2019 American Transplant Congress » Poster Session A: Biomarkers, Immune Monitoring and Outcomes

Date: Saturday, June 1, 2019

Time: 5:30pm-7:30pm

Location: Hall C & D

Session Type: Poster Session

Meeting: 2019 American Transplant Congress

5:30pm-7:30pm: A Prognostic Biomarker to Estimate the Likelihood of Developing De Novo Donor Specific Antibody in Kidney Transplant Recipients

S. Kawakita¹, L. M. Rebellato², K. P. Briley², A. Q. Maldonado³, C. E. Haisch², P. Bolin², S. A. Kendrick⁴, H. Jones⁴, K. McLawhorn⁴, D. Leeser², V. Jucaud¹, V. Burnett¹, M. J. Everly¹

5:30pm-7:30pm: A Prognostic Model to Identify Deceased Donor Kidney Transplant Recipients at High Risk for Delayed Graft Function

S. Kawakita, J. L. Beaumont, M. J. Everly

5:30pm-7:30pm: Absolute Quantification of Micro RNA and Messenger RNA Using a Customized Amplicon in Real Time Quantitative Polymerase Chain Reaction Assays

C. Li, C. Snopkowski, M. Cassidy, B. Botticelli, S. Albakry, J. R. Lee, M. Lubetzky, D. Dadhania, H. Yang, R. Ding, T. Muthukumar, M. Suthanthiran

5:30pm-7:30pm: Application of Small Molecule Fluorescent Probes in Early Activation Imaging of CD8+ T Lymphocytes

P. Rong, X. Zhou

5:30pm-7:30pm: Assessment of the Relationship between Inflammation and Glomerular Filtration Rate

J. B. Ramirez-Gonzalez¹, L. E. Morales-BuenRostro², J. Furuzawa-Carballeda³, L. Garcia-Covarrubias⁴, R. L. Pacheco-Domínguez⁵, R. Durazo-Arvizu⁶, J. Alberu³, E. N. Cuevas-Medina⁷, M. López-Cervantes⁵, R. A. Osorio-Juárez⁵

5:30pm-7:30pm: B Cell Derived Exosomes Are Associated with Antibody Mediated Rejection in Kidney Transplant Recipients Desensitized for a Positive Cross-Match

D. Cucchiari¹, V. Tubita², M. J. Ramirez-Bajo², J. Rovira², F. E. Borràs³, L. Carreras-Planella³, A. Hertig⁴, F. Oppenheimer¹, F. Diekmann¹, I. Revuelta¹

5:30pm-7:30pm: Cell Coding Transcriptomic Analysis Of Serial Blood And Biopsy Samples In A Large Cohort Of Kidney Transplant Recipients

W. Zhang¹, Z. Yi¹, Z. Sun¹, K. Keung², C. Wei¹, C. Xi¹, S. Farouk¹, M. Menon¹, P. Cravedi¹, P. O'Connell², B. Murphy¹

5:30pm-7:30pm: Characterization of HLA Antibodies by C3d Assay and IgG Subclasses in Sensitized Kidney Transplant Patients

A. Casillas-Abundis, J. M. Arreola-Guerra, J. Alberu, M. I. Solis-G, L. Llorente, J. Granados, M. Vilatoba, R. Cruz-Martinez, L. Morales-Buenrostro, A. G. Contreras

5:30pm-7:30pm: Characterization of Intra-Exosomal Cargoes of Circulating Donor Heart Specific Exosomes in Murine Heart Transplantation Model

J. Harmon, V. Korutla, L. Korutla, R. Hu, S. Rostami, A. Habertheuer, P. Zielinski, A. Freas, C. Ram, A. Naji, M. Davis, P. Vallabhajosyula

5:30pm-7:30pm: Clinical, Aging, Morphometric Measures & Adverse Outcomes in Kidney Transplant Recipients

A. Muzaale¹, N. Chu¹, H. Ying¹, B. Ross², D. Segev¹, M. McAdams-Demarco¹

5:30pm-7:30pm: Donor-Derived Cell-Free DNA is Associated Specifically with Antibody Mediated Injury in Patients with Renal Allograft Dysfunction

B. Obrisca¹, C. Blosser², I. De Castro², C. Johnson², B. Sorohan¹, L. Sibulesky², R. Bakthavatsalam², G. Ismail¹, N. Leca²

5:30pm-7:30pm: Dynamic Characterization of Cells in the Perfusate from Cold Ischemic Liver Grafts

R. J. de Vries, C. Pendexter, S. E. Cronin, B. Marques, J. F. Markmann, S. L. Stott, H. Yeh, M. Toner, K. Uygun, S. N. Tessier

