Am J Transplant, Volume 5, Suppl 3 Archives - Page 159 of 170 - ATC Abstracts

2015 American Transplant Congress
The Role of Inflammasome Components in Renal Tubular Epithelial Cell Injury
S. Kasimsetty, A. Shigeoka, D. McKay.
Medicine, UCSD, La Jolla, CA.
Background:Inflammasomes are multiprotein complexes of pattern recognition receptors (PRRs) recognized as key triggers of cellular injury. TLRs provide the first signal for induction of the…
2015 American Transplant Congress
Diabetes Exacerbates Liver Ischemia and Reperfusion Injury By Activating the AGE-RAGE Pathway in Kupffer Cells
S. Yue, J. Zhu, J. Rao, J. Kupiec-Weglinski, R. Busuttil, Y. Zhai.
Surgery, UCLA, Los Angeles, CA.
Although pre-transplant diabetes has been documented as a risk factor for mortality post-liver transplant, the underlying mechanism remains obscure. In a murine liver partial warm…
2015 American Transplant Congress
NK Cells of Kidney Transplant Recipients Show a Reduced Capacity to Produce Cytokines But Retain Their Cytotoxic Capacity
U. Hoffmann,¹ C. Neudoerfl,¹ K. Daemen,¹ J. Keil,¹ C. Blume,^2,3 F. Lehner,⁴ H. Haller,² C. Falk.^1,5
¹Inst. of Transplant Immunology, IFB-Tx, Hanover Medical School, Hanover, Germany; ²Dept. of Nephrology and Hypertension, Hanover Medical School, Hanover, Germany; ³Inst. of Technical Chemistry, Leibniz University Hanover, Hanover, Germany; ⁴Dept. of General, Visceral, and Transplantation Surgery, Hanover Medical School, Hanover, Germany; ⁵German Center for Infection Research, Braunschweig, Germany.
The role of NK cells in either graft rejection or tolerance induction is still discussed controversially. In order to clarify the effect of long-term immunosuppression…
2015 American Transplant Congress
Pharmacokinetics of Everolimus (EVL) in Elderly Recipients Under Low-Tacrolimus(TAC)/Everolimus in the First Year After Renal Transplantation. Data from the NEverOLd Trial
E. David-Neto,¹ P. Romano,² F. Agena,¹ P. Ebner,² A. Triboni,¹ F. Ramos,¹ N. Galante,¹ F. Lemos.¹
¹Renal Transplantation Service, Hospital das Clinicas – University of São Paulo School of Medicine, Sao Paulo, Brazil; ²Division of Central Laboratory, Hospital das Clinicas – University of São Paulo School of Medicine, Sao Paulo, Brazil.
Elderly ( >60 years) recipients are being renal transplanted more frequently. The pharmacokinetics studies (PK) of immunosuppressive drugs in healthy volunteers, rarely, if ever, include…
2015 American Transplant Congress
mTOR-Based CNI Minimization Vs Withdrawal in African American Kidney Transplant Recipients
J. Fleming,¹ D. Taber,² N. Pilch,¹ H. Meadows,¹ C. Mardis,¹ J. McGillicuddy,² S. Nadig,² K. Chavin,² P. Baliga,² C. Bratton.²
¹Pharmacy, Medical University of South Carolina, Charleston, SC; ²Surgery, Medical University of South Carolina, Charleston, SC.
The purpose of this study was to compare mTOR-based CNI withdrawal vs. minimization in African American (AA) kidney transplant (KTx) recipients.METHODS: This was a single-center,…
2015 American Transplant Congress
A Noninvasive Diagnostic Test of Renal Allograft Rejection Using Urinary-Cell mRNA: A Comparison of Droplet Digital and Real-Time PCR
J.-W. Seo, H. Moon, A. Lee, Y.-W. Choi, Y. Kim, J.-Y. Moon, S.-H. Lee.
Division of Nephrology, Department on Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.
Background: The diagnosis of acute rejection in kidney transplantation is still standardized by an invasive renal biopsy. Noninvasive tests and biomarkers that can replace the…
2015 American Transplant Congress
Liver Transplantation for Primary Liver Malignancies Vs. Neuroendocrine Metastases: Analysis of the UNOS Dataset
V. Vilchez,¹ M. Shah,¹ M. Daily,¹ S. Krohmer,² D. Davenport,¹ E. Maynard,¹ R. Gedaly.¹
¹Department of Surgery - Transplant Section, University of Kentucky, Lexington, KY; ²Department of Radiology, University of Kentucky, Lexington, KY.
Objective: To determine outcome in patients undergoing LT for NETs, and compared them with outcomes in patients with primary liver malignancies such as Hepatocellular Carcinoma…
2015 American Transplant Congress
Association Between Polymorphisms of PPM1E Gene and Tumor Size of Hepatocellular Carcinoma Patients
M.-S. Park,¹ S.-K. Kim.²
¹Surgery, Kyung Hee University Hospital, Seoul, Korea; ²Pharmacology, Kyung Hee University, Seoul, Korea.
The protein phosphatase, Mg2+/Mn2+ dependent, 1E (PPM1E) inactivates multiple substrates including 5'-AMP activate protein kinases (AMPK) which inhibits the growth and survival of cancer cells.…
2015 American Transplant Congress
Risk Factors for Graft Loss in Pediatric Renal Transplant Recipients After Transfer of Care
B. Coyne,^1,2 P. Hollen,^1,2 Y. Guofen,³ K. Brayman.⁴
¹Department of Pediatrics, University of Virginia Health System, Charlottesville, VA; ²School of Nursing, University of Virginia, Charlottesville, VA; ³Department of Public Health Sciences, University of Virginia Health System, Charlottesville, VA; ⁴Department of Surgery, University of Virginia Health System, Charlottesville, VA.
Improvements in immunosuppression and transplant surgical technique have increased the survival of children with end-stage renal disease. These patients have complex needs, and the current…
2015 American Transplant Congress
The Impact of Ureteral Complications After Pediatric Renal Transplantation
J. Finkelstein,¹ J. Pak,¹ N. Jain,¹ P. Sandoval,² S. Alam.¹
¹Pediatric Urology/Nephrology, Morgan Stanley Children's Hospital, New York, NY; ²Surgery, Columbia University College of Physicians & Surgeons, New York, NY.
Introduction: The incidence of acute renal allograft rejection has declined with advances in immunosuppression, making the evaluation of other risk factors for graft failure vital.…