Am J Transplant, Volume 5, Suppl 3 Archives - Page 163 of 170 - ATC Abstracts

2015 American Transplant Congress
Differences in Genetic Variants That Influence Long-Term Graft Function Between Pancreas Transplant Donors and Recipients
M. Simmonds,¹ C. Duff,¹ A. Hamilton,¹ S. Mittal,^2,3,4 M. Barnardo,^2,3 S. Fuggle,^2,3 P. Friend,^2,3 S. Gough.^1,4
¹Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford, United Kingdom; ²Oxford Transplant Centre, Oxford University Hospitals NHS Trust, Oxford, United Kingdom; ³Nufﬁeld Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; ⁴Oxford National Institute for Health Research Biomedical Research Centre, Oxford, United Kingdom.
Genetic variation in caveolin-1, involved in signal transduction and tissue fibrosis, within pancreas transplant donors has been previously shown to correlate with decreased long-term graft…
2015 American Transplant Congress
Emotional Bonding in Recipients of Deceased Donor Kidney Transplants (DDRT): Associated Factors and Effect on Medication Adherence
A. Cerrato, M. Salifu, M. Markell.
Division of Nephrology, SUNY Downstate Medical Center, Brooklyn, NY.
The feelings of the kidney recipient towards his or her donor are complex and may affect behavior in the post-transplant period. We studied 152 DDRT…
2015 American Transplant Congress
Hypothermic Machine Perfusion Improves Kidney Viability through Amelioration of Vasospasm and Edema of Podocytes and Renal Tubular Epithelial Cells
Z. Zhong,¹ Z. Liu,¹ Z. Fu,² Y. Zhang,² D. Ko,³ Y. Wang,¹ Q. Ye.^1,2
¹Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, China; ²The 3rd Xiangya Hospital of Central South University, Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology, Changsha, Hunan, China; ³Massachusetts General Hospital, Department of Urology, Boston, MA.
Hypothermic machine perfusion (MP) may improve outcome after transplantation from donors after cardiac death (DCD) kidneys, but protective mechanisms of MP remain largely unknown. To…
2015 American Transplant Congress
Regional Mismatch Between Liver Supply and Demand: An Argument for a More Open Market
J. Lai, S. Sen, J. Dodge, H. Hayssen, J. Roberts.
UCSF, San Francisco, CA.
Background: Geographic disparities in liver transplantation (LT) are well recognized. But the degree to which regional variation in deceased donor deficits contributes to wait-list mortality…
2015 American Transplant Congress
Adherence Time-Profiles of Renal Transplant Patients During the Three First Years Post-Transplantation
C. Villeneuve,^1,2,3 C. Monchaud,^1,2,3 M. Essig,^2,4 M.-L. Laroche,^1,3 A. Coubret,¹ I. Lacroix,⁵ S. Bouchet,^6,7,8 D. Fruit,^1,2,3 P. Merville,⁹ N. Kamar,^10,11,12 P. Marquet,^1,2,3 A. Rousseau.^2,13
¹Pharmacology, Toxicology and Pharmacovigilance, CHU Limoges, Limoges, France; ²UMR-850, INSERM, Limoges, France; ³Laboratory of Pharmacology, Univ Limoges, Limoges, France; ⁴Nephrology, Dialysis and Transplantation, CHU Limoges, Limoges, France; ⁵Laboratory of Clinical Pharmacology, CHU Toulouse, Toulouse, France; ⁶UMR-876, INSERM, Bordeaux, France; ⁷Clinical Pharmacology, Toxicology, CHU Bordeaux, CHU Bordeaux, France; ⁸University Victor Ségalen Bordeaux 2, Bordeaux, France; ⁹Department of Nephrology, CHU Bordeaux, CHU Bordeaux, France; ¹⁰Department of Nephrology and Organ Transplantation, CHU Toulouse, Toulouse, France; ¹¹Univ Toulouse, Toulouse, France; ¹²UMR-1043, IFR-BMT, INSERM, Toulouse, France; ¹³Biophysics, Faculty of Pharmacy, Limoges, France.