5:30pm-7:30pm: Elevated Urinary Injury Biomarkers in Deceased Donors Are Not Associated with Long-Term Kidney Transplant Outcomes

N. Koyawala, I. E. Hall, Y. Jia, S. G. Mansour, P. P. Reese, H. R. Thiessen-Philbrook, E. Akalin, J. S. Bromberg, M. D. Doshi, M. N. Harhay, S. Mohan, T. Muthukumar, B. Schroppel, P. Singh, F. L. Weng, C. R. Parikh

5:30pm-7:30pm: Evaluating Adherence to Immunosuppressive Drugs through Trackyourmed® an Innovative Qr Code-Scanner App in Renal Transplantation: Preliminary Results from i-COM Trial

E. Melilli¹, M. Meneghini¹, N. Montero¹, A. Coloma¹, I. Revuelta², F. Moreso³, V. Torregrosa², J. Grinyo¹, O. Bestard¹

5:30pm-7:30pm: Evaluation of Delayed Renal Allograft Function after DCD with New Biomarkers in Donor Blood

X. Zheng

5:30pm-7:30pm: Evidence to Support the Use of Kidney Allograft Function as a Clinical Trial Outcome Measure

M. Kadatz, J. Gill, S. Clark, J. S. Gill

5:30pm-7:30pm: External Validation of Donor-Derived Cell-Free DNA to Detect Rejection in Kidney Transplant Recipients

E. Huang, S. Sethi, A. Peng, R. Najjar, A. Vo, S. Jordan

5:30pm-7:30pm: Galectin-3 Levels Are Associated with the Incidence and Severity of Chronic GVHD One Year after Allogeneic Hematopoietic Cell Transplantation

N. Navarro-Alvarez¹, A. R. Andrews¹, Z. DeFilipp², Y. A. Chen², V. T. Ho³, J. Ritz³, T. R. Spitzer⁴, C. A. Huang⁵

5:30pm-7:30pm: Hepatoblastoma Tumors Requiring Liver Transplantation Manifest Dysregulated Ciliary, Autophagy and Cell Cycling Pathways in Systems Biology Analysis

T. Narayanan¹, M. Ningappa², B. W. Higgs², S. Subramaniam³, R. Sindhi²

5:30pm-7:30pm: High Urinary Neutrophil Gelatinase Lipocalins (NGAL) Levels in Kidney Perfusates as Predictor of a Better Renal Function

A. Angeletti, C. Donadei, V. De Pace, I. Capelli, V. Corradetti, C. Zannini, F. Alviano, L. Bonsi, G. Comai, M. Ravaioli, G. La Manna

5:30pm-7:30pm: Human Leukocyte Antigen Class I (HLA-I) Antibodies in Patients Undergoing Liver Transplantation: Implications for Platelet Transfusion Support

M. Wong¹, R. Narra², M. Selim¹, M. A. Zimmerman¹, A. Padmanabhan³, J. C. Hong¹

5:30pm-7:30pm: IE-1 Specific T Cell Receptor Repertoire Diversity and Protection against CMV Reactivation

M. Lucia Perez¹, F. Rubelt¹, S. Busque¹, C. O. Esquivel¹, S. M. Krams¹, O. Bestard², O. M. Martinez¹

5:30pm-7:30pm: Impact of IgG Subclass and C1q Binding Donor-Specific HLA Antibodies on Antibody Mediated Rejection in Kidney Transplant Recipients

H. Lee¹, J. Ryu¹, S. Yun¹, T. Ban², E. Ko², C. Yang², E. Oh¹

5:30pm-7:30pm: Increase in Proinflammatory CD14++CD16+ Monocytes in Samples from Aspiration Cytology Compared with Peripheral Blood in Kidney Transplant Patients with Borderline Rejection

T. Vazquez-Sanchez¹, A. Caballero-Gonzalez², E. Sola¹, P. Ruiz-Esteban¹, E. Marques¹, J. Alonso-Titos¹, E. Palma¹, C. Jironda¹, M. Cabello¹, V. Lopez¹, P. Hidalgo¹, M. Leon¹, D. Hernandez¹

5:30pm-7:30pm: Involvement of Genetic Variation and Related Gene Expression Changes on Acute Rejection in Renal Transplant Recipients

H. Hwang¹, J. Seo¹, J. Kim¹, Y. Kim¹, J. Moon¹, K. Jeong¹, C. Kim², J. Park³, B. Chung⁴, Y. Kim⁵, S. Lee¹

5:30pm-7:30pm: Liquid Biopsy for Chronic Rejection after Kidney Transplantation. A Novel Non-Invasive Biomarker Involved in Inflammatory Amplifier

