Am J Transplant, Volume 5, Suppl 3 Archives - Page 162 of 170 - ATC Abstracts

2015 American Transplant Congress
Distinctive Roles of mTORC1 Vs. mTORC2 in Liver Ischemia-Reperfusion Injury
H. Zhou,^1,2 J. Zhu,^1,3 S. Yue,¹ M. Zhang,³ R. Busuttil,¹ Q. Xia,³ J. Kupiec-Weglinski,¹ Y. Zhai.¹
¹The Dumont-UCLA Transplant Center, UCLA, Los Angeles; ²Liver Transplant Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China; ³Liver Surgery, Renji Hospital, Shanghai Jiaotong University, Shanghai, China.
Mammalian target of rapamycin (mTOR) exists in two complexes to regulate diverse biological processes. Although mTOR complex 1, the canonical target of rapamycin, has been…
2015 American Transplant Congress
Treatment of Hepatitis C Virus in Kidney Transplant Recipients With Direct Acting Anti-Viral Agents: Early Results in 12 Cases
A. Sharfuddin,¹ T. Taber,¹ M. Mujtaba,¹ M. Yaqub,¹ D. Mishler,¹ P. Kwo,² R. Vuppalanchi.²
¹Medicine/Nephrology, Indiana University, Indianapolis; ²Medicine/Hepatology, Indiana University, Indianapolis.
Background: Recently approved direct acting antiviral agents (DAA) for treatment of HCV are interferon sparing allowing an attractive treatment option for kidney transplant recipient with…
2015 American Transplant Congress
Complement Inhibition Via the Lectin Pathway Improves Experimental Cardiac Graft Survival
J. Kindermann,^1,2 M. Waechter,^1,2 R. Bruno,¹ M. Langenmayer,³ T. Dudler,⁴ W. Schwaeble,⁵ E. Kleinert,¹ T. Mayr,^1,2 H. Christian,² R. Wanke,³ J.-M. Abicht,⁶ S. Guethoff.¹
¹Transregio Collaborative Research Center 127, Ludwig-Maximilians University, Munich, Germany; ²Department of Cardiac Surgery, Ludwig-Maximilians University, Munich, Germany; ³Institute of Veterinary Pathology, Ludwig-Maximilians University, Munich, Germany; ⁴Omeros Corporation, Seattle, WA; ⁵Department of Infection, Immunity, and Inflammation, Leicester University, Leicester, United Kingdom; ⁶Department of Anaesthesiology, Ludwig-Maximilians University, Munich, Germany.
Purpose: While complement activation via both the classical as well as the lectin pathway is believed to contribute to allograft loss, their relative contribution is…
2015 American Transplant Congress
Evaluation of Leflunomide for the Treatment of BK Viremia and Biopsy Proven BK Nephropathy: A Single Center Experience
N. Nesselhauf,¹ J. Strutt,² B. Bastani.¹
¹Saint Louis University Hospital, St. Louis, MO; ²Minneapolis VA Health Care System, Minneapolis, MN.
Purpose:The objective was to evaluate the use of leflunomide in BK viremia (BKV) and biopsy proven BK nephropathy (BKN) in kidney and kidney-pancreas transplant recipients.Methods:We…
2015 American Transplant Congress
A Relative Survival Model to Compare the Risk of Mortality in Patients Awaiting Kidney Transplantation Versus Already Transplanted Patients
M. Lorent,^1,2 K. Trébern-Launay,^2,1 C. Legendre,⁴ H. Kreis,⁴ G. Mourad,⁵ V. Garrigue,⁵ L. Rostaing,⁶ N. Kamar,⁶ M. Kessler,⁷ M. Ladrière,⁷ E. Morelon,⁸ F. Buron,⁸ M. Giral,^2,3 Y. Foucher.^1,2
¹EA 4275 - SPHERE bioStatistics, Pharmacoepidemiology and Human Sciences Research, Nantes University, Nantes, France; ²Institut de Transplantation, Urologie, Néphrologie (ITUN), Inserm U1064, CHU de Nantes, Nantes, France; ³CIC Biotherapy, CHU Nantes, Nantes, France; ⁴Service de Transplantation Rénale et de Soins Intensifs, Hôpital Necker, APHP Paris, Paris, France; ⁵Service de Néphrologie-Transplantation, Hôpital Lapeyronie, Montpellier, France; ⁶Service de Néphrologie, HTA, Dialyse et Transplantation d'Organes, CHU Rangueil, Toulouse, France; ⁷Service de Transplantation Rénale, CHU Brabois, Nancy, France; ⁸Service de Néphrologie, Transplantation et Immunologie Clinique, Hôpital Edouard Herriot, Lyon, France.
Introduction: It would be useful for physicians in some specific cases to identify whom patients could not benefit of kidney transplantations.Patients and method: To answer…
2015 American Transplant Congress
Is Organ Transplantation from Trypanosoma cruzi-Infected Donors Safe? An Autopsy-Based Study of Parasite Persistence in Chronic Chagasic Patients
L. Benvenuti, A. Roggério.
Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.
Introduction: Chagas' disease, endemic in Latin America, is caused by infection with the protozoan Trypanosoma cruzi. The disease can affect the heart and/or the gastrointestinal…
2015 American Transplant Congress
A Prospective Pilot Study Evaluating the Safety and Efficacy of Everolimus for the Prevention of CMV and BK Viral Infection (BKV) in Broadly Sensitized Kidney Transplant Recipients Following Desensitization With IVIG and Rituximab: Interim Analysis
J. Kahwaji,¹ S. Louie,¹ A. Vo,¹ J. Choi,¹ M. Toyoda,² S. Ge,² P. Wongsaroj,¹ A. Peng,¹ R. Villicana,¹ S. Jordan.¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ²Transplant Immunology Lab, Cedars-Sinai Medical Center, Los Angeles, CA.
Introduction: Everolimus, a second generation mTOR inhibitor, may prevent CMV and BKV infection after kidney transplantation. Broadly sensitized patients are at greater risk of viral…
2015 American Transplant Congress
Outcomes of Eculizumab (ANTI-C5) Therapy for Treatment of Refractory Antiobdy-Mediated Rejection (ABMR) and Thrombotic Microangiopathy (TMA)
P. Wongsaroj,¹ J. Choi,¹ A. Vo,¹ J. Kahwaji,¹ A. Peng,¹ R. Villicana,¹ M. Haas,² S. Jordan.¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ²Pathology, Cedars-Sinai Medical Center, Los Angeles, CA.
Introduction: ABMR results from DSA binding to donor endothelium initiating the classical complement pathway. This results in the formation of terminal MAC (C5b-C9) complex and…
2015 American Transplant Congress
De Novo Donor-Specific HLA Antibodies After Kidney Transplantation Are Associated With Donation After Circulatory Death and HLA-DQ Mismatch
G. Dreyer,¹ D. Roelen,² S. Brand-Schaaf,² O. Dekkers,³ M. Reinders,¹ F. Claas,² J. de Fijter.¹
¹Nephrologie, LUMC, Leiden, Netherlands; ²Immunohaematology and Blood Transfusion, LUMC, Leiden, Netherlands; ³Clinical Epidemiology, Aarhus Medical Center, Aarhus C, Denmark.
Introduction: De novo donor-specific HLA-antibodies (dnDSA) have been associated with rejection and inferior kidney graft survival. The purpose of this study was to investigate the…
2015 American Transplant Congress
Association of De Novo Antibody-Mediated Rejection and Increased Hospital Costs Following Kidney Transplant in Immunologically Low-Risk Patients
S. Kulkarni,¹ I. Hall.²
¹Section of Organ Transplantation & Immunology, Yale University, New Haven, CT; ²Section of Nephrology, Yale University, New Haven, CT.
While antibody-mediated rejection (AMR) is likely the primary cause of kidney transplant (KTx) failure, and its treatment can be considered expensive, incremental center costs for…