ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    Effect of Donor Age On Pancreas Transplantation Outcome

    A. Rathnasamy Muthusamy,1 G. Vrakas,1 S. Mittal,1 S. Reddy,1 I. Quiroga,1 J. Gilbert,1 R. Ploeg,2 E. Sharples,1 S. Sinha,1 A. Vaidya,1 P. Friend.2

    1Transplant Surgery, Churchill Hospital, Oxford, United Kingdom; 2Nuffield Department of Surgery, University of Oxford, Oxford, United Kingdom.

    The global increase in the average donor age over the last decade has resulted in widespread acceptance of pancreases from older donors for transplantation. This…
  • 2015 American Transplant Congress

    Endovascular Salvage of a Pancreas Allograft Having Developed a Large AV Fistula and Aneurysm

    N. Katariya,1 R. Batra,1 A. Moss,1 K. Reddy,1 A. Mathur,1 E. Huettl,2 S. Naidu,2 A. Singer.1

    1Surgery, Mayo Clinic, Phoenix, AZ; 2Radiology, Mayo Clinic, Phoenix, AZ.

    We present an unusual case of a late, large pancreas allograft arteriovenous fistula and aneurysm rescued from threatened rupture or need for transplant pancreatectomy by…
  • 2015 American Transplant Congress

    Application of the Clavien Classification of Surgical Complications to Robotic Kidney Transplantation

    R. Garcia Roca, C. Martinez Parra, I. Tzvetanov, H. Jeon, E. Benedetti, J. Oberholzer.

    Surgery, Transplant Division, University of Illinois Hospital and Health Sciences, Chicago, IL.

    INTRODUCTIONThe Clavien-Dindo Classification of complications after a surgical procedure is an objective measure of outcomes and serves as a comparison tool to evaluate procedure safety…
  • 2015 American Transplant Congress

    DNA Methylation of the IFNγ Promoter in CD8+ T Cell Subsets Is Modulated by CMV Infection but not by Alloreactivity in Kidney Transplantation Patients

    K. Boer,1 E. de Wit,1 L. Hofland,2 M. Betjes,1 C. Baan.1

    1Internal Medicine - Nephrology and Transplantation, Erasmus University Medical Center, Rotterdam, Netherlands; 2Internal Medicine - Endocrinology, Erasmus University Medical Center, Rotterdam, Netherlands.

    Introduction DNA methylation plays a critical role in the function of cells, including cells of the immune system. Little is known about the methylation status…
  • 2015 American Transplant Congress

    Frequencies of CD4+25hiFoxp3+ T Cells in Long-Term Follow-Up of Sirolimus-Converted Kidney Transplant Recipients

    O. Traitanon,1,2 A. Alvarado,1 E. Tantisattamo,1,2 A. Shetty,1,2 M. Ansari,1,2 J. Mathew,1 J. Leventhal,1 V. Mas,3 L. Gallon.1,2

    1Comprehensive Transplant Center, Northwestern University, Chicago, IL; 2Medicine-Nephrology, Northwestern University, Chicago, IL; 3Surgery, University of Virginia, Charlottesville, VA.

    Background: Tacrolimus(TAC) and Sirolimus(SRL) are commonly used immunosuppressive drugs in kidney transplantation. SRL has been shown to induce the expansion of regulatory T cells in…
  • 2015 American Transplant Congress

    Development and Validation of a Genotype Guided Tacrolimus Dosing Equation for African American (AA) Kidney Transplant Recipients

    K. Sanghavi,1 R. Brundage,1 M. Miller,2 D. Schaldt,3 A. Israni,3 W. Guan,4 W. Oetting,1 R. Mannon,5 R. Remmel,1 A. Matas,6 P. Jacobson.1

    1College of Pharmacy, University of MN, Minneapolis, MN; 2Dept of Psychology, University of MN, Minneapolis, MN; 3Minneapolis Medical Research Foundation, Hennepin County Medical Center, Minneapolis, MN; 4Dept of Biostatistics, University of MN, Minneapolis, MN; 5Dept of Nephrology, University of AL, Birmingham, AL; 6Dept of Surgery, University of MN, Minneapolis, MN.

    Tacrolimus (tac) has a strong exposure-response relationship with high inter-individual variability in troughs and dose. Tac dose requirements for AA patients are higher than Caucasians,…
  • 2015 American Transplant Congress

    CMV prevalence in Mauritian and Indonesian Cynomolgus Macaques: Significance in Transplantation and CMV Disease Models

    K. Premanand,1 E. Szilagyi,1 J. Yu,1 R. Patel,1 A. Antony,1 M. Willman,2 D. Berman-Weinberg,2 D. Han,2 A. Vaidya,3 E. Silva,3 K. McHenry,3 D. Salomon,4 N. Kenyon,2 A. Bartholomew.1

    1University of Illinois, Chicago; 2Univerisity of Miami, Miami; 3University of Illinois, Urbana; 4Scripps, San Diego.

    Despite the finding that most macaques express high serologic titers of anti-CMV antibody, susceptibility to disease appears to be variable post-transplant. This observation led us…
  • 2015 American Transplant Congress

    T Cell Specific Up Regulation of Nrf2 Regulated Antioxidant Response Protects from Kidney Ischemia Reperfusion Injury in Mice

    S. Noel,1 M. Martina,2 S. Bandapalle,1 S. Reddy,3 L. Racusen,2 A. Hamad,2 H. Rabb.1

    1Department of Medicine, Johns Hopkins University, Baltimore, MD; 2Department of Pathology, Johns Hopkins University, Baltimore, MD; 3Department of Pediatrics, University of Illinois, Chicago, IL.

    Background: T lymphocytes mediate important pathophysiological roles during ischemia reperfusion injury (IRI). Transcription factor Nrf2 is protective during experimental kidney IRI and thought to be…
  • 2015 American Transplant Congress

    Cross-Linking of MHC Class I Induces Unique Transcriptional Profiles Associated With Regulation of Both T and B Cells That Precedes Induction of Allo- and Auto-Immunity Leading to Obliterative Airway Disease

    D. Nayak, M. Sharma, Z. Xu, A. Gelman, T. Mohanakumar.

    Surgery, Washington Univ Sch of Med, St. Louis, MO.

    Background: Incidences of chronic rejection, bronchiolitis obliterans syndrome (BOS), remain a major challenge to lung transplantation and development of allo- and auto-immunity has been proposed…
  • 2015 American Transplant Congress

    Pregnancy After Renal Transplantation: Unfavorable Outcomes in Sensitized Patients

    M. Ajaimy, M. Lubetzky, L. Kamal, G. De Bocardo, E. Akalin.

    Einstein/Montefiore Transplant Center, Bronx.

    Background: The objective of our study was to describe pregnancy and allograft outcomes in sensitized kidney recipients in a predominantly Hispanic and African-American population.Methods: This…
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