Y. Takada¹, D. Kamimura², H. Higuchi¹, D. Iwami¹, K. Hotta¹, N. Iwahara¹, N. Shinohara¹, M. Murakami²

5:30pm-7:30pm: Matrix Metalloproteinase-9 and Neutrophil Extracellular Traps in Human and Mouse Liver Ischemia and Reperfusion Injury

S. Duarte, A. Zarrinpar, R. W. Busuttil, A. J. Coito

5:30pm-7:30pm: Monitoring Inflammatory Cytokine Levels in Kidney Transplant Patients (KTx Pts) with Chronic Antibody Mediated Rejection (cABMR) Treated with Clazakizumab (CLZ, Humanized Anti-IL-6 Monoclonal Antibody)

S. Ge¹, A. Petrosyan¹, M. Chu¹, N. Ammerman², A. Vo², S. C. Jordan², X. Zhang³, M. Toyoda¹

5:30pm-7:30pm: NK Cell Quantification by Paraffin Immunohistochemistry is Not Predictive of Graft Outcome in 1-Year Surveillance Biopsies

J. Barnes¹, F. Suliman², A. Shammout¹, E. A. Farkash¹

5:30pm-7:30pm: Next Gen ABO Antibody Assessment: Development of a Bead-Based ABO Antibody Detection Assay

A. Halpin¹, J. Pearcey², B. Motyka², S. Maier², J. Zhou³, T. L. Lowary⁴, C. W. Cairo⁴, L. J. West¹

5:30pm-7:30pm: Non-Invasive Monitoring of the Kidney Allograft

S. Bontha¹, G. Darville¹, C. Kuscu¹, C. Kuscu², A. Bajwa¹, J. Eason³, D. Maluf⁴, V. Mas⁵

5:30pm-7:30pm: Novel Flow-Based Assay to Identify Allo-Specific T Cell Exhaustion

N. Tanimine¹, C. Rickert¹, K. Lee¹, K. Deng¹, N. Feeney¹, C. Leguern¹, B. Burrell², J. Markmann¹

5:30pm-7:30pm: Post-Reperfusion Hepatic Beta-Catenin Activation Regulates Graft Damage, Inflammatory Responses and Transplant Outcomes

H. Hirao, K. Kadono, S. Kageyama, K. Nakamura, T. Ito, J. Aziz, K. J. Dery, F. M. Kaldas, R. W. Busuttil, J. W. Kupiec‐Weglinski

5:30pm-7:30pm: Pre-Transplant Donor-Specific IFN-γ ELISPOT as a Predictor of Allograft Rejection: A Diagnostic Test Accuracy Meta-Analysis

S. Farouk¹, I. Gandolfini², N. Montero³, E. Crespo⁴, M. Jarque⁴, M. Meneghini⁴, U. Maggiore², O. Bestard³, P. Cravedi¹

5:30pm-7:30pm: Predicting Allograft Outcomes of Renal Transplantation with Pretransplant Metrics

J. Tchervenkov¹, M. Nguyen², S. Negi¹, S. Paraskevas¹

5:30pm-7:30pm: Predicting Post-Transplant Graft Function in Deceased Donor Kidney Transplant Recipients

K. Archer¹, Y. Zhang¹, V. Bontha², J. Eason³, L. Gallon⁴, E. Akalin⁵, D. Maluf², V. Mas²

5:30pm-7:30pm: Proteomics Reveals Molecular Window and Metabolism of Normothermically Perfused Human Kidneys

A. Weissenbacher¹, H. Huang², A. Thorne³, L. M. Lo Faro³, J. Hunter³, R. Ploeg³, C. C. Coussios⁴, P. J. Friend³, B. Kessler⁵

5:30pm-7:30pm: RNA Sequencing Identifies a Differential Role of Coding and Non-Coding Genes by Types of Rejection

S. Pineda¹, O. Bestard², T. K. Sigdel¹, M. Sirota³, M. Sarwal¹

5:30pm-7:30pm: Rapid Detection of Kidney Transplant Injury by Quantifying Donor-Derived Cell-Free Deoxyribonucleic Acid via Massively Multiplex Polymerase Chain Reaction

T. K. Sigdel¹, F. Acosta², S. Navarro², B. Zimmermann², Z. P. Demko², S. Moshkevich², P. R. Billings², M. M. Sarwal¹

5:30pm-7:30pm: Subclinical Rejection by Biopsy or Gene Expression Profile Predicts Long Term Kidney Function in Patients in the CTOT08 Trial

R. Heilman¹, D. Taber², K. Guo³, S. Brietigam³, j. charette³, S. Kurian⁴, M. Abecassis³, J. Friedewald³

5:30pm-7:30pm: Subtyping Of Histologically Stable Kidney Transplants In Molecular Meta-analysis

D. Rychkov¹, T. Sigdel², J. Liberto², M. Sarwal², M. Sirota³

5:30pm-7:30pm: Surveillance Biopsy Utilization Reported Higher In Transplant Centers Performing Over 100 Kidney Transplants Per Year.

