Am J Transplant, Volume 5, Suppl 3 Archives - Page 18 of 170 - ATC Abstracts

2015 American Transplant Congress
Change in Physical Function Following Kidney Transplantation
E. Lorenz, A. Cheville, B. Kotajarvi, F. Cosio, N. LeBrasseur.
Mayo Clinic, Rochester, MN.
Introduction: Improved physical function is associated with increased survival in the general population. Little is known about whether physical function improves following kidney transplant. The…
2015 American Transplant Congress
Differences in Reactivity of HLA-Specific Antibodies May Be Explained By Differences in Their Affinities for Selected Epitopes on HLA Proteins
S. Daga,^1,2 D. Lowe,⁶ R. Buchli,⁵ J. Collard,⁵ A. Mulder,⁸ C. McMurtrey,^4,5 H. Moyse,⁷ N. Evans,⁷ N. Krishnan,² W. Hildebrand,^4,5 F. Claas,⁸ D. Briggs,³ D. Zehnder,^1,2 D. Mitchell,¹ R. Higgins.^1,2
¹Clinical Sciences Research Laboratories, University of Warwick, Coventry, United Kingdom; ²Renal Unit, University Hospital, Coventry and Warwickshire NHS Trust, Coventry, United Kingdom; ³Department of Histocompatibility and Immunogenetics, NHS Blood and Transplant, Birmingham, United Kingdom; ⁴University of Oklahoma Health Science Center, Oklahoma City; ⁵Pure Protein LLC, Oklahoma City; ⁶Department of Histocompatibility and Immunogenetics, Royal Liverpool University Hospital, Liverpool, United Kingdom; ⁷School of Engineering, University of Warwick, Coventry, United Kingdom; ⁸Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands.
Affinity of IgG immunoglobulins for antigen varies and matures within the evolution of immune responses. Affinity is likely to be different for different epitope-antibody interactions…
2015 American Transplant Congress
Gene Expression of Kidney Biopsies Reveals Common Mechanisms of Rejection and a Cluster of Co-Expressed Genes Predictive of Long-term Outcomes
B. Modena,¹ S. Kurian,¹ J. Friedewald,² F. Harrison,¹ T. Gelbart,¹ S. Head,¹ M. Abecassis,² D. Salomon.¹
¹The Scripps Research Institute, La Jolla; ²Northwestern University, Chicago.
Purpose: Acute rejection (AR) still affects 8-14% of kidney transplants and rates of 10-year graft loss remain unchanged in part due to chronic rejection (CR).…
2015 American Transplant Congress
The Role of Skin-Specific Immunobiology and Major Histocompatibility Complex Sharing in Vascularized Composite Allograft Tolerance
D. Leonard, K. Shanmugarajah, H. Powell, A. Albritton, C. Mallard, D. Sachs, C. Cetrulo, Jr., J. Kurtz.
Transplantation Biology Research Center, Massachusetts General Hospital, Boston, MA.
Background: We have developed a reproducible model for induction of tolerance of all components of VCAs across haploidentical MHC barriers in miniature swine. The purpose…
2015 American Transplant Congress
Immunomodulatory Strategies Directed Towards Tolerance of Vascularized Composite Allografts
M. Madariaga, K. Shanmugarajah, S. Michel, V. Villani, G. La Muraglia II, R. Torabi, D. Leonard, M. Randolph, R. Colvin, K. Yamada, J. Madsen, C. Cetrulo, Jr., D. Sachs.
Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Background: Achieving tolerance of vascularized composite allografts (VCAs) would improve the risk-to-benefit ratio in patients who undergo this life-enhancing transplant. Kidney co-transplantation along with a…
2015 American Transplant Congress
Tissue Engineering Human Kidneys for Costimulation Blockade
L. Brasile,¹ N. Henry,¹ A. Meyer,¹ B. Stubenitsky.²
¹BREONICS, Inc., Watervliet, NY; ²Surgery, University of Utrecht, Utrecht, Netherlands.
Methods for preserving organs have employed hypothermic conditions. At these temperatures metabolism is 4% of normal. Tissue engineering of organs cannot be done without significant…
2015 American Transplant Congress
B-Cell Activation in Acute Kidney Injury and Delayed Graft Function
M. Schiffer,¹ F. Wiehler,¹ R. Song,¹ R. Chen,¹ L. Schiffer,¹ M. Mengel,² H. Haller,¹ F. Gueler.¹
¹Nephrology, Hannover Medical School, Hannover, Germany; ²Pathology, University of Alberta, Edmonton, Canada.
Background:Acute kidney injury (AKI) is a relevant complication after kidney transplantation and also after non-renal solid organ transplantation. Growing evidence points towards an important role…
2015 American Transplant Congress
Lessons Learned from the Clinical Use of Normothermic Regional Perfusion (nRP) in Uncontrolled Donation After Circulatory Death (DCD)
C. Antoine,¹ E. Savoye,¹ F. Gaudez,² G. Cheisson,³ M. Videcoq,⁴ B. Barrou,⁵ National Steering Committee of Donation After Circulatory Death.¹
¹Medical and Scientific Department, Agence de la Biomedecine, LA Plaine Saint Denis, Saint Denis, France; ²Department of Urology, Saint Louis Hospital, Paris, France; ³Department of Anesthesia and Critical Care, Bicetre Hospital, Kremlin Bicetre, Val de Marne, France; ⁴Department of Transplantation, Edouard Herriot Hospital Group, Lyon, Rhones Alpes, France; ⁵Department of Anesthesia and Critical Care, Hôtel-Dieu Hospital, Nantes, Pays de la Loire, France; ⁶Department of Urology, University Hospital La Pitie, Paris, France.
The national protocol for the uDCD program restricts donor age < 55 y, no flow period < 30 min and total warm ischemia time (WIT)…
2015 American Transplant Congress
Evolution of GFR Outcomes During the First Year of Transplant According to the Kidney Donor Risk Index Transplantation in México. The Experience of a Single Center
J. Aguilar-Frasco, J. Arreola-Guerra, L. Paláu, V. Visag, M. Vilatobá, A. Contreras, A. Sanchez, J. Alberu.
Transplantation, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", México, DF, Mexico.
Several scoring systems have been proposed to evaluate the quality of kidneys from deceased donors (DD). Recently, Kidney Donor Risk Index (KDRI) was introduced in…
2015 American Transplant Congress
No Pharmacokinetic Interaction Between Pantoprazole and Mycophenolic Acid in Renal Transplant Patents: A Randomized Crossover Study
O. Rissling, P. Glander, P. Hambach, M. Mai, S. Brakemeier, D. Klonower, F. Halleck, E. Singer, E. Schrezenmeier, M. Duerr, H. Neumayer, K. Budde.
Department of Nephrology, Charité University Hospital, Berlin, Germany.
Mycophenolic acid (MPA) is used as an immunosuppressive agent in renal transplant (tx) patients (pts). 2 formulations are on the market: The prodrug Mycophenolate-Mofetil (MMF)…