Non-adherence to immunosuppressants (IS) has been reported to increase morbidity and mortality of transplant patients.Our objective was to investigate adherence to IS in renal transplant…
2015 American Transplant Congress
ASKP1240 in De Novo Kidney Transplant Recipients
R. Harland,¹ G. Klintmalm,² H. Yang,³ S. Jensik,⁴ T. Shah,⁵ P. West-Thielke,⁶ F. Shihab,⁷ W. Zhang,⁸ V. Santos,⁸ R. Tainaka,⁸ X. Wang,⁸ R. First,⁸ J. Holman.⁸
¹East Carolina University, Greenville, NC; ²Baylor University Medical Center, Dallas, TX; ³Pinnacle Health System, Harrisburg, PA; ⁴Rush University, Chicago, IL; ⁵Transplant Research Institute, Los Angeles, CA; ⁶University of Illinois Chicago, Chicago, IL; ⁷University of Utah Health Science Center, Salt Lake City, UT; ⁸Astellas Pharma Global Development, Northbrook, IL.
Primary objective was to evaluate the efficacy and safety of ASKP1240, antagonistic anti-CD40 antibody, in either a CNI free regimen or a CNI minimization regimen…
2015 American Transplant Congress
Depression of Complement Regulatory Factors in Human and Rat Renal Grafts in Association With Progress of Acute Cellular Rejection
K. Yamanaka,^１ T. Kato,^１ Y. Kakuta,¹ T. Abe,¹ R. Imamura,¹ A. Maeda,² S. Miyagawa,² N. Nonomura.¹
¹Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; ²Organ Transplantation, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Introduction and ObjectiveIt is commonly known that complements play important roles in antibody mediated rejection in renal transplantation. However, the association of complements with progression…
2015 American Transplant Congress
Plasmapheresis – A Previously Unrecognised Risk Factor for BK Viraemia
E. Olayos,¹ K. Barraclough,² R. Walker,³ R. Masterson,² H. Peter,² C. Solomon.⁴
¹St Vincents Hospital, Fitroy, Victoria, Australia; ²Nephrology, Royal Melbourne Hospital, Parkville, Victoria, Australia; ³Nephrology, The Alfred Hospital, Prahran, Victoria, Australia; ⁴Nephrology, Western Hospital, Footscray, Victoria, Australia.
BK nephropathy is an important preventable cause of graft loss, with the only universally accepted risk factor being overall burden of immunosuppression. In the absence…
2015 American Transplant Congress
Differential Intragraft Gene Expression Profiles in Patients With Sterile Leukocyturia
M. Ajaimy,¹ P. O Broin,² Y. Bao,¹ J. Lindower,¹ A. Golden,² E. Akalin.¹
¹Transplantation, Einstein/Montefiore Transplant Center, Bronx; ²Computational Genomics Facility, Albert/Einstein College of Medicine, Bronx.
Objective: We aimed to investigate if sterile leukocyturia reflects increased intragraft immune activity and gene expression profiles of transplant kidney biopsies differ from patients without…
2015 American Transplant Congress
Speed of Onset of Donor Brain Death Leads to Differences in Renal Function and Expression of Inflammatory and Oxidative Stress Markers in Rat Kidneys
D. Hoeksma,¹ R. Rebolledo,² M. Hottenrott,³ Y. Bodar,¹ H. Leuvenink.¹
¹Abdominal Surgery, University Medical Center Groningen, Groningen, Netherlands; ²Faculty of Medicine, University of Chile, Santiago, Chile; ³Cardiothoracic Surgery, University Medical Center Groningen, Groningen, Netherlands.
IntroductionDonor brain death (BD) is an independent risk factor for primary and delayed renal graft function. Furthermore, the speed of onset of brain death, traumatic…