2015 American Transplant Congress
Activation of FXR Protects Against Liver Ischemia and Reperfusion Injury (IRI) in Mice Via the PI 3-Kinase/Akt (PI3K/Akt) Pathway
Background: FXR is a ligand-dependent transcription factor belonging to the nuclear hormone receptor superfamily, which plays important roles in lipid metabolism, glucose homeostasis, inflammatory responses…2015 American Transplant Congress
CD52-Negative NK Cells Are Abundant in the Liver and Less Susceptible to Alemtuzumab Treatment
Background: T-cell depleting strategies have become an integral part of immunosuppressive regimens in organ transplantation. Alemtuzumab is a humanized monoclonal antibody against CD52, a cell-surface…2015 American Transplant Congress
Plasma 4β-Hydroxycholesterol Measurement as a Potential Biomarker for CYP3A5 Activity in Informing Tacrolimus Dosing
Background—Recently, 4β-hydroxycholesterol (4β-OHC) has been shown to be an endogenous marker of P450 3A activity in clinical practice (Diczfalusy et al, 2011). 4β-OHC concentration increases…2015 American Transplant Congress
"What's the Mileage?" Determining the Length of Time in Which Renal Function Returns to Pre-Calcineurin Discontinuation Levels in Patients With Interstitial Fibrosis
The Ohio State University, Columbus.
Calcineurin Inhibitors (CNI) use may be associated with progressive renal dysfunction. Clinical trials have shown that CNI minimization or discontinuation may aid in improvement in…2015 American Transplant Congress
Reduction of Tacrolimus With Everolimus Addition in Maintenance Immunosuppression Improves Calcineurin Inhibitor-Induced Arteriolopathy in Kidney Allografts
Objectives: Although conversion of calcineurin inhibitor (CNI)-based immunosuppression to everolimus (EVR) has been shown to improve graft function, no histopathological evidence has been reported. The…2015 American Transplant Congress
Vitamin D Supplementation and Acute Rejection Following Kidney Transplantation
1Barnes-Jewish Hospital, St. Louis, MO; 2Washington University in St. Louis, St. Louis, MO.
Purpose: Low serum levels of vitamin D have been associated with deleterious effects post-transplantation, including increased risk of rejection. Low serum vitamin D levels are…2015 American Transplant Congress
Characteristics and Outcomes of Patients With Incidental Hepatocellular Carcinoma Detected in the Explanted Liver Following Transplant
Introduction: Despite pre-operative cross-sectional imaging, incidental hepatocellular carcinoma (iHCC) is sometimes diagnosed upon histological examination of the liver explant following transplantation for another indication. Whilst…2015 American Transplant Congress
Health Utilities in Pediatric Liver Transplant Recipients
Pediatrics, Northwestern U, Chicago.
Health Utilities (HU) are preference based measures of health states required for cost effectiveness studies. We measured HU and health related quality of life (HRQOL)…2015 American Transplant Congress
Home Dried Blood Spot Monitoring; a New Tool for Measuring Variability in Tacrolimus Blood Levels Over Time
Oregon Health & Science University, Portland, OR.
PURPOSE: The measurement of variability in Tacrolimus (TAC) blood trough levels has been proposed to reflect the consistency with medication intake and adherence. A standard…2015 American Transplant Congress
Identification of CXCR5+EBV-Specific CD8+ T Cells in Peripheral Blood of Pediatric Heart Transplant Recipients Correlates With IL-21 Production and EBV Reactivation
Approximately 70% of EBV asymptomatic pediatric heart transplant (HTx) recipients carry chronic EBV loads in peripheral blood. These EBV loads may occur due to impaired…
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