2022 American Transplant Congress » Biomarkers: Clinical Outcomes

Date: Tuesday, June 7, 2022

Time: 7:00pm-8:00pm

Location: Hynes Halls C & D

Session Type: Poster Abstract

Meeting: 2022 American Transplant Congress

7:00pm-8:00pm: A Novel Approach to Non-Invasive Multimodality Testing with Allosure and Allomap Predicts Microvascular Inflammation with High Accuracy in Kidney Transplant Recipients

S. Parajuli, F. Aziz, N. Garg, S. E. Panzer, K. Van Hyfte, K. Degner, S. Reese, L. Ptak, N. Wilson, A. Djamali

7:00pm-8:00pm: A Novel Mismatch That Modulates the Innate Alloresponse Risk Stratifies Renal Transplant Patients

H. Dai, K. Abou Daya, M. Oberbarnscheidt, R. Mehta, C. Macedo, D. Metes, Q. Xu, A. Zeevi, P. Randhawa, F. Lakkis, A. Cherukuri

7:00pm-8:00pm: A Novel, High Throughput Droplet Digital PCR-Based Indel Quantification Method for the Detection of Circulating Donor-Derived Cell-Free DNA After Kidney Transplantation

J. G. Verhoeven¹, K. Boer¹, A. M. Peeters¹, M. C. Clahsen-van Groningen², J. I. Roodnat¹, J. van de Wetering¹, D. Nieboer³, D. A. Bost⁴, C. C. Baan¹, D. A. Hesselink¹

7:00pm-8:00pm: A Three-gene Peripheral Blood Potential Diagnosis Signature Associated With Autophagy For Antibody-mediated Rejection In Renal Transplantation

Y. Wang, Y. Xu, H. Zhang, X. Hu

7:00pm-8:00pm: Acute Tubular Injury and Necrosis Do Not Lead to Meaningful Elevations in Donor-Derived Cell-Free DNA (dd-cfDNA)

S. R. Allam¹, M. Cooper², D. Kumar³, T. Maw⁴, A. Wiseman⁵, P. Chuang⁶, G. Shekhtman⁷, N. Agrawal⁷, J. Zeng⁷, E. Huang⁸

7:00pm-8:00pm: Analysis of Sars-Cov-2-Specific T-Cell Responses Using Novel Single-Cell Multiplexed Isolight in Covid-19 Convalescents

Y. Sambandam¹, J. He¹, N. Vanderhyde², L. Gallon¹, J. Leventhal¹, J. Mathew¹

7:00pm-8:00pm: Analytical Evaluation and Comparison to STR of an Accurate and Sensitive Microchimerism Monitoring Tool for Liver Transplant Recipients

A. S. Kothari¹, C. Egidio¹, J. Miles², N. Gulbahce¹, S. Dholakia³, M. Grskovic⁴

7:00pm-8:00pm: Antibody Response and Molecular Graft Surveillance in Kidney Transplant Recipients Following Sars-CoV-2 Vaccination

N. M. Ali¹, J. Miles², S. Mehta¹, V. Tatapudi¹, Z. Stewart¹, B. Lonze¹, M. Mangiola¹, C. DiMaggio¹, E. Weldon¹, I. Saeed¹, J. Leonard¹, R. Herati¹, J. Thomas¹, J. Michael¹, C. Hickson¹, K. Cartiera¹, R. Montgomery¹

7:00pm-8:00pm: Association of Pre-Transplant Anti A1 IgM Antibody Titers with Survival Outcomes in A2/A2B to B Kidney Transplantation

M. Fallahzadeh, D. Shaffer, A. El Chediak, I. Feurer, S. Rega, J. L. Triozzi, S. Shawar

7:00pm-8:00pm: Baseline Levels and Early Post-Transplant Kinetics of Donor-Derived Cell-Free DNA Following Liver Transplantation

S. Florman¹, D. Axelrod², J. Miles³, E. Vaskova³, D. Kilam³, K. Dhanireddy⁴, V. Subramanian⁴

7:00pm-8:00pm: Clinical Utility of Donor-Derived Cell-Free DNA During the Period of Recovery of Renal Function After Kidney Transplantation