D. M. Lee¹, R. First¹, S. Rose¹, M. Abecassis²

5:30pm-7:30pm: Symptom Burden after Living Donor Kidney Transplant Measured with the Functional Assessment of Cancer Therapy – Kidney Symptom Index is Associated with Worse Transplant Outcomes

J. Peipert, J. Caicedo-Ramirez, K. Ensor, J. Friedewald, M. Abecassis, D. Cella, D. Ladner, Z. Butt

5:30pm-7:30pm: The Combination of 3-Month Estimated Glomerular Filtration Rate and Proteinuria is a Valuable Tool for Evaluating Long-Term Kidney Graft Survival

C. Mottola¹, N. Girerd², K. Duarte³, A. Aarnink⁴, M. Kessler⁵, L. Frimat⁶, S. Girerd⁶

5:30pm-7:30pm: The Polish Troubled Kidney Transplant Biopsy Study: External Validation of the Molecular Microscope System

M. Myślak¹, D. Deborska-Materkowska², M. Ciszek², J. Mazurkiewicz¹, A. Debska-Slizien³, P. F. Halloran⁴, A. Perkowska-Ptasińska⁵

5:30pm-7:30pm: Transcriptional Changes in PBMC Associated with Development of Infection and Rejection in Older and Younger Kidney Transplant Recipients

J. Schaenman¹, M. Rossetti², E. Liang¹, O. E. Beaird¹, S. Bunnapradist³, E. F. Reed², S. Cole⁴

5:30pm-7:30pm: Transcriptome Profiling Of Renal Transplant Biopsies With Acute Cellular Rejection From Patients On Calcineurin Inhibitor-based Or Cni-avoidance Immunosuppression

D. Dobi¹, F. Vincenti², Z. G. Laszik¹

5:30pm-7:30pm: Urinary Biomarkers- CXCL9 and CXCL10 for Non-Invasive, Early Diagnosis of Rejection in Pediatric Renal Transplantation

R. P. George¹, B. Hanberry², I. Dave², B. Lee², R. Garro¹, C. McCracken², B. Warshaw¹

5:30pm-7:30pm: Urinary Exosomal microRNA as a Non-Invasive Biomarker for the Diagnosis of Acute Rejection in Kidney Transplant Recipients

J. Seo¹, Y. Lee¹, S. Jung¹, Y. Kim¹, J. Moon¹, K. Jeong¹, C. Kim², J. Park³, B. Chung⁴, Y. Kim⁵, S. Lee¹

5:30pm-7:30pm: Urine Uromodulin Associates with Deceased Donor Acute Kidney Injury and Allograft Failure

S. G. Mansour¹, I. Hall², P. Reese³, T. Ashkar⁴, Y. Jia⁴, H. Thiessen-Philbrook⁴, M. Doshi⁵, C. R. Parikh⁴

5:30pm-7:30pm: Use Of Perirenal Adipose Tissue As A Source Of Donor Cells Allowing Evaluation Of Endothelial Inflammation And Quality Of Expanded Criteria Kidneys

R. Boissier¹, L. Lyonnet², P. Francois³, M. Meunier⁴, B. Gondran-Tellier⁵, T. Legris⁶, J. Magalon⁵, C. Picard⁷, F. Dignat George⁵, E. Lechevallier⁸, G. Karsenty⁸, F. Sabatier⁹, P. Paul¹

5:30pm-7:30pm: Using Multidimensional Quality of Life Measurement to Better Understand the Benefit of Living Donor Kidney Transplant

J. Peipert, J. Caicedo-Ramirez, K. Ensor, J. Friedewald, M. Abecassis, D. Cella, Z. Butt, D. Ladner

5:30pm-7:30pm: Utility of AlloSure Monitoring in Simultaneous Kidney and Pancreas Recipients

J. A. Klein, A. Gupta, P. Budhiraja, D. Cibrik

5:30pm-7:30pm: Utilizing Imagestream Technology to Determine Hepatocellular CD38 Localization

Y. Lee, J. Kim, B. F. Reader, C. Akateh, K. R. Maynard, K. W. Washburn, J. L. Zweier, B. A. Whitson, S. M. Black

5:30pm-7:30pm: Whole-Exome Sequencing Identifies PMS1 and DYRK1A Genes Contributing to Occurrence of Liver Cancer

Y. Zhao, B. Yang, D. Chen, L. Wei, Z. Chen

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