Am J Transplant, Volume 5, Suppl 3 Archives - Page 18 of 170 - ATC Abstracts

2015 American Transplant Congress
CD27^low NK Cells Prolong Allograft Survival in Mice By Inhibiting CD8⁺ T Cell Responses Through Controlling Graft-Derived Donor DCs
A. Kroemer,^1,2 M. Lantow,¹ E. Eggenhofer,¹ M. Sabet-Baktach,¹ P. Renner,¹ H. Schlitt,¹ E. Geissler.¹
¹Department of Surgery, University Hospital Regensburg, Regensburg, Germany; ²Georgetown Transplant Institute, Washington, DC.
The underlying mechanisms by which distinct NK cell subsets promote either allograft rejection or survival remain unclear. Here, we tested the hypothesis that distinctively mature…
2015 American Transplant Congress
Anti-Donor T-Cell Immunity Is a Continuum Immune Process Favouring Subclinical Rejection After Kidney Transplantation
E. Crespo,¹ M. Lucia,¹ J. Cruzado,^1,2 S. Luque,¹ E. Melilli,² A. Manonelles,^1,2 N. Sala,² J. Grinyó,^1,2 O. Bestard.^1,2
¹Experimental Nephrology Laboratory, IDIBELL, Barcelona, Spain; ²Nephrology Department and Renal Transplant Unit, Bellvitge University Hospital, Barcelona, Spain.
Subclinical T-cell mediated rejection (sc-TCR) accounts for a major cause of kidney allograft loss and is unexpectedly found in a rather important number of protocol…
2015 American Transplant Congress
Interim Safety Experience in Transplant Patients Treated With Belatacept (Nulojix) in the Post-Approval Setting
T. Kou, J. Braga, S. Sibabrata, J. Preston, M. Harler, A. Gomez.
Bristol-Myers Squibb Company, Princeton, NJ.
Purpose: Belatacept is a selective T-cell costimulation blocker indicated for prophylaxis of organ rejection in adult patients receiving a kidney transplant in combination with basiliximab…
2015 American Transplant Congress
Outcomes of Live Kidney Donors Who Develop End Stage Renal Disease
A. Muzaale, A. Massie, L. Kucirka, D. Segev.
Johns Hopkins, Baltimore.
Kidney donors can develop ESRD after donation, but the outcomes of those who do remain poorly characterized.Methods: Using USRDS and SRTR data, we compared access…
2015 American Transplant Congress
MELD/PELD 35+ Candidates Benefit from Regional Sharing
E. Edwards,¹ A. Harper,¹ R. Hirose,² D. Mulligan.³
¹Research, UNOS, Richmond, VA; ²Divsion of Transplant, UCSF Medical Center, San Francisco, CA; ³Department of Surgery, Yale New Haven Hospital, New Haven, CT.
Background: Based on a proposal from the Liver and Intestinal Organ Transplantation Committee, the OPTN implemented regional sharing for MELD/PELD 35+ candidates on June 18,…
2015 American Transplant Congress
Psychiatric Recommendations for Patients Pursing Kidney Transplantation
M. Jesse, A. Eshelman, T. Rosetti, M. Abouljoud, J. Denny, A. Patel, D. Kim.
Transplant Institute, Henry Ford Health System, Detroit, MI.
Introduction: End-stage renal disease patients have high rates of psychiatric and cognitive pathologies. Despite this, renal transplant candidates do not routinely undergo comprehensive psychiatric evaluation.…
2015 American Transplant Congress
Belatacept-Treated Patients Had Better Graft Survival at 7-Years Post-Transplant Compared With Cyclosporine-Treated Patients: Final Results from BENEFIT
F. Vincenti,¹ J. Grinyó,² L. Rostaing,³ K. Rice,⁴ S. Steinberg,⁵ M. Moal,⁶ M. Polinsky,⁷ U. Meier-Kriesche,⁷ C. Larsen.⁸
¹Univ of Calif, San Francisco; ²Univ Hosp Bellvitge, Barcelona, Spain; ³Univ Hosp and INSERM U563,IFR-BMT, Toulouse, France; ⁴Baylor Univ Med Ctr, Dallas; ⁵Sharp Memorial Hosp, San Diego; ⁶Hôp de La Cavale Blanche, Brest, France; ⁷BMS, Lawrenceville; ⁸Emory Univ Transpl Ctr, Atlanta.
Background: At 3yrs, improvement in renal function was seen in kidney transplant recipients treated with belatacept (bela) vs cyclosporine (CsA) in BENEFIT. Here we report…
2015 American Transplant Congress
Epigenetic Reprogramming of Murine Cytomegalovirus Immediate Early Genes Induced By Renal Transplantation
M. Hummel,¹ X.-F. Liu,¹ C. Jie,¹ Z. Zhang,¹ S. Yan,¹ J.-J. Wang,¹ S. Kurian,² D. Salomon,² M. Abecassis.¹
¹Comprehensive Transplant Center, Northwestern University, Chicago, IL; ²Dept of Molecular and Experimental Medicine, The Scripps Research Institute, LaJolla, CA.
Background: Reactivation of latent CMV is a significant infectious complication in solid organ transplant recipients. MCMV is a valuable model for studying molecular mechanisms controlling…
2015 American Transplant Congress
Correlates of Clinical Course of Polyomavirus BK Infection With Long-Term Outcome of BK Virus-Associated Nephropathy in Renal Transplant Patients
G. Huang, C.-X. Wang, J.-G. Fei, J. Qiu, S.-X. Deng, J. Li, G.-D. Chen, Q. Fu, R.-H. Deng, L.-Z. Chen.
Department of Organ Transplantation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Background: Identification of risk factors for the long-term outcome of BK virus (BKV) -associated nephropathy(BKVAN) may improve renal transplant outcome. Methods: Between 2006 and 2014,…
2015 American Transplant Congress
Histologic Findings in Pre-transplant AT1Rab + ve Patients Point to an Increase in Sub-Intimal Fibrosis During Acute Rejection and in 12 mo. Protocol Renal Graft Biopsies
A. González-Almada, J. Arreola-Guerra, E. Cuevas, M. Vilatoba, A. Contreras, A. Sanchez-Cedillo, J. Alberu, N. Uribe-Uribe.
1Transplantation, 1aNephrology-Mineral Metabolism, 1bPathology, Inst Nal de Ciencias Medicas y Nutricion SZ, Mexico City, Distrito Federal, Mexico.
Previous reports have described an increase in arteritis during acute rejection (AR) in angiotensin II type 1 receptor antibody (AT1Rab) positive (ve+) kidney transplant recipients…