2015 American Transplant Congress
Lymphotoxin Controls Treg Interactions With Lymphatic Endothelial Cells and Interstitial Migration In Vivo
University of Maryland, Baltimore, MD.
Introduction: Lymphotoxin (LT) coordinates the development, organization and structure of lymphoid organs, and LTβreceptor (LTβR) is involved in thymocyte migration. However, LT has no described…2015 American Transplant Congress
Protecting Older Patients from Dialysis: The Survival Benefit of Preemptive Transplant With High KDPI Allografts
BACKGROUND: Mortality on dialysis remain markedly elevated in patients over 60 years old. Preemptive kidney transplantation (PreKT) represents a means of avoiding the risks of…2015 American Transplant Congress
Induction of a Costimulation-Susceptible Repertoire: A Case for Depletional Prior to Belatacept
1Surgery, Duke University, Durham, NC; 2Transplant Center, Emory University, Atlanta, GA.
Belatacept offers highly specific costimulation blockade to prevent recipient alloimmune responses with reduced toxicity. However, when applied with nondepletional induction therapy belatacept-based regimens have higher…2015 American Transplant Congress
Defining the Role of CD57+CD4 T Cells in Belatacept-Resistant Rejection
1Duke University, Durham, NC; 2Emory University, Atlanta, GA; 3Bristol-Myers Squibb, Princeton, NJ.
Purpose: We have shown that CD57+PD1- CD4 T cells are present in higher numbers in the peripheral blood and allograft biopsies of patients who experienced…2015 American Transplant Congress
Erythropoietin (EPO) Has Treg Sparing Immunosuppressive Effects On Human Alloreactive T Cells
Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY.
Extending previous work showing that EPO inhibits alloreactive effector T cell proliferation by uncoupling IL2 receptor signaling (JASN 2014), we tested the effects of EPO…2015 American Transplant Congress
Glomerular Disease (GD) After Kidney Transplant (KTx): Etiologies, Risk Factors and Consequences
1Nephrology, Mayo Clinic, Rochester, MN; 2Pathology, Mayo Clinic, Rochester, MN.
Introduction. Recipients who develop KTx GD may have reduced function and higher risk of graft loss. Using protocol and clinical biopsies we sought to determine…2015 American Transplant Congress
The C1q-Binding Assays and Clinical Outcomes in Kidney Transplantation
Background: Contradictory conclusions have emerged from clinical trials when testing the predictive value of C1q-binding donor-specific HLA-antibodies (HLA-DSA). The aim of this study was to…2015 American Transplant Congress
A Randomized Study Comparing Parathyroidectomy Versus Cinacalcet to Treat Hypercalcemia in Kidney Allograft Recipients With Persistent Hyperparathyroidism
Purpose: Cinacalcet corrects hypercalcemia and hypophosphatemia in patients with persistent hyperparathyroidism (HPT) after kidney transplantation (KT). This study (NCT011178450) was designed to evaluate whether subtotal…2015 American Transplant Congress
Donor-Derived Tumor Transmission Events. A Summary of 2008-2013 Data from the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC)
Purpose: Transmission of donor malignancy via transplantation is an uncommon but significant occurrence. The OPTN Disease Transmission Advisory Committee (DTAC) has monitored such complications since…2015 American Transplant Congress
Chimeric Thymus Versus Antigen Presenting Thymus for the Induction of Tolerance: Donor DCs in Vascularized Thymus Grafts Play an Essential Role in the Induction of Tolerance
We have demonstrated that thymus plays an important role in transplantation tolerance in MHC inbred large animals. We have established a technique of isolated vascularized…
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