Am J Transplant, Volume 5, Suppl 3 Archives - Page 55 of 170 - ATC Abstracts

2015 American Transplant Congress
Induction With ATG Is Not Associated With Increased Infections After Kidney Transplant Among HIV Positive Patients: Results of a National Study
L. Kucirka,¹ C. Durand,¹ S. Bae,¹ J. Locke,² D. Segev.¹
¹JHU, Baltimore; ²UAB, Birmingham.
Anti-thymocyte globulin (ATG) is widely used for induction, particularly for those at high risk for rejection. HIV+ kidney transplant (KT) recipients have 3 fold higher…
2015 American Transplant Congress
The Use of Eculizumab to Treat the Highly Sensitized Patient Awaiting Heart Transplant
J. Patel, D. Dilibero, M. Kittleson, S. Sana, F. Liou, D. Chang, A. Hage, L. Czer, A. Trento, N. Reinsmoen, J. Kobashigawa.
Cedars-Sinai Heart Institute, Los Angeles, CA.
Purpose: Highly sensitized patients (pts) awaiting heart transplantation remain a significant challenge due to prolonged often prohibitive wait times for suitable organs and increased rejection…
2015 American Transplant Congress
Kidney Double Negative TCR αβ + Cells: Newly Described Intra-Renal Kidney Lymphocytes That Respond to Ischemia Reperfusion in Mice
M. Martina,¹ S. Bandapalle,² S. Noel,² A. Saxena,¹ A. Hamad,¹ H. Rabb.²
¹Pathology, Johns Hopkins University, Baltimore, MD; ²Medicine, Johns Hopkins University, Baltimore, MD.
Background TCRαβ+CD4-CD8- double negative (DN) T cells with immunoregulatory function are a significant component of T cells residing in the kidney. The exact role of…
2015 American Transplant Congress
Metrics of Global Health Status Signal Early Hospital Readmission Risk After Kidney Transplantation
M. Harhay,¹ A. Hill,² W. Wang,² O. Even-Shoshan,² A. Mussell,¹ J. Karlawish,³ R. Bloom,¹ H. Feldman,¹ J. Silber,² P. Reese.¹
¹Medicine, Division of Nephrology, University of Pennsylvania, Philadelphia, PA; ²Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA; ³Medicine, Division of Geriatrics, University of Pennsylvania, Philadelphia, PA.
Background: Early (≤30 days) hospital readmission (EHR) after kidney transplantation (KT) is common, with diverse causes that likely include poor pre-KT health status. Transplant providers…
2015 American Transplant Congress
Hydrogen Sulfide Restores Protective Capacity of University of Wisconsin Solution During Normothermic Preservation
J. Grewal,¹ I. Lobb,¹ M. Whiteman,³ A. Sener.^1,2
¹Microbiology & Immunology, University of Western Ontario, London, ON, Canada; ²Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; ³Experimental Therapeutics, University of Exeter Medical School, Exeter, England, United Kingdom.
Organ preservation solution is crucial in mitigating effects of ischemia reperfusion injury (IRI) associated with transplantation. Although University of Wisconsin (UW) solution is ideally suited…
2015 American Transplant Congress
A Common Gene Signature Across Multiple Studies Identifies Biomarkers and Functional Regulation in Tolerance to Renal Allograft
D. Baron,^1,2,3 G. Ramstein,⁴ M. Chesneau,^1,2,3 Y. Echasseriau,^1,2,3 A. Pallier,^1,2,3 C. Paul,^1,2,3 N. Degauque,^1,2,3 M. Hernandez-Fuentes,⁵ A. Sanchez-Fueyo,⁶ K. Newell,⁷ M. Giral,^1,2,3 J.-P. Soulillou,^1,2,3 R. Houlgatte,^8,9 S. Brouard.^1,2,3
¹UMR 1064 - CRTI, INSERM, Nantes, Loire Atlantique (44), France; ²ITUN, CHU de Nantes, Nantes, Loire Atlantique (44), France; ³Faculté de Médecine, Université de Nantes, Nantes, Loire Atlantique (44), France; ⁴UMR 6241 - LINA, Université de Nantes, Nantes, Loire Atlantique (44), France; ⁵MRC Centre for Transplantation, King's College London, London, United Kingdom; ⁶Institute of Liver Studies, King's College Hospital, London, United Kingdom; ⁷Department of Surgery, Emory University, Atlanta, GA; ⁸U954 - LNGERE, INSERM, Nancy, France; ⁹DRCI, CHU de Nancy, Nancy, France.
Patients tolerant to a kidney graft display a specific blood transcriptional pattern but reported results from five distinct studies hardly overlapped, raising the question of…
2015 American Transplant Congress
TIM-4 Identifies IL-17 Expressing Pro-Inflammatory Be-17 Cells That Promote Allograft Rejection
Q. Ding, K. Mohib, D. Rothstein.
Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA.
We identified TIM-1 as an inclusive marker for IL-10+ regulatory B cells (TIM-1+ Bregs), which prolong islet allograft survival (GS). We recently found that TIM-4,…
2015 American Transplant Congress
Socioeconomic Status of Local Vs Exported Liver Recipients and Their Donors
J. Adler,¹ J. Hyder,² J. Markmann,¹ H. Yeh.¹
¹Massachusetts General Hospital, Boston, MA; ²Mayo Clinic, Rochester, MN.
INTRODUCTION: Broader sharing has been proposed as a solution to decrease geographic disparities in liver transplantation, with the hope that this will also neutralize the…
2015 American Transplant Congress
Regulatory T Cells Expanded by Activated iNKT Cells Facilitate Migration of Donor Dendritic Cells Into the Recipient Thymus and Subsequent Establishment of Clonal Deletion
T. Hirai,¹ R. Shibahara,¹ S. Miyairi,¹ M. Ikemiyagi,¹ K. Omoto,¹ Y. Ishii,² K. Tanabe.¹
¹Department of Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Laboratory for Vaccine Design, RINEK Center for IMS, Yokohama, Japan.
We previously reported that combination therapy using liposomal α-galactosylceramide (lipo-αGC) and anti-CD154 mAb could expand regulatory T cells (Tregs) in vivo through activation of the…
2015 American Transplant Congress
Risk of Cause-Specific ESRD in Live Kidney Donors
S. Anjum, A. Muzaale, A. Massie, S. Bae, D. Segev.
Johns Hopkins, Baltimore.
The purpose of this study is to investigate the risk of developing cause-specific ESRD in live kidney donors over time.METHODS: We studied a cohort of…