⁴ M. Altinel.³

5:30pm-7:30pm: Comparison of Microvascular Inflammation in Renal Allograft Tissue between ABO Incompatible and ABO Compatible Kidney Transplantation

E. Ko,^1,2 B. Choi,^1,2 C. Park,^1,2 Y. Kim,^1,2 C. Yang,^1,2 B. Chung.^1,2

5:30pm-7:30pm: Defining Response to Standard of Care Treatment in Kidney Recipients with Antibody-Mediated Rejection: Role of C1q-Binding Donor-Specific Anti-HLA Antibodies

Y. Bouatou, D. Viglietti, O. Aubert, A. Loupy, C. Lefaucheur.

5:30pm-7:30pm: Diagnosis of Antibody-Mediated Rejection after Kidney Transplantation by Blood Expression of Genes Involved in IFN Signaling

M. Matz,¹ Q. Zhang,¹ F. Heinrich,² C. Lorkowski,¹ K. Wu,³ P. Durek,² N. Lachmann,⁴ M-.F. Mashreghi,² K. Budde.¹

5:30pm-7:30pm: Diagnostic Usefulness of Medullary C4d Staining in Renal Allografts

J. Von Visger,¹ C. Von Visger, A. Satoskar,² T. Nadasdy,² J. Hemminger,² S. Brodsky.²

5:30pm-7:30pm: Do Protocol Biopsies in the Highly Sensitized Improve Renal Allograft Survival? A Single Center Evaluation of 2 Year Graft Function

S. Kuppachi, R. Kalil, M. Fraer, M. Sanders, M. Swee, Z. Stewart, C. Thomas.

5:30pm-7:30pm: Donor-Derived Cell-Free DNA Outperforms Serum Creatinine Changes for Identifying Kidney Transplant Rejection

M. Weir,¹ D. Hiller,² J. Yee,² A. Matas.³

5:30pm-7:30pm: Early Experience Using Donor-Derived Cell-Free DNA for Detection of Rejection in Kidney Transplantation

E. Huang, A. Vo, J. Choi, A. Peng, S. Sethi, R. Najjar, S. Jordan.

5:30pm-7:30pm: Eculizumab for the Treatment of Antibody Mediated Rejection in Kidney Transplant Recipients: A Single Center Experience

A. Chi, J. Phillips, D. Quan.

5:30pm-7:30pm: Efficacy and Safety of Tocilizumab in Treatment of Acute Antibody Mediated Rejection

K. Venkatachalam, D. Reem, M. Andrew, R. Delos Santos, T. Alhamad.

5:30pm-7:30pm: Eluates from Fine-Needle Allograft Biopsy Increase Donor-Specific Antibody Identification in Antibody Mediated Rejection

A. Girnita,^1,2 E. Portwood,² P. Brailey,² M. Cuffy,¹ M. Cardi,¹ F. Paterno,¹ T. Diwan,¹ S. Shah,¹ A. Govil,¹ R. Alloway,¹ E. Woodle.¹

5:30pm-7:30pm: Immunologic Impact of Tocilizumab Treatment in Kidney Transplant Recipients with Allograft Inflammation

J. Leung, S. Chandran, F. Vincenti, Q. Tang.

5:30pm-7:30pm: Impact of De Novo DSA (DnDSA) on Outcomes in HLA-Sensitized (HS) Patients Transplanted after IVIG + Rituximab Desensitization (DES)

A. Vo,¹ O. Aubert,² H. Edmund,¹ A. Peng,¹ R. Najjar,¹ S. Supreet,¹ J. Choi,¹ K. Lim,¹ S. Jordan.¹

5:30pm-7:30pm: Impact of Pretransplant Donor-Specific Antibodies on Kidney Allograft Recipients with Negative Flow Cytometry Crossmatches

H. Kwon, Y. Kim, J. Choi, S. Shin, J. Jung, M. Cho, J. Kim, D. Han.

5:30pm-7:30pm: Influence of X-Ray Repair Cross-Complementing Group (XRCC) Genes Polymorphisms on the Development of Antibody-Mediated Rejection (ABMR) in Renal Transplant Recipients

Z. Wang, Z. Han, J. Tao, R. Tan, M. Gu.

5:30pm-7:30pm: Interstitial Inflammation is Correlated with DQ Antibodies in Kidney Transplant Recipients

C. Harris, L. Anderson, R. Khaim, J. Choudhuri, R. Shapiro, S. Florman, F. Salem, M. Menon.

5:30pm-7:30pm: Is the NETos Increased in Acute Antibody Mediated Rejection?

R. Villca-Gonzales,¹ J. Torres-Ruiz,² D. Gomez-Martin,² J. Alberu,³ L. Morales-Buenrostro.¹

5:30pm-7:30pm: Magnitude of Pre-Biopsy Decline in Renal Function and Its Association with Allograft Rejection

S. Voora,¹ P. Ahearn,¹ M. Tavakol,² K. Johansen,^1,3 E. Ku.¹

5:30pm-7:30pm: Molecular Monitoring for Kidney Allograft Injury Following HLA Incompatible Transplantation

A. Jackson,¹ B. Iglehart,¹ S. Bagnasco,³ N. Desai.²

5:30pm-7:30pm: NK Cells in Allograft Kidney Biopsies during Rejection: Detection, Quantification, and Precise Localization Using Multiplex Immunofluorescence

