2015 American Transplant Congress
Damage Associated Molecular Patterns (DAMPs)-Activated Neutrophil Extracellular Trap Formation Exacerbates Liver Ischemia/Reperfusion Injury
Department of Surgery, University of Pittsburgh, Pittsburgh, PA.
Liver ischemia/reperfusion (I/R) injury is a clinically important phenomenon encountered during transplantation that contributes to initial graft function and subsequent allograft rejection. Formation of neutrophil…2015 American Transplant Congress
Non-Invasive Immune Monitoring Assay in Transplant Recipients
A reliable non-invasive assay of immune responsiveness would help to predict the development of chronic rejection, stable function or tolerance in transplant recipients. Our aim…2015 American Transplant Congress
Low Molecular Weight Hyaluronan Increases MIG and MCP-1 Production in Cardiac Allografts
1Immunology, Cleveland Clinic, Cleveland, OH; 2Pathobiology, Cleveland Clinic, Cleveland, OH.
Macrophages engage in extracellular matrix remodeling both degrading and synthesizing hyaluronan. Hyaluronan is a high molecular weight ( > 1000 kDa) extracellular matrix component that…2015 American Transplant Congress
Once-a-Day Administration of CNIs, mTOR and MMF Is Safe in De Novo Renal Transplant Recipients: 1-Year Results of a Pilot Study
Surgery - Renal Transplant Unit, Catholic University of the Sacred Heart, Rome, Italy.
Introduction. The half-lives of Tacrolimus, Everolimus, Cyclosporine and Mofetil Micofenolate (MMF) are respectively: 43, 30, 27 and 18 hours. Once-daily dosing of these drugs is…2015 American Transplant Congress
Acute Kidney Injury in the MELD Era of Liver Transplantation. Are Calcineurin Inhibitors So Problematic for Renal Function?
Acute kidney injury(AKI)after liver transplantation (LT) is common.Calcineurin inhibitors(CNI)have to be well-balanced.The aims were analyze the specific effect of CNI on AKI in a cohort…2015 American Transplant Congress
Intrapatient Variability of Tacrolimus Blood Concentrations Following Renal Transplant – Acute Rejection or No Connection?
Background: A high degree of intrapatient variability (IPV) of tacrolimus blood concentrations has been associated with poor long-term outcome (1). Periods of under-exposure with increased…2015 American Transplant Congress
Listing for Liver Transplantation of Patients With Hepatocellular Carcinoma Using the Extended Toronto Criteria; an Intention-to-Treat Analysis
Multi-Organ Transplant, Toronto General Hospital. University of Toronto, Toronto, ON, Canada.
The role of liver transplantation for patients whose HCC exceeds Milan criteria remains controversial. At the University of Toronto, we have reported survivals of a…2015 American Transplant Congress
An Analysis of Health-Related Quality of Life in Liver Transplantion for Hepatocellular Carcinoma
Vanderbilt Transplant Center, Vanderbilt University Medical Center, Nashville, TN.
Background:There is a disproportionate waiting time and an unclear survival benefit between hepatocellular carcinoma (HCC) versus non-HCC liver transplant recipients. However, there is paucity of…2015 American Transplant Congress
Pediatric Liver Transplantation: An Outcome Analysis of a 30-Year Single Center Experience
Introduction: In this study we aim to assess factors influencing long-term patient and graft survival as well as surgical parameters and risk factors influencing organ…2015 American Transplant Congress
Preemptive Rituximab Therapy of Epstein-Barr Virus (EBV) Infection to Prevent Post-Transplant Lymphoproliferative Disease (PTLD) After Pediatric Solid Organ Transplantation (SOT)
Purpose: More than 90% of pediatric PTLD after solid organ transplantation is associated with EBV infection. Reduction in immunosuppression is the first step to prevent…
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