Y. C. Dreige¹, G. Bittencourt Pereira Lima¹, M. Cristelli¹, M. Nakamura¹, R. D. Foresto¹, P. Pierry¹, R. Ponsirenas², J. Levi¹, J. Medina¹, H. Tedesco¹

7:00pm-8:00pm: Comparative Analysis of kSORT Assay for Predicting Acute Renal Allograft Rejection Under Belatacept-Based Immunosuppression

H. Hames¹, M. Sarwal², I. Damm², E. Yanqui¹, A. Burg¹, A. Christianson¹, A. R. Shields¹, D. Hildeman¹, R. R. Alloway¹, E. S. Woodle¹

7:00pm-8:00pm: DCD and AKI Kidneys Experiencing DGF as a Platform for the Study of Adaptive Repair

B. Bussolati¹, S. Da Sacco², A. Asthana³, L. N. Byers³, L. Perin⁴, M. S. Garner³, B. Sharda³, A. C. Farney³, C. J. Jay³, R. J. Stratta³, S. J. Walker⁵, G. Orlando³

7:00pm-8:00pm: Delta Changes in Donor-Derived Cell-Free DNA (dd-cfDNA) Complement the Donor Fraction in Kidney Transplant Surveillance

A. Wiseman¹, M. Jagadeesan², G. Gupta³, V. Rao⁴, M. Narayanan⁵, N. Agrawal⁶, G. Shekhtman⁶, Y. Fu⁶, K. Pinney⁶, S. Anand⁷

7:00pm-8:00pm: Detection of Early Graft Injury After Liver Transplantation with Blood-Bile Ratio of Tacrolimus: The TUBE Trial

M. M. Pascale¹, G. Bianco¹, L. Ferri¹, F. Giovinazzo¹, A. Liguori², G. Marrone², A. Grieco², S. Agnes¹

7:00pm-8:00pm: Diagnosis of Acute Graft Rejection After Kidney Transplantation Using Metabolome Analysis by Liquid Biopsy Approach

H. Iwamoto¹, O. Konno¹, Y. Kihara¹, M. Okihara¹, I. Akashi¹, T. Ueno¹, M. Sugimoto²

7:00pm-8:00pm: Differential Impact of Subclinical Kidney Transplant Rejection in Young Adults

S. Raza¹, G. Agarwal¹, H. Fatima¹, R. Gaston¹, V. Hauptfeld-Dolesjek¹, B. Julian¹, C. Kew¹, V. Kumar¹, S. Mehta¹, S. Ong¹, F. Rosenblum¹, G. Towns¹, R. Mannon², M. Seifert¹

7:00pm-8:00pm: Do Early Trends of Donor-Derived Cell Free DNA Predict Long Term Kidney Allograft Outcomes?

S. Park¹, K. Guo², L. Zhao², C. Rebello², J. Friedewald²

7:00pm-8:00pm: Donor-Derived Cell-Free DNA Trends Before and After Rejection Vary Based on Timing of Rejection

C. Rebello¹, K. Guo¹, S. Park², B. Kinsella¹, L. Zhao¹, J. Friedewald¹

7:00pm-8:00pm: Donor-Derived Cell-Free DNA and Gene Expression Profiling for Surveillance of Renal Allograft Injury and Rejection

A. N. Carrier, A. Crane, M. Pinedo, A. Bartosic, A. Haririan, J. R. Scalea, M. R. Weir, J. S. Bromberg

7:00pm-8:00pm: Donor/Recipient Variabilities and Dd-cfdna Level

I. Gani¹, L. Mulloy¹, R. Mallavarapu¹, M. Saeed¹, R. Kapoor², A. Mirza¹

7:00pm-8:00pm: Elevated Donor-Derived Cell-Free DNA (dd-cfDNA) in the Early Post-Transplant Period is Associated with an Increased Incidence of Adverse Clinical Outcomes in Kidney Transplant Recipients

D. Wojciechowski¹, A. Patel², S. Anand³, J. Klein⁴, A. Paramesh⁵, P. Sood⁶, G. Shekhtman⁷, N. Agrawal⁷, M. Fei⁷, K. Qu⁷, D. C. Brennan⁸

7:00pm-8:00pm: Evaluating Long Term Outcomes in Kidney Transplant Patients with TruGraf Gene Expression and TRAC Dd-cfdna in the TRULO Study

P. West-Thielke, W. Ally, J. Hickey, L. Stach, J. Fleming, T. Cober, A. Kawano, I. Agboli, C. Miller, J. Holman

7:00pm-8:00pm: Galectin-3 Discriminates Patients with Advanced Cirrhosis and Predicts Post-Liver Transplant Infectious Complications

E. Cervantes-Alvarez¹, M. Vilatobá¹, J. Argemi², N. Limon-de la Rosa¹, O. Mendez-Guerrero¹, C. Huang³, D. Kershenobich¹, R. Bataller⁴, A. Torre⁵, N. Navarro-Alvarez¹

7:00pm-8:00pm: Galectin-3 is Predictive of 30-Day Acute Rejection Following Liver Transplantation

D. Yoeli, T. Ferrell, I. Rodriguez, N. Limon De La Rosa, N. Nakra, Z. Wang, E. Cervantes-Alvarez, R. Choudhury, M. Adams, T. Nydam, E. Pomfret, C. Huang, H. Moore, N. Navarro Alvarez

7:00pm-8:00pm: High TTV Load Before First Vaccine Dose is Associated with Poor Serological Response to Covid-19 Vaccination in Lung Transplant Recipients

C. C. Van Leer Buter¹, R. A. Hoek², E. A. Verschuuren³, R. D. de Vries⁴, D. van Baarle¹, M. van der Heiden¹, H. G. Niesters¹, C. GeurtsvanKessel⁴

7:00pm-8:00pm: Identification Of A Novel Peripheral Blood Six-gene Signature Diagnosing Subclinical Acute Rejection After Renal Transplantation

H. Zhang, Y. Xu, Y. Wang, X. Hu

7:00pm-8:00pm: Impact of Donor Type, Cold Ischemia Time, and Induction Type on Baseline Donor-Derived Cell-Free DNA in Kidney Transplant Recipients

K. K. Sureshkumar¹, A. Grazier², B. Chopra¹

7:00pm-8:00pm: Impact of HMGB-1 SNPs on Comorbidities and Postoperative Complications in Liver Transplant Recipients

N. Tsukiyama¹, Y. Tanaka¹, Y. Imaoka¹, A. Seidakhmetov¹, R. Nakano¹, N. Tanimine¹, D. Marlen¹, M. Ohira², H. Tahara¹, K. Ide¹, H. Ohdan¹

7:00pm-8:00pm: Impact of Sars-CoV-2 Vaccination on Donor-Derived Cell Free DNA Levels in Renal Transplant Recipients

H. Alvarado Verduzco, E. Daniel, D. Kim, A. Hussain, S. Mohan, D. Cohen

7:00pm-8:00pm: Impact of Varying Levels of Normal Range Baseline Donor Derived Cell Free DNA on Medium-Term Outcomes Following Kidney Transplantation

K. K. Sureshkumar¹, A. Grazier², B. Chopra¹

7:00pm-8:00pm: Inflammation After Kidney Transplantation Is Associated With Overall- And Death-censored Graft Loss

T. F. Heldal, T. Jenssen, A. Hartmann, K. Heldal, A. Asberg

7:00pm-8:00pm: Interleukin-31 (IL-31) and Leukemia Inhibitory Factor (LIF) Are Upregulated in Acute Rejection of Kidney Allograft

I. Striz, L. Krupickova, M. Fialova, M. Novotny, E. Cecrdlova, O. Viklicky

7:00pm-8:00pm: Kidney Allograft Injury is Reflected in the DNA Cargo of Urinary Extracellular Vesicles

I. Sedej¹, M. Štalekar², M. Tušek Žnidarič², K. Goričar³, N. Kojc⁴, P. Kogovšek², V. Dolžan³, M. Lenassi³, M. Arnol¹

7:00pm-8:00pm: Kidney Transplant Recipients Not Reaching the Expected Post-Transplant Creatinine Range Most Likely Show Calcineurin-Inhibitor Nephrotoxicity Upon Histology

S. von Moos¹, K. Valkova¹, L. Matter¹, T. F. Müller¹, T. Schachtner²

7:00pm-8:00pm: Kinetics of dd-cfDNA in Kidney Transplant Recipients Following Sars-CoV-2 Vaccination Booster Administration

N. M. Ali¹, S. Mehta¹, V. Tatapudi¹, A. Mattoo¹, I. Soomro¹, J. Benstein¹, H. Neumann¹, F. Zervou¹, J. Miles², R. Montgomery¹

7:00pm-8:00pm: Long Term Longitudinal TTV Measurements in Lung Transplant Recipients

E. Gore¹, C. Rondaan¹, E. A. Verschuuren², L. Gard¹, H. G. Niesters¹, C. van Leer-Buter¹

7:00pm-8:00pm: Month 1 Donor Derived Cell Free DNA Levels Predict Future Kidney Transplant Rejection

B. M. Kinsella¹, K. Guo¹, C. Rebello¹, L. Zhao¹, S. Park², J. Friedewald¹

7:00pm-8:00pm: Mycophenolate Mofetil-Related Diarrhea and Beta-Glucuronidase Activity Following Kidney Transplantation

G. C. Onyeaghala¹, S. Elmer¹, D. Schladt¹, P. Yang¹, M. Wagner², L. Teigen², M. Al-Kofahi², B. Wu², W. Guan², C. Staley², S. Riad², A. Matas³, R. Remmel², W. Oetting², C. R. Dorr¹, P. Jacobson⁴, A. Israni¹

7:00pm-8:00pm: Myeloid Molecular Signature of Ischemia-Reperfusion Injury in Human Liver Transplantation

R. A. Sosa¹, R. Ahn², A. Terry¹, Z. Qian², F. Li¹, S. Sen¹, T. Ito³, B. V. Naini¹, F. Kaldas³, A. Hoffmann², R. W. Busuttil³, D. W. Gjertson¹, J. Kupiec-Weglinski³, E. F. Reed¹

7:00pm-8:00pm: Novel Peripheral Molecular Markers Predict Premature Graft Loss: Lessons Learned from Operational Tolerance Assessment

O. Viklicky¹, A. Le², J. Klema², E. Girmanova³, P. Mrazova³, A. Massart⁴, D. Abramowitz⁴, M. Abramowicz⁴, P. Hruba³

7:00pm-8:00pm: PCR-Enhanced Performance Characteristics of TruGraf Gene Expression Profile in Kidney Transplant

P. West-Thielke¹, J. Fleming¹, C. Miller¹, N. Grund¹, A. Sutton¹, R. Sinha², M. Miller², S. Kleiboeker², J. Weems³

7:00pm-8:00pm: Peripheral Blood Immune Cell Profiles of Corneal Transplant with and without Acute Rejection

J. Hjortdal¹, M. Griffin², C. C. Murphy³, S. Brouard⁴, N. Degauque⁴

7:00pm-8:00pm: Plasma Donor-Derived Cell-Free DNA Longitudinal Kinetics After Kidney Transplantation in Children

R. Dandamudi¹, S. Federman², R. Woodward², S. Dholakia², L. Walther¹, V. Dharnidharka¹

7:00pm-8:00pm: Plasma Galectin-3 is Predictive of Post-Transplant Infection in Pediatric Liver Transplant Recipients

D. Yoeli, A. Chaidez, Y. Luo, J. Huang, N. Limon De La Rosa, N. Nakra, Z. Wang, E. Cervantes-Alvarez, M. Adams, C. Mack, C. Huang, N. Navarro-Alvarez

7:00pm-8:00pm: Post-Operative Day 1 Galectin-3 is Predictive of Early Allograft Dysfunction in Liver Transplantation

D. Yoeli, T. Ferrell, I. Rodriguez, N. Limon De La Rosa, N. Nakra, Z. Wang, E. Cervantes-Alvarez, R. Choudhury, M. Adams, T. Nydam, E. Pomfret, C. Huang, N. Navarro Alvarez, H. Moore

7:00pm-8:00pm: Prospective Evaluation of Donor-Derived Cell-Free DNA (dd-cfDNA) in Monitoring Response to Anti-Rejection Treatment in Kidney Transplant Recipients with Indication Biopsy

L. Benning¹, A. Fink², F. Kälble¹, C. Speer¹, C. Nusshag¹, M. Zeier¹, C. Süsal³, C. Morath¹, T. Tran²

7:00pm-8:00pm: RBBP7 as a Novel Biomarker for the Molecular Diagnosis of BK Virus-Associated Nephropathy

W. Yicun, W. Yuxuan, H. Xiaopeng

7:00pm-8:00pm: Re-Examining the Optimal Threshold for Donor Derived Cell Free DNA in Renal Allograft Rejection

H. Murad¹, M. Merzkani¹, M. Ji¹, S. Chang¹, A. Malone¹, R. Delos Santos¹, T. Alhamad²

7:00pm-8:00pm: Significance of Gene Polymorphism on Infectious Complications and Rejection After Liver Transplantation

H. Egawa¹, T. Kato¹, Y. Kotera¹, Y. Hirata¹, S. Yamashita¹, S. Ariizumi¹, T. Ishizuka¹, Y. Tanaka², H. Ohdan³

7:00pm-8:00pm: Single Cell Transcriptomics Reveal Allograft Immune Cell Patterns Associated with Histological Features of Acute Cellular Rejection in Liver Transplantation

L. Tran¹, A. Zahorchak¹, C. Macedo¹, T. Tabib², F. Lakkis³, A. Humar¹, D. Metes¹, A. Thomson¹

7:00pm-8:00pm: Single Center Early Experience with Urinary Multi Biomarker – Qsant

Y. A. Qazi, W. Mon, C. Choi, M. Smogorzewski

7:00pm-8:00pm: Single-cell Transcriptomic Analysis Of Peripheral Blood Reveals The Disparate Subsets Of Innate Immune Cells In Kidney Transplant Recipient With BK Virus Infection

H. BAE¹, J. Ryu², J. Jang¹, J. Lee¹, G. Ko¹, H. PARK¹, E. Oh³

7:00pm-8:00pm: Technology-Driven Performance Improvement of a Biomarker Panel in Kidney Transplant: OmniGraf

P. West-Thielke, C. Miller, N. Grund, A. Sutton, R. Sinha, M. Miller, S. Kleiboeker, J. Weems

7:00pm-8:00pm: The Effect of Tacrolimus and Mycophenolic Acid on Torque Teno Virus Loads in Kidney Transplant Recipients

A. van Rijn, S. Meziyerh, D. van der Helm, T. van Gelder, A. Kroes, J. de Fijter, D. Moes, J. Rotmans, A. de Vries, M. Feltkamp

7:00pm-8:00pm: The Evolution of Hypogammaglobulinemia in Kidney Transplant Recipients and Its Associated Risk Factors

E. Jo¹, S. Min², A. Han³

7:00pm-8:00pm: The Prediction of Renal Allograft Rejection by Time-Dependent Two-Signature Predictors

M. Liao¹, Q. Fu², L. Wei³, H. Yang³, G. Zhao³, S. Deng³, J. F. Markmann²

7:00pm-8:00pm: The Role Of Combined Gene Expression Profiling And Donor-derived Cell-free Dna In Differentiating Acute Rejection In Liver Transplant Recipients

S. Park¹, M. Kandpal², K. Guo², S. Kleiboeker³, R. Sinha⁴, M. Abecassis⁵, J. Levitsky⁶

7:00pm-8:00pm: Trends in Donor Derived Cell Free DNA Before and After Cellular and Antibody Mediated Rejection

K. Guo¹, J. Friedewald¹, C. Rebello¹, B. Kinsella¹, S. Park², L. Zhao¹

7:00pm-8:00pm: Utility of Donor Derived Cell-Free DNA in Liver Transplantation

A. Zarrinpar, D. Lewis, C. Warren, S. Duarte

7:00pm-8:00pm: Validation of Trugraf Gene Expression Profile in a Multicenter Cohort (TOGETHER Study)

M. Mai¹, W. Park², R. Heilman³, B. Smith², R. First⁴, J. Fleming⁴, P. West-Thielke⁴, J. Holman⁴, M. Stegall²

7:00pm-8:00pm: Variability of Serum Klotho and FGF-23 Levels During the First Two Years After Kidney Transplantation

T. Vazquez-Sanchez¹, M. Sanchez-Niño², P. Ruiz-Esteban¹, V. López¹, J. Delgado¹, A. Ortiz³, D. Hernández¹

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