M. Terada,¹ J. Duong Van Huyen,² F. Drieux,⁴ C. Legendre,³ P. Bruneval,¹ M. Rabant.²

5:30pm-7:30pm: Noninvasive Detection of Infection and Rejection in Renal Transplant Patients

Y. Zhou,¹ Y. Cheng,¹ T. Chiang,² G. Yang,² X. Li,² F. Zeng,² X. Wang,¹ J. Ge,² X. Hu,² H. Shi,¹ T. Wang,² L. Liu.³

5:30pm-7:30pm: Protocolar Biopsies in Patients with Subclinical De Novo DSA in Kidney Transplantation

D. Bertrand,¹ M. Jaureguy,² C. Garrouste,³ J. Sayegh,⁴ N. Bouvier,⁵ S. Caillard,⁶ L. Lanfranco,⁷ A. Galinier,⁸ A. François,⁹ F. Hau,¹⁰ I. Etienne,¹ P. Gatault.¹¹

5:30pm-7:30pm: Repeat Kidney Transplant Patients with Active Rejection Have Elevated Donor-Derived Cell-Free DNA

S. Mehta,¹ J. Chang,² T. Hailey,¹ D. Hiller,³ M. Grskovic,³ J. Yee,³ R. Mannon.¹

5:30pm-7:30pm: Serum Treatment with Fetal Bovine Serum Significantly Increases Luminex-Based HLA Antibody Assay Specificity by Reducing Heterophile Antibody Interference

A. Jaramillo,¹ J. House,¹ L. Nelson,¹ S. Stoll,¹ R. Ridgley,¹ H. Khamash.²

5:30pm-7:30pm: Significance of Antibody-Mediated Vascular Rejection (AMVR) on Graft Survival: Correlation with Pure Antibody-Mediated Rejection (AMR)

B. Ozdemir,¹ F. Ozdemir,² A. Terzi,² G. Ozdemir,¹ A. Ok Atilgan,¹ E. Ayvazoglu Soy,³ A. Akdur,³ G. Moray,³ M. Haberal.³

5:30pm-7:30pm: Single Center Experience in Use of Check Point Inhibitors and Outcomes in Kidney Transplant Recipients

K. Venkatachalam, R. Delos Santos, T. Alhamad.

5:30pm-7:30pm: Subclass Distribution of DSA Analyzed by Mass Spectrometry Predicts the Risk of Humoral Rejection

V. Pernin,^1,2 N. Bec,³ C. Larroque,³ C. Duperray,² G. Mourad,¹ M. Lequintrec.^1,2

5:30pm-7:30pm: Temporal Variability of IgG Subclasses

D. Pinelli, M. Gopalakrishnan, A. Joong, P. Thrush, A. Tambur.

5:30pm-7:30pm: The Complexity of HLA-DQ

D. Pinelli, A. Tambur.

5:30pm-7:30pm: The Impact of Pre-Transplant Donor Specific Antibodies (DSA) on AMR Rates in HIV-Infected Kidney Transplant Recipients Inducted with IL-2 RA

S. Farouk, B. Rollins, V. Delaney, N. Singh, V. Sehgal, R. Kent, M. Menon, R. Shapiro, S. Florman, G. DeBoccardo.

5:30pm-7:30pm: The Promising Approach in Difficult Atypical Hemolytic Uremic Syndrome Series in Renal Transplantation

B. Yelken,¹ S. Gorcin,¹ E. Demir,² C. Karatas,³ E. Arpali,⁴ B. Akyollu,³ B. Kocak,⁴ O. Elbasi,⁵ E. Eksioğlu,⁵ A. Turkmen.²

5:30pm-7:30pm: The Treatment of Antibody-Mediated Rejection in Kidney Transplantation: An Updated Systematic Review and Meta-Analysis

S. Wan,^1,2 T. Ying,^1,2 K. Wyburn,^1,2 D. Roberts,^3,4 M. Wyld,^1,2 S. Chadban.^1,2

5:30pm-7:30pm: Title: Donor-Derived Cell Free DNA Predicts Development of Clinically Significant Changes in Donor Specific Antibody Following Kidney Transplant

A. Brubaker,¹ D. Stoltz,¹ M. Grskovic,² R. Woodward,² A. Gallo.¹

5:30pm-7:30pm: Urinary C-X-C Motif Chemokines 13 is a Noninvasive Biomarker of Antibody-Mediated Renal Allograft Rejection

D. Chen, J. Chen.

5:30pm-7:30pm: Urinary Chemokine CXCL-10 in Long Term Renal Transplant Patients Associates with Urinary Tract Infections and Microvascular Damage

G. Irish,^1,2 M. Hockley,^1,2 S. Kireta,^1,2 J. Johnson,^1,2 R. Carroll.^1,2

5:30pm-7:30pm: Validation Study of Gene Expression Signatures Associated with Antibody-Mediated Rejection (ABMR) and Cell-Mediated Rejection (CMR) in Renal Allograft Biopsies (Bx) Suggests Complexity of Molecular Diagnosis for ABMR Compared to CMR

H. Zhang,¹ C. Nast,² J. Doldron,² M. Cheung,² A. Vo,³ S. Jordan,³ M. Toyoda.¹

5:30pm-7:30pm: Waning Enthusiasm for a Once Promising Test: C1q Testing Does Not Provide Prognostic Information for DSA Screening Protocols

A. Gilbert, D. Li, M. Awwad, S. Rosen-Bronson, P. Abrams, J. Verbesey, G. Vranic, M. Cooper.

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