Session Time: 5:30pm-6:30pm
Presentation Time: 5:30pm-6:30pm
Location: Exhibit Hall E
Background: To study the impact on renal function and histological changes in patients(pts) with acute clinical rejection(ACR) and subclinical rejection(SCR) from 3 to 12 month(m) post-transplant.
Methods: We prospectively followed pts(n=138) for 1 year who had kidney transplant at our center from Jan to Sept 2013. Protocol biopsies were performed at 3 and 12m post-transplant(n=60). The pts were divided into 4 groups(gp) based on 3m protocol biopsies: those with SCR(gp1), without rejection(gp2), with ACR(gp3) and without biopsy(gp4). All rejection pts(n=31) were treated per our center's protocol. Serum creatinine and eGFR were measured at 3, 6 and 12m. Acute and chronic composite scores were calculated for the 3-and-12m biopsies. Data was analyzed using repeat measures ANOVA, T-test and chi-square.
Results: There were no significant differences in baseline demographics and other variables. Renal function was worse at 3 and 6 m post-transplant in pts with ACR but was not different within the pts in each gp. Acute composite scores improved, without statistical significance, from 3 to 12 m in pts with ACR and SCR. There was no significant change in mean chronic composite scores from 3 to 12m in those pts.
|Mean Acute Composite Score(i+t+v+g+PTC+c4d)|
|Mean Chronic Composite Score(ct+cv+ci+cg)|
Conclusion: Diagnosis and treatment of ACR and SCR resulted in stabilization of renal function and prevented progression towards chronicity per renal histological score from 3 to 12m post-transplant.
To cite this abstract in AMA style:Chen S, Mehta R, Sood P, Randhawa P, Shah N, Wu C, Tevar A, Hariharan S. A Prospective Study of Renal Function and Histological Changes in Renal Transplant Recipients With Acute Clinical and Subclinical Rejection [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/a-prospective-study-of-renal-function-and-histological-changes-in-renal-transplant-recipients-with-acute-clinical-and-subclinical-rejection/. Accessed February 28, 2